C L Cunningham

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Time-dependent negative reinforcement of ethanol intake by alleviation of acute withdrawal
    Christopher L Cunningham
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239, USA
    Biol Psychiatry 73:249-55. 2013
  2. ncbi request reprint Spatial location is critical for conditioning place preference with visual but not tactile stimuli
    Christopher L Cunningham
    Department of Behavioral Neuroscience L470, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Behav Neurosci 120:1115-32. 2006
  3. ncbi request reprint Injection timing determines whether intragastric ethanol produces conditioned place preference or aversion in mice
    Christopher L Cunningham
    Department of Behavioral Neuroscience and Portland Alcohol Research Center L470, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97201 3098, USA
    Pharmacol Biochem Behav 72:659-68. 2002
  4. ncbi request reprint Distal and proximal pre-exposure to ethanol in the place conditioning task: tolerance to aversive effect, sensitization to activating effect, but no change in rewarding effect
    Christopher L Cunningham
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Psychopharmacology (Berl) 160:414-24. 2002
  5. ncbi request reprint Apparatus bias and place conditioning with ethanol in mice
    Christopher L Cunningham
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Psychopharmacology (Berl) 170:409-22. 2003
  6. ncbi request reprint Competition between ethanol-induced reward and aversion in place conditioning
    Christopher L Cunningham
    Department of Behavioral Neurosciences L470, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Learn Behav 31:273-80. 2003
  7. ncbi request reprint Ethanol-induced conditioned place aversion in mice
    C L Cunningham
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, The Oregon Health Sciences University, 97201 3098, USA
    Behav Pharmacol 11:591-602. 2000
  8. ncbi request reprint Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice
    C L Cunningham
    Department of Behavioral Neuroscience, Oregon Health Sciences University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Pharmacol Biochem Behav 67:693-9. 2000
  9. pmc Proximal ethanol pretreatment interferes with acquisition of ethanol-induced conditioned place preference
    Christopher L Cunningham
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Pharmacol Biochem Behav 85:612-9. 2006
  10. ncbi request reprint Genetic differences in cocaine-induced conditioned place preference in mice depend on conditioning trial duration
    C L Cunningham
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    Psychopharmacology (Berl) 146:73-80. 1999

Research Grants

  1. MODULATION OF ALCOHOL REINFORCEMENT
    Christopher Cunningham; Fiscal Year: 1992
  2. Dependence Driven Alterations in Ethanol Reinforcement
    Christopher Cunningham; Fiscal Year: 2007
  3. MODULATION OF ALCOHOL REINFORCEMENT
    Christopher Cunningham; Fiscal Year: 2007
  4. MODULATION OF ALCOHOL REINFORCEMENT
    Christopher L Cunningham; Fiscal Year: 2010

Detail Information

Publications53

  1. pmc Time-dependent negative reinforcement of ethanol intake by alleviation of acute withdrawal
    Christopher L Cunningham
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239, USA
    Biol Psychiatry 73:249-55. 2013
    ..Drinking to alleviate the symptoms of acute withdrawal is included in diagnostic criteria for alcoholism, but the contribution of acute withdrawal relief to high alcohol intake has been difficult to model in animals...
  2. ncbi request reprint Spatial location is critical for conditioning place preference with visual but not tactile stimuli
    Christopher L Cunningham
    Department of Behavioral Neuroscience L470, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Behav Neurosci 120:1115-32. 2006
    ..However, spatial location per se was not an effective CS. These studies suggest that CPP conditioned to tactile cues is mediated by brain systems different from those mediating CPP conditioned to visual-spatial cues...
  3. ncbi request reprint Injection timing determines whether intragastric ethanol produces conditioned place preference or aversion in mice
    Christopher L Cunningham
    Department of Behavioral Neuroscience and Portland Alcohol Research Center L470, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97201 3098, USA
    Pharmacol Biochem Behav 72:659-68. 2002
    ..More specifically, in both cases, CPA can be attributed to an initial, short-lived aversive effect, whereas CPP can be attributed to a delayed rewarding effect of ethanol...
  4. ncbi request reprint Distal and proximal pre-exposure to ethanol in the place conditioning task: tolerance to aversive effect, sensitization to activating effect, but no change in rewarding effect
    Christopher L Cunningham
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Psychopharmacology (Berl) 160:414-24. 2002
    ..However, there are very few demonstrations of either tolerance or sensitization to ethanol's rewarding or reinforcing effects...
  5. ncbi request reprint Apparatus bias and place conditioning with ethanol in mice
    Christopher L Cunningham
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Psychopharmacology (Berl) 170:409-22. 2003
    ..This issue is important because the mechanisms underlying a drug's effect in the place-conditioning procedure may differ depending on whether the apparatus is biased or unbiased...
  6. ncbi request reprint Competition between ethanol-induced reward and aversion in place conditioning
    Christopher L Cunningham
    Department of Behavioral Neurosciences L470, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Learn Behav 31:273-80. 2003
    ....
  7. ncbi request reprint Ethanol-induced conditioned place aversion in mice
    C L Cunningham
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, The Oregon Health Sciences University, 97201 3098, USA
    Behav Pharmacol 11:591-602. 2000
    ....
  8. ncbi request reprint Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice
    C L Cunningham
    Department of Behavioral Neuroscience, Oregon Health Sciences University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Pharmacol Biochem Behav 67:693-9. 2000
    ..Overall, this study strongly supports the conclusion that dopamine D2 receptors normally influence ethanol reward in mice...
  9. pmc Proximal ethanol pretreatment interferes with acquisition of ethanol-induced conditioned place preference
    Christopher L Cunningham
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Pharmacol Biochem Behav 85:612-9. 2006
    ..Thus, one would expect ethanol agonists, when administered in close proximity to CS-ethanol pairings, to interfere with control of ethanol seeking by that CS...
  10. ncbi request reprint Genetic differences in cocaine-induced conditioned place preference in mice depend on conditioning trial duration
    C L Cunningham
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    Psychopharmacology (Berl) 146:73-80. 1999
    ..This finding contrasts with other studies showing greater sensitivity of DBA/2J mice to the rewarding effects of ethanol and morphine in the place conditioning task...
  11. ncbi request reprint Drug-induced conditioned place preference and aversion in mice
    Christopher L Cunningham
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Nat Protoc 1:1662-70. 2006
    ..Potential problems in the design and interpretation of place conditioning studies are discussed. A typical experiment lasts 2 weeks...
  12. ncbi request reprint Rapid induction of Pavlovian approach to an ethanol-paired visual cue in mice
    Christopher L Cunningham
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Psychopharmacology (Berl) 192:231-41. 2007
    ..Although many studies have shown Pavlovian conditioned approach to cues paired with natural reinforcers, it has been quite difficult to induce such behavior with drug reinforcers...
  13. pmc Genetically correlated effects of selective breeding for high and low methamphetamine consumption
    J M Wheeler
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA
    Genes Brain Behav 8:758-71. 2009
    ....
  14. pmc Sensitivity to rewarding or aversive effects of methamphetamine determines methamphetamine intake
    S Shabani
    Department of Behavioral Neuroscience and Methamphetamine Abuse Research Center, Oregon Health and Science University, Portland, OR 97239, USA
    Genes Brain Behav 10:625-36. 2011
    ....
  15. ncbi request reprint Genes on mouse chromosomes 2 and 9 determine variation in ethanol consumption
    T J Phillips
    Veterans Administration Medical Center, R and D 32, 3710 SW US Veterans Hospital Rd, Portland, Oregon 97201, USA
    Mamm Genome 9:936-41. 1998
    ..These data suggest that the determinants of these two measures are genetically diverse, but may share some common genetic elements...
  16. pmc Intragastric self-infusion of ethanol in high- and low-drinking mouse genotypes after passive ethanol exposure
    T L Fidler
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Genes Brain Behav 10:264-75. 2011
    ..Overall, these studies suggest that the IG self-infusion procedure is a potentially useful new tool for studying genetic and environmental influences on excessive ethanol intake and preference in mice...
  17. ncbi request reprint Mapping genes that regulate density of dopamine transporters and correlated behaviors in recombinant inbred mice
    A Janowsky
    Research Service, Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    J Pharmacol Exp Ther 298:634-43. 2001
    ..The results suggest that there is a gene(s) on proximal chromosome 19 that strongly influences DAT expression in neostriatum and may influence psychostimulant-induced activity and thermal responses...
  18. ncbi request reprint Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice
    F O Risinger
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health Sciences University, 97201 3098, USA
    Alcohol Clin Exp Res 22:1234-44. 1998
    ..Some of these genes appear to influence taste sensitivity, whereas others appear to mediate sensitivity to aversive pharmacological effects of ethanol...
  19. ncbi request reprint Intravenous self-administration of ethanol in beta-endorphin-deficient mice
    N J Grahame
    Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, USA
    Alcohol Clin Exp Res 22:1093-8. 1998
    ..These findings may indicate that BE is not essential for the postingestive reinforcing effects of ethanol in these animals...
  20. ncbi request reprint Ethanol-induced conditioned taste aversion in 15 inbred mouse strains
    Julie Broadbent
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, 97201 3098, USA
    Behav Neurosci 116:138-48. 2002
    ..These results do not support the hypothesis that ethanol-induced taste aversion is mediated by the drug's rewarding properties...
  21. ncbi request reprint Effects of maternal strain on ethanol responses in reciprocal F1 C57BL/6J and DBA/2J hybrid mice
    K I Gabriel
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR, USA
    Genes Brain Behav 7:276-87. 2008
    ..The current findings indicate that maternal environment may contribute to variance in EtOH-induced hypothermia and EtOH intake, although effects on EtOH intake appear to be dependent upon the type of EtOH exposure...
  22. pmc Effects of disconnection of amygdala dopamine and nucleus accumbens N-methyl-d-aspartate receptors on ethanol-seeking behavior in mice
    Christina M Gremel
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR, USA
    Eur J Neurosci 31:148-55. 2010
    ..Nevertheless, these findings provide evidence showing that Acb NMDA receptors play an important role in the expression of ethanol-conditioned behavior...
  23. ncbi request reprint Role of test activity in ethanol-induced disruption of place preference expression in mice
    Christina M Gremel
    Department of Behavioral Neuroscience, L470, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Psychopharmacology (Berl) 191:195-202. 2007
    ..We hypothesized that this interference effect was due to large ethanol-induced increases in activity...
  24. ncbi request reprint DBA/2J mice develop stronger lithium chloride-induced conditioned taste and place aversions than C57BL/6J mice
    F O Risinger
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, L470, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Pharmacol Biochem Behav 67:17-24. 2000
    ..Rather, these data appear more consistent with previous studies showing strain differences in lithium pharmacokinetics and in general sensitivity to aversive events...
  25. doi request reprint Internet resources for genomic, bioinformatics, and medical genetics information
    Tamara J Phillips
    Veterans Affairs Medical Center and Oregon Health and Science University, Portland, Oregon, USA
    Curr Protoc Neurosci . 2003
    ....
  26. pmc FOS expression induced by an ethanol-paired conditioned stimulus
    Katherine G Hill
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239 3098, United States
    Pharmacol Biochem Behav 87:208-21. 2007
    ..Overall, these data suggest an important role for the mesolimbic dopamine pathway, extended amygdala and hippocampus in ethanol-induced conditioning...
  27. ncbi request reprint Effects of topiramate on ethanol and saccharin consumption and preferences in C57BL/6J mice
    Kara I Gabriel
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Alcohol Clin Exp Res 29:75-80. 2005
    ..The current experiment examined the effects of topiramate on ethanol drinking in mice using a continuous access, two-bottle choice procedure...
  28. pmc Involvement of amygdala dopamine and nucleus accumbens NMDA receptors in ethanol-seeking behavior in mice
    Christina M Gremel
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR, USA
    Neuropsychopharmacology 34:1443-53. 2009
    ..These are the first studies in any species to show a role for amygdala dopamine receptors and the first studies in mice to implicate accumbens NMDA receptors in ethanol-induced conditioned effects...
  29. ncbi request reprint GABA(A) receptors modulate ethanol-induced conditioned place preference and taste aversion in mice
    J A Chester
    Department of Behavioral Neuroscience, and Portland Alcohol Research Center, Oregon Health Sciences University, 97201 3098, USA
    Psychopharmacology (Berl) 144:363-72. 1999
    ..GABA(A) receptor antagonists have been shown to reduce ethanol self-administration and ethanol-induced conditioned taste aversion (CTA) in rats, suggesting a role for the GABA(A) receptor in modulating ethanol's motivational effects...
  30. ncbi request reprint Rewarding effect of the neuroactive steroid 3 alpha-hydroxy-5 alpha-pregnan-20-one in mice
    D A Finn
    Dept of Veteran Affairs Medical Center Portland, OR 97201, USA
    Pharmacol Biochem Behav 56:261-4. 1997
    ..These results provide the first demonstration that 3 alpha,5 alpha-P, an endogenous modulator of GABAA receptor function, possesses rewarding properties using the conditioned place preference paradigm...
  31. ncbi request reprint Reestablishing an intragastric ethanol self-infusion model in rats
    Tara L Fidler
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Alcohol Clin Exp Res 30:414-28. 2006
    ..The present experiments were designed to reestablish a model that uses passive intragastric (IG) infusion of ethanol to induce tolerance/dependence/withdrawal before allowing rats to self-infuse ethanol intragastrically...
  32. ncbi request reprint Place conditioning: what does it add to our understanding of ethanol reward?
    Fred O Risinger
    Department of Behavioral Neuroscience, Portlannd Alcohol Research Center, Oregon Health and Science University, Portland, Oregon 97201 3098, USA
    Alcohol Clin Exp Res 26:1444-52. 2002
    ..Cunningham; and (4) Utilization of place conditioning for understanding the neuropharmacology of the rewarding effects of ethanol, by Fred O. Risinger...
  33. ncbi request reprint Reduced ethanol-induced conditioned taste aversion and conditioned place preference in GIRK2 null mutant mice
    Katherine G Hill
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97201 3098, USA
    Psychopharmacology (Berl) 169:108-14. 2003
    ..Under some conditions, GIRK2 knockout mice consume more ethanol than wild types, but it is unclear whether they do so because they are more sensitive to ethanol's rewarding effects or less sensitive to its aversive effects...
  34. pmc Schedule of passive ethanol exposure affects subsequent intragastric ethanol self-infusion
    Tara L Fidler
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Alcohol Clin Exp Res 33:1909-23. 2009
    ..The present studies examined temporal and other parameters of chronic ethanol exposure on subsequent intragastric (IG) self-infusion of ethanol...
  35. pmc Reference-dose place conditioning with ethanol in mice: empirical and theoretical analysis
    Peter A Groblewski
    Department of Behavioral Neuroscience, L470, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Psychopharmacology (Berl) 201:97-106. 2008
    ..A frequently expressed criticism of the conditioned place preference (CPP) procedure is that it sometimes lacks a graded dose-response curve for many drugs...
  36. ncbi request reprint Conditioned place aversion induced by intragastric administration of ethanol in rats
    Tara L Fidler
    Psychology Department, Linfield College, McMinnville, OR 97128, USA
    Pharmacol Biochem Behav 77:731-43. 2004
    ..Both groups showed strong CPA. Overall, the present findings are consistent with previous findings of CPA in heterogeneous rats, suggesting that the aversive postabsorptive effects of ethanol produce CPA...
  37. doi request reprint Roles of the nucleus accumbens and amygdala in the acquisition and expression of ethanol-conditioned behavior in mice
    Christina M Gremel
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 28:1076-84. 2008
    ..For the first time, these results demonstrate the role of the Acb and Amy in the acquisition and expression of ethanol-induced conditioned reward...
  38. ncbi request reprint Enhanced ethanol-, but not cocaine-induced, conditioned place preference in Apoe(-/-) mice
    Anita J Bechtholt
    Department of Behavioral Neuroscience, MC L470, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098
    Pharmacol Biochem Behav 77:783-92. 2004
    ..While the exact mechanisms underlying these effects of apoE are unknown, these data support a possible role for apoE in modulating the conditioned rewarding properties of ethanol...
  39. ncbi request reprint Genetic correlational analyses of ethanol reward and aversion phenotypes in short-term selected mouse lines bred for ethanol drinking or ethanol-induced conditioned taste aversion
    Tamara J Phillips
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Neurosci 119:892-910. 2005
    ..The interpretation of ethanol-induced CTA as more genetically distinct must be tempered by the inability to test the CTA lines beyond Selection Generation 2...
  40. ncbi request reprint Allopregnanolone does not influence ethanol-induced conditioned place preference in DBA/2J mice
    Kara I Gabriel
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Psychopharmacology (Berl) 176:50-6. 2004
    ....
  41. ncbi request reprint The role of NMDA receptor binding sites in ethanol place conditioning
    Janel M Boyce-Rustay
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Neurosci 118:822-34. 2004
    ..Moreover, these results suggest CGP-37849 modulates ethanol place conditioning by impairing the ability to learn these tasks...
  42. ncbi request reprint Topiramate does not affect the acquisition or expression of ethanol conditioned place preference in DBA/2J or C57BL/6J mice
    Christina M Gremel
    Department of Behavioral Neuroscience and the Portland Alcohol Research Center, Oregon Health and Science University, Portland 97239 3098, USA
    Alcohol Clin Exp Res 30:783-90. 2006
    ....
  43. pmc Inhibition of extracellular signal-regulated kinase (ERK) activity with SL327 does not prevent acquisition, expression, and extinction of ethanol-seeking behavior in mice
    Peter A Groblewski
    Dept of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Behav Brain Res 217:399-407. 2011
    ..Together, these data suggest that EtOH-related learning and EtOH reward in mice, as assessed with CPP, are not impaired by the systemically administered MEK-inhibitor SL327...
  44. pmc Effects of D-cycloserine on extinction and reconditioning of ethanol-seeking behavior in mice
    Peter A Groblewski
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon
    Alcohol Clin Exp Res 33:772-82. 2009
    ..Thus, the current experiments examined the effects of DCS on the extinction and subsequent reconditioning of ethanol-induced CPP in mice...
  45. ncbi request reprint Handling blocks expression of conditioned place aversion but not conditioned place preference produced by ethanol in mice
    Anita J Bechtholt
    Department of Behavioral Neuroscience L470, Portland Alcohol Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Pharmacol Biochem Behav 79:739-44. 2004
    ..However, animals conditioned for CPP exhibited robust CPP, regardless of handling. These findings provide additional evidence that the conditioned rewarding and aversive effects of ethanol are mediated by different neural mechanisms...
  46. pmc Treatment of experimental autoimmune encephalomyelitis with alpha lipoic acid and associative conditioning
    Richard E Jones
    VA Medical Center, 3710 SW Veterans Hospital Road, Portland, OR 97239, USA
    Brain Behav Immun 22:538-43. 2008
    ..These results demonstrate an approach for conducting therapeutic conditioning trials in EAE mice and suggest considerations for future investigations...
  47. ncbi request reprint Ethanol-induced conditioned place preference is expressed through a ventral tegmental area dependent mechanism
    Anita J Bechtholt
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Behav Neurosci 119:213-23. 2005
    ..These findings indicate that the conditioned rewarding effect of ethanol is expressed through a VTA-dependent mechanism that involves both opioid and GABA(B) receptors...
  48. ncbi request reprint Harnessing the mouse to unravel the genetics of human disease
    T J Phillips
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR, USA
    Genes Brain Behav 1:14-26. 2002
    ..We assert that unique combinations of classical approaches with current behavioral and molecular genomic approaches will more rapidly advance the field...
  49. ncbi request reprint GABA(A) receptor modulation of the rewarding and aversive effects of ethanol
    Julia A Chester
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97201 3098, USA
    Alcohol 26:131-43. 2002
    ....
  50. ncbi request reprint Lack of effect of dopamine receptor blockade on expression of ethanol-induced conditioned place preference in mice
    Shelly D Dickinson
    Psychology Department, Amherst College, P O Box 5000, Amherst, MA 01002 5000, USA
    Psychopharmacology (Berl) 165:238-44. 2003
    ..However, ethanol place conditioning studies have less consistently demonstrated a role for DA in conditioned place preference...
  51. ncbi request reprint Trait or state?
    John C Crabbe
    Science 317:1033-5; author reply 1033-5. 2007
  52. doi request reprint Intravenous self-administration of ethanol in mice
    Nicholas J Grahame
    Indiana University Purdue University at Indianapolis, Indianapolis, Indiana, USA
    Curr Protoc Neurosci . 2002
    ..This unit describes a method for assessing the reinforcing effects of alcohol in mice using the most widely accepted procedure for assessing drug reward: intravenous self-administration...
  53. ncbi request reprint Devaluation of ethanol reinforcement
    Herman H Samson
    Center for the Neurobehavioral Study of Alcohol, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Alcohol 32:203-12. 2004
    ..These findings support the assumption that postingestive effects contribute to the reinforcement produced by self-administered ethanol in rats...

Research Grants14

  1. MODULATION OF ALCOHOL REINFORCEMENT
    Christopher Cunningham; Fiscal Year: 1992
    ..Such efforts should help us to recognize increased risk of alcohol abuse, to devise more efficient and effective treatments for alcoholism and to outline more effective prevention strategies...
  2. Dependence Driven Alterations in Ethanol Reinforcement
    Christopher Cunningham; Fiscal Year: 2007
    ..By improving our understanding of these processes, we can identify more effective treatment and prevention strategies. ..
  3. MODULATION OF ALCOHOL REINFORCEMENT
    Christopher Cunningham; Fiscal Year: 2007
    ..These studies could prove to be especially useful in the evaluation of putative pharmacotherapies intended to reduce alcohol craving and in the design of behavioral interventions to decrease ethanol-seeking behavior. ..
  4. MODULATION OF ALCOHOL REINFORCEMENT
    Christopher L Cunningham; Fiscal Year: 2010
    ..g., cue-exposure therapy) to decrease ethanol-seeking behavior. ..