Zhengrong Cui

Summary

Affiliation: Oregon State University
Country: USA

Publications

  1. ncbi request reprint Plasmid DNA-entrapped nanoparticles engineered from microemulsion precursors: in vitro and in vivo evaluation
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    Bioconjug Chem 13:1319-27. 2002
  2. ncbi request reprint Learning from viruses: the necrotic bodies of tumor cells with intracellular synthetic dsRNA induced strong anti-tumor immune responses
    Zhengrong Cui
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA
    Pharm Res 24:1645-52. 2007
  3. ncbi request reprint Topical immunization onto mouse skin using a microemulsion incorporated with an anthrax protective antigen protein-encoding plasmid
    Zhengrong Cui
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA
    Int J Pharm 317:187-91. 2006
  4. ncbi request reprint Lecithin-based cationic nanoparticles as a potential DNA delivery system
    Zhengrong Cui
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, 97331, USA
    Int J Pharm 313:206-13. 2006
  5. ncbi request reprint Non-invasive immunization on the skin using DNA vaccine
    Zhengrong Cui
    Oregon State University, College of Pharmacy, Department of Pharmaceutical Sciences, Corvallis, OR 97331, USA
    Curr Drug Deliv 3:29-35. 2006
  6. ncbi request reprint Synthetic double-stranded RNA poly(I:C) as a potent peptide vaccine adjuvant: therapeutic activity against human cervical cancer in a rodent model
    Zhengrong Cui
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA
    Cancer Immunol Immunother 55:1267-79. 2006
  7. ncbi request reprint Liposome-polycation-DNA (LPD) particle as a carrier and adjuvant for protein-based vaccines: therapeutic effect against cervical cancer
    Zhengrong Cui
    Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, 633 Salk Hall, Pittsburgh, PA 15213, USA
    Cancer Immunol Immunother 54:1180-90. 2005
  8. ncbi request reprint Immunostimulation mechanism of LPD nanoparticle as a vaccine carrier
    Zhengrong Cui
    Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Pharm 2:22-8. 2005
  9. ncbi request reprint Nasal immunization with anthrax protective antigen protein adjuvanted with polyriboinosinic-polyribocytidylic acid induced strong mucosal and systemic immunities
    Brian R Sloat
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA
    Pharm Res 23:1217-26. 2006
  10. pmc Strong antibody responses induced by protein antigens conjugated onto the surface of lecithin-based nanoparticles
    Brian R Sloat
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, United States
    J Control Release 141:93-100. 2010

Collaborators

  • Russell J Mumper
  • Leaf Huang
  • CHRISTIANE V LOHR
  • Stephen D Hursting
  • Marianna Foldvari
  • Yongqun He
  • Anshul Gupte
  • Moses O Oyewumi
  • Brian R Sloat
  • Xinran Li
  • B Leticia Rodriguez
  • Michael A Sandoval
  • Uyen M Le
  • Nijaporn Yanasarn
  • Dharmika S P Lansakara-P
  • John DiGiovanni
  • Amit Kumar
  • Woon Gye Chung
  • Saijie Zhu
  • Piyanuch Wonganan
  • Kaoru Kiguchi
  • Dalia S Shaker
  • Gang Xiao
  • Zhen Yu
  • Annie M Dierling
  • REBECCA E DE ANGEL
  • Jorge M Blando
  • Richard Weiss
  • Uyen Minh Le
  • Kay A Fischer
  • Fu Qiu
  • Dileep P Vangasseri
  • Cheng Hsuan Hsu
  • Steven Jay
  • Abdulaziz M Aldayel
  • Matthew G Hogan
  • Mangalika Warthaka
  • Sarah M Dunlap
  • Yuriko Kiguchi
  • Melisande Holzer
  • Wendy Maury
  • Evan C Unger
  • Andrew M Hau
  • Darryl G L Kaurin
  • Weihsu Chen
  • Louis D Falo
  • David A Hokey
  • Michael Jay
  • William Fountain

Detail Information

Publications61

  1. ncbi request reprint Plasmid DNA-entrapped nanoparticles engineered from microemulsion precursors: in vitro and in vivo evaluation
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    Bioconjug Chem 13:1319-27. 2002
    ..Due to the apparent stability of these pDNA-entrapped nanoparticles in the blood, they may have potential for systemic gene therapy applications requiring cell and/or tissue-specific delivery...
  2. ncbi request reprint Learning from viruses: the necrotic bodies of tumor cells with intracellular synthetic dsRNA induced strong anti-tumor immune responses
    Zhengrong Cui
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA
    Pharm Res 24:1645-52. 2007
    ..We propose to learn from viruses by generating dead tumor cells having synthetic dsRNA delivered inside them to allow the dsRNA to promote the cross-presentation of dead tumor cells...
  3. ncbi request reprint Topical immunization onto mouse skin using a microemulsion incorporated with an anthrax protective antigen protein-encoding plasmid
    Zhengrong Cui
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA
    Int J Pharm 317:187-91. 2006
    ..This topical anthrax DNA vaccine has the potential to be combined with a vaccine, such as the current AVA, to produce a simplified and more convenient dosing schedule...
  4. ncbi request reprint Lecithin-based cationic nanoparticles as a potential DNA delivery system
    Zhengrong Cui
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, 97331, USA
    Int J Pharm 313:206-13. 2006
    ..Finally, when plasmid DNA was adsorbed on their surface, the lecithin nanoparticles successfully transfected cells in culture. These lecithin-based nanoparticles may hold great potentials as a DNA (vaccine) delivery system...
  5. ncbi request reprint Non-invasive immunization on the skin using DNA vaccine
    Zhengrong Cui
    Oregon State University, College of Pharmacy, Department of Pharmaceutical Sciences, Corvallis, OR 97331, USA
    Curr Drug Deliv 3:29-35. 2006
    ..With further improvement and optimization, non-invasive immunization onto the skin with DNA vaccine should be able to elicit reliable and efficacious immune response to a variety of antigens...
  6. ncbi request reprint Synthetic double-stranded RNA poly(I:C) as a potent peptide vaccine adjuvant: therapeutic activity against human cervical cancer in a rodent model
    Zhengrong Cui
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA
    Cancer Immunol Immunother 55:1267-79. 2006
    ..Double-stranded RNA may hold a great potential as an adjuvant to induce cellular immune responses for tumor immunotherapy...
  7. ncbi request reprint Liposome-polycation-DNA (LPD) particle as a carrier and adjuvant for protein-based vaccines: therapeutic effect against cervical cancer
    Zhengrong Cui
    Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, 633 Salk Hall, Pittsburgh, PA 15213, USA
    Cancer Immunol Immunother 54:1180-90. 2005
    ..LPD could be a potent vaccine carrier and/or adjuvant for many antigens...
  8. ncbi request reprint Immunostimulation mechanism of LPD nanoparticle as a vaccine carrier
    Zhengrong Cui
    Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Pharm 2:22-8. 2005
    ....
  9. ncbi request reprint Nasal immunization with anthrax protective antigen protein adjuvanted with polyriboinosinic-polyribocytidylic acid induced strong mucosal and systemic immunities
    Brian R Sloat
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA
    Pharm Res 23:1217-26. 2006
    ..We propose to develop a nasal anthrax vaccine using anthrax protective antigen (PA) protein as the antigen and synthetic double-stranded RNA in the form of polyriboinosinic-polyribocytidylic acid (pI:C) as an adjuvant...
  10. pmc Strong antibody responses induced by protein antigens conjugated onto the surface of lecithin-based nanoparticles
    Brian R Sloat
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, United States
    J Control Release 141:93-100. 2010
    ..This novel nanoparticle system has the potential to serve as a universal protein-based vaccine carrier capable of inducing strong immune responses...
  11. doi request reprint Nasal immunization with the mixture of PA63, LF, and a PGA conjugate induced strong antibody responses against all three antigens
    Brian R Sloat
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA
    FEMS Immunol Med Microbiol 52:169-79. 2008
    ..The anti-PGA Abs were shown to have complement-mediated bacteriolytic activity. After further optimization, this triantigen nasal vaccine candidate is expected to become one of the newer generation anthrax vaccines...
  12. pmc Towards preserving the immunogenicity of protein antigens carried by nanoparticles while avoiding the cold chain
    Brian R Sloat
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, United States
    Int J Pharm 393:197-202. 2010
    ..To our knowledge, the present study represents an early attempt to preserve the immunogenicity of the protein antigens carried by nanoparticles without refrigeration...
  13. ncbi request reprint Coating of mannan on LPD particles containing HPV E7 peptide significantly enhances immunity against HPV-positive tumor
    Zhengrong Cui
    Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Pharm Res 21:1018-25. 2004
    ..Mannan, which potentially targets antigen-presenting cells, was coated on LPD to further enhance its antitumor activity...
  14. pmc Preparation and characterization of novel coenzyme Q10 nanoparticles engineered from microemulsion precursors
    Cheng Hsuan Hsu
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    AAPS PharmSciTech 4:E32. 2003
    ..1 cells was over 4-fold higher than that of the CoQ10-free nanoparticles (P < .05). In conclusion, CoQ10-NPs with potential application for oral CoQ10 delivery were engineered readily from microemulsion precursors...
  15. ncbi request reprint Nasal immunization with a dual antigen anthrax vaccine induced strong mucosal and systemic immune responses against toxins and bacilli
    Brian R Sloat
    College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA
    Vaccine 24:6405-13. 2006
    ..These findings demonstrated that it is feasible to develop a novel dual-action nasal anthrax vaccine...
  16. ncbi request reprint A thermo-sensitive polymeric gel containing a gadolinium (Gd) compound encapsulated into liposomes significantly extended the retention of the Gd in tumors
    Uyen Minh Le
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA
    Drug Dev Ind Pharm 34:413-8. 2008
    ..This similar concept may be applied to prolong the retention of other cytotoxic chemicals in tumors, and thus, improve their anti-tumor efficacy...
  17. pmc Nanoparticles engineered from lecithin-in-water emulsions as a potential delivery system for docetaxel
    Nijaporn Yanasarn
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, United States
    Int J Pharm 379:174-80. 2009
    ..5-fold. These lecithin-based nanoparticles have the potential to be a novel biocompatible and efficacious delivery system for docetaxel...
  18. pmc Permeation of antigen protein-conjugated nanoparticles and live bacteria through microneedle-treated mouse skin
    Amit Kumar
    University of Texas at Austin, College of Pharmacy, Pharmaceutics Division, USA
    Int J Nanomedicine 6:1253-64. 2011
    ..Permeation of live bacteria, which are physically nanoparticles or microparticles, through mouse skin pretreated with microneedles was also studied to evaluate the potential risk of microbial infection...
  19. ncbi request reprint The effect of co-administration of adjuvants with a nanoparticle-based genetic vaccine delivery system on the resulting immune responses
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Eur J Pharm Biopharm 55:11-8. 2003
    ..In conclusion, CT (topical) and LA (s.c.) are potential adjuvants to further enhance immune responses using a novel cationic nanoparticle-based DNA vaccine delivery system...
  20. ncbi request reprint Strong mucosal and systemic immunities induced by nasal immunization with anthrax protective antigen protein incorporated in liposome-protamine-DNA particles
    Brian R Sloat
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, 97331, USA
    Pharm Res 23:262-9. 2006
    ..We propose to develop a nasal anthrax vaccine using anthrax protective antigen (PA) protein carried by liposome-protamine-DNA (LPD) particles...
  21. ncbi request reprint Intradermal immunization with novel plasmid DNA-coated nanoparticles via a needle-free injection device
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    J Biotechnol 102:105-15. 2003
    ..In conclusion, a combination of a novel cationic nanoparticle-based DNA delivery system with ID jet injection led to enhanced antibody production, Th-1/Th-2 balanced cytokine release, and enhanced splenocyte proliferation...
  22. ncbi request reprint Immunization by application of DNA vaccine onto a skin area wherein the hair follicles have been induced into anagen-onset stage
    Dalia S Shaker
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA
    Mol Ther 15:2037-43. 2007
    ..This represents a novel approach to enhancing the immune response induced by a topically applied DNA vaccine...
  23. ncbi request reprint Coating of cationized protein on engineered nanoparticles results in enhanced immune responses
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Int J Pharm 238:229-39. 2002
    ..In contrast, cGal-coated nanoparticles significantly enhanced both the Th1 and Th2 cytokines. The results demonstrated the utility of antigen-coated nanoparticles to enhance both the humoral and Th1-type immune responses, in parallel...
  24. pmc Replicase-based plasmid DNA shows anti-tumor activity
    B Leticia Rodriguez
    Pharmaceutics Division, College of Pharmacy, University of Texas, Austin, TX 78712, USA
    BMC Cancer 11:110. 2011
    ....
  25. ncbi request reprint Genetic immunization using nanoparticles engineered from microemulsion precursors
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington 40536 0082, USA
    Pharm Res 19:939-46. 2002
    ..The IgG titer to expressed beta-galactosidase and the cytokine release from isolated splenocytes after stimulation were determined on 28 days...
  26. ncbi request reprint Long-circulating gadolinium-encapsulated liposomes for potential application in tumor neutron capture therapy
    Uyen M Le
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA
    Int J Pharm 312:105-12. 2006
    ..This Gd-DTPA encapsulated liposome may be used to deliver Gd into solid tumors for NCT and tumor imaging...
  27. pmc Just getting into cells is not enough: mechanisms underlying 4-(N)-stearoyl gemcitabine solid lipid nanoparticle's ability to overcome gemcitabine resistance caused by RRM1 overexpression
    Piyanuch Wonganan
    Pharmaceutics Division, The University of Texas at Austin, College of Pharmacy, Austin, TX 78712, USA
    J Control Release 169:17-27. 2013
    ....
  28. pmc A nanoparticle depot formulation of 4-(N)-stearoyl gemcitabine shows a strong anti-tumour activity
    Saijie Zhu
    Pharmaceutics Division, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA
    J Pharm Pharmacol 65:236-42. 2013
    ..The objective of this study is to test the feasibility of using a subcutaneous depot formulation to administer a cytotoxic anti-cancer drug for systemic therapy...
  29. ncbi request reprint Evaluation of the immune response induced by a nasal anthrax vaccine based on the protective antigen protein in anaesthetized and non-anaesthetized mice
    Brian R Sloat
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA
    J Pharm Pharmacol 58:439-47. 2006
    ..Data collected in this study are expected to be useful for future anthrax nasal vaccine studies when mice are used as a model...
  30. ncbi request reprint Physical characterization and macrophage cell uptake of mannan-coated nanoparticles
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    Drug Dev Ind Pharm 29:689-700. 2003
    ..DSC provided evidence that the nanoparticles were not a physical mixture of their individual components. Finally, cell binding and uptake studies demonstrated that the nanoparticles have potential application for cell-specific targeting...
  31. ncbi request reprint Tumor chemo-immunotherapy using gemcitabine and a synthetic dsRNA
    Uyen M Le
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA
    Cancer Biol Ther 7:440-7. 2008
    ..This approach represents a promising therapy to improve the clinical outcomes for tumors sensitive to both dsRNA and gemcitabine...
  32. pmc Localized irradiation of tumors prior to synthetic dsRNA therapy enhanced the resultant anti-tumor activity
    Uyen M Le
    Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331, USA
    Radiother Oncol 90:273-9. 2009
    ..We sought to devise and validate a new strategy to improve the in vivo anti-tumor activity by integrating localized irradiation into dsRNA therapy...
  33. ncbi request reprint Microparticles and nanoparticles as delivery systems for DNA vaccines
    Zhengrong Cui
    Center for Pharmaceutical Science and Technology, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Crit Rev Ther Drug Carrier Syst 20:103-37. 2003
    ..In this review, the application of microparticles and nanoparticles as DNA vaccine delivery systems will be critically reviewed with a primary focus on those systems that have generated in vivo immune responses...
  34. pmc Transcutaneous DNA immunization following waxing-based hair depilation elicits both humoral and cellular immune responses
    Gang Xiao
    The University of Texas at Austin, College of Pharmacy, Austin, TX 78723, USA
    Eur J Pharm Biopharm 82:212-7. 2012
    ..Moreover, we provided additional evidence supporting that hair follicles are essential for this mode of TC DNA immunization...
  35. pmc Control of solid tumor growth in mice using EGF receptor-targeted RNA replicase-based plasmid DNA
    B Leticia Rodriguez
    College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA
    Nanomedicine (Lond) 7:475-91. 2012
    ..In the present study, the feasibility of further improving the anti-tumor activity of the RNA replicase-based plasmid by targeting it into tumors cells was evaluated...
  36. pmc Negatively charged liposomes show potent adjuvant activity when simply admixed with protein antigens
    Nijaporn Yanasarn
    Pharmaceutics Division, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
    Mol Pharm 8:1174-85. 2011
    ..Simply admixing certain negatively charged liposomes with certain protein antigens of interest may represent a novel platform for vaccine development...
  37. ncbi request reprint Novel ethanol-in-fluorocarbon microemulsions for topical genetic immunization
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    Pharm Res 20:16-23. 2003
    ..We sought to enhance the immune responses induced by DNA-based vaccines after topical application by developing novel ethanol-in-fluorocarbon (E/F) microemulsion systems to aid in the delivery of plasmid DNA (pDNA)...
  38. ncbi request reprint Immunostimulation of dendritic cells by cationic liposomes
    Dileep P Vangasseri
    Center for Pharmacogenetics, School of Pharmacy, Pittsburgh, Pennsylvania, USA
    Mol Membr Biol 23:385-95. 2006
    ..Based on the structure-specific activation of dendritic cells by cationic lipids, a model for the immunostimulation of DC by such lipids is proposed...
  39. ncbi request reprint Topical immunization using nanoengineered genetic vaccines
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    J Control Release 81:173-84. 2002
    ..All pDNA-coated nanoparticles, especially the mannan-coated pDNA-nanoparticles with DOPE, resulted in significant enhancement in both antigen-specific IgG titers (16-fold) and splenocyte proliferation over 'naked' pDNA alone...
  40. ncbi request reprint Gadolinium incorporated reconstituted chylomicron emulsion for potential application in tumor neutron capture therapy
    Annie M Dierling
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR, USA
    Eur J Pharm Biopharm 62:275-81. 2006
    ..This chylomicron emulsion may be used to deliver Gd into solid tumors for NCT...
  41. ncbi request reprint Genetic immunization by jet injection of targeted pDNA-coated nanoparticles
    Russell J Mumper
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 907 Rose Street, Lexington, KY 40536 0082, USA
    Methods 31:255-62. 2003
    ....
  42. ncbi request reprint DNA vaccine
    Zhengrong Cui
    Department of Pharmaceutical Sciences, College of Pharmacy Oregon State University, Corvallis, Oregon 97331, USA
    Adv Genet 54:257-89. 2005
    ..Therefore, current effort has been shifted to understanding the different performance of the DNA vaccine in mouse and large animal models and on how to transfer the success of the DNA vaccine in small animals to large animals and humans...
  43. pmc Antitumor activity of tumor-targeted RNA replicase-based plasmid that expresses interleukin-2 in a murine melanoma model
    B Leticia Rodriguez
    Pharmaceutics Division, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
    Mol Pharm 10:2404-15. 2013
    ..The RNA replicase-based, IL2-expressing plasmid may have applications in melanoma gene therapy...
  44. pmc Silencing of ribonucleotide reductase subunit M1 potentiates the antitumor activity of gemcitabine in resistant cancer cells
    Piyanuch Wonganan
    Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA
    Cancer Biol Ther 13:908-14. 2012
    ..These findings suggest that silencing RRM1 expression using siRNA could potentially be an effective strategy to overcome gemcitabine resistance...
  45. pmc Transcutaneous DNA immunization following waxing-based hair depilation
    Brian R Sloat
    The University of Texas at Austin, College of Pharmacy, Pharmaceutics Division, Austin, Texas 78712, USA
    J Control Release 157:94-102. 2012
    ..Transcutaneous DNA immunization by modifying the hair follicle cycle may hold a great promise in inducing strong and functional immune responses...
  46. pmc EGFR-targeted stearoyl gemcitabine nanoparticles show enhanced anti-tumor activity
    Michael A Sandoval
    Pharmaceutics Division, The University of Texas at Austin, College of Pharmacy, Austin, Texas 78712, USA
    J Control Release 157:287-96. 2012
    ..In conclusion, active targeting of the GemC18-NPs into EGFR-over-expressed tumors can further enhance their anti-tumor activity...
  47. pmc The extent of the uptake of plasmid into the skin determines the immune responses induced by a DNA vaccine applied topically onto the skin
    Zhen Yu
    Department of Pharmaceutical Sciences, College of Pharmacy Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA
    J Pharm Pharmacol 63:199-205. 2011
    ..In the present study, we further investigated the mechanism of immune enhancement...
  48. ncbi request reprint Targeting primaquine into liver using chylomicron emulsions for potential vivax malaria therapy
    Annie M Dierling
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA
    Int J Pharm 303:143-52. 2005
    ..This emulsion could be developed into a promising delivery system to target PQ into hepatocytes for vivax malaria therapy...
  49. ncbi request reprint Biodistribution and tumor-accumulation of gadolinium (Gd) encapsulated in long-circulating liposomes in tumor-bearing mice for potential neutron capture therapy
    Uyen M Le
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 231 Pharmacy Building, Corvallis, OR 97331, USA
    Int J Pharm 320:96-103. 2006
    ..Alternative strategies may have to be adopted in order to use NCT to treat large, advanced solid tumors, although for which, Gd-NCT might be advantageous over boron-NCT...
  50. pmc Stearoyl gemcitabine nanoparticles overcome resistance related to the over-expression of ribonucleotide reductase subunit M1
    Woon Gye Chung
    The University of Texas at Austin, College of Pharmacy, Pharmaceutics Division, Austin, Texas 78712, USA
    J Control Release 157:132-40. 2012
    ..To our best knowledge, this represents the first report demonstrating that a nanoparticle formulation of gemcitabine overcomes gemcitabine resistance related to ribonucleotide reductase M1 over-expression...
  51. ncbi request reprint Strong T cell type-1 immune responses to HIV-1 Tat (1-72) protein-coated nanoparticles
    Zhengrong Cui
    Center for Pharmaceutical Science and Technology, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Vaccine 22:2631-40. 2004
    ..3-fold greater than that from mice immunized with Tat and Alum. These studies warrant further investigation of these nanoparticles to enhance both antibody and cellular-based immune responses...
  52. ncbi request reprint Buccal transmucosal delivery of calcitonin in rabbits using thin-film composites
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    Pharm Res 19:1901-6. 2002
    ..Alternative and more cost-effective dosage forms for the delivery of calcitonin are needed. We sought to deliver sCT transmucosally using a previously reported mucoadhesive bilayer thin-film composite (TFC) via the buccal route...
  53. ncbi request reprint Novel D-penicillamine carrying nanoparticles for metal chelation therapy in Alzheimer's and other CNS diseases
    Zhengrong Cui
    Department of Pharmaceutical Sciences, Center for Pharmaceutical Science and Technology, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Eur J Pharm Biopharm 59:263-72. 2005
    ..These results indicate that nanoparticles have potential to deliver D-penicillamine to the brain for the prevention of Abeta (1-42) accumulation, as well as to reduce metal ion accumulation in other CNS diseases...
  54. pmc Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses
    Moses O Oyewumi
    Department of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH 44272, USA
    Expert Rev Vaccines 9:1095-107. 2010
    ..The information gathered could lead to strategies to optimize the performance of nano-microparticles as immune adjuvants...
  55. ncbi request reprint Intranasal administration of plasmid DNA-coated nanoparticles results in enhanced immune responses
    Zhengrong Cui
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington 40536 0082, USA
    J Pharm Pharmacol 54:1195-203. 2002
    ..An enhanced splenocyte proliferative response was also observed after immunization with the pDNA-coated nanoparticles. It was concluded that these plasmid DNA-coated nanoparticles may have potential for immunization via the nasal route...
  56. pmc Relationship between the size of nanoparticles and their adjuvant activity: data from a study with an improved experimental design
    Xinran Li
    The University of Texas at Austin, College of Pharmacy, Pharmaceutics Division, Austin, TX 78723, USA
    Eur J Pharm Biopharm 78:107-16. 2011
    ..Future studies attempting to correlate the size of nanoparticles and their adjuvant activities need to consider formulation parameters to ensure that the particles are different only in size and are stable before and after injection...
  57. ncbi request reprint CD4+ T helper cell response is required for memory in CD8+ T lymphocytes induced by a poly(I:C)-adjuvanted MHC I-restricted peptide epitope
    Fu Qiu
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA
    J Immunother 30:180-9. 2007
    ..Thus, future efforts of using synthetic dsRNA as an adjuvant to induce specific and long-lasting memory CTL immune responses should include the provision of an appropriate TH cell response...
  58. ncbi request reprint Transmucosal delivery of testosterone in rabbits using novel bi-layer mucoadhesive wax-film composite disks
    Steven Jay
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 907 Rose Street, Lexington, Kentucky 40536 0082, USA
    J Pharm Sci 91:2016-25. 2002
    ..2 +/- 3.2% with a coefficient of variation of 6.4%. It was concluded that these bi-layer mucoadhesive WFCs disks could deliver physiologically relevant amounts of insoluble drugs such as testosterone across the buccal mucosa...
  59. pmc Stearoyl gemcitabine nanoparticles overcome obesity-induced cancer cell resistance to gemcitabine in a mouse postmenopausal breast cancer model
    REBECCA E DE ANGEL
    College of Pharmacy, Pharmaceutics Division, University of Texas at Austin, Austin, TX, USA
    Cancer Biol Ther 14:357-64. 2013
    ..These findings have important clinical implications for cancer chemotherapies involving gemcitabine or other nucleoside analogs in the context of obesity...
  60. doi request reprint Aluminum hydroxide nanoparticles show a stronger vaccine adjuvant activity than traditional aluminum hydroxide microparticles
    Xinran Li
    The University of Texas at Austin, College of Pharmacy, Pharmaceutics Division, Austin, TX 78712, USA
    J Control Release 173:148-57. 2014
    ..Simply reducing the particle size of the traditional aluminum hydroxide adjuvant into nanometers represents a novel and effective approach to improve its adjuvanticity. ..
  61. ncbi request reprint Bilayer films for mucosal (genetic) immunization via the buccal route in rabbits
    Zhengrong Cui
    Division of Pharmaceutical Sciences College of Pharmacy University of Kentucky, Lexington 40536 0082, USA
    Pharm Res 19:947-53. 2002
    ..A novel mucoadhesive bilayer film was developed to test the feasibility of this route of immunization in rabbits...

Research Grants6

  1. Anthrax DNA vaccine for non-invasive immunization on skin
    Zhengrong Cui; Fiscal Year: 2007
    ..Moreover, the elucidation of the mechanism of immune induction by this vaccine and the demonstration of its efficacy will enable the application of this microemulsion in developing vaccines for other human and animal diseases. ..
  2. A tri-antigen nasal anthrax vaccine against toxins and vegetative bacilli
    Zhengrong Cui; Fiscal Year: 2007
    ..The same vaccine or its modified version can also be used in agricultural industries to vaccinate cattle. ..