John Crabbe


Affiliation: Oregon Health and Science University
Country: USA


  1. Crabbe J, Metten P, Savarese A, OZBURN A, Schlumbohm J, Spence S, et al. Ethanol Conditioned Taste Aversion in High Drinking in the Dark Mice. Brain Sci. 2019;9: pubmed publisher
    ..These experiments support the conclusion that one reason contributing to the willingness of HDID mice to drink to the point of intoxication is a genetic insensitivity to the aversive effects of ethanol. ..
  2. Crabbe J. Use of animal models of alcohol-related behavior. Handb Clin Neurol. 2014;125:71-86 pubmed publisher
    ..They have also identified areas where genetic influences are consistent across behavioral assays and have been used to model genetic differences among humans at different risk for AUD. ..
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    Crabbe J, Metten P, Gallaher E, Belknap J. Genetic determinants of sensitivity to pentobarbital in inbred mice. Psychopharmacology (Berl). 2002;161:408-16 pubmed
    ..That is, genetically influenced sensitivity to PB is not monolithic, but is somewhat specific to the particular response variable studied, a result that also characterizes genetic control of responses to other drugs. ..
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    Crabbe J, Metten P, Ponomarev I, Prescott C, Wahlsten D. Effects of genetic and procedural variation on measurement of alcohol sensitivity in mouse inbred strains. Behav Genet. 2006;36:536-52 pubmed
    ..In certain instances, substrain seems to matter little, while in others, substrains differed a great deal. These data are generally encouraging about the stability of genetic differences. ..
  5. Crabbe J, Spence S, Brown L, Metten P. Alcohol preference drinking in a mouse line selectively bred for high drinking in the dark. Alcohol. 2011;45:427-40 pubmed publisher
    ..We conclude that drinking in the dark shows some genetic overlap with other tests of preference drinking, but that the degree of genetic commonality depends on the model used. ..
  6. Crabbe J, Harkness J, Spence S, Huang L, Metten P. Intermittent availability of ethanol does not always lead to elevated drinking in mice. Alcohol Alcohol. 2012;47:509-17 pubmed publisher
    ..We conclude that 4 h of IA is likely insufficient to elevate drinking in mice. The lack of effect in HDID mice and their controls further suggests that not all genotypes respond to intermittency. ..
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    Crabbe J, Metten P, Cameron A, Wahlsten D. An analysis of the genetics of alcohol intoxication in inbred mice. Neurosci Biobehav Rev. 2005;28:785-802 pubmed
    ..This caveat likely extends to many behavioral domains (e.g. learning and memory, anxiety). ..
  8. Crabbe J. Review. Neurogenetic studies of alcohol addiction. Philos Trans R Soc Lond B Biol Sci. 2008;363:3201-11 pubmed publisher
    ..In a few instances, interesting parallels have been revealed between genetic risk in humans and studies in non-human animal models. Future approaches are likely to be increasingly complex. ..
  9. Crabbe J, Schlumbohm J, Hack W, Barkley Levenson A, Metten P, Lattal K. Fear conditioning in mouse lines genetically selected for binge-like ethanol drinking. Alcohol. 2016;52:25-32 pubmed publisher
    ..However, HDID mice are shown to be a suitable model for studying the role of conditioned fear specifically in binge-like drinking. ..

More Information


  1. Crabbe J. Progress With Nonhuman Animal Models of Addiction. J Stud Alcohol Drugs. 2016;77:696-9 pubmed
    ..The valuable findings from the past will endure, and the sidetracks will be forgotten. ..
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    Crabbe J, Wahlsten D, Dudek B. Genetics of mouse behavior: interactions with laboratory environment. Science. 1999;284:1670-2 pubmed
    ..For some tests, the magnitude of genetic differences depended upon the specific testing lab. Thus, experiments characterizing mutants may yield results that are idiosyncratic to a particular laboratory. ..
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    Crabbe J, Cotnam C, Cameron A, Schlumbohm J, Rhodes J, Metten P, et al. Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests. Genes Brain Behav. 2003;2:201-13 pubmed
    ..These results suggest that different specific versions of a test reflect the influence of different genes, and that genetic influences on different tests were also distinct. ..
  4. Crabbe J, Bell R, Ehlers C. Human and laboratory rodent low response to alcohol: is better consilience possible?. Addict Biol. 2010;15:125-44 pubmed publisher
    ..Additionally, the genetically mediated mechanisms underlying this endophenotype need to be characterized further across species...
  5. Crabbe J, OZBURN A, Metten P, Barkley Levenson A, Schlumbohm J, Spence S, et al. High Drinking in the Dark (HDID) mice are sensitive to the effects of some clinically relevant drugs to reduce binge-like drinking. Pharmacol Biochem Behav. 2017;160:55-62 pubmed publisher
    ..Both drugs reduced binge-like drinking. However, naltrexone failed to reduce drinking in HDID mice. Thus, HDID mice may represent a useful model for screening novel compounds. ..