Affiliation: Oregon Health and Science University
- Crabbe J. Progress With Nonhuman Animal Models of Addiction. J Stud Alcohol Drugs. 2016;77:696-9 pubmed..The valuable findings from the past will endure, and the sidetracks will be forgotten. ..
- Crabbe J, Wahlsten D, Dudek B. Genetics of mouse behavior: interactions with laboratory environment. Science. 1999;284:1670-2 pubmed..For some tests, the magnitude of genetic differences depended upon the specific testing lab. Thus, experiments characterizing mutants may yield results that are idiosyncratic to a particular laboratory. ..
- Crabbe J, Cotnam C, Cameron A, Schlumbohm J, Rhodes J, Metten P, et al. Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests. Genes Brain Behav. 2003;2:201-13 pubmed..These results suggest that different specific versions of a test reflect the influence of different genes, and that genetic influences on different tests were also distinct. ..
- Crabbe J, Bell R, Ehlers C. Human and laboratory rodent low response to alcohol: is better consilience possible?. Addict Biol. 2010;15:125-44 pubmed publisher..Additionally, the genetically mediated mechanisms underlying this endophenotype need to be characterized further across species...
- Crabbe J, OZBURN A, Metten P, Barkley Levenson A, Schlumbohm J, Spence S, et al. High Drinking in the Dark (HDID) mice are sensitive to the effects of some clinically relevant drugs to reduce binge-like drinking. Pharmacol Biochem Behav. 2017;160:55-62 pubmed publisher..Both drugs reduced binge-like drinking. However, naltrexone failed to reduce drinking in HDID mice. Thus, HDID mice may represent a useful model for screening novel compounds. ..