John Crabbe

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Ethanol drinking in withdrawal seizure-prone and -resistant selected mouse lines
    John C Crabbe
    Portland Alcohol Research Center, Veterans Affairs Medical Center, Oregon Health and Science University, Portland, OR 97239, USA
    Alcohol 47:381-9. 2013
  2. pmc Ethanol sensitivity in high drinking in the dark selectively bred mice
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, and VA Medical Center, Portland, OR 97239, USA
    Alcohol Clin Exp Res 36:1162-70. 2012
  3. pmc Ethanol tolerance and withdrawal severity in high drinking in the dark selectively bred mice
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health, Portland, OR 97239, USA
    Alcohol Clin Exp Res 36:1152-61. 2012
  4. pmc Intermittent availability of ethanol does not always lead to elevated drinking in mice
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, VA Medical Center R and D 12, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA
    Alcohol Alcohol 47:509-17. 2012
  5. pmc Translational behaviour-genetic studies of alcohol: are we there yet?
    J C Crabbe
    VA Medical Center R and D12 Portland Alcohol Research Center Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Genes Brain Behav 11:375-86. 2012
  6. pmc Modeling the diagnostic criteria for alcohol dependence with genetic animal models
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Curr Top Behav Neurosci 13:187-221. 2013
  7. ncbi request reprint Use of genetic analyses to refine phenotypes related to alcohol tolerance and dependence
    J C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health Sciences University, USA
    Alcohol Clin Exp Res 25:288-92. 2001
  8. ncbi request reprint Genetic determinants of sensitivity to pentobarbital in inbred mice
    John C Crabbe
    Department of Behavioral Neuroscience, VA Medical Center, Oregon Health and Science University, Portland, OR 97201, USA
    Psychopharmacology (Berl) 161:408-16. 2002
  9. ncbi request reprint Alcohol and genetics: new models
    John C Crabbe
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Portland, Oregon 97201, USA
    Am J Med Genet 114:969-74. 2002
  10. pmc Preclinical studies of alcohol binge drinking
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University and VA Medical Center, Portland, Oregon 97239, USA
    Ann N Y Acad Sci 1216:24-40. 2011

Research Grants

  1. GENETIC VULNERABILITY TO DRUGS OF ABUSE
    John Crabbe; Fiscal Year: 1992
  2. GENETIC VULNERABILITY TO DRUGS OF ABUSE
    John Crabbe; Fiscal Year: 2002
  3. IBANGS Annual Meeting support
    John Crabbe; Fiscal Year: 2005
  4. BEHAVIORAL GENOMICS OF ALCOHOL NEUROADAPTATION
    John Crabbe; Fiscal Year: 2007
  5. IBANGS Annual Meeting support
    John Crabbe; Fiscal Year: 2007
  6. Selective Breeding for Drinking in the Circadian Dark
    John Crabbe; Fiscal Year: 2007

Detail Information

Publications116 found, 100 shown here

  1. pmc Ethanol drinking in withdrawal seizure-prone and -resistant selected mouse lines
    John C Crabbe
    Portland Alcohol Research Center, Veterans Affairs Medical Center, Oregon Health and Science University, Portland, OR 97239, USA
    Alcohol 47:381-9. 2013
    ..These results provide further evidence that 2-bottle ethanol preference and DID are genetically distinguishable traits. ..
  2. pmc Ethanol sensitivity in high drinking in the dark selectively bred mice
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, and VA Medical Center, Portland, OR 97239, USA
    Alcohol Clin Exp Res 36:1162-70. 2012
    ..High Drinking in the Dark-1 (HDID-1) mice were in selected generation S18, and the replicate HDID-2 line in generation S11...
  3. pmc Ethanol tolerance and withdrawal severity in high drinking in the dark selectively bred mice
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health, Portland, OR 97239, USA
    Alcohol Clin Exp Res 36:1152-61. 2012
    ..Tolerance and withdrawal symptoms are 2 of the 7 diagnostic criteria for alcohol dependence. Withdrawal severity has been found in mouse studies to be negatively genetically correlated with EtOH preference drinking...
  4. pmc Intermittent availability of ethanol does not always lead to elevated drinking in mice
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, VA Medical Center R and D 12, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA
    Alcohol Alcohol 47:509-17. 2012
    ..water 3X/week (Prior studies have offered ethanol during 24 h periods, either continuously or intermittently.)...
  5. pmc Translational behaviour-genetic studies of alcohol: are we there yet?
    J C Crabbe
    VA Medical Center R and D12 Portland Alcohol Research Center Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Genes Brain Behav 11:375-86. 2012
    ..It identifies several features of AD where genetic animal models have been particularly useful, and tries to identify understudied areas where there is good promise for further genetic animal model work...
  6. pmc Modeling the diagnostic criteria for alcohol dependence with genetic animal models
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Curr Top Behav Neurosci 13:187-221. 2013
    ..We suggest areas where more research could clarify this attempt to align the rodent and human data...
  7. ncbi request reprint Use of genetic analyses to refine phenotypes related to alcohol tolerance and dependence
    J C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health Sciences University, USA
    Alcohol Clin Exp Res 25:288-92. 2001
    ..However, rigorous understanding of both gene-gene and gene-environment interactions will be required to interpret genetic experiments clearly...
  8. ncbi request reprint Genetic determinants of sensitivity to pentobarbital in inbred mice
    John C Crabbe
    Department of Behavioral Neuroscience, VA Medical Center, Oregon Health and Science University, Portland, OR 97201, USA
    Psychopharmacology (Berl) 161:408-16. 2002
    ..We postulated that genetic determinants of different responses to pentobarbital (PB) in mice would differ from response to response...
  9. ncbi request reprint Alcohol and genetics: new models
    John C Crabbe
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Portland, Oregon 97201, USA
    Am J Med Genet 114:969-74. 2002
    ..Progress in gene identification will also depend crucially on the precise description of the phenotypes being mapped so that their pleiotropic range of influence on the multi-behavioral phenotypic syndrome can be determined...
  10. pmc Preclinical studies of alcohol binge drinking
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University and VA Medical Center, Portland, Oregon 97239, USA
    Ann N Y Acad Sci 1216:24-40. 2011
    ....
  11. pmc Alcohol preference drinking in a mouse line selectively bred for high drinking in the dark
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University and VA Medical Center, USA
    Alcohol 45:427-40. 2011
    ..We conclude that drinking in the dark shows some genetic overlap with other tests of preference drinking, but that the degree of genetic commonality depends on the model used...
  12. pmc The complexity of alcohol drinking: studies in rodent genetic models
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Genet 40:737-50. 2010
    ..We report here results from a second replicate of that selection and compare them with the first replicate...
  13. pmc Human and laboratory rodent low response to alcohol: is better consilience possible?
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University and VA Medical Center, Portland, OR 97239, USA
    Addict Biol 15:125-44. 2010
    ..Additionally, the genetically mediated mechanisms underlying this endophenotype need to be characterized further across species...
  14. ncbi request reprint Provisional mapping of quantitative trait loci for chronic ethanol withdrawal severity in BXD recombinant inbred mice
    J C Crabbe
    Portland Alcohol Research Center, Department of Veterans Affairs, Oregon, USA
    J Pharmacol Exp Ther 286:263-71. 1998
    ..Several of the QTLs map near potential candidate genes. These provisional linkages will now be confirmed or rejected using additional genetically segregating populations...
  15. pmc A line of mice selected for high blood ethanol concentrations shows drinking in the dark to intoxication
    John C Crabbe
    Portland Alcohol Research Center, Portland, Oregon, USA
    Biol Psychiatry 65:662-70. 2009
    ..We report progress toward the development of a new genetic animal model for high levels of alcohol drinking...
  16. pmc Review. Neurogenetic studies of alcohol addiction
    John C Crabbe
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, VA Medical Center R and D 12, 3710 Southwest US Veterans Hospital Road, Portland, OR 97239, USA
    Philos Trans R Soc Lond B Biol Sci 363:3201-11. 2008
    ..In a few instances, interesting parallels have been revealed between genetic risk in humans and studies in non-human animal models. Future approaches are likely to be increasingly complex...
  17. ncbi request reprint Festina lente: late-night thoughts on high-throughput screening of mouse behavior
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, and VA Medical Center R and D 12, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, USA
    Nat Neurosci 7:1175-9. 2004
    ..Finally, high throughput may not always be an appropriate goal. We discuss the role of automated data collection and unique data-mining algorithms, and the question of the ethological relevance of behavioral tests...
  18. ncbi request reprint An analysis of the genetics of alcohol intoxication in inbred mice
    John C Crabbe
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, and VA Medical Center R and D 12, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA
    Neurosci Biobehav Rev 28:785-802. 2005
    ..This caveat likely extends to many behavioral domains (e.g. learning and memory, anxiety)...
  19. ncbi request reprint Genetic contributions to addiction
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, and VA Medical Center, Portland, Oregon, USA
    Annu Rev Psychol 53:435-62. 2002
    ..Future directions for further contribution of animal models studies to our understanding of the brain dysregulations characteristic of addictions are identified...
  20. ncbi request reprint Genetic determinants of sensitivity to diazepam in inbred mice
    J C Crabbe
    Department of Behavioral Neuroscience, Oregon Health Sciences University, Veterans Affairs Medical Center, Portland 97201, USA
    Behav Neurosci 112:668-77. 1998
    ..That is, genetically influenced sensitivity to DZ is not monolithic but is somewhat specific to the particular response variable studied, a result that also characterizes genetic control of responses to other drugs...
  21. ncbi request reprint Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests
    J C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
    Genes Brain Behav 2:201-13. 2003
    ..These results suggest that different specific versions of a test reflect the influence of different genes, and that genetic influences on different tests were also distinct...
  22. ncbi request reprint Effects of genetic and procedural variation on measurement of alcohol sensitivity in mouse inbred strains
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, 97239, USA
    Behav Genet 36:536-52. 2006
    ..In certain instances, substrain seems to matter little, while in others, substrains differed a great deal. These data are generally encouraging about the stability of genetic differences...
  23. ncbi request reprint Pharmacogenetic studies of alcohol self-administration and withdrawal
    John C Crabbe
    Portland Alcohol Research Center and Department of Behavioral Neuroscience, Oregon Health and Science University and Veterans Affairs Medical Center, Portland, OR 97239, USA
    Psychopharmacology (Berl) 174:539-60. 2004
  24. ncbi request reprint Genetics of mouse behavior: interactions with laboratory environment
    J C Crabbe
    Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, Portland, OR 97201, USA
    Science 284:1670-2. 1999
    ..For some tests, the magnitude of genetic differences depended upon the specific testing lab. Thus, experiments characterizing mutants may yield results that are idiosyncratic to a particular laboratory...
  25. ncbi request reprint Genotypic differences in ethanol sensitivity in two tests of motor incoordination
    John C Crabbe
    VA Medical Center, R and D 12 3710 SW US Veterans Hospital Rd, Portland, OR 97239, USA
    J Appl Physiol (1985) 95:1338-51. 2003
    ..These results make clear that a single set of task parameters is insufficient to characterize genetic influences on behavior. Several other issues affect the interpretation of data using these tests...
  26. ncbi request reprint Potential pleiotropic effects of Mpdz on vulnerability to seizures
    C Fehr
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Genes Brain Behav 3:8-19. 2004
    ....
  27. ncbi request reprint Ethanol-regulated gene expression of neuroendocrine specific protein in mice: brain region and genotype specificity
    G L Schafer
    Oregon Health Sciences University, Portland Alcohol Research Center, and VA Medical Center, Portland, OR 97201, USA
    Brain Res 897:139-49. 2001
    ..Overall, the results indicate a complex pattern of ethanol-induced regulation of the putative mouse homologue of RTN1 and suggest that specific brain regional changes may be involved in the expression of physical dependence...
  28. ncbi request reprint Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice
    J C Crabbe
    Research Service, VA Medical Center, Portland, Oregon
    J Pharmacol Exp Ther 269:184-92. 1994
    ..abstract truncated at 250 words)..
  29. ncbi request reprint Quantitative trait loci affecting methamphetamine responses in BXD recombinant inbred mouse strains
    J E Grisel
    Research Service, Veterans Affairs Medical Center, Portland, OR 97201, USA
    J Neurosci 17:745-54. 1997
    ..In several instances, QTLs appeared to overlap, which is consistent with idea that common neural substrates underlie some responses to psychostimulants...
  30. ncbi request reprint Use of recombinant inbred strains for studying genetic determinants of responses to alcohol
    J C Crabbe
    Oregon Health Sciences University, Portland, USA
    Alcohol Alcohol Suppl 2:67-71. 1994
    ..A cluster of genes (Scn1, Scn2, Scn3) code for voltage-sensitive sodium channel proteins. These genes are plausible candidates for affecting withdrawal HIC...
  31. ncbi request reprint Sensitivity and tolerance to ethanol in mouse lines selected for ethanol-induced hypothermia
    K E Browman
    Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, 3710 Southwest US Veterans Hospital Road, Portland, OR 97201, USA
    Pharmacol Biochem Behav 67:821-9. 2000
    ..All three COLD lines developed significant tolerance, while the HOT lines did not. The HOT and COLD mice provide a genetic model to study mechanisms mediating acute EtOH-induced hypothermia as well as tolerance development...
  32. pmc Cocaine-induced seizure thresholds: quantitative trait loci detection and mapping in two populations derived from the C57BL/6 and DBA/2 mouse strains
    H S Hain
    Department of Behavioral Neuroscience, Oregon Health Sciences University, and Research Service, Veterans Affairs Medical Center, Portland, Oregon, USA
    J Pharmacol Exp Ther 293:180-7. 2000
    ..0015), both associated with clonic seizures on chromosomes 9 (proximal) and 15 (distal). Both QTLs on chromosome 9 were sex-specific, with much larger effects on the phenotype seen in females than in males...
  33. ncbi request reprint Influence of ethanol on thermoregulation: mapping quantitative trait loci
    L I Crawshaw
    Department of Biology, Portland State University, Portland, 97207, USA
    Physiol Genomics 7:159-69. 2001
    ..To our knowledge, this is the first report of QTLs that underlie changes in regulation as well as the disruption of a physiological regulatory system...
  34. ncbi request reprint Scheduled access to ethanol results in motor impairment and tolerance in female C57BL/6J mice
    K Cronise
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, United States
    Pharmacol Biochem Behav 81:943-53. 2005
    ....
  35. ncbi request reprint Localization of genes affecting alcohol drinking in mice
    T J Phillips
    Veterans Administration Medical Center, Oregon Health Sciences University, Portland
    Alcohol Clin Exp Res 18:931-41. 1994
    ..In general, our results suggest that saccharin and ethanol consumption are determined by the actions of multiple genes (QTL), some in common, and suggest specific map locations of several such QTL on the mouse genome...
  36. ncbi request reprint Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice
    K J Buck
    Portland Alcohol Research Center and Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Neurosci 17:3946-55. 1997
    ..Syntenic conservation between human and mouse chromosomes suggests that human homologs of genes that increase risk for physiological dependence may localize to 1q21-q32, 2q24-q37/11p13, 9p21-p23/1p32-p22.1, and 5q32-q35...
  37. ncbi request reprint Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors
    J C Crabbe
    Department of Veterans, Affairs Medical Center, Portland, Oregon, USA
    Nat Genet 14:98-101. 1996
    ....
  38. ncbi request reprint On the integration of alcohol-related quantitative trait loci and gene expression analyses
    Robert Hitzemann
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon 97201, USA
    Alcohol Clin Exp Res 28:1437-48. 2004
    ..This study was undertaken to determine whether the process of moving from QTL to quantitative trait gene (QTG) could be accelerated by the integration of functional genomics (gene expression) into the analysis strategy...
  39. ncbi request reprint Ethanol-induced activation and rapid development of tolerance may have some underlying genes in common
    I Ponomarev
    Department of Behavioral Neuroscience, Oregon Health and Science University Portland Alcohol Research Center and VA Medical Center Portland, OR, USA
    Genes Brain Behav 1:82-7. 2002
    ..In summary, these results supported a genetic association between ethanol-induced activation and rapid development of tolerance...
  40. ncbi request reprint Harnessing the mouse to unravel the genetics of human disease
    T J Phillips
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR, USA
    Genes Brain Behav 1:14-26. 2002
    ..We assert that unique combinations of classical approaches with current behavioral and molecular genomic approaches will more rapidly advance the field...
  41. ncbi request reprint Selected line difference in sensitivity to a GABAergic neurosteroid during ethanol withdrawal
    D A Finn
    Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, Oregon Health and Science University, Portland, OR 97239, USA
    Genes Brain Behav 5:53-63. 2006
    ..These findings suggest that mice selectively bred for differences in EtOH withdrawal severity are differentially sensitive to ALLO during EtOH withdrawal...
  42. ncbi request reprint Drug withdrawal convulsions and susceptibility to convulsants after short-term selective breeding for acute ethanol withdrawal
    P Metten
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health Sciences University and Department of Veteran s Affairs Medical Center, Portland 97201, USA
    Behav Brain Res 95:113-22. 1998
    ..No line differences were detected. These results indicate that genes influencing severity of withdrawal from several depressant drugs are largely different from those affecting susceptibility to GABAergic or glutamatergic convulsants...
  43. doi request reprint Three murine anxiety models: results from multiple inbred strain comparisons
    L C Milner
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, VA Medical Center, Portland, OR 97239, USA
    Genes Brain Behav 7:496-505. 2008
    ..However, these findings may not necessarily generalize to other unconditioned anxiety-like behavioral tests...
  44. ncbi request reprint Fine mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11
    H M Hood
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97006 8921, USA
    Genes Brain Behav 5:1-10. 2006
    ....
  45. ncbi request reprint Characterization of the parallel rod floor apparatus to test motor incoordination in mice
    H M Kamens
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University and VA Medical Center, Portland, OR 97239, USA
    Genes Brain Behav 4:253-66. 2005
    ....
  46. ncbi request reprint Type I and type II error rates for quantitative trait loci (QTL) mapping studies using recombinant inbred mouse strains
    J K Belknap
    Research Service, VA Medical Center, Oregon Health Sciences University, Portland 97201, USA
    Behav Genet 26:149-60. 1996
    ..This flexibility in setting RI alpha values is appropriate only when adequate protection against Type I errors comes from the F2 (or other) confirmation test(s)...
  47. ncbi request reprint Chronic ethanol differentially alters susceptibility to chemically induced convulsions in withdrawal seizure-prone and -resistant mice
    D A Finn
    Portland Alcohol Research Center, Department of Veterans Affairs, Oregon 97201, USA
    J Pharmacol Exp Ther 288:782-90. 1999
    ..This supports a role for EAA systems in determining genetic susceptibility to alcohol withdrawal...
  48. ncbi request reprint Alcohol and genetics: new animal models
    K E Browman
    Dept of Behavioral Neuroscience, Portland Alcohol Research Center, VA Medical Center R and D12, Portland, OR 97201, USA
    Mol Med Today 5:310-8. 1999
    ..Ultimately, findings from animal models that investigate the function of specific genes could aid the development of pharmacotherapies to treat alcohol dependence...
  49. ncbi request reprint Genetic association between chronic ethanol withdrawal severity and acoustic startle parameters WSP and WSR mice
    I Ponomarev
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health Sciences University and VA Medical Center, 97201, USA
    Alcohol Clin Exp Res 23:1730-5. 1999
    ..Any differences on a nonselected (correlated) trait between the opposite-selected lines is strong evidence for pleiotropic effects of the genes fixed by selection...
  50. ncbi request reprint Sensitivity and tolerance to ethanol-induced incoordination and hypothermia in HAFT and LAFT mice
    N R Rustay
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97201, USA
    Pharmacol Biochem Behav 70:167-74. 2001
    ..Furthermore, these experiments show that AFT measured by the stationary dowel generalizes to AFT measured by the fixed-speed rotarod...
  51. ncbi request reprint Genomewide search for epistasis in a complex trait: pentobarbital withdrawal convulsions in mice
    H M Hood
    Portland Alcohol Research Center and Department of Behavioral Neuroscience, Oregon Health Sciences University, 97201, USA
    Behav Genet 31:93-100. 2001
    ..0004). This modifier is in the same genomic vicinity as loci detected for a variety of withdrawal and seizure phenotypes...
  52. ncbi request reprint QTL analysis and genomewide mutagenesis in mice: complementary genetic approaches to the dissection of complex traits
    J K Belknap
    Research Service, Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    Behav Genet 31:5-15. 2001
    ..We argue that these two complementary genetic methods have much to offer in efforts to highlight genes and pathways most likely to influence the susceptibility and progression of common diseases in human populations...
  53. ncbi request reprint Mapping genes that regulate density of dopamine transporters and correlated behaviors in recombinant inbred mice
    A Janowsky
    Research Service, Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    J Pharmacol Exp Ther 298:634-43. 2001
    ..The results suggest that there is a gene(s) on proximal chromosome 19 that strongly influences DAT expression in neostriatum and may influence psychostimulant-induced activity and thermal responses...
  54. ncbi request reprint Acute neuroactive steroid withdrawal in withdrawal seizure-prone and withdrawal seizure-resistant mice
    M T Reilly
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health Sciences University, Portland, OR 97201, USA
    Pharmacol Biochem Behav 67:709-17. 2000
    ....
  55. ncbi request reprint Anxiety and sensitivity to ethanol and pentobarbital in alcohol withdrawal seizure-prone and withdrawal seizure-resistant mice
    A L Atkins
    Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland Alcohol Research Center, USA
    Alcohol Clin Exp Res 24:1743-9. 2000
    ..Withdrawal severity is one factor that may contribute to the development of alcoholism and/or substance abuse, and anxiety is another. We sought to explore whether these factors are genetically related...
  56. ncbi request reprint Anxiety-like behavior in mice in two apparatuses during withdrawal from chronic ethanol vapor inhalation
    C L Kliethermes
    Department of Behavioral Neuroscience, Oregon Health and Science University and the Portland Alcohol Research Center, VA Medical Center, Portland, Oregon 97239, USA
    Alcohol Clin Exp Res 28:1012-9. 2004
    ..Ethanol vapor inhalation offers an advantage over liquid diet consumption in that the onset of withdrawal can be temporally controlled more precisely, allowing studies of the development of withdrawal symptoms...
  57. ncbi request reprint Elevated prodynorphin expression associated with ethanol withdrawal convulsions
    A S Beadles-Bohling
    Portland Alcohol Research Center, Research Service, Oregan Health Sciences University, Portland, OR 97201, USA
    Neurochem Int 37:463-72. 2000
    ..Our findings suggest that prodynorphin expression is modulated during ethanol withdrawal convulsions, or alternatively, prodynorphin may mediate the severity of ethanol withdrawal convulsions...
  58. ncbi request reprint Sensitivity to ethanol-induced motor incoordination in 5-HT(1B) receptor null mutant mice is task-dependent: implications for behavioral assessment of genetically altered mice
    S L Boehm
    Portland Alcohol Research Center, Veterans Affairs Medical Center, Oregon 97201, USA
    Behav Neurosci 114:401-9. 2000
    ..These experiments suggest that within a behavioral domain, alternative tests of function are not equivalent, so multiple assessment tools should be used to avoid misinterpretation of gene function...
  59. ncbi request reprint Quantitative trait loci affecting ethanol sensitivity in BXD recombinant inbred mice
    K E Browman
    Portland Alcohol Research Center, Department of Veterans Affairs Medical Center and Department of Behavioral Neuroscience, Oregon Health Sciences University, 97201, USA
    Alcohol Clin Exp Res 24:17-23. 2000
    ..Many QTL analyses have been performed in BXD recombinant inbred (RI) strains of mice derived from a cross of C57BL/6J (B6) and DBA/2J (D2) progenitor strains...
  60. ncbi request reprint Differential change in neuroactive steroid sensitivity during ethanol withdrawal
    D A Finn
    Portland Alcohol Research Center, Research Service, Veterans Affairs Medical Center and Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, OR 97201, USA
    J Pharmacol Exp Ther 292:394-405. 2000
    ..These results suggest that sensitization to the anticonvulsant effect of 3alpha,5alpha-P during EtOH withdrawal does not generalize across all genotypes nor does it generalize to all of the pharmacological effects of 3alpha,5alpha-P...
  61. ncbi request reprint Identification of neuroendocrine-specific protein as an ethanol-regulated gene with mRNA differential display
    G L Schafer
    Oregon Health Sciences University, Portland Alcohol Research Center, and Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    Mamm Genome 9:979-82. 1998
    ..4-kb transcript in WSP mice. No effects of ethanol were observed for WSR mice. These preliminary findings suggest that mNSP represents a novel ethanol-induced gene in mice selected for genetic susceptibility to severe ethanol withdrawal...
  62. ncbi request reprint Regulation of central synaptic transmission by 5-HT(1B) auto- and heteroreceptors
    H Morikawa
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Mol Pharmacol 58:1271-8. 2000
    ..Furthermore, this study underscores the role played by presynaptic 5-HT(1B) receptors in mediating the effects of cocaine on synaptic transmission...
  63. doi request reprint The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits
    Robert Hitzemann
    Portland Alcohol Research Center, Veterans Affairs Medical Center, Portland, 97239, OR, USA
    Mamm Genome 25:12-22. 2014
    ..Each of these issues is discussed, providing an initial framework for complex cross study design and planning. ..
  64. doi request reprint Internet resources for genomic, bioinformatics, and medical genetics information
    Tamara J Phillips
    Veterans Affairs Medical Center and Oregon Health and Science University, Portland, Oregon, USA
    Curr Protoc Neurosci . 2003
    ....
  65. ncbi request reprint NMDA receptor subunit mRNA and protein expression in ethanol-withdrawal seizure-prone and -resistant mice
    J N Mason
    Medical Research Service, Department of Veterans Affairs Medical Center, Portland Alcohol Research Center, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Alcohol Clin Exp Res 25:651-60. 2001
    ....
  66. ncbi request reprint Gene expression induced by drugs of abuse
    Justin S Rhodes
    VA Medical Center, Portland, OR 97239, USA
    Curr Opin Pharmacol 5:26-33. 2005
    ..g. stress, altered body temperature or energy metabolism)...
  67. pmc Voluntary ethanol consumption in 22 inbred mouse strains
    Naomi Yoneyama
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Alcohol 42:149-60. 2008
    ..37-0.45). These results add new strains to the strain mean database that will facilitate the identification of genetic relationships between voluntary ethanol consumption, saccharin preference, and other phenotypes...
  68. pmc 5-HT2C and GABAB receptors influence handling-induced convulsion severity in chromosome 4 congenic and DBA/2J background strain mice
    Matthew T Reilly
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Veterans Affairs Medical Center and Oregon Health and Science University, Portland, Oregon 97239, USA
    Brain Res 1198:124-31. 2008
    ..However, additional genes reside within the congenic interval and may also influence CNS hyperexcitability...
  69. pmc Decreased anticonvulsant efficacy of allopregnanolone during ethanol withdrawal in female Withdrawal Seizure-Prone vs. Withdrawal Seizure-Resistant mice
    Ethan H Beckley
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA
    Neuropharmacology 54:365-74. 2008
    ....
  70. ncbi request reprint The parallel rod floor test: a measure of ataxia in mice
    Helen M Kamens
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    Nat Protoc 2:277-81. 2007
    ..Unlike many other methods for assessing incoordination, the parallel rod floor test yields similar patterns of genetic sensitivity across a range of variant forms of the apparatus...
  71. ncbi request reprint Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41)
    Deborah A Finn
    Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon Veterans Affairs Medical Center, Oregon, USA
    Alcohol Clin Exp Res 31:939-49. 2007
    ..The present studies provide additional behavioral validation and initial pharmacological validation of this withdrawal-associated drinking procedure...
  72. ncbi request reprint Use of a novel mouse genotype to model acute benzodiazepine withdrawal
    Pamela Metten
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, and Department of Veterans Affairs Medical Center, Portland, OR 97239, USA
    Behav Genet 37:160-70. 2007
    ..Withdrawal convulsions were seen after all of the drugs by at least one method, suggesting that BZR agonists as a class elicit acute physical dependence in this susceptible genotype...
  73. pmc Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades
    Douglas Wahlsten
    Department of Psychology, University of Alberta, Edmonton, AB, Canada T6G 2E9
    Proc Natl Acad Sci U S A 103:16364-9. 2006
    ..Phenotypic drift over decades for most of the behaviors examined appears to be minimal...
  74. ncbi request reprint Alcohol-related genes: contributions from studies with genetically engineered mice
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, and Department of Veterans Affairs Medical Center, USA
    Addict Biol 11:195-269. 2006
    ..Novel modulatory effects of protein kinase C and G protein-activated inwardly rectifying K+ (GIRK) channels are also suggested. Some newer research with cannabinoid systems is promising, and has led to ongoing clinical trials...
  75. ncbi request reprint Pharmacological and genetic influences on hole-board behaviors in mice
    Christopher L Kliethermes
    Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, CA 94608, USA
    Pharmacol Biochem Behav 85:57-65. 2006
    ..However, the results with the genetically heterogeneous mice and HEB and LEB mice suggest that some aspects of the dopaminergic system are involved in head dipping...
  76. doi request reprint Overview of mouse assays of ethanol intoxication
    John C Crabbe
    Portland VA Medical Center, Portland, Oregon, USA
    Curr Protoc Neurosci . 2008
    ..Whether or not a test is conducted in naïve mice or as part of a test battery can influence sensitivity, and do so in a strain-dependent manner. This unit reviews existing tests and recommends several...
  77. ncbi request reprint Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum
    Douglas Wahlsten
    Department of Psychology and Centre for Neuroscience, University of Alberta, Edmonton, Alta, Canada T6G 2E9
    Brain Res 971:47-54. 2003
    ..Brain size varied greatly among strains but for any one strain was almost identical in mice housed for 5 weeks in the two laboratories. Sex differences in brain weight and forebrain commissure sizes were not statistically significant...
  78. ncbi request reprint Mapping murine loci for physical dependence on ethanol
    Kari J Buck
    Portland Alcohol Research Center, and Department of Behavioral Neuroscience, Oregon Health and Science University, VA Medical Center, Research Service mailcode RD40, 3710 SW US Veteran s Hospital Road, Portland, OR 97201, USA
    Psychopharmacology (Berl) 160:398-407. 2002
    ..A quantitative trait locus (QTL) identifies the genomic location of a gene (or genes) affecting a trait of interest...
  79. ncbi request reprint Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene
    Christoph Fehr
    Portland Alcohol Research Center and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Neurosci 22:3730-8. 2002
    ..These analyses, and evidence using interval-specific congenic lines, show that alcohol withdrawal severity is genetically correlated with MPDZ status, indicating that MPDZ variants may influence alcohol withdrawal liability...
  80. ncbi request reprint Mapping of quantitative trait loci underlying ethanol metabolism in BXD recombinant inbred mouse strains
    Judith E Grisel
    Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, Oregon Health and Science University, Portland, Oregon 97201, USA
    Alcohol Clin Exp Res 26:610-6. 2002
    ..However, these variant genes are either alcohol or aldehyde dehydrogenases, and the identification of new gene products that contribute to variation in alcohol metabolism would be useful...
  81. ncbi request reprint A novel method to assess initial sensitivity and acute functional tolerance to hypnotic effects of ethanol
    Igor Ponomarev
    Department of Behavioral Neuroscience, Oregon Health and Science University, Veterans Administration Medical Center R and D 12, 3710 SW U S Veterans Hospital Road, Portland, OR 97201, USA
    J Pharmacol Exp Ther 302:257-63. 2002
    ..These results show that the novel method is a sensitive tool for the measurement of initial sensitivity and detection of AFT to the hypnotic effects of ethanol...
  82. ncbi request reprint Initial sensitivity, tolerance and cross-tolerance to allopregnanolone- and ethanol-induced hypothermia in selected mouse lines
    Abraham A Palmer
    Portland Alcohol Research Center, Portland, OR 97201, USA
    Psychopharmacology (Berl) 162:313-22. 2002
    ..We also postulated that tolerance would develop to these two drugs by similar mechanisms, such that tolerance to one would impart cross-tolerance to the other...
  83. ncbi request reprint Different data from different labs: lessons from studies of gene-environment interaction
    Douglas Wahlsten
    Centre for Neuroscience and Department of Psychology, University of Alberta, Edmonton, AB T6G 2E9, Canada
    J Neurobiol 54:283-311. 2003
    ..Implications for behavioral screening of targeted and induced mutations in mice are discussed...
  84. pmc Assessment of genetic susceptibility to ethanol intoxication in mice
    Nathan R Rustay
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, and Veterans Affairs Medical Center, 3710 Southwest U S Veterans Hospital Road R and D 12, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 100:2917-22. 2003
    ....
  85. ncbi request reprint In search of a better mouse test
    Douglas Wahlsten
    Department of Psychology and Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada T6G 2E9
    Trends Neurosci 26:132-6. 2003
    ..The optimal apparatus configuration for certain genetic or pharmacological analyses might depend on the particular laboratory environment. Despite our best efforts, the mice will continue to win some innings...
  86. ncbi request reprint Of mice and their environments
    John C Crabbe
    Science 299:1313-4. 2003
  87. ncbi request reprint Genetic animal models of anxiety
    Deborah A Finn
    Department of Veterans Affairs Medical Center, Oregon Health and Science University, Portland, OR 97239 USA
    Neurogenetics 4:109-35. 2003
    ..Expression array technologies have as yet not been employed, but can be expected to implicate novel candidates and neurobiological pathways...
  88. ncbi request reprint Influence of task parameters on rotarod performance and sensitivity to ethanol in mice
    Nathan R Rustay
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, and VA Medical Center, Portland, OR 97239, USA
    Behav Brain Res 141:237-49. 2003
    ..These data also underscore the need to employ multiple behavioral assays in order to model a complex domain such as "ataxia" or "coordination."..
  89. pmc Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis
    Megan K Mulligan
    Waggoner Center for Alcohol and Addiction Research and Sections of Neurobiology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:6368-73. 2006
    ..The present study demonstrates the use of (i) a microarray meta-analysis to analyze a behavioral phenotype (in this case, alcohol preference) and (ii) a congenic strain for identification of cis regulation...
  90. ncbi request reprint Validation of a modified mirrored chamber sensitive to anxiolytics and anxiogenics in mice
    Christopher L Kliethermes
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, VAMC Research R and D 12, Department of Veterans Affairs Medical Center, Portland, OR 97239, USA
    Psychopharmacology (Berl) 169:190-7. 2003
    ..Anxiety is a common disorder in humans that exists in many forms, and animal models of human anxiety are typically employed for the discovery of anxiolytic drugs with human therapeutic potential...
  91. ncbi request reprint Characterization of acute functional tolerance to the hypnotic effects of ethanol in mice
    Igor Ponomarev
    Portland Alcohol Research Center, VA Medical Center, and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    Alcohol Clin Exp Res 28:991-7. 2004
    ..However, AFT to the hypnotic effects of ethanol has not been well characterized. The present study explored this form of AFT using a novel method of monitoring LRR in mice...
  92. ncbi request reprint The syntaxin binding protein 1 gene (Stxbp1) is a candidate for an ethanol preference drinking locus on mouse chromosome 2
    Christoph Fehr
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, and US Department of Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    Alcohol Clin Exp Res 29:708-20. 2005
    ..5, p = 3 x 10(-16)). The specific gene(s) in the QTL interval responsible for phenotypic variation in ethanol preference drinking has not been identified...
  93. ncbi request reprint A procedure to produce high alcohol intake in mice
    Deborah A Finn
    Portland Alcohol Research Center, VAMC Research and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Psychopharmacology (Berl) 178:471-80. 2005
    ....
  94. ncbi request reprint Observer-rated ataxia: rating scales for assessment of genetic differences in ethanol-induced intoxication in mice
    Pamela Metten
    Department of Veterans Affairs Medical Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Appl Physiol (1985) 97:360-8. 2004
    ..Modest strain mean correlations among behaviors indicate that these behaviors are probably under control of largely different genes and that ataxia rating scales should rate separate behaviors on discrete scales...
  95. ncbi request reprint Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice
    Justin S Rhodes
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, and VA Medical Center, Portland, Oregon 97239, USA
    Physiol Behav 84:53-63. 2005
    ..We discuss advantages of the model for high-throughput screening assays where the goal is to find other genotypes of mice that drink excessively, or to screen drugs for their efficacy in blocking excessive drinking...
  96. ncbi request reprint Ethanol's effects on gait dynamics in mice investigated by ventral plane videography
    Ajit Kale
    The CuraVita Corporation, Boston, Massachusetts, USA
    Alcohol Clin Exp Res 28:1839-48. 2004
    ..Therefore, we applied a new imaging technique to record and quantify coordinated gait dynamics in mice in response to ethanol...
  97. ncbi request reprint Genetic analysis of rapid tolerance to ethanol's incoordinating effects in mice: inbred strains and artificial selection
    Nathan R Rustay
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, and Department of Veterans Affairs Medical Center, Portland, Oregon 97239 USA
    Behav Genet 34:441-51. 2004
    ..These studies provide evidence for a genetic contribution to rapid tolerance and support a genetic link between rapid and chronic tolerance to ethanol's ataxic effects...
  98. ncbi request reprint Let's not discourage innovative approaches to complex questions
    Tamara J Phillips
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon, USA
    Alcohol Clin Exp Res 28:1607-8. 2004
  99. ncbi request reprint Selection for pentobarbital withdrawal severity: correlated differences in withdrawal from other sedative drugs
    Christopher L Kliethermes
    Department of Behavioral Neuroscience, Oregon Health and Science University and the Portland Alcohol Research Center, Veterans Affairs Medical Center, c o Portland VA Medical Center, Portland, OR 97239, USA
    Brain Res 1009:17-25. 2004
    ..These results indicate that some of the same genes that affect the severity of withdrawal from pentobarbital also influence ethanol and zolpidem withdrawal, but that diazepam withdrawal may be less influenced by these genes...
  100. ncbi request reprint Interaction of chronic ethanol exposure and finasteride: sex and strain differences
    Deborah A Finn
    Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, VAMC Research R and D 49, 3710 SW U S Veterans Hospital Road, Portland, OR 97239, USA
    Pharmacol Biochem Behav 78:435-43. 2004
    ..Finasteride pretreatment significantly decreased blood EtOH concentration (BEC) upon initiation of withdrawal, suggesting that finasteride may affect withdrawal severity via an alteration in EtOH pharmacokinetics...
  101. ncbi request reprint Effects of finasteride on chronic and acute ethanol withdrawal severity in the WSP and WSR selected lines
    Rebecca E Gorin
    Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    Alcohol Clin Exp Res 29:939-48. 2005
    ..Using the Withdrawal Seizure-Prone (WSP) and Withdrawal Seizure-Resistant (WSR) selected lines, in the present studies we examined the effect of finasteride on acute and chronic EtOH withdrawal severity...

Research Grants21

  1. GENETIC VULNERABILITY TO DRUGS OF ABUSE
    John Crabbe; Fiscal Year: 1992
    ....
  2. GENETIC VULNERABILITY TO DRUGS OF ABUSE
    John Crabbe; Fiscal Year: 2002
    ..abstract_text> ..
  3. IBANGS Annual Meeting support
    John Crabbe; Fiscal Year: 2005
    ..This young society represents an opportunity to attract a core group of young investigators to alcohol research during their formative years. ..
  4. BEHAVIORAL GENOMICS OF ALCOHOL NEUROADAPTATION
    John Crabbe; Fiscal Year: 2007
    ..The other new feature in the renewal is a pilot project that will perform the first clinical study in the PARC, a clinical trial of metoclopramide, to see whether impulsivity predicts response. ..
  5. IBANGS Annual Meeting support
    John Crabbe; Fiscal Year: 2007
    ..This young society presents an opportunity to attract a core group of young investigators during their formative years to neurobehavioral genetics and the pursuit of research improving human health. ..
  6. Selective Breeding for Drinking in the Circadian Dark
    John Crabbe; Fiscal Year: 2007
    ..We will initially target the lateral septum and its afferent and efferent connections. Finally, we will breed additional naive mice and ship them to other interested investigators. ..