Research Topics
| Jessica R CastleSummaryAffiliation: Oregon Health and Science University Country: USA Publications
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Detail Information
Publications
The accuracy benefit of multiple amperometric glucose sensors in people with type 1 diabetesJessica R Castle
Department of Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health and Science University, Portland, Oregon, USA
Diabetes Care 35:706-10. 2012..To improve glucose sensor accuracy in subjects with type 1 diabetes by using multiple sensors and to assess whether the benefit of redundancy is affected by intersensor distance...
Novel use of glucagon in a closed-loop system for prevention of hypoglycemia in type 1 diabetesJessica R Castle
Department of Medicine, Division of Endocrinology, Oregon Health and Science University, Portland, Oregon, USA
Diabetes Care 33:1282-7. 2010..To minimize hypoglycemia in subjects with type 1 diabetes by automated glucagon delivery in a closed-loop insulin delivery system...
Factors influencing the effectiveness of glucagon for preventing hypoglycemiaJessica R Castle
Oregon Health and Science University, Portland, Oregon 97239, USA
J Diabetes Sci Technol 4:1305-10. 2010..Administration of small, intermittent doses of glucagon during closed-loop insulin delivery markedly reduces the frequency of hypoglycemia. However, in some cases, hypoglycemia occurs despite administration of glucagon in this setting...
Continuous glucose monitoring in subjects with type 1 diabetes: improvement in accuracy by correcting for background currentJoseph El Youssef
Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Diabetes Technol Ther 12:921-8. 2010..We also tested whether increasing the frequency of sensor calibration would improve sensor accuracy...
Development of a fully automated closed loop artificial pancreas control system with dual pump delivery of insulin and glucagonPeter G Jacobs
Portland VA Medical Center and the Oregon Health and Sciences University, Portland, OR 97239, USA
Conf Proc IEEE Eng Med Biol Soc 2011:397-400. 2011..Results from this work may ultimately lead to development of a portable, easy to use, artificial pancreas device that can enable far better glycemic control in patients with diabetes...
Amperometric glucose sensors: sources of error and potential benefit of redundancyJessica R Castle
Oregon Health Services University, Portland, Oregon, USA
J Diabetes Sci Technol 4:221-5. 2010..If an array with three or more sensors were available, it would likely allow even better accuracy with the use of voting...
A controlled study of the effectiveness of an adaptive closed-loop algorithm to minimize corticosteroid-induced stress hyperglycemia in type 1 diabetesJoseph El Youssef
Oregon Health and Science University, Portland, Oregon, USA
J Diabetes Sci Technol 5:1312-26. 2011..6 ± 0.5%. We conclude that an adaptive algorithm that frequently estimates insulin sensitivity and adjusts gain factors is capable of minimizing corticosteroid-induced stress hyperglycemia...
Safe glycemic management during closed-loop treatment of type 1 diabetes: the role of glucagon, use of multiple sensors, and compensation for stress hyperglycemiaW Kenneth Ward
Oregon Health and Science University, Portland, Oregon 97239, USA
J Diabetes Sci Technol 5:1373-80. 2011..Elements such as the use of glucagon to minimize hypoglycemia, adaptation to changes in insulin sensitivity, and sensor redundancy will likely increase safety during outpatient use of closed-loop glycemic control systems...
Stable liquid glucagon formulations for rescue treatment and bi-hormonal closed-loop pancreasMelanie A Jackson
Oregon Health and Science University OHSU, 3181 SW Sam Jackson Park Road, OP05DC, Portland, OR 97239, USA
Curr Diab Rep 12:705-10. 2012..Assays for cyclic AMP (cAMP) or its downstream effector, protein kinase A (PKA), in engineered cell systems, are more reliable and suitable for inexpensive, high-throughput assessment of bioactivity...
Discomfort from an alkaline formulation delivered subcutaneously in humans: albumin at pH 7 versus pH 10W Kenneth Ward
Legacy Health and Legacy Research Institute, Portland, OR, USA
Clin Drug Investig 32:433-8. 2012..There is a paucity of data regarding tolerability of alkaline drugs administered subcutaneously. The aim of this study was to assess the tolerability of alkaline preparations of human albumin delivered subcutaneously to healthy humans...
