Sean M Bugel
Affiliation: Oregon State University
Bugel S, Wehmas L, La Du J, Tanguay R. Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium. Toxicol Appl Pharmacol. 2016;296:31-41 pubmed publisher
..These studies help advance our understanding of tamoxifen's non-classical mode of action and implicate a possible role for MMPs in tissues such as skin. ..
Bugel S, Tanguay R. Multidimensional chemobehavior analysis of flavonoids and neuroactive compounds in zebrafish. Toxicol Appl Pharmacol. 2018;344:23-34 pubmed publisher
..Overall, the integrative zebrafish platform provides a useful framework for comparatively evaluating high-content chemobehavioral data for sets of structurally- and mechanistically-related flavonoids and neuroactive compounds. ..
Bugel S, White L, Cooper K. Inhibition of vitellogenin gene induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is mediated by aryl hydrocarbon receptor 2 (AHR2) in zebrafish (Danio rerio). Aquat Toxicol. 2013;126:1-8 pubmed publisher
..This work provides evidence for AHR2 dependent cross-talk inhibition of vitellogenin genes and offers insight into anti-estrogenic reproductive effects observed in oviparous species exposed to AHR agonist contaminants. ..
Bugel S, Bonventre J, Tanguay R. Comparative Developmental Toxicity of Flavonoids Using an Integrative Zebrafish System. Toxicol Sci. 2016;154:55-68 pubmed
..This integrative zebrafish platform provides a useful framework for evaluating flavonoid developmental toxicity and hazard prioritization. ..