A C Buenafe

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. doi request reprint Diurnal rhythms are altered in a mouse model of multiple sclerosis
    Abigail C Buenafe
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    J Neuroimmunol 243:12-7. 2012
  2. pmc Regulatory T cells play a role in T-cell receptor CDR2 peptide regulation of experimental autoimmune encephalomyelitis
    Abigail C Buenafe
    Neuroimmunology Research, Department of Veterans Affairs Medical Center, Portland, OR 97239, USA
    Immunology 135:168-79. 2012
  3. pmc Prevention and treatment of experimental autoimmune encephalomyelitis with clonotypic CDR3 peptides: CD4(+) Foxp3(+) T-regulatory cells suppress interleukin-2-dependent expansion of myelin basic protein-specific T cells
    Abigail C Buenafe
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Immunology 130:114-24. 2010
  4. pmc Recombinase-activating gene 1-associated expression of the myelin basic protein 1-11-specific transgenic T-cell receptor in H-2b mice
    Abigail C Buenafe
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci Res 87:42-9. 2009
  5. doi request reprint A telemetric study of physiologic changes in mice with induced autoimmune encephalomyelitis
    Abigail C Buenafe
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Lab Anim (NY) 37:361-8. 2008
  6. ncbi request reprint Lipopolysaccharide pretreatment modulates the disease course in experimental autoimmune encephalomyelitis
    Abigail C Buenafe
    Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    J Neuroimmunol 182:32-40. 2007
  7. ncbi request reprint Specificity of regulatory CD4+CD25+ T cells for self-T cell receptor determinants
    Abigail C Buenafe
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci Res 76:129-40. 2004
  8. ncbi request reprint Rat RT1.B-transfected fibroblast lines process and present myelin antigens and activate T cells to induce experimental autoimmune encephalomyelitis
    A C Buenafe
    Department of Neurology, Oregon Health Sciences University, Portland, OR 97201, USA
    J Neuroimmunol 112:106-14. 2001
  9. ncbi request reprint Vaccination with BV8S2 protein amplifies TCR-specific regulation and protection against experimental autoimmune encephalomyelitis in TCR BV8S2 transgenic mice
    H Offner
    Portland Veterans Affairs Medical Center, Department of Neurology, Oregon Health Sciences University 97201, USA
    J Immunol 161:2178-86. 1998
  10. ncbi request reprint A TCR V alpha CDR3-specific motif associated with Lewis rat autoimmune encephalomyelitis and basic protein-specific T cell clones
    A C Buenafe
    Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    J Immunol 158:5472-83. 1997

Collaborators

Detail Information

Publications16

  1. doi request reprint Diurnal rhythms are altered in a mouse model of multiple sclerosis
    Abigail C Buenafe
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    J Neuroimmunol 243:12-7. 2012
    ..The results presented here indicate that disturbances in clock-regulated rhythms are associated with EAE and present a suitable model for investigating the relationship between circadian disruption and autoimmune inflammatory disease...
  2. pmc Regulatory T cells play a role in T-cell receptor CDR2 peptide regulation of experimental autoimmune encephalomyelitis
    Abigail C Buenafe
    Neuroimmunology Research, Department of Veterans Affairs Medical Center, Portland, OR 97239, USA
    Immunology 135:168-79. 2012
    ..Hence, TCR CDR2 peptide therapy is effective in regulating heterogeneous, pathogenic T-cell populations through the activity of the Foxp3(+) regulatory T cell population...
  3. pmc Prevention and treatment of experimental autoimmune encephalomyelitis with clonotypic CDR3 peptides: CD4(+) Foxp3(+) T-regulatory cells suppress interleukin-2-dependent expansion of myelin basic protein-specific T cells
    Abigail C Buenafe
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Immunology 130:114-24. 2010
    ....
  4. pmc Recombinase-activating gene 1-associated expression of the myelin basic protein 1-11-specific transgenic T-cell receptor in H-2b mice
    Abigail C Buenafe
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci Res 87:42-9. 2009
    ..Thus, the presence of a functional rag1 gene was required for the expression of the MBP-specific TgTCR on the H-2(b) background. Given the role for RAG1, the results have important implications for T-cell repertoire development...
  5. doi request reprint A telemetric study of physiologic changes in mice with induced autoimmune encephalomyelitis
    Abigail C Buenafe
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Lab Anim (NY) 37:361-8. 2008
    ..Further investigation may establish these methods as a system for studying the relationships between MS progression and autonomic regulation of physiological status...
  6. ncbi request reprint Lipopolysaccharide pretreatment modulates the disease course in experimental autoimmune encephalomyelitis
    Abigail C Buenafe
    Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    J Neuroimmunol 182:32-40. 2007
    ..Thus, exposure to LPS prior to EAE induction affects antigen presentation and may modulate the expression of inflammatory regulators that impact the autoimmune disease course...
  7. ncbi request reprint Specificity of regulatory CD4+CD25+ T cells for self-T cell receptor determinants
    Abigail C Buenafe
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci Res 76:129-40. 2004
    ..Inhibitory activity of TCR-reactive T cells required cell-cell contact and involved CTLA-4, GITR, IL-10, and IL-17. Thus, the T-T regulatory network includes Treg cells with specificity directed toward self-TCR determinants...
  8. ncbi request reprint Rat RT1.B-transfected fibroblast lines process and present myelin antigens and activate T cells to induce experimental autoimmune encephalomyelitis
    A C Buenafe
    Department of Neurology, Oregon Health Sciences University, Portland, OR 97201, USA
    J Neuroimmunol 112:106-14. 2001
    ..Thus, the RT1.B molecule is functionally expressed on the surface of transfected Dap.3 fibroblasts and is capable of MHC Class II-restricted, antigen-specific presentation to rat T cells...
  9. ncbi request reprint Vaccination with BV8S2 protein amplifies TCR-specific regulation and protection against experimental autoimmune encephalomyelitis in TCR BV8S2 transgenic mice
    H Offner
    Portland Veterans Affairs Medical Center, Department of Neurology, Oregon Health Sciences University 97201, USA
    J Immunol 161:2178-86. 1998
    ..These results suggest that immune regulation occurs through a nondeletional cytokine-driven suppressive mechanism...
  10. ncbi request reprint A TCR V alpha CDR3-specific motif associated with Lewis rat autoimmune encephalomyelitis and basic protein-specific T cell clones
    A C Buenafe
    Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    J Immunol 158:5472-83. 1997
    ..Thus, we demonstrate that the Asn3+ V alpha CDR3 motif is strongly associated with experimental autoimmune encephalomyelitis in the Lewis rat and propose that it plays a role in TCR recognition of a specific BP peptide/MHC complex...
  11. ncbi request reprint Estrogen inhibits systemic T cell expression of TNF-alpha and recruitment of TNF-alpha(+) T cells and macrophages into the CNS of mice developing experimental encephalomyelitis
    Atsushi Ito
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97201, USA
    Clin Immunol 102:275-82. 2002
    ..We propose that the mechanism of E2 protection may involve both systemic inhibition of TNF-alpha expression and local (CNS) recruitment of inflammatory cells, with modest effects on TNF-alpha expression by resident CNS microglial cells...
  12. ncbi request reprint Endogenous CD4+BV8S2- T cells from TG BV8S2+ donors confer complete protection against spontaneous experimental encephalomyelitis (Sp-EAE) in TCR transgenic, RAG-/- mice
    Agata Matejuk
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    J Neurosci Res 71:89-103. 2003
    ..These three Sp-EAE protective T cell subpopulations possessed distinctive properties and induced a variety of effects in T/R- recipients, thus implicating differing mechanisms of protection...
  13. ncbi request reprint Estrogen inhibition of EAE involves effects on dendritic cell function
    Hong Yan Liu
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    J Neurosci Res 70:238-48. 2002
    ..Thus, E2 treatment appears to have multiple effects on the DC population, which may contribute to a down-regulation or block in the activation of Th1 cells involved in the induction of EAE...
  14. ncbi request reprint Production, characterization, and immunogenicity of a soluble rat single chain T cell receptor specific for an encephalitogenic peptide
    Rachel H McMahan
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    J Biol Chem 278:30961-70. 2003
    ..Immune recognition of the C14 scTCR protein as an antigen revealed that limited regions of the TCR may be more likely to induce responsiveness...
  15. ncbi request reprint T-cell hybridoma specific for myelin oligodendrocyte glycoprotein-35-55 peptide produced from HLA-DRB1*1501-transgenic mice
    Yuan K Chou
    Neuroimmunology Research and Tykeson Multiple Sclerosis Research Laboratory, Veterans Affairs Medical Center, and Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci Res 77:670-80. 2004
    ....
  16. ncbi request reprint IL-7 enhances Ag-specific human T cell response by increasing expression of IL-2R alpha and gamma chains
    Y K Chou
    Veterans Affairs Medical Center, Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    J Neuroimmunol 96:101-11. 1999
    ..These studies demonstrate that IL-7 promotes the growth and survival of circulating Ag-specific human Th1 cells through a mechanism that probably involves the gammac common receptor for IL-2 family members that includes IL-7...