C K Buckway
Affiliation: Oregon Health and Science University
- Mutation of three critical amino acids of the N-terminal domain of IGF-binding protein-3 essential for high affinity IGF bindingC K Buckway
Department of Pediatrics, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
J Clin Endocrinol Metab 86:4943-50. 2001..The mutants provide a tool for future studies directed at IGF-dependent and IGF-independent actions of IGF-binding protein-3...
- Should we treat genetic syndromes?R G Rosenfield
Department of Pediatrics, Doernbecher Children s Hospital, Oregon Health Sciences University, Portland 97062, USA
J Pediatr Endocrinol Metab 13:971-81. 2000..If responsiveness to GH is the most important criterion for GH therapy, these "other" conditions warrant an open-minded, prospective evaluation...
- Growth hormone insensitivity syndromes: lessons learned and opportunities missedR G Rosenfeld
Department of Pediatrics, Oregon Health Sciences University, Portland, Oreg 97201, USA
Horm Res 55:36-9. 2001..Finally, the use of IGF-I to treat GHI has a number of limitations, and work is underway to develop alternative therapies...
- Insulin-like growth factor binding protein-3 generation as a measure of GH sensitivityC K Buckway
Department of Genetics, Stanford University, Stanford, California 94305, USA
J Clin Endocrinol Metab 87:4754-65. 2002..Failure to raise both IGF-I and IGFBP-3 lowered sensitivity to 82-86% with low-dose GH, and 86-91% with high-dose GH...