Affiliation: Oregon Health and Science University
Brooks V, Freeman K, Qi Y. Time course of synergistic interaction between DOCA and salt on blood pressure: roles of vasopressin and hepatic osmoreceptors. Am J Physiol Regul Integr Comp Physiol. 2006;291:R1825-34 pubmed
..With time, combined DOCA-salt induces marked changes in the regulation of the autonomic nervous system, which may favor hypertension development. ..
Brooks V, Shi Z, Holwerda S, Fadel P. Obesity-induced increases in sympathetic nerve activity: sex matters. Auton Neurosci. 2015;187:18-26 pubmed publisher
..This information is required not only to refine treatment options for obese premenopausal women but also to potentially reveal new therapeutic avenues in obese men and women. ..
Shi Z, Li B, Brooks V. Role of the Paraventricular Nucleus of the Hypothalamus in the Sympathoexcitatory Effects of Leptin. Hypertension. 2015;66:1034-41 pubmed publisher
Shi Z, Cassaglia P, Gotthardt L, Brooks V. Hypothalamic Paraventricular and Arcuate Nuclei Contribute to Elevated Sympathetic Nerve Activity in Pregnant Rats: Roles of Neuropeptide Y and Î±-Melanocyte-Stimulating Hormone. Hypertension. 2015;66:1191-8 pubmed publisher
Brooks V, Freeman K, Clow K. Excitatory amino acids in rostral ventrolateral medulla support blood pressure during water deprivation in rats. Am J Physiol Heart Circ Physiol. 2004;286:H1642-8 pubmed
..05). These data suggest that water deprivation increases EAA drive to the RVLM, in part by increasing responsiveness of the RVLM to EAA such as glutamate. ..
Brooks V, Dampney R, Heesch C. Pregnancy and the endocrine regulation of the baroreceptor reflex. Am J Physiol Regul Integr Comp Physiol. 2010;299:R439-51 pubmed publisher
Brooks V, Cassaglia P, Zhao D, Goldman R. Baroreflex function in females: changes with the reproductive cycle and pregnancy. Gend Med. 2012;9:61-7 pubmed publisher
..As a result, peripartum hemorrhage is a major cause of human maternal death. ..
Cassaglia P, Shi Z, Brooks V. Insulin increases sympathetic nerve activity in part by suppression of tonic inhibitory neuropeptide Y inputs into the paraventricular nucleus in female rats. Am J Physiol Regul Integr Comp Physiol. 2016;311:R97-R103 pubmed publisher
..Moreover, the steadily increasing rise in LSNA induced by ArcN insulin is also dependent on PVN MC3/4R. ..
Brooks V, Hatton D. Chronic ANG II infusion and reflex control of norepinephrine and corticosterone in conscious rabbits. Am J Physiol. 1997;272:R487-96 pubmed
..05), even when the hypertension was nearly maintained by phenylephrine infusion. In conclusion, chronic increases in ANG II may have a global baroreflex resetting effect by a mechanism that is in part independent of the hypertension...