Robert Brenner

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Molecular and functional aspects of menstruation in the macaque
    Robert M Brenner
    Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA
    Rev Endocr Metab Disord 13:309-18. 2012
  2. pmc A critical period of progesterone withdrawal precedes menstruation in macaques
    Ov D Slayden
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA
    Reprod Biol Endocrinol 4:S6. 2006
  3. pmc Role of nonhuman primate models in the discovery and clinical development of selective progesterone receptor modulators (SPRMs)
    Kristof Chwalisz
    TAP Pharmaceutical Products Inc, Lake Forest, Illinois, USA
    Reprod Biol Endocrinol 4:S8. 2006
  4. ncbi request reprint Steroid receptors in blood vessels of the rhesus macaque endometrium: a review
    Robert M Brenner
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Sciences University, 505 NW 185th Ave, Beaverton, OR 97006, USA
    Arch Histol Cytol 67:411-6. 2004
  5. pmc Basic and applied biology of the primate reproductive tract--a symposium in honor of the career of Dr Robert M Brenner: introduction and overview
    Robert M Brenner
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Reprod Biol Endocrinol 4:S2. 2006
  6. ncbi request reprint A role for the androgen receptor in the endometrial antiproliferative effects of progesterone antagonists
    Robert M Brenner
    Oregon National Primate Research Center, 505 N W 185th Avenue, Beaverton, OR 97006, USA
    Steroids 68:1033-9. 2003
  7. ncbi request reprint Immunocytochemical assessment of mitotic activity with an antibody to phosphorylated histone H3 in the macaque and human endometrium
    Robert M Brenner
    Oregon National Primate Research Center, 505 NW 185th Ave, Beaverton 97006, USA
    Hum Reprod 18:1185-93. 2003
  8. ncbi request reprint Premenstrual and menstrual changes in the macaque and human endometrium: relevance to endometriosis
    Robert M Brenner
    Oregon Regional Primate Research Center, Oregon Health Sciences University, Beaverton 97006, USA
    Ann N Y Acad Sci 955:60-74; discussion 86-8, 396-406. 2002
  9. pmc Intrauterine administration of CDB-2914 (Ulipristal) suppresses the endometrium of rhesus macaques
    Robert M Brenner
    Division of Reproductive Sciences, Oregon National Primate Research Center, OHSU, Beaverton, OR 97006, USA
    Contraception 81:336-42. 2010
  10. ncbi request reprint Progesterone receptor antagonists and the endometrial antiproliferative effect
    Robert M Brenner
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon 97006, USA
    Semin Reprod Med 23:74-81. 2005

Research Grants

Collaborators

Detail Information

Publications28

  1. pmc Molecular and functional aspects of menstruation in the macaque
    Robert M Brenner
    Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA
    Rev Endocr Metab Disord 13:309-18. 2012
    ..In this chapter we review some basic aspects of menstruation, with special emphasis on the macaque model and its relevance to the clinical issues of irregular and heavy menstrual bleeding (HMB)...
  2. pmc A critical period of progesterone withdrawal precedes menstruation in macaques
    Ov D Slayden
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA
    Reprod Biol Endocrinol 4:S6. 2006
    ..We concluded that upregulation of MMPs is essential to menses induction, but that after the critical period, menses will occur even if some MMPs are experimentally blocked...
  3. pmc Role of nonhuman primate models in the discovery and clinical development of selective progesterone receptor modulators (SPRMs)
    Kristof Chwalisz
    TAP Pharmaceutical Products Inc, Lake Forest, Illinois, USA
    Reprod Biol Endocrinol 4:S8. 2006
    ..These studies provided the first evidence of uterus-selective effects of asoprisnil and structurally related compounds, and the rationale for clinical development of asoprisnil...
  4. ncbi request reprint Steroid receptors in blood vessels of the rhesus macaque endometrium: a review
    Robert M Brenner
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Sciences University, 505 NW 185th Ave, Beaverton, OR 97006, USA
    Arch Histol Cytol 67:411-6. 2004
    ..We concluded that any direct effects of E on endometrial vessels would be mediated by ERbeta, and that the actions of P and A, and possibly some of E, were indirectly mediated through perivascular stromal cells...
  5. pmc Basic and applied biology of the primate reproductive tract--a symposium in honor of the career of Dr Robert M Brenner: introduction and overview
    Robert M Brenner
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Reprod Biol Endocrinol 4:S2. 2006
  6. ncbi request reprint A role for the androgen receptor in the endometrial antiproliferative effects of progesterone antagonists
    Robert M Brenner
    Oregon National Primate Research Center, 505 N W 185th Avenue, Beaverton, OR 97006, USA
    Steroids 68:1033-9. 2003
    ..These data implicate the AR as a functional component of the mechanism through which progesterone antagonists induce endometrial antiproliferative effects in the presence of estrogens...
  7. ncbi request reprint Immunocytochemical assessment of mitotic activity with an antibody to phosphorylated histone H3 in the macaque and human endometrium
    Robert M Brenner
    Oregon National Primate Research Center, 505 NW 185th Ave, Beaverton 97006, USA
    Hum Reprod 18:1185-93. 2003
    ..We assessed the value of two mitotic markers as immunocytochemical reagents for measuring mitotic rates in endometrium...
  8. ncbi request reprint Premenstrual and menstrual changes in the macaque and human endometrium: relevance to endometriosis
    Robert M Brenner
    Oregon Regional Primate Research Center, Oregon Health Sciences University, Beaverton 97006, USA
    Ann N Y Acad Sci 955:60-74; discussion 86-8, 396-406. 2002
    ..Additional research on these and other factors in premenstrual and menstrual endometrium may deepen our understanding of both the establishment and progression of this debilitating disease...
  9. pmc Intrauterine administration of CDB-2914 (Ulipristal) suppresses the endometrium of rhesus macaques
    Robert M Brenner
    Division of Reproductive Sciences, Oregon National Primate Research Center, OHSU, Beaverton, OR 97006, USA
    Contraception 81:336-42. 2010
    ..To test its effects when delivered by an intrauterine system (IUS), we prepared control and UPA-filled IUS and evaluated their effects in rhesus macaques...
  10. ncbi request reprint Progesterone receptor antagonists and the endometrial antiproliferative effect
    Robert M Brenner
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon 97006, USA
    Semin Reprod Med 23:74-81. 2005
    ..Various PR modulators have great promise as gynecological therapeutics, but additional research is needed to improve our understanding of their endometrial effects...
  11. ncbi request reprint Vascular proliferation and vascular endothelial growth factor expression in the rhesus macaque endometrium
    Nihar R Nayak
    Division of Reproductive Sciences, Oregon Regional Primate Research Center, Beaverton, Oregon 97006, USA
    J Clin Endocrinol Metab 87:1845-55. 2002
    ..These results implicate VEGF of stromal origin in endometrial vascular proliferation...
  12. ncbi request reprint Assessment of menstruation in the vervet (Cercopithecus aethiops)
    Rebecca L Carroll
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Am J Primatol 69:901-16. 2007
    ..Because strong similarities exist between the endometrium of vervets, macaques and women, we conclude that vervets can provide a useful animal model for studies on hormone regulation of menstruation...
  13. ncbi request reprint Flutamide counteracts the antiproliferative effects of antiprogestins in the primate endometrium
    Ov D Slayden
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    J Clin Endocrinol Metab 88:946-9. 2003
    ..1 +/- 3.8 (P < 0.05). FLU also blocked the hyalinizing degradation of the spiral arteries typically induced by APs. These results indicate that many of the antiendometrial effects of APs in primates may involve the AR...
  14. ncbi request reprint Hormonal regulation and localization of estrogen, progestin and androgen receptors in the endometrium of nonhuman primates: effects of progesterone receptor antagonists
    Ov D Slayden
    Division of Reproductive Sciences, Oregon National Primate Research Center, 505 NW 185th Ave, Beaverton, OR 97006, USA
    Arch Histol Cytol 67:393-409. 2004
    ..This endometrial antiproliferative effect is the basis of the clinical use of PA to control various diseases such as endometriosis...
  15. ncbi request reprint Estrogen enhances cystatin C expression in the macaque vagina
    Ov D Slayden
    Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    J Clin Endocrinol Metab 89:883-91. 2004
    ..Elevated cystatin C, by suppressing cysteine proteinase activity, may strengthen the vaginal wall and mitigate the potential for pelvic floor prolapse...
  16. ncbi request reprint Anti-proliferative effects of progesterone antagonists in the primate endometrium: a potential role for the androgen receptor
    Robert M Brenner
    Oregon National Primate Research Center, Beaverton 97006, USA
    Reproduction 124:167-72. 2002
    ..This brief review evaluates the implications of these findings...
  17. ncbi request reprint Estrogen increases collagen I and III mRNA expression in the pelvic support tissues of the rhesus macaque
    Amanda L Clark
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, USA
    Am J Obstet Gynecol 192:1523-9. 2005
    ..Our aim was to study the effect of estradiol and raloxifene on collagen synthesis, by measuring the expression collagen I and III mRNA...
  18. ncbi request reprint Cellular expression and hormonal regulation of neuropilin-1 and -2 messenger ribonucleic Acid in the human and rhesus macaque endometrium
    Ariane Germeyer
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, 300 Pasteur Drive, HH 333, Stanford, California 94305 5317, USA
    J Clin Endocrinol Metab 90:1783-90. 2005
    ..The findings extend our understanding of VEGF action in the primate endometrium...
  19. ncbi request reprint The rhesus macaque as an animal model for pelvic organ prolapse
    Lesley N Otto
    Division of Urogynecology and Reproductive Pelvic Surgery, Department of Obstetrics and Gynecology, Oregon Health Science University, Portland 97201, USA
    Am J Obstet Gynecol 186:416-21. 2002
    ....
  20. pmc VEGF blockade inhibits angiogenesis and reepithelialization of endometrium
    Xiujun Fan
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    FASEB J 22:3571-80. 2008
    ..In summary, we provide novel experimental data indicating that VEGF is essential for endometrial neoangiogenesis during postmenstrual/postpartum repair...
  21. pmc Antiprogestin-releasing intrauterine devices: a novel approach to endometrial contraception
    Nihar R Nayak
    Department of Obstetrics and Gynecology, Stanford University, Stanford, CA 94305, USA
    Contraception 75:S104-11. 2007
    ..Therefore, AP IUDs may provide novel contraceptive devices with minimal breakthrough bleeding...
  22. ncbi request reprint Selective progesterone receptor modulators (SPRMs): a novel therapeutic concept in endometriosis
    Kristof Chwalisz
    TAP Pharmaceutical Products Incorporated, Lake Forest, Illinois 60045, USA
    Ann N Y Acad Sci 955:373-88; discussion 389-93, 396-406. 2002
    ..Due to endometrial selectivity and favorable pharmacological profile, SPRMs may have advantages over the current medical treatments of this disease. Other emerging therapeutic approaches for this disease are also mentioned...
  23. ncbi request reprint Local levonorgestrel regulation of androgen receptor and 17beta-hydroxysteroid dehydrogenase type 2 expression in human endometrium
    Kevin A Burton
    Centre for Reproductive Biology, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Hum Reprod 18:2610-7. 2003
    ....
  24. pmc Regulation of human endometrial function: mechanisms relevant to uterine bleeding
    Hilary O D Critchley
    Department of Reproductive and Developmental Sciences, University of Edinburgh, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Reprod Biol Endocrinol 4:S5. 2006
    ..The development of novel strategies to manage these clinically significant problems depends on such new understanding as does the development of new contraceptives which avoid the endometrial side effect of breakthrough bleeding...
  25. ncbi request reprint Antiprogestins as a model for progesterone withdrawal
    Hilary O D Critchley
    Obstetrics and Gynaecology, Centre for Reproductive Biology, University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, UK
    Steroids 68:1061-8. 2003
    ....
  26. ncbi request reprint Expression, localization and hormonal control of angiopoietin-1 in the rhesus macaque endometrium: potential role in spiral artery growth
    Nihar R Nayak
    Department of Gynecology and Obstetrics, Stanford University, Stanford, CA 94305 5317, USA
    Mol Hum Reprod 11:791-9. 2005
    ..These data suggest, for the first time, that Ang-1 may play a key role in the P-dependent growth of the unique spiral arteries in the primate endometrium...
  27. ncbi request reprint Novel hepatocyte growth factor/scatter factor isoform transcripts in the macaque endometrium and placenta
    J Suzanne Lindsey
    Pharmaceutical Sciences Department, Texas Tech University Health Science Center School of Pharmacy, 1300 Coulter Drive, Amarillo, TX 79106, USA
    Mol Hum Reprod 8:81-7. 2002
    ..HGF/SF function in endometrium and placenta may involve complex interactions between the isoforms of HGF/SF and those of c-Met...

Research Grants8

  1. HORMONAL CONTROL OF THE FEMALE REPRODUCTIVE TRACT
    Robert Brenner; Fiscal Year: 2004
    ..The VEGF family and MMPs during menstrual induction. 2. VEFG-HGF interactions in MMP regulation. 3. KGF-VEGF interactions in spiral artery growth. 4. HGF and VEGF antagonists during menstruation. ..
  2. Suppression of Breakthrough Bleeding in LNG-IUS Users
    Robert Brenner; Fiscal Year: 2004
    ..The proposal brings basic scientists and clinicians together for a "bench to bedside" approach that will advance women's health and improve contraceptive technology. ..