Research Topics
Species | MATTHEW BLIZIOTESSummaryAffiliation: Oregon Health and Science University Country: USA Publications
Research Grants
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Detail Information
Publications
Bone histomorphometric and biomechanical abnormalities in mice homozygous for deletion of the dopamine transporter geneM Bliziotes
Portland VA Medical Center and Oregon Health Sciences University, 97201, USA
Bone 26:15-9. 2000..The ultimate bending load (femoral strength) for the DAT-/- mice was 30% lower than the wild-type mice (p = 0.004). Thus, deletion of the DAT gene results in deficiencies in skeletal structure and integrity...
Reduced G-protein-coupled-receptor kinase 2 activity results in impairment of osteoblast functionM Bliziotes
Portland VA Medical Center, Portland, OR 97201, USA
Bone 27:367-73. 2000..Thus, GRK2 may regulate growth factor responsiveness in osteoblasts by modulating multiprotein complex formation following receptor tyrosine kinase activation...
Neurotransmitter action in osteoblasts: expression of a functional system for serotonin receptor activation and reuptakeM M Bliziotes
Portland VA Medical Center, Portland, Oregon 97201, USA
Bone 29:477-86. 2001..5-HT potentiates the PTH-induced increase in AP-1 activity in UMR cells. These results demonstrate that osteoblastic cells express a functional serotonin system, with mechanisms for responding to and regulating uptake of 5-HT...
Periosteal remodeling at the femoral neck in nonhuman primatesMichael Bliziotes
Oregon Health and Science University, Portland, USA
J Bone Miner Res 21:1060-7. 2006..Our studies are the first to systematically document periosteal turnover at the femoral neck...
Serotonin transporter and receptor expression in osteocytic MLO-Y4 cellsM Bliziotes
Portland VA Medical Center, Portland, OR 97239, USA
Bone 39:1313-21. 2006..Thus, osteocytes, as well as osteoblasts, are capable of 5-HT synthesis, and express functional receptor and transporter components of the 5-HT signal transduction system...
Update in serotonin and boneMichael Bliziotes
Department of Medicine, Oregon Health and Science University and Portland VA Medical Center, Portland, Oregon 97239, USA
J Clin Endocrinol Metab 95:4124-32. 2010..Serotonin (5-HT) may be an important regulatory agent in bone, and agents that modify 5-HT signaling, such as selective serotonin reuptake inhibitors (SSRIs), are in widespread clinical use...
Vitamin D insufficiency in internal medicine residentsE M Haney
Division of General Internal Medicine and Geriatrics, Oregon Health and Science University, Portland, Oregon, USA
Calcif Tissue Int 76:11-6. 2005..Increased educational efforts to promote healthy dietary and lifestyle choices that allow attainment and maintenance of skeletal health are appropriate in this population...
Research Grants
- THE FUNCTION OF NEUROTRANSMITTERS IN BONE BIOLOGYMATTHEW BLIZIOTES; Fiscal Year: 2009..This research should contribute to new treatment and prevention regimens for osteoporosis and thus have a significant positive impact on the health care of the aging population. ..
