Affiliation: Oregon Health and Science University
- Bethea C, Reddy A, Robertson N, Coleman K. Effects of aromatase inhibition and androgen activity on serotonin and behavior in male macaques. Behav Neurosci. 2013;127:400-14 pubmed publisher..95). In summary, androgens induced aggressive behavior but they did not regulate serotonin. Altogether, the data suggest that aromatase activity supports serotonin production and that androgens increase aggression by another mechanism. ..
- Bethea C, Belikova Y, Phu K, Mammerella G. Reproductive steroid receptors and actions in the locus coeruleus of male macaques: Part of an aggression circuit?. Prog Neuropsychopharmacol Biol Psychiatry. 2016;71:210-22 pubmed publisher..Estrogen, either from metabolism of T or from de novo synthesis, appears necessary for robust CRH innervation of the LC, which differs from female macaques. ..
- Lima F, Leite C, Bethea C, Anselmo Franci J. Progesterone increased ?-endorphin innervation of the locus coeruleus, but ovarian steroids had no effect on noradrenergic neurodegeneration. Brain Res. 2017;1663:1-8 pubmed publisher..In addition, we did not find compelling evidence of neurodegeneration or neuroprotection by HRT in the LC of Rhesus monkeys. ..