CYNTHIA BETHEA

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. doi request reprint The effect of short moderate stress on the midbrain corticotropin-releasing factor system in a macaque model of functional hypothalamic amenorrhea
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Portland, Oregon Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon Electronic address
    Fertil Steril 100:1111-21. 2013
  2. doi request reprint Effects of aromatase inhibition and androgen activity on serotonin and behavior in male macaques
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    Behav Neurosci 127:400-14. 2013
  3. pmc The effect of short-term stress on serotonin gene expression in high and low resilient macaques
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, United States
    Prog Neuropsychopharmacol Biol Psychiatry 44:143-53. 2013
  4. pmc Function and innervation of the locus ceruleus in a macaque model of Functional Hypothalamic Amenorrhea
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Neurobiol Dis 50:96-106. 2013
  5. pmc The effect of long-term ovariectomy on midbrain stress systems in free ranging macaques
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Brain Res 1488:24-37. 2012
  6. pmc Effect of ovarian steroids on gene expression related to synapse assembly in serotonin neurons of macaques
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    J Neurosci Res 90:1324-34. 2012
  7. pmc Ovarian steroids increase glutamatergic related gene expression in serotonin neurons of macaques
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Mol Cell Neurosci 49:251-62. 2012
  8. doi request reprint Effect of ovarian hormones on survival genes in laser captured serotonin neurons from macaques
    Cynthia L Bethea
    Division of Reproductive Sciences, and Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    J Neurochem 105:1129-43. 2008
  9. pmc Neurobiology of stress-induced reproductive dysfunction in female macaques
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Mol Neurobiol 38:199-230. 2008
  10. pmc Expression profile of differentiating serotonin neurons derived from rhesus embryonic stem cells and comparison to adult serotonin neurons
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Gene Expr Patterns 9:94-108. 2009

Research Grants

  1. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
  2. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA BETHEA; Fiscal Year: 2007
  3. Rhesus Embryonic Stem Cell-Derived Serotonin Neurons
    CYNTHIA BETHEA; Fiscal Year: 2007
  4. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA BETHEA; Fiscal Year: 2005
  5. Steroid Regulation of Serotonin in Males
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010

Collaborators

Detail Information

Publications36

  1. doi request reprint The effect of short moderate stress on the midbrain corticotropin-releasing factor system in a macaque model of functional hypothalamic amenorrhea
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Portland, Oregon Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon Electronic address
    Fertil Steril 100:1111-21. 2013
    ..To study the effect of moderate stress on corticotropin-releasing factor (CRF) components in the serotonergic midbrain region in a monkey model of functional hypothalamic amenorrhea...
  2. doi request reprint Effects of aromatase inhibition and androgen activity on serotonin and behavior in male macaques
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    Behav Neurosci 127:400-14. 2013
    ..95). In summary, androgens induced aggressive behavior but they did not regulate serotonin. Altogether, the data suggest that aromatase activity supports serotonin production and that androgens increase aggression by another mechanism...
  3. pmc The effect of short-term stress on serotonin gene expression in high and low resilient macaques
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, United States
    Prog Neuropsychopharmacol Biol Psychiatry 44:143-53. 2013
    ..These data suggest that the serotonin system may set the sensitivity or resilience of the individual, but serotonin-related gene expression may not rapidly respond to moderate stress in nonhuman primates...
  4. pmc Function and innervation of the locus ceruleus in a macaque model of Functional Hypothalamic Amenorrhea
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Neurobiol Dis 50:96-106. 2013
    ..We hypothesize that elevated NE with low serotonin functionality ultimately leads to stress-induced infertility. In contrast, high serotonin functionality maintains ovulation in the presence of stress even with elevated NE...
  5. pmc The effect of long-term ovariectomy on midbrain stress systems in free ranging macaques
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Brain Res 1488:24-37. 2012
    ..The greater expression of CRF-R1 could cause a greater inhibition of serotonin upon a stress-induced increase in CRF as well...
  6. pmc Effect of ovarian steroids on gene expression related to synapse assembly in serotonin neurons of macaques
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    J Neurosci Res 90:1324-34. 2012
    ..Supplemental P treatment suppressed E-induced gene expression. In summary, ovarian steroids target gene expression of adhesion molecules in serotonin neurons that are important for synapse assembly...
  7. pmc Ovarian steroids increase glutamatergic related gene expression in serotonin neurons of macaques
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Mol Cell Neurosci 49:251-62. 2012
    ..Their induction by ovarian steroids indicates a complex upregulation of multiple components in the glutamate cycle and antioxidation, in addition to spine proliferation...
  8. doi request reprint Effect of ovarian hormones on survival genes in laser captured serotonin neurons from macaques
    Cynthia L Bethea
    Division of Reproductive Sciences, and Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    J Neurochem 105:1129-43. 2008
    ..The data indicate that ovarian steroids target the cytokine-signaling pathway, caspase-dependent and -independent pathways and cell cycle proteins to promote serotonin neuron survival...
  9. pmc Neurobiology of stress-induced reproductive dysfunction in female macaques
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Mol Neurobiol 38:199-230. 2008
    ..We speculate that with the application of stress, the dysfunction of these neural systems becomes exacerbated and reproductive function ceases...
  10. pmc Expression profile of differentiating serotonin neurons derived from rhesus embryonic stem cells and comparison to adult serotonin neurons
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Gene Expr Patterns 9:94-108. 2009
    ..This analysis suggests that the 366.4 cell line possesses cues for serotonin differentiation at early stages of differentiation, but that ESC-derived serotonin neurons are still immature...
  11. pmc Protective actions of ovarian hormones in the serotonin system of macaques
    Cynthia L Bethea
    Divisions of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, United States
    Front Neuroendocrinol 30:212-38. 2009
    ..The survival of serotonin neurons would support cognition and mental health...
  12. doi request reprint Effect of ovarian hormones on genes promoting dendritic spines in laser-captured serotonin neurons from macaques
    C L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR97006, USA
    Mol Psychiatry 15:1034-44. 2010
    ....
  13. pmc Effects of citalopram on serotonin and CRF systems in the midbrain of primates with differences in stress sensitivity
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, United States
    J Chem Neuroanat 41:200-18. 2011
    ....
  14. pmc Long-term ovariectomy decreases serotonin neuron number and gene expression in free ranging macaques
    C L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Neuroscience 192:675-88. 2011
    ..This may be due to serotonin cell death or to a negative impact on a long-term developmental process in young female macaques...
  15. ncbi request reprint Ovarian steroid treatment decreases corticotropin-releasing hormone (CRH) mRNA and protein in the hypothalamic paraventricular nucleus of ovariectomized monkeys
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Neuropsychopharmacology 33:546-56. 2008
    ..These results suggest that this hormone treatment regimen may increase stress resilience in surgically menopausal primates...
  16. ncbi request reprint Differential expression of progestin receptor isoforms in the hypothalamus, pituitary, and endometrium of rhesus macaques
    C L Bethea
    Division of Reproductive Science, Oregon Regional Primate Research Center, Beaverton 97006, USA
    Endocrinology 139:677-87. 1998
    ....
  17. ncbi request reprint Characterization of reproductive steroid receptors and response to estrogen in a rat serotonergic cell line
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    J Neurosci Methods 127:31-41. 2003
    ....
  18. ncbi request reprint Anxious behavior and fenfluramine-induced prolactin secretion in young rhesus macaques with different alleles of the serotonin reuptake transporter polymorphism (5HTTLPR)
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    Behav Genet 34:295-307. 2004
    ..These neurobehavioral data support recent neuroimaging findings in humans indicating the importance of the 5HTTLPR for amygdala-dependent anxious behavior...
  19. ncbi request reprint Diverse actions of ovarian steroids in the serotonin neural system
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon Regional Primate Research Center, Beaverton 97006, USA
    Front Neuroendocrinol 23:41-100. 2002
    ....
  20. ncbi request reprint Sensitivity to stress-induced reproductive dysfunction linked to activity of the serotonin system
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    Fertil Steril 83:148-55. 2005
    ..To use a nonhuman primate model and determine whether individuals sensitive to stress-induced reproductive dysfunction have lower activity of central serotonergic neurons under nonstressed conditions...
  21. ncbi request reprint Serotonin-related gene expression in female monkeys with individual sensitivity to stress
    C L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, 505 Northwest 185th Avenue, Beaverton, OR 97006, USA
    Neuroscience 132:151-66. 2005
    ....
  22. ncbi request reprint Effects of oral estrogen, raloxifene and arzoxifene on gene expression in serotonin neurons of macaques
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon Regional Primate Research Center, Beaverton, OR 97006, USA
    Psychoneuroendocrinology 27:431-45. 2002
    ..However, the responses to E were more variable and less robust with the oral dosing paradigm compared to a chronic implant paradigm...
  23. ncbi request reprint Amniotic fluid prolactin is decreased by experimental intrauterine infection or interleukin-1beta infusion but not via prostaglandins in pregnant rhesus macaques
    C L Bethea
    Division of Reproductive Sciences, Oregon Regional Primate Research Center, Beaverton 97006, USA
    Biol Reprod 58:1385-93. 1998
    ..The effect of IL-1beta on amniotic fluid prolactin does not appear to be mediated by PGs and may involve a direct effect of IL-1beta on decidual cells...
  24. pmc Nuclear factor kappa B in the dorsal raphe of macaques: an anatomical link for steroids, cytokines and serotonin
    Cynthia L Bethea
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Psychiatry Neurosci 31:105-14. 2006
    ....
  25. ncbi request reprint A second tryptophan hydroxylase isoform, TPH-2 mRNA, is increased by ovarian steroids in the raphe region of macaques
    Rachel L Sanchez
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Brain Res Mol Brain Res 135:194-203. 2005
    ..007, respectively). In conclusion, ovarian steroids stimulate TPH-2 mRNA expression, which could in turn cause an increase in serotonin synthesis. This would impact many of the neural functions that are governed by serotonin...
  26. ncbi request reprint Effects of ovarian steroids and raloxifene on proteins that synthesize, transport, and degrade serotonin in the raphe region of macaques
    Lisa J Smith
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR, USA
    Neuropsychopharmacology 29:2035-45. 2004
    ..The expression of the degradative enzymes suggests a complex combination of gene transcription, post-transcriptional processing, and substrate feedback mechanisms...
  27. ncbi request reprint Preliminary array analysis reveals novel genes regulated by ovarian steroids in the monkey raphe region
    Arubala P Reddy
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Psychopharmacology (Berl) 180:125-40. 2005
    ..These changes could promote cellular resilience in the region where serotonin neurons originate...
  28. ncbi request reprint Ovarian steroid regulation of 5-HT1A receptor binding and G protein activation in female monkeys
    Nick Z Lu
    Division of Reproductive Sciences, Oregon Regional Primate Research Center, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Neuropsychopharmacology 27:12-24. 2002
    ....
  29. ncbi request reprint Ovarian steroid regulation of monoamine oxidase-A and -B mRNAs in the macaque dorsal raphe and hypothalamic nuclei
    Chrisana Gundlah
    Division of Reproductive Services, Oregon Regional Primate Research Center, Beaverton, OR 97006, USA
    Psychopharmacology (Berl) 160:271-82. 2002
    ..Another control point in aminergic neurotransmission involves degradation by MAO. This enzyme occurs in two isoforms, A and B, which have different substrate preferences...
  30. ncbi request reprint Serotonin neurons derived from rhesus monkey embryonic stem cells: similarities to CNS serotonin neurons
    Ugur Salli
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton 97006, USA
    Exp Neurol 188:351-64. 2004
    ....
  31. pmc Serotonin in microdialysate from the mediobasal hypothalamus increases after progesterone administration to estrogen primed macaques
    Maria Luisa Centeno
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, United States
    Eur J Pharmacol 555:67-75. 2007
    ..0001; t-test). Since the increase in serotonin is delayed by approximately 40 h after progesterone-injection, we speculate that the action of progesterone may involve either nuclear progestin receptors or membrane progestin receptors...
  32. ncbi request reprint Corticotropin-releasing hormone and pro-opiomelanocortin gene expression in female monkeys with differences in sensitivity to stress
    Maria Luisa Centeno
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Neuroendocrinology 86:277-88. 2007
    ....
  33. pmc Functional characterization of rhesus embryonic stem cell-derived serotonin neurons
    Yukari Tokuyama
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Exp Biol Med (Maywood) 235:649-57. 2010
    ..Together, these findings demonstrate the feasibility of our protocol to direct different primate ESC lines to serotonin neurons with physiological characteristics, which makes them a useful in vitro model system...
  34. pmc Estradiol increases alpha7 nicotinic receptor in serotonergic dorsal raphe and noradrenergic locus coeruleus neurons of macaques
    Maria Luisa Centeno
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    J Comp Neurol 497:489-501. 2006
    ..These results constitute an important antecedent for study of the effects of nicotine and ovarian steroid hormones in the physiological functions regulated by the DR and the LC in women...
  35. ncbi request reprint Hypothalamic expression of serotonin 1A, 2A and 2C receptor and GAD67 mRNA in female cynomolgus monkeys with different sensitivity to stress
    Maria Luisa Centeno
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Brain Res 1142:1-12. 2007
    ....
  36. pmc Chronic consumption of a high-fat diet during pregnancy causes perturbations in the serotonergic system and increased anxiety-like behavior in nonhuman primate offspring
    Elinor L Sullivan
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon 97006, USA
    J Neurosci 30:3826-30. 2010
    ..These findings have important clinical implications as they demonstrate that exposure to maternal HFD consumption during gestation, independent of obesity, increases the risk of developing behavioral disorders such as anxiety...

Research Grants13

  1. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
    ..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
  2. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA BETHEA; Fiscal Year: 2007
    ..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
  3. Rhesus Embryonic Stem Cell-Derived Serotonin Neurons
    CYNTHIA BETHEA; Fiscal Year: 2007
    ..The knowledge obtained from this work will lead to novel treatments for psychoneuropathologies. ..
  4. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA BETHEA; Fiscal Year: 2005
    ..These experiments will (1) further the hypothesis that E and P increase serotonin neural function and (2) initiate investigations of the mechanism of action of E and P in serotonin neurons. ..
  5. Steroid Regulation of Serotonin in Males
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
    ..A regulatory mechanism is proposed that could lead to a novel treatment in psychiatric illnesses with explosive rage and impulse disorders. ..