LUIZ EDUARDO BERMUDEZ

Summary

Affiliation: Oregon State University
Country: USA

Publications

  1. pmc Secreted Mycobacterium tuberculosis Rv3654c and Rv3655c proteins participate in the suppression of macrophage apoptosis
    Lia Danelishvili
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, United States of America
    PLoS ONE 5:e10474. 2010
  2. pmc Identification of virulence determinants of Mycobacterium avium that impact on the ability to resist host killing mechanisms
    Yong Jun Li
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    J Med Microbiol 59:8-16. 2010
  3. pmc Inhibition of the Plasma-Membrane-Associated Serine Protease Cathepsin G by Mycobacterium tuberculosis Rv3364c Suppresses Caspase-1 and Pyroptosis in Macrophages
    Lia Danelishvili
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University Corvallis, OR, USA
    Front Microbiol 2:281. 2011
  4. pmc Identification of (+)-erythro-mefloquine as an active enantiomer with greater efficacy than mefloquine against Mycobacterium avium infection in mice
    Luiz E Bermudez
    Kuzell Institute for Arthritis and Infectious Diseases, San Francisco, California, USA
    Antimicrob Agents Chemother 56:4202-6. 2012
  5. pmc Surface proteome of "Mycobacterium avium subsp. hominissuis" during the early stages of macrophage infection
    Michael McNamara
    Department of Biomedical Sciences, Department of Chemistry, Oregon State University, Corvallis, Oregon, USA
    Infect Immun 80:1868-80. 2012
  6. pmc Virulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages
    Samradhni S Jha
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    BMC Microbiol 10:100. 2010
  7. ncbi request reprint Effects of macrolides and ketolides on mycobacterial infections
    Luiz E Bermudez
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    Curr Pharm Des 10:3221-8. 2004
  8. pmc EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium
    Luiz E Bermudez
    Department of Biomedical Sciences, College of Veterinary Medicine, 101 Magruder Hall, Oregon State University, Corvallis, OR 97331 4802, USA
    Antimicrob Agents Chemother 51:1666-70. 2007
  9. ncbi request reprint Intracellular phenotype of Mycobacterium avium enters macrophages primarily by a macropinocytosis-like mechanism and survives in a compartment that differs from that with extracellular phenotype
    Luiz E Bermudez
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    Cell Biol Int 28:411-9. 2004
  10. ncbi request reprint Role of type I cytokines in host defense against Mycobacterium avium infection
    Lia Danelishvilli
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331 8797, USA
    Curr Pharm Des 9:61-5. 2003

Research Grants

  1. GENES ASSOCIATED WITH M AVIUM PATHOGENESIS
    Luiz Bermudez; Fiscal Year: 1999
  2. Genes Associated with Mycobacterium avium Pathogenesis
    Luiz Bermudez; Fiscal Year: 2007
  3. Post Translation Regulation in Mycobacteria
    Luiz Bermudez; Fiscal Year: 2007
  4. Genes Associated with M .avium Pathogenesis
    Luiz Bermudez; Fiscal Year: 2006
  5. Genes Associated with M .avium Pathogenesis
    Luiz Bermudez; Fiscal Year: 2005
  6. Genes Associated with M .avium Pathogenesis
    Luiz Bermudez; Fiscal Year: 2004
  7. MYCOBACTERIAL ENVIRONMENT WITHIN MACROPHAGES
    Luiz Bermudez; Fiscal Year: 2003
  8. GENES ASSOCIATED WITH M AVIUM PATHOGENESIS
    Luiz Bermudez; Fiscal Year: 2002
  9. Target for Mefloquine in Mycobacteria
    Luiz Bermudez; Fiscal Year: 2002
  10. MYCOBACTERIAL ENVIRONMENT WITHIN MACROPHAGES
    Luiz Bermudez; Fiscal Year: 2002

Collaborators

Detail Information

Publications49

  1. pmc Secreted Mycobacterium tuberculosis Rv3654c and Rv3655c proteins participate in the suppression of macrophage apoptosis
    Lia Danelishvili
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, United States of America
    PLoS ONE 5:e10474. 2010
    ..The mechanisms by which M. tuberculosis H37Rv strain suppress apoptosis and escapes human macrophage killing was investigated...
  2. pmc Identification of virulence determinants of Mycobacterium avium that impact on the ability to resist host killing mechanisms
    Yong Jun Li
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    J Med Microbiol 59:8-16. 2010
    ..9). Mutants MAV_4292, MAV_0385 and MAV_4264 were susceptible to nitric oxide in vitro. The study of individual mutants can potentially lead to new knowledge about M. avium pathogenic mechanisms...
  3. pmc Inhibition of the Plasma-Membrane-Associated Serine Protease Cathepsin G by Mycobacterium tuberculosis Rv3364c Suppresses Caspase-1 and Pyroptosis in Macrophages
    Lia Danelishvili
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University Corvallis, OR, USA
    Front Microbiol 2:281. 2011
    ..In summary, M. tuberculosis prevents macrophage pyroptosis by a novel mechanism involving cytoplasmic surveillance proteins...
  4. pmc Identification of (+)-erythro-mefloquine as an active enantiomer with greater efficacy than mefloquine against Mycobacterium avium infection in mice
    Luiz E Bermudez
    Kuzell Institute for Arthritis and Infectious Diseases, San Francisco, California, USA
    Antimicrob Agents Chemother 56:4202-6. 2012
    ..Thus, (+)-erythro-mefloquine is the active enantiomer of mefloquine against M. avium and perhaps other mycobacteria...
  5. pmc Surface proteome of "Mycobacterium avium subsp. hominissuis" during the early stages of macrophage infection
    Michael McNamara
    Department of Biomedical Sciences, Department of Chemistry, Oregon State University, Corvallis, Oregon, USA
    Infect Immun 80:1868-80. 2012
    ..Additionally, surface-exposed proteins are excellent targets for the host adaptive immune system, and their identification can inform the development of novel treatments, diagnostic tools, and vaccines for mycobacterial disease...
  6. pmc Virulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages
    Samradhni S Jha
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    BMC Microbiol 10:100. 2010
    ..This mutant, in contrast to the wild-type bacterium, was shown both to have impaired the ability to replicate within macrophages and to have prevented phagosome/lysosome fusion...
  7. ncbi request reprint Effects of macrolides and ketolides on mycobacterial infections
    Luiz E Bermudez
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    Curr Pharm Des 10:3221-8. 2004
    ..Telithromycin has a carbamate group linked to an imidazolium and pyridium nucleus at C11-C12. In mice model, both telithromycin and ABT-733 were active in vivo against MAC...
  8. pmc EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium
    Luiz E Bermudez
    Department of Biomedical Sciences, College of Veterinary Medicine, 101 Magruder Hall, Oregon State University, Corvallis, OR 97331 4802, USA
    Antimicrob Agents Chemother 51:1666-70. 2007
    ..05). Further evaluation of EDP-420 in the treatment of MAC disease is warranted...
  9. ncbi request reprint Intracellular phenotype of Mycobacterium avium enters macrophages primarily by a macropinocytosis-like mechanism and survives in a compartment that differs from that with extracellular phenotype
    Luiz E Bermudez
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    Cell Biol Int 28:411-9. 2004
    ..These data suggest that uptake of extracellular fluid is part of M. avium IG phenotype uptake by macrophages, and that the IG phenotype inhabits a slightly different vacuole than that of EG...
  10. ncbi request reprint Role of type I cytokines in host defense against Mycobacterium avium infection
    Lia Danelishvilli
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331 8797, USA
    Curr Pharm Des 9:61-5. 2003
    ..avium activity in macrophages. M. avium-specific CD8+ T cells undergo apoptosis early in the infection. Therefore, the immune mechanisms of the host and bacterial strategies for survival are complex and fascinating...
  11. ncbi request reprint The efficacy of clarithromycin and the bicyclolide EDP-420 against Mycobacterium avium in a mouse model of pulmonary infection
    Luiz E Bermudez
    Kuzell Institute for Arthritis and Infectious Diseases, California Pacific Medical Center Research Institute, San Francisco, USA
    J Infect Dis 197:1506-10. 2008
    ..These results suggest that this animal model can be used to evaluate novel regimens against MAC disease and that compounds with high concentration in the lung might have a significant impact on the outcome of MAC lung disease...
  12. pmc Thiosemicarbazole (thiacetazone-like) compound with activity against Mycobacterium avium in mice
    Luiz E Bermudez
    Kuzell Institute for Arthritis and Infectious Diseases, California Pacific Medical Center Research Institute, San Francisco, California 94115, USA
    Antimicrob Agents Chemother 47:2685-7. 2003
    ..A combination of SRI-286 and moxifloxacin was significantly more active than single drug regimens in liver and spleen...
  13. pmc Peyer's patch-deficient mice demonstrate that Mycobacterium avium subsp. paratuberculosis translocates across the mucosal barrier via both M cells and enterocytes but has inefficient dissemination
    Luiz E Bermudez
    Kuzell Institute, California Pacific Medical Center Research Institute, San Francisco, California 94115, USA
    Infect Immun 78:3570-7. 2010
    ..In summary, M. avium subsp. paratuberculosis interacts with the intestinal mucosa by crossing both Peyer's patches and non-Peyer's patch areas but does not translocate or disseminate efficiently...
  14. ncbi request reprint Mefloquine, moxifloxacin, and ethambutol are a triple-drug alternative to macrolide-containing regimens for treatment of Mycobacterium avium disease
    Luiz E Bermudez
    Kuzell Institute for Arthritis and Infectious Diseases, California Pacific Medical Center Research Institute, San Francisco, California, USA
    J Infect Dis 187:1977-80. 2003
    ..1-log reduction of CLR-R after 4 weeks, and 2.17-log reduction in MAC/mL blood. Treatment of MAC 101 CLR-S strain had comparable results...
  15. pmc A subinhibitory concentration of clarithromycin inhibits Mycobacterium avium biofilm formation
    George Carter
    Kuzell Institute, California Pacific Medical Center Research Institute, San Francisco, California, USA
    Antimicrob Agents Chemother 48:4907-10. 2004
    ..Antibiotics with activity against the bacterium could inhibit biofilm formation. Clarithromycin inhibits biofilm formation but has no activity against established biofilm...
  16. pmc CD4+ T cells but Not CD8+ or gammadelta+ lymphocytes are required for host protection against Mycobacterium avium infection and dissemination through the intestinal route
    Mary Petrofsky
    Dept of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    Infect Immun 73:2621-7. 2005
    ..The ingestion of small numbers of M. avium cells induces a protective immune response in the intestines against subsequent infection. However, the bacteria remain viable in intestinal lymph nodes and might disseminate later...
  17. ncbi request reprint In vivo and in vitro growth of Mycobacterium marinum at homoeothermic temperatures
    Michael L Kent
    Department of Microbiology, Center for Fish Disease Research, Oregon State University, Corvallis, OR 97331 3804, USA
    FEMS Microbiol Lett 257:69-75. 2006
    ..Significant differences of growth in vitro and in vivo were observed. All fish strains caused both footpad and deep tissue infections, and two, which grew very poorly or not all at 37 degrees C, proliferated in mammalian macrophages...
  18. ncbi request reprint The fadD2 gene is required for efficient Mycobacterium avium invasion of mucosal epithelial cells
    Tapen Dam
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331 USA
    J Infect Dis 193:1135-42. 2006
    ..Mycobacterium avium is capable of invading the intestinal epithelial cells, which requires cytoskeleton rearrangement and protein phosphorylation in the host cell. However, little is known about the mechanism...
  19. pmc SRI-286, a thiosemicarbazole, in combination with mefloquine and moxifloxacin for treatment of murine Mycobacterium avium complex disease
    Luiz E Bermudez
    Kuzell Institute, California Pacific Medical Center Research Institute, San Francisco, California, USA
    Antimicrob Agents Chemother 48:3556-8. 2004
    ..We infected C57 beige mice and treated them with mefloquine, SRI-286, and moxifloxacin. SRI-286 (80 mg/kg) was bactericidal in the liver. Mefloquine plus moxifloxacin or mefloquine plus SRI-286 were better than mefloquine alone...
  20. ncbi request reprint A Mycobacterium avium PPE gene is associated with the ability of the bacterium to grow in macrophages and virulence in mice
    Yongjun Li
    Kuzell Institute for Arthritis and Infectious Diseases, California Pacific Medical, Center Research Institute San Francisco, CA 94115, USA
    Cell Microbiol 7:539-48. 2005
    ..These results revealed a role for this PPE gene in the growth of M. avium in macrophages and in virulence in mice...
  21. ncbi request reprint Characterization of biofilm formation by clinical isolates of Mycobacterium avium
    George Carter
    Laboratory of Bacterial Pathogenesis, Kuzell Institute and Liposome Research Laboratory, California Pacific Medical Center Research Institute, San Francisco, CA, USA
    J Med Microbiol 52:747-52. 2003
    ..Identification of M. avium genes involved in biofilm formation and further studies of the effect of antimicrobials on the establishment of biofilm may identify approaches for inhibiting M. avium biofilm formation and colonization...
  22. ncbi request reprint Identification of Mycobacterium avium genes up-regulated in cultured macrophages and in mice
    Lia Danelishvili
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    FEMS Microbiol Lett 239:41-9. 2004
    ..Evaluation of most expressed genes in M. smegmatis confirmed their up-regulation in M. avium after 24 h infection of macrophages in vitro and mice...
  23. pmc Mycobacterium tuberculosis uptake by recipient host macrophages is influenced by environmental conditions in the granuloma of the infectious individual and is associated with impaired production of interleukin-12 and tumor necrosis factor alpha
    Yong Jun Li
    Kuzell Institute for Arthritis and Infectious Diseases, California Pacific Medical Center Research Institute, San Francisco, California 94115, USA
    Infect Immun 70:6223-30. 2002
    ..The results suggest that M. tuberculosis in vivo may be adapted to gain access to the intracellular environment in a very efficient fashion and may do so by using different receptors from the complement and mannose receptors...
  24. ncbi request reprint Elemental analysis of Mycobacterium avium-, Mycobacterium tuberculosis-, and Mycobacterium smegmatis-containing phagosomes indicates pathogen-induced microenvironments within the host cell's endosomal system
    Dirk Wagner
    Kuzell Institute for Arthritis and Infectious Diseases, San Francisco, CA 94115, USA
    J Immunol 174:1491-500. 2005
    ..tuberculosis vacuoles exhibited retarded acquisition of iron compared with phagosomes with wild-type M. tuberculosis. This is a unique approach to define the environmental conditions within the pathogen-containing compartment...
  25. pmc Genomic approach to identifying the putative target of and mechanisms of resistance to mefloquine in mycobacteria
    Lia Danelishvili
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, 105 Magruder Hall, Corvallis, OR 97331 8797, USA
    Antimicrob Agents Chemother 49:3707-14. 2005
    ..avium genes associated with M. smegmatis resistant to mefloquine were sequenced. Two groups of genes were identified: one affecting membrane transport and one gene that apparently is involved in regulation of cellular replication...
  26. ncbi request reprint Mycobacterium avium infection of macrophages results in progressive suppression of interleukin-12 production in vitro and in vivo
    Dirk Wagner
    Laboratory of Bacterial Pathogenesis, Kuzell Institute for Arthritis and Infectious Diseases, California Pacific Medical Center Research Institute, San Francisco, California 94115, USA
    J Leukoc Biol 71:80-8. 2002
    ..Our data indicate that M. avium infection of macrophages suppresses IL-12 production by infected cells and that the suppression was not a result of the presence of IL-10 and TGF beta 1 in the culture supernatant...
  27. ncbi request reprint The ability to form biofilm influences Mycobacterium avium invasion and translocation of bronchial epithelial cells
    Yoshitaka Yamazaki
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    Cell Microbiol 8:806-14. 2006
    ..Mutants had impaired ability to cause infection in mice, as well. The ability to form biofilm appeared to be associated with the invasiveness of MAC A5...
  28. pmc The ability of Mycobacterium avium subsp. paratuberculosis to enter bovine epithelial cells is influenced by preexposure to a hyperosmolar environment and intracellular passage in bovine mammary epithelial cells
    Dilip Patel
    Department of Food Science, Oregon State University, Corvallis, OR 97331, USA
    Infect Immun 74:2849-55. 2006
    ..001). Microarray analysis of intracellular M. avium subsp. paratuberculosis RNA indicates the increased transcription of genes which might be associated with an invasive phenotype...
  29. ncbi request reprint Mycobacterium tuberculosis infection causes different levels of apoptosis and necrosis in human macrophages and alveolar epithelial cells
    Lia Danelishvili
    Kuzell Institute for Arthritis and Infectious Diseases, California Pacific Medical Center Research Institute, San Francisco, CA 94115, USA
    Cell Microbiol 5:649-60. 2003
    ..Our results showed that the differential induction of apoptosis between macrophages and alveolar epithelial cells represents specific strategies of M. tuberculosis for survival in the host...
  30. pmc Species of environmental mycobacteria differ in their abilities to grow in human, mouse, and carp macrophages and with regard to the presence of mycobacterial virulence genes, as observed by DNA microarray hybridization
    Melanie J Harriff
    Department of Biomedical Sciences, College of Veterinary Medicine, 105 Magruder, Oregon State University, Corvallis, OR 97331, USA
    Appl Environ Microbiol 74:275-85. 2008
    ..Further understanding of the role these genes play in host specificity and pathogenicity will be important to gain insight into the zoonotic potential of certain EM as well as their mechanisms of virulence...
  31. pmc Mycobacterium avium genes MAV_5138 and MAV_3679 are transcriptional regulators that play a role in invasion of epithelial cells, in part by their regulation of CipA, a putative surface protein interacting with host cell signaling pathways
    Melanie J Harriff
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon 97331, USA
    J Bacteriol 191:1132-42. 2009
    ..avium complex have a novel mechanism for activating cytoskeletal rearrangement, prompting uptake by host epithelial cells, and that this mechanism is regulated in part by fadD2, MAV_5138, and MAV_3679...
  32. doi request reprint A Mycobacterium avium subsp. paratuberculosis LuxR regulates cell envelope and virulence
    Marta Alonso-Hearn
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon 97331, USA
    Innate Immun 16:235-47. 2010
    ..Here we show that LuxR regulates virulence determinants and is involved in mycobacteria adaptation to the host...
  33. ncbi request reprint Pathogenesis of nontuberculous mycobacteria infections
    Jeffery McGarvey
    Kuzell Institute, California Pacific Medical Center Research Institute, 2200 Webster Street, Suite 305, San Francisco, CA 94115, USA
    Clin Chest Med 23:569-83. 2002
    ..It turns out that M avium is a fascinating pathogen after all. The increasing knowledge about M avium pathogenesis may one day provide means for a more effective prophylaxis as well as for treatment of the infection...
  34. pmc Identification of Mycobacterium avium pathogenicity island important for macrophage and amoeba infection
    Lia Danelishvili
    Department of Biomedical Sciences, College of Veterinary Medicine, and Microbiology, Oregon State University, Corvallis, OR 97331, USA
    Proc Natl Acad Sci U S A 104:11038-43. 2007
    ..The defect in the ability of the mutants to invade both cells was highly similar, suggesting that M. avium might have evolved mechanisms that are used to enter amoebas and human macrophages...
  35. pmc The efficiency of the translocation of Mycobacterium tuberculosis across a bilayer of epithelial and endothelial cells as a model of the alveolar wall is a consequence of transport within mononuclear phagocytes and invasion of alveolar epithelial cells
    Luiz E Bermudez
    Kuzell Institute for Arthritis and Infectious Diseases, California Pacific Medical Center Research Institute, University of California, San Francisco, California, USA
    Infect Immun 70:140-6. 2002
    ..We identified two potential mechanisms by which M. tuberculosis gains access to deeper tissues, by translocating across epithelial cells and by traveling into the blood vessels within monocytes...
  36. pmc Identification of Mycobacterium avium genes that affect invasion of the intestinal epithelium
    Elizabeth Miltner
    Kuzell Institute for Arthritis and Infectious Diseases, San Francisco, California, USA
    Infect Immun 73:4214-21. 2005
    ....
  37. ncbi request reprint In vivo efficacy of phage therapy for Mycobacterium avium infection as delivered by a nonvirulent mycobacterium
    Lia Danelishvili
    Department of Biomedical Sciences, College of Veterinary Medicine, Department of Microbiology, College of Science, Oregon State University, 105 Magruder Hall, Corvallis, OR 97331 8797, USA
    Microb Drug Resist 12:1-6. 2006
    ..These in vivo studies confirmed the in vitro findings that an avirulent mycobacterium can be used as a carrier to deliver antimycobacterial phage intracellularly...
  38. pmc Mimicry of the pathogenic mycobacterium vacuole in vitro elicits the bacterial intracellular phenotype, including early-onset macrophage death
    Julie Early
    Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331, USA
    Infect Immun 79:2412-22. 2011
    ....
  39. ncbi request reprint Mycobacterium avium genes upregulated upon infection of Acanthamoeba castellanii demonstrate a common response to the intracellular environment
    Rachel Tenant
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
    Curr Microbiol 52:128-33. 2006
    ..These results showed that the GFP promoter library in M. smegmatis is a valid system for studying gene upregulation in M. avium systems, and that many M. avium genes are commonly upregulated following macrophage and amoeba infection...
  40. pmc Mycobacterium avium genes associated with the ability to form a biofilm
    Yoshitaka Yamazaki
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, 105 Magruder Hall, Corvallis, OR 97331, USA
    Appl Environ Microbiol 72:819-25. 2006
    ..In conclusion, it appears that GPL biosynthesis, including the GDP-mannose biosynthesis pathway, is the most important pathway involved in the production of M. avium biofilm...
  41. pmc The Mycobacterium avium subsp. paratuberculosis MAP3464 gene encodes an oxidoreductase involved in invasion of bovine epithelial cells through the activation of host cell Cdc42
    Marta Alonso-Hearn
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331 4802, USA
    Infect Immun 76:170-8. 2008
    ..These findings reveal a novel signaling pathway activated during M. avium subsp. paratuberculosis entry that links the product of MAP3464 gene to activation of Cdc42 in the host cell...
  42. ncbi request reprint Clinical, microbiological, and immunological characteristics in HIV-infected subjects at risk for disseminated Mycobacterium avium complex disease: an AACTG study
    Rob Roy MacGregor
    Infectious Diseases Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    AIDS Res Hum Retroviruses 21:689-95. 2005
    ..MAC-specific T cell responses apparently develop and persist during DMAC, but are dysfunctional or too infrequent to prevent persistence...
  43. pmc A Mycobacterium marinum mel2 mutant is defective for growth in macrophages that produce reactive oxygen and reactive nitrogen species
    Selvakumar Subbian
    Department of Microbial and Molecular Pathogenesis, Texas A and M University Health Sciences Center, 471 Reynolds Medical Building, College Station, TX 77843, USA
    Infect Immun 75:127-34. 2007
    ..These observations demonstrate that the M. marinum mel2 locus plays a role in resistance to ROS and RNS produced by activated macrophages...
  44. pmc Genetic and phenotypic differences between Legionella pneumophila strains
    Mustapha M Samrakandi
    Department of Veterinary and Biomedical Sciences, University of Nebraska, Lincoln, Lincoln, Nebraska 68583, USA
    J Clin Microbiol 40:1352-62. 2002
    ..These studies emphasize the importance of further investigation into the genetic makeup of these strains, which is likely to lead to the identification of additional factors involved in Legionella pathogenesis...
  45. ncbi request reprint Elemental analysis of the Mycobacterium avium phagosome in Balb/c mouse macrophages
    Dirk Wagner
    Division of Infectious Diseases, Department of Internal Medicine, University of Freiburg, Freiburg, Germany
    Biochem Biophys Res Commun 344:1346-51. 2006
    ..We hypothesize that a potassium channel is abundant in the phagosome in macrophages that may be related to microbiocidal killing, similar to the requirement of potassium channels for microbiocidal function in neutrophils...
  46. ncbi request reprint Differential virulence of Mycobacterium avium strains isolated from HIV-infected patients with disseminated M. avium complex disease
    Kiyofumi Ohkusu
    Department of Pathology and Laboratory Medicine, Childrens Hospital Los Angeles and University of Southern California, Los Angeles, California 90027, USA
    J Infect Dis 190:1347-54. 2004
    ..There were significant differences in the virulence properties, and these differences may provide insight into the interplay between microbial pathogenesis and host defense...
  47. ncbi request reprint Virulent mycobacteria and the many aspects of macrophage uptake
    Lia Danelishvili
    Future Microbiol 2:461-4. 2007
  48. ncbi request reprint fecB, a gene potentially involved in iron transport in Mycobacterium avium, is not induced within macrophages
    Dirk Wagner
    Division of Infectious Diseases, Department of Internal Medicine II, University of Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    FEMS Microbiol Lett 247:185-91. 2005
    ..In macrophages, M. avium fec B was not induced during the early phase of infection, suggesting that the iron concentration in the mycobacterial phagosome is not sufficiently low to stimulate the expression of fecB in M. avium...
  49. ncbi request reprint Killing of Mycobacterium avium and Mycobacterium tuberculosis by a mycobacteriophage delivered by a nonvirulent mycobacterium: a model for phage therapy of intracellular bacterial pathogens
    Lawrence Broxmeyer
    Med America Research, Whitestone, New York, USA
    J Infect Dis 186:1155-60. 2002
    ..In addition, the M. smegmatis vacuole harboring TM4 fuses with the M. avium vacuole in macrophages. These results suggest a potentially novel concept to kill intracellular pathogenic bacteria and warrant future development...

Research Grants18

  1. GENES ASSOCIATED WITH M AVIUM PATHOGENESIS
    Luiz Bermudez; Fiscal Year: 1999
    ..The applicants believe that the studies outlined in this proposal will provide excellent tools for the identification of novel genes associated with mechanisms of pathogenesis of M. avium.m. ..
  2. Genes Associated with Mycobacterium avium Pathogenesis
    Luiz Bermudez; Fiscal Year: 2007
    ..An initial screen of 3000 mutants resulted in the identification of a number of virulent determinants, such as PPE genes, polyketide synthases, MmpL proteins, ABC transporters, and several genes of unknown function. ..
  3. Post Translation Regulation in Mycobacteria
    Luiz Bermudez; Fiscal Year: 2007
    ..This work has the potential to unveil mechanisms used by mycobacteria to regulate virulence genes in the environment of the host. In case we confirm our hypothesis, future work will address the role of Ion in M. tuberculosis ..
  4. Genes Associated with M .avium Pathogenesis
    Luiz Bermudez; Fiscal Year: 2006
    ..An initial screen of 3000 mutants resulted in the identification of a number of virulent determinants, such as PPE genes, polyketide synthases, MmpL proteins, ABC transporters, and several genes of unknown function. ..
  5. Genes Associated with M .avium Pathogenesis
    Luiz Bermudez; Fiscal Year: 2005
    ..An initial screen of 3000 mutants resulted in the identification of a number of virulent determinants, such as PPE genes, polyketide synthases, MmpL proteins, ABC transporters, and several genes of unknown function. ..
  6. Genes Associated with M .avium Pathogenesis
    Luiz Bermudez; Fiscal Year: 2004
    ..An initial screen of 3000 mutants resulted in the identification of a number of virulent determinants, such as PPE genes, polyketide synthases, MmpL proteins, ABC transporters, and several genes of unknown function. ..
  7. MYCOBACTERIAL ENVIRONMENT WITHIN MACROPHAGES
    Luiz Bermudez; Fiscal Year: 2003
    ..We believe that the proposed studies will generate important information about the phagosome environment and the mycobacterial response to it. ..
  8. GENES ASSOCIATED WITH M AVIUM PATHOGENESIS
    Luiz Bermudez; Fiscal Year: 2002
    ..The applicants believe that the studies outlined in this proposal will provide excellent tools for the identification of novel genes associated with mechanisms of pathogenesis of M. avium.m. ..
  9. Target for Mefloquine in Mycobacteria
    Luiz Bermudez; Fiscal Year: 2002
    ..avium is exposed to mefloquine. This work, focused on an active anti-mycobacterial compound, has the potential to unveil new target(s) in both M. avium and M. tuberculosis. ..
  10. MYCOBACTERIAL ENVIRONMENT WITHIN MACROPHAGES
    Luiz Bermudez; Fiscal Year: 2002
    ..We believe that the proposed studies will generate important information about the phagosome environment and the mycobacterial response to it. ..
  11. MYCOBACTERIAL ENVIRONMENT WITHIN MACROPHAGES
    Luiz Bermudez; Fiscal Year: 2002
    ..We believe that the proposed studies will generate important information about the phagosome environment and the mycobacterial response to it. ..
  12. MYCOBACTERIAL ENVIRONMENT WITHIN MACROPHAGES
    Luiz Bermudez; Fiscal Year: 2001
    ..We believe that the proposed studies will generate important information about the phagosome environment and the mycobacterial response to it. ..
  13. GENES ASSOCIATED WITH M AVIUM PATHOGENESIS
    Luiz Bermudez; Fiscal Year: 2001
    ..The applicants believe that the studies outlined in this proposal will provide excellent tools for the identification of novel genes associated with mechanisms of pathogenesis of M. avium.m. ..
  14. GENES ASSOCIATED WITH M AVIUM PATHOGENESIS
    Luiz Bermudez; Fiscal Year: 2000
    ..The applicants believe that the studies outlined in this proposal will provide excellent tools for the identification of novel genes associated with mechanisms of pathogenesis of M. avium.m. ..
  15. MYCOBACTERIAL ENVIRONMENT WITHIN MACROPHAGES
    Luiz Bermudez; Fiscal Year: 2000
    ..We believe that the proposed studies will generate important information about the phagosome environment and the mycobacterial response to it. ..
  16. Genes Associated with Mycobacterium avium Pathogenesis
    LUIZ EDUARDO BERMUDEZ; Fiscal Year: 2010
    ..M. avium forms biofilm and lives within macrophages. Only a few antimicrobials have activity against it. The knowledge about pathogenic mechanisms of infection is needed to improve effective therapy. ..