J K Belknap

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Genetic diversity and striatal gene networks: focus on the heterogeneous stock-collaborative cross (HS-CC) mouse
    Ovidiu D Iancu
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA
    BMC Genomics 11:585. 2010
  2. pmc The PhenoGen informatics website: tools for analyses of complex traits
    Sanjiv V Bhave
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    BMC Genet 8:59. 2007
  3. ncbi request reprint Short-term selective breeding as a tool for QTL mapping: ethanol preference drinking in mice
    J K Belknap
    VA Medical Center, Portland, Oregon 97201, USA
    Behav Genet 27:55-66. 1997
  4. ncbi request reprint Effect of within-strain sample size on QTL detection and mapping using recombinant inbred mouse strains
    J K Belknap
    Research Service 151W, Oregon Health Sciences University, Portland 97201, USA
    Behav Genet 28:29-38. 1998
  5. ncbi request reprint Chromosome substitution strains: some quantitative considerations for genome scans and fine mapping
    John K Belknap
    Research Service R and D 5, Veterans Affairs Medical Center, and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Mamm Genome 14:723-32. 2003
  6. ncbi request reprint Type I and type II error rates for quantitative trait loci (QTL) mapping studies using recombinant inbred mouse strains
    J K Belknap
    Research Service, VA Medical Center, Oregon Health Sciences University, Portland 97201, USA
    Behav Genet 26:149-60. 1996
  7. ncbi request reprint The replicability of QTLs for murine alcohol preference drinking behavior across eight independent studies
    J K Belknap
    Research Service R and D5, Department of Veterans Affairs Medical Center, Portland Alcohol Research Center, and Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Mamm Genome 12:893-9. 2001
  8. ncbi request reprint QTL analysis and genomewide mutagenesis in mice: complementary genetic approaches to the dissection of complex traits
    J K Belknap
    Research Service, Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    Behav Genet 31:5-15. 2001
  9. ncbi request reprint Mapping genes that regulate density of dopamine transporters and correlated behaviors in recombinant inbred mice
    A Janowsky
    Research Service, Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    J Pharmacol Exp Ther 298:634-43. 2001
  10. ncbi request reprint Genes on mouse chromosomes 2 and 9 determine variation in ethanol consumption
    T J Phillips
    Veterans Administration Medical Center, R and D 32, 3710 SW US Veterans Hospital Rd, Portland, Oregon 97201, USA
    Mamm Genome 9:936-41. 1998

Detail Information

Publications65

  1. pmc Genetic diversity and striatal gene networks: focus on the heterogeneous stock-collaborative cross (HS-CC) mouse
    Ovidiu D Iancu
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA
    BMC Genomics 11:585. 2010
    ..Brain (striatum) gene expression data were obtained using the Illumina Mouse WG 6.1 array, and the data sets were interrogated using a weighted gene co-expression network analysis (WGCNA)...
  2. pmc The PhenoGen informatics website: tools for analyses of complex traits
    Sanjiv V Bhave
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    BMC Genet 8:59. 2007
    ..Managing this diverse data and integrating with other biological data are major challenges for the bioinformatics community. Comprehensive new tools are needed to store, integrate and analyze the data efficiently...
  3. ncbi request reprint Short-term selective breeding as a tool for QTL mapping: ethanol preference drinking in mice
    J K Belknap
    VA Medical Center, Portland, Oregon 97201, USA
    Behav Genet 27:55-66. 1997
    ..Combining the BXD and two-way selection line results, the most probable QTL was found on chromosome 3 (near the adhl locus; LOD approximately 2.9), other probable QTLs were found with LOD 2.4-2.6...
  4. ncbi request reprint Effect of within-strain sample size on QTL detection and mapping using recombinant inbred mouse strains
    J K Belknap
    Research Service 151W, Oregon Health Sciences University, Portland 97201, USA
    Behav Genet 28:29-38. 1998
    ..However, with DNA pooling, this advantage is greatly reduced and may be reversed depending on the values of hRI2 and n...
  5. ncbi request reprint Chromosome substitution strains: some quantitative considerations for genome scans and fine mapping
    John K Belknap
    Research Service R and D 5, Veterans Affairs Medical Center, and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Mamm Genome 14:723-32. 2003
    ..To serve as guidelines for planning experiments, methods to estimate sample sizes for QTL detection are presented for the initial genome scan and for subsequent fine mapping...
  6. ncbi request reprint Type I and type II error rates for quantitative trait loci (QTL) mapping studies using recombinant inbred mouse strains
    J K Belknap
    Research Service, VA Medical Center, Oregon Health Sciences University, Portland 97201, USA
    Behav Genet 26:149-60. 1996
    ..This flexibility in setting RI alpha values is appropriate only when adequate protection against Type I errors comes from the F2 (or other) confirmation test(s)...
  7. ncbi request reprint The replicability of QTLs for murine alcohol preference drinking behavior across eight independent studies
    J K Belknap
    Research Service R and D5, Department of Veterans Affairs Medical Center, Portland Alcohol Research Center, and Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Mamm Genome 12:893-9. 2001
    ..Two other QTLs on Chrs 1 (distal) and 11 (mid) were less consistent, but still reached overall significance (P <.0001)...
  8. ncbi request reprint QTL analysis and genomewide mutagenesis in mice: complementary genetic approaches to the dissection of complex traits
    J K Belknap
    Research Service, Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    Behav Genet 31:5-15. 2001
    ..We argue that these two complementary genetic methods have much to offer in efforts to highlight genes and pathways most likely to influence the susceptibility and progression of common diseases in human populations...
  9. ncbi request reprint Mapping genes that regulate density of dopamine transporters and correlated behaviors in recombinant inbred mice
    A Janowsky
    Research Service, Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    J Pharmacol Exp Ther 298:634-43. 2001
    ..The results suggest that there is a gene(s) on proximal chromosome 19 that strongly influences DAT expression in neostriatum and may influence psychostimulant-induced activity and thermal responses...
  10. ncbi request reprint Genes on mouse chromosomes 2 and 9 determine variation in ethanol consumption
    T J Phillips
    Veterans Administration Medical Center, R and D 32, 3710 SW US Veterans Hospital Rd, Portland, Oregon 97201, USA
    Mamm Genome 9:936-41. 1998
    ..These data suggest that the determinants of these two measures are genetically diverse, but may share some common genetic elements...
  11. doi request reprint Mapping a locus for alcohol physical dependence and associated withdrawal to a 1.1 Mb interval of mouse chromosome 1 syntenic with human chromosome 1q23.2-23.3
    L Kozell
    Department of Veterans Affairs Medical Center, Portland, OR, USA
    Genes Brain Behav 7:560-7. 2008
    ..Thus, the fine mapping of this QTL and analyses of the genes within the QTL interval can inform developing models for genetic determinants of alcohol dependence in humans...
  12. ncbi request reprint Genomewide search for epistasis in a complex trait: pentobarbital withdrawal convulsions in mice
    H M Hood
    Portland Alcohol Research Center and Department of Behavioral Neuroscience, Oregon Health Sciences University, 97201, USA
    Behav Genet 31:93-100. 2001
    ..0004). This modifier is in the same genomic vicinity as loci detected for a variety of withdrawal and seizure phenotypes...
  13. ncbi request reprint Genetic analysis of the corticosterone response to ethanol in BXD recombinant inbred mice
    A J Roberts
    Department of Medical Psychology, Oregon Health Sciences University, Portland, USA
    Behav Neurosci 109:1199-208. 1995
    ..Overall these results indicate that gene action significantly influences stress responsiveness and suggest possible chromosomal locations of these genes...
  14. ncbi request reprint Sex and genotype determine the selective activation of neurochemically-distinct mechanisms of swim stress-induced analgesia
    J S Mogil
    Research Service 151W, VA Medical Center, Portland, Oregon 97201, USA
    Pharmacol Biochem Behav 56:61-6. 1997
    ..These findings support the hypothesis that genetic factors and sex, in addition to stressor parameters, can determine the selective recruitment of alternative central mechanisms of pain inhibition...
  15. ncbi request reprint Potential pleiotropic effects of Mpdz on vulnerability to seizures
    C Fehr
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Genes Brain Behav 3:8-19. 2004
    ....
  16. ncbi request reprint Identification of a sex-specific quantitative trait locus mediating nonopioid stress-induced analgesia in female mice
    J S Mogil
    Department of Behavioral Neuroscience and Veterans Affairs Medical Center, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Neurosci 17:7995-8002. 1997
    ..The present data provide further evidence of the existence of a female-specific SIA mechanism and highlight the important role of both genetic background and gender in the inhibition of pain...
  17. ncbi request reprint Use of recombinant inbred strains for studying genetic determinants of responses to alcohol
    J C Crabbe
    Oregon Health Sciences University, Portland, USA
    Alcohol Alcohol Suppl 2:67-71. 1994
    ..A cluster of genes (Scn1, Scn2, Scn3) code for voltage-sensitive sodium channel proteins. These genes are plausible candidates for affecting withdrawal HIC...
  18. ncbi request reprint Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/6 and DBA/2 strains
    J K Belknap
    Research Service 151W, VA Med Ctr, Portland, OR 97201, USA
    Life Sci 57:PL117-24. 1995
    ....
  19. ncbi request reprint Stereotypic behaviors in mice selectively bred for high and low methamphetamine-induced stereotypic chewing
    A L Atkins
    Department of Behavioral Neuroscience, Oregon Health and Sciences University, 3710 SW US Veterans Hospital Road, R and D5, Portland, OR 97201, USA
    Psychopharmacology (Berl) 157:96-104. 2001
    ..We sought to determine whether stereotypic behaviors other than number of repetitive chewing episodes were altered by the selective breeding process...
  20. ncbi request reprint Localization of genes affecting alcohol drinking in mice
    T J Phillips
    Veterans Administration Medical Center, Oregon Health Sciences University, Portland
    Alcohol Clin Exp Res 18:931-41. 1994
    ..In general, our results suggest that saccharin and ethanol consumption are determined by the actions of multiple genes (QTL), some in common, and suggest specific map locations of several such QTL on the mouse genome...
  21. ncbi request reprint Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice
    K J Buck
    Portland Alcohol Research Center and Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Neurosci 17:3946-55. 1997
    ..Syntenic conservation between human and mouse chromosomes suggests that human homologs of genes that increase risk for physiological dependence may localize to 1q21-q32, 2q24-q37/11p13, 9p21-p23/1p32-p22.1, and 5q32-q35...
  22. pmc Cocaine-induced seizure thresholds: quantitative trait loci detection and mapping in two populations derived from the C57BL/6 and DBA/2 mouse strains
    H S Hain
    Department of Behavioral Neuroscience, Oregon Health Sciences University, and Research Service, Veterans Affairs Medical Center, Portland, Oregon, USA
    J Pharmacol Exp Ther 293:180-7. 2000
    ..0015), both associated with clonic seizures on chromosomes 9 (proximal) and 15 (distal). Both QTLs on chromosome 9 were sex-specific, with much larger effects on the phenotype seen in females than in males...
  23. ncbi request reprint Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice
    J C Crabbe
    Research Service, VA Medical Center, Portland, Oregon
    J Pharmacol Exp Ther 269:184-92. 1994
    ..abstract truncated at 250 words)..
  24. ncbi request reprint Quantitative trait loci affecting methamphetamine responses in BXD recombinant inbred mouse strains
    J E Grisel
    Research Service, Veterans Affairs Medical Center, Portland, OR 97201, USA
    J Neurosci 17:745-54. 1997
    ..In several instances, QTLs appeared to overlap, which is consistent with idea that common neural substrates underlie some responses to psychostimulants...
  25. ncbi request reprint Genetic sensitivity to hot-plate nociception in DBA/2J and C57BL/6J inbred mouse strains: possible sex-specific mediation by delta2-opioid receptors
    J S Mogil
    Department of Behavioral Neuroscience and VA Medical Center, Oregon Health Sciences University, Portland 97201, USA
    Pain 70:267-77. 1997
    ..These data support the possibility that Oprd1 is a QTL mediating HP sensitivity in mice, and more generally illustrate the important roles of genetic background and gender in the perception of pain...
  26. ncbi request reprint Drug withdrawal convulsions and susceptibility to convulsants after short-term selective breeding for acute ethanol withdrawal
    P Metten
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health Sciences University and Department of Veteran s Affairs Medical Center, Portland 97201, USA
    Behav Brain Res 95:113-22. 1998
    ..No line differences were detected. These results indicate that genes influencing severity of withdrawal from several depressant drugs are largely different from those affecting susceptibility to GABAergic or glutamatergic convulsants...
  27. ncbi request reprint Quantitative trait loci associated with brain weight in the BXD/Ty recombinant inbred mouse strains
    J K Belknap
    Research Service 151W, VA Medical Center, Portland, OR
    Brain Res Bull 29:337-44. 1992
    ..The genetic correlation between brain and body weight was low (r = 0.28), indicating that these two traits are largely genetically independent in the BXD RI series...
  28. ncbi request reprint Genetic determinants of sensitivity to diazepam in inbred mice
    J C Crabbe
    Department of Behavioral Neuroscience, Oregon Health Sciences University, Veterans Affairs Medical Center, Portland 97201, USA
    Behav Neurosci 112:668-77. 1998
    ..That is, genetically influenced sensitivity to DZ is not monolithic but is somewhat specific to the particular response variable studied, a result that also characterizes genetic control of responses to other drugs...
  29. ncbi request reprint Mapping quantitative trait loci that influence femoral cross-sectional area in mice
    Robert F Klein
    Department of Medicine, Oregon Health and Science University, Portland 97201 3098, USA
    J Bone Miner Res 17:1752-60. 2002
    ..The identification of the genes responsible for geometric differences in bone development should reveal fundamentally important processes in the control of skeletal integrity...
  30. ncbi request reprint The syntaxin binding protein 1 gene (Stxbp1) is a candidate for an ethanol preference drinking locus on mouse chromosome 2
    Christoph Fehr
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, and US Department of Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    Alcohol Clin Exp Res 29:708-20. 2005
    ..5, p = 3 x 10(-16)). The specific gene(s) in the QTL interval responsible for phenotypic variation in ethanol preference drinking has not been identified...
  31. ncbi request reprint Pharmacogenetic evidence for the involvement of 5-hydroxytryptamine (Serotonin)-1B receptors in the mediation of morphine antinociceptive sensitivity
    H S Hain
    Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, Oregon, USA
    J Pharmacol Exp Ther 291:444-9. 1999
    ..These data collectively support a role for 5-HT(1B) receptors in the mediation of morphine antinociception and support the contention that polymorphisms in the Htr1b gene may underlie individual differences in morphine sensitivity...
  32. ncbi request reprint Single-locus control of saccharin intake in BXD/Ty recombinant inbred (RI) mice: some methodological implications for RI strain analysis
    J K Belknap
    Research Service 151W, VA Medical Center, Portland Oregon
    Behav Genet 22:81-100. 1992
    ..One of these, the D12nyu1 locus on chromosome 12, was independently supported in a panel of standard (non-RI) inbred strains also tested for saccharin preference. It is unclear whether this reflects the sac locus...
  33. ncbi request reprint Quantitative trait loci for acute behavioral sensitivity to paraoxon
    F O Risinger
    Department of Behavioral Neuroscience, L470, Portland Alcohol Research Center, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Neurotoxicol Teratol 22:667-74. 2000
    ....
  34. pmc The alpha 3 subunit gene of the nicotinic acetylcholine receptor is a candidate gene for ethanol stimulation
    H M Kamens
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, VA Medical Center, Portland, OR 97239, USA
    Genes Brain Behav 8:600-9. 2009
    ..Chrna3 is a candidate gene for the acute locomotor stimulant response to ethanol that deserves further examination...
  35. ncbi request reprint Oligogenic determination of morphine analgesic magnitude: a genetic analysis of selectively bred mouse lines
    J S Mogil
    Research Service 151W, VA Medical Center, Portland, Oregon 97201, USA
    Behav Genet 25:397-406. 1995
    ....
  36. doi request reprint Internet resources for genomic, bioinformatics, and medical genetics information
    Tamara J Phillips
    Veterans Affairs Medical Center and Oregon Health and Science University, Portland, Oregon, USA
    Curr Protoc Neurosci . 2003
    ....
  37. ncbi request reprint Where are the mu receptors that mediate opioid analgesia? An autoradiographic study in the HAR and LAR selection lines
    J K Belknap
    Research Service, VA Medical Center, Portland, OR
    J Addict Dis 10:29-44. 1991
    ..These results strongly suggest that mu receptors in a portion of the DRN are involved in mediating analgesia due to systemically administered opioids in this population of mice...
  38. ncbi request reprint Harnessing the mouse to unravel the genetics of human disease
    T J Phillips
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR, USA
    Genes Brain Behav 1:14-26. 2002
    ..We assert that unique combinations of classical approaches with current behavioral and molecular genomic approaches will more rapidly advance the field...
  39. ncbi request reprint Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene
    Christoph Fehr
    Portland Alcohol Research Center and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Neurosci 22:3730-8. 2002
    ..These analyses, and evidence using interval-specific congenic lines, show that alcohol withdrawal severity is genetically correlated with MPDZ status, indicating that MPDZ variants may influence alcohol withdrawal liability...
  40. ncbi request reprint Functional antagonism of mu-, delta- and kappa-opioid antinociception by orphanin FQ
    J S Mogil
    VA Medical Center, Oregon Health Sciences University, Portland 97201, USA
    Neurosci Lett 214:131-4. 1996
    ..We conclude, therefore, that OFQ functionally antagonizes mu (and (opioid receptors, and may play a general role in opioid modulation...
  41. pmc A method for mapping intralocus interactions influencing excessive alcohol drinking
    Tamara J Phillips
    Veterans Affairs Medical Center, Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR, 97239, USA
    Mamm Genome 21:39-51. 2010
    ..No evidence was found for epistasis between any pair of significant or suggestive QTLs. This indicates that the hybrid overdominance is due to intralocus interactions at the level of individual QTL...
  42. pmc The complexity of alcohol drinking: studies in rodent genetic models
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Genet 40:737-50. 2010
    ..We report here results from a second replicate of that selection and compare them with the first replicate...
  43. ncbi request reprint Complex-trait genetics: emergence of multivariate strategies
    Tamara J Phillips
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97201, USA
    Nat Rev Neurosci 3:478-85. 2002
    ....
  44. ncbi request reprint Genetic determinants of sensitivity to pentobarbital in inbred mice
    John C Crabbe
    Department of Behavioral Neuroscience, VA Medical Center, Oregon Health and Science University, Portland, OR 97201, USA
    Psychopharmacology (Berl) 161:408-16. 2002
    ..We postulated that genetic determinants of different responses to pentobarbital (PB) in mice would differ from response to response...
  45. ncbi request reprint Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice
    Justin S Rhodes
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, and VA Medical Center, Portland, Oregon 97239, USA
    Physiol Behav 84:53-63. 2005
    ..We discuss advantages of the model for high-throughput screening assays where the goal is to find other genotypes of mice that drink excessively, or to screen drugs for their efficacy in blocking excessive drinking...
  46. ncbi request reprint A procedure to produce high alcohol intake in mice
    Deborah A Finn
    Portland Alcohol Research Center, VAMC Research and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Psychopharmacology (Berl) 178:471-80. 2005
    ....
  47. ncbi request reprint Selection for pentobarbital withdrawal severity: correlated differences in withdrawal from other sedative drugs
    Christopher L Kliethermes
    Department of Behavioral Neuroscience, Oregon Health and Science University and the Portland Alcohol Research Center, Veterans Affairs Medical Center, c o Portland VA Medical Center, Portland, OR 97239, USA
    Brain Res 1009:17-25. 2004
    ..These results indicate that some of the same genes that affect the severity of withdrawal from pentobarbital also influence ethanol and zolpidem withdrawal, but that diazepam withdrawal may be less influenced by these genes...
  48. ncbi request reprint Regulation of bone mass in mice by the lipoxygenase gene Alox15
    Robert F Klein
    Bone and Mineral Research Unit, Department of Medicine, School of Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Science 303:229-32. 2004
    ..Pharmacologic inhibitors of this enzyme improved bone density and strength in two rodent models of osteoporosis. These results suggest that drugs targeting the 12/15-lipoxygenase pathway merit investigation as a therapy for osteoporosis...
  49. pmc Genetic correlates of morphine withdrawal in 14 inbred mouse strains
    Pamela Metten
    Portland Alcohol Research Center, Department of Veterans Affairs, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Drug Alcohol Depend 99:123-31. 2009
    ....
  50. ncbi request reprint Heritability of the blood pressure response to acute ethanol exposure in five inbred strains of mice
    D C Hatton
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health Sciences University, Portland 97201, USA
    Alcohol Clin Exp Res 24:1483-7. 2000
    ....
  51. ncbi request reprint Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for complex trait analysis
    Robert W Williams
    Portland Alcohol Research Center, Oregon Health Sciences University, 97239, USA
    Mamm Genome 15:637-47. 2004
    ..Thus, the LXS panel provides a powerful new resource for mapping complex traits across many systems and disciplines and should prove to be of great utility in modeling the genetics of complex diseases in human populations...
  52. pmc Multivariate analyses reveal common and drug-specific genetic influences on responses to four drugs of abuse
    John K Belknap
    Research Service, Veterans Affairs Medical Center, Department of Behavioral Neuroscience and the Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239, USA
    Trends Pharmacol Sci 29:537-43. 2008
    ..Thus, similar analyses should be applicable to other laboratories, traits and genotypes...
  53. ncbi request reprint NMDA receptor subunit mRNA and protein expression in ethanol-withdrawal seizure-prone and -resistant mice
    J N Mason
    Medical Research Service, Department of Veterans Affairs Medical Center, Portland Alcohol Research Center, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Alcohol Clin Exp Res 25:651-60. 2001
    ....
  54. pmc Evaluation of levodopa dose and magnitude of dopamine depletion as risk factors for levodopa-induced dyskinesia in a rat model of Parkinson's disease
    Daniel B Putterman
    Research Service, Portland VA Medical Center, RD 61, 3710 SW U S Veterans Hospital Rd, Portland, OR 97207, USA
    J Pharmacol Exp Ther 323:277-84. 2007
    ..Although levodopa dose and level of dopamine depletion are significant risk factors for LID, we conclude that other factors must contribute to LID susceptibility...
  55. ncbi request reprint Identification of quantitative trait loci for chemical/inflammatory nociception in mice
    Sonya G Wilson
    Department of Psychology and Neuroscience Program, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    Pain 96:385-91. 2002
    ..Identification of the genes underlying these QTLs may illuminate the basis of individual differences in inflammatory pain, and lead to novel analgesic treatment strategies...
  56. ncbi request reprint Chromosomal loci influencing chronic alcohol withdrawal severity
    Susan E Bergeson
    Waggoner Center for Alcohol and Addiction Research, Section of Neurobiology, University of Texas, Austin, Texas 78712, USA
    Mamm Genome 14:454-63. 2003
    ....
  57. ncbi request reprint Chromosomal loci influencing the susceptibility to the parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    Marco Sedelis
    Institute of Physiological Psychology I, and Center for Biological and Medical Research, Heinrich Heine University of Dusseldorf, 40225 Dusseldorf, Germany
    J Neurosci 23:8247-53. 2003
    ..Several mechanisms that are possibly involved in the control of the action of MPTP on the nigrostriatal system are discussed...
  58. pmc The nature and identification of quantitative trait loci: a community's view
    Oduola Abiola
    Nat Rev Genet 4:911-6. 2003
    ..Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?..
  59. pmc Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis
    Megan K Mulligan
    Waggoner Center for Alcohol and Addiction Research and Sections of Neurobiology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:6368-73. 2006
    ..The present study demonstrates the use of (i) a microarray meta-analysis to analyze a behavioral phenotype (in this case, alcohol preference) and (ii) a congenic strain for identification of cis regulation...
  60. ncbi request reprint Gene expression differences in mice divergently selected for methamphetamine sensitivity
    Abraham A Palmer
    Columbia Genome Center, Columbia University, 1150 St Nicholas Ave, New York, New York 10032, USA
    Mamm Genome 16:291-305. 2005
    ..The identified genes provide excellent candidates for future hypothesis-driven studies, translational genetic studies, and pharmacological interventions...
  61. ncbi request reprint Identification of QTLs influencing alcohol preference in the High Alcohol Preferring (HAP) and Low Alcohol Preferring (LAP) mouse lines
    Paula J Bice
    Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    Behav Genet 36:248-60. 2006
    ..19; p<0.0008) than male mice (LOD=1.19). This study provides additional evidence and confirmation that specific regions on chromosomes 9 and perhaps 2 are important for alcohol preference...
  62. ncbi request reprint How replicable are mRNA expression QTL?
    Jeremy L Peirce
    Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mamm Genome 17:643-56. 2006
    ..Finally, we note that while trans-acting QTL do not replicate well between data sets in general, at least one cluster of trans-acting QTL on distal Chr 1 is notably preserved between data sets...
  63. pmc SNPs matter: impact on detection of differential expression
    Nicole A R Walter
    Nat Methods 4:679-80. 2007
  64. ncbi request reprint The Collaborative Cross, a community resource for the genetic analysis of complex traits
    Gary A Churchill
    The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA
    Nat Genet 36:1133-7. 2004
    ..The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease...
  65. ncbi request reprint Complex genetics of interactions of alcohol and CNS function and behavior
    Douglas B Matthews
    Department of Psychology, University of Memphis, Memphis, Tennessee 38152, USA
    Alcohol Clin Exp Res 29:1706-19. 2005
    ..J. Hitzemann, and (5) The use of gene arrays in conjunction with transgenic and selected animals to understand anxiety in alcoholism, by. B. Tabakoff...

Research Grants23

  1. GENE MAPPING FOR SENSITIVITY TO COCAINE AND AMPHETAMINE
    John Belknap; Fiscal Year: 2001
    ..The proposed studies build on 5 years of previous work and represent progress toward the identification of specific genes underlying susceptibility to aspects of psychostimulant toxicity and activation/sensitization. ..
  2. ALCOHOL PREDISPOSITION--COMPARATIVE WITHDRAWAL SYNDROMES
    John Belknap; Fiscal Year: 2003
    ..Finally, DD-PCR will also be used to detect differential regulation due to alcohol withdrawal without regard to genotype (QTL), for this will pick up additional genes not polymorphic in our mouse populations. ..
  3. Alcohol selected mice: Comparative withdrawal syndromes
    John Belknap; Fiscal Year: 2007
    ..We will use the newly available Affymetrix mouse 430 2.0 Genechip(r) representing the vast majority of all genes in the mouse genome. ..
  4. ALCOHOL PREDISPOSITION: COMPARATIVE WITHDRAWAL SYNDROMES
    John Belknap; Fiscal Year: 1992
    ..The latter technique in particular will allow the detection of very small changes in receptor density caused by chronic intoxication and subsequent withdrawal from ethanol...