Bruce Bebo

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint Hypothesis: a possible role for mast cells and their inflammatory mediators in the pathogenesis of autoimmune encephalomyelitis
    B F Bebo
    Department of Neuroimmunology, VA Medical Center, Portland, Oregon 97201, USA
    J Neurosci Res 45:340-8. 1996
  2. ncbi request reprint Evidence that pregnancy specific glycoproteins regulate T-Cell function and inflammatory autoimmune disease during pregnancy
    Bruce F Bebo
    Neurological Sciences Institute, Oregon Health and Science University, Portland, OR, USA
    Curr Drug Targets Inflamm Allergy 4:231-7. 2005
  3. ncbi request reprint Low-dose estrogen therapy ameliorates experimental autoimmune encephalomyelitis in two different inbred mouse strains
    B F Bebo
    Department of Veterans Affairs, Neuroimmunology Research, Oregon Health Sciences University, Portland, OR 97201, USA
    J Immunol 166:2080-9. 2001
  4. ncbi request reprint Interleukin 7 is a potent co-stimulator of myelin specific T cells that enhances the adoptive transfer of experimental autoimmune encephalomyelitis
    B F Bebo
    Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    Cytokine 12:324-31. 2000
  5. ncbi request reprint Androgens alter the cytokine profile and reduce encephalitogenicity of myelin-reactive T cells
    B F Bebo
    Department of Neurology, Oregon Health Sciences University, Portland, USA
    J Immunol 162:35-40. 1999
  6. ncbi request reprint Gonadal hormones influence the immune response to PLP 139-151 and the clinical course of relapsing experimental autoimmune encephalomyelitis
    B F Bebo
    Department of Neurology, Oregon Health Sciences University, Portland, USA
    J Neuroimmunol 84:122-30. 1998
  7. ncbi request reprint Gender differences in experimental autoimmune encephalomyelitis develop during the induction of the immune response to encephalitogenic peptides
    B F Bebo
    Department of Neurology, Oregon Health Sciences University, Portland, Oregon
    J Neurosci Res 52:420-6. 1998
  8. ncbi request reprint CD44 overexpression by oligodendrocytes: a novel mouse model of inflammation-independent demyelination and dysmyelination
    Therese M F Tuohy
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton 97006, USA
    Glia 47:335-45. 2004
  9. ncbi request reprint Dysregulation of the hypothalamic-pituitary-gonadal axis in experimental autoimmune encephalomyelitis and multiple sclerosis
    Scott C Foster
    The Neurological Sciences Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Neuroimmunol 140:78-87. 2003
  10. ncbi request reprint Hyperalgesia in an animal model of multiple sclerosis
    Sue A Aicher
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Pain 110:560-70. 2004

Research Grants

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Hypothesis: a possible role for mast cells and their inflammatory mediators in the pathogenesis of autoimmune encephalomyelitis
    B F Bebo
    Department of Neuroimmunology, VA Medical Center, Portland, Oregon 97201, USA
    J Neurosci Res 45:340-8. 1996
    ..Mast cell mediators may play an important role in autoimmune encephalomyelitis and multiple sclerosis by promoting the entry of autoreactive T cells and the recruitment of nonspecific monocytes across the blood:brain barrier...
  2. ncbi request reprint Evidence that pregnancy specific glycoproteins regulate T-Cell function and inflammatory autoimmune disease during pregnancy
    Bruce F Bebo
    Neurological Sciences Institute, Oregon Health and Science University, Portland, OR, USA
    Curr Drug Targets Inflamm Allergy 4:231-7. 2005
    ..In this report, we will review evidence implicating PSGs as important immunoregulatory proteins and discuss our recent findings regarding the mechanisms by which PSGs regulate T-cell function...
  3. ncbi request reprint Low-dose estrogen therapy ameliorates experimental autoimmune encephalomyelitis in two different inbred mouse strains
    B F Bebo
    Department of Veterans Affairs, Neuroimmunology Research, Oregon Health Sciences University, Portland, OR 97201, USA
    J Immunol 166:2080-9. 2001
    ....
  4. ncbi request reprint Interleukin 7 is a potent co-stimulator of myelin specific T cells that enhances the adoptive transfer of experimental autoimmune encephalomyelitis
    B F Bebo
    Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    Cytokine 12:324-31. 2000
    ..These results suggest that IL-7 may be a critical co-stimulatory factor that enhances the extrathymic expansion of inflammatory T cells and may play an important role in the pathogenesis of a number of inflammatory autoimmune disorders...
  5. ncbi request reprint Androgens alter the cytokine profile and reduce encephalitogenicity of myelin-reactive T cells
    B F Bebo
    Department of Neurology, Oregon Health Sciences University, Portland, USA
    J Immunol 162:35-40. 1999
    ....
  6. ncbi request reprint Gonadal hormones influence the immune response to PLP 139-151 and the clinical course of relapsing experimental autoimmune encephalomyelitis
    B F Bebo
    Department of Neurology, Oregon Health Sciences University, Portland, USA
    J Neuroimmunol 84:122-30. 1998
    ..Our data suggests an important regulatory role for androgens on the immune response to PLP 139-151 and the clinical course of R-EAE...
  7. ncbi request reprint Gender differences in experimental autoimmune encephalomyelitis develop during the induction of the immune response to encephalitogenic peptides
    B F Bebo
    Department of Neurology, Oregon Health Sciences University, Portland, Oregon
    J Neurosci Res 52:420-6. 1998
    ..Disease severity was more strongly linked to the sex of the donor T cells, indicating that gender influences the immune response primarily during the induction phase...
  8. ncbi request reprint CD44 overexpression by oligodendrocytes: a novel mouse model of inflammation-independent demyelination and dysmyelination
    Therese M F Tuohy
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton 97006, USA
    Glia 47:335-45. 2004
    ..These findings suggest that CNPase-CD44 mice are a novel model for noninflammatory progressive demyelinating disease and support a potential role for CD44 proteins expressed by glial cells in promoting demyelination...
  9. ncbi request reprint Dysregulation of the hypothalamic-pituitary-gonadal axis in experimental autoimmune encephalomyelitis and multiple sclerosis
    Scott C Foster
    The Neurological Sciences Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Neuroimmunol 140:78-87. 2003
    ..Gender differences in the sensitivity of the hypothalamic-pituitary-gonadal (HPG) axis to inflammation may be an important factor regulating the duration and severity of central nervous system (CNS) autoimmunity...
  10. ncbi request reprint Hyperalgesia in an animal model of multiple sclerosis
    Sue A Aicher
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Pain 110:560-70. 2004
    ..These results suggest that both active and passive EAE are useful models of MS-related pain...
  11. ncbi request reprint Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation
    Stephen A Back
    Department of Pediatrics, School of Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Nat Med 11:966-72. 2005
    ..HMW hyaluronan may therefore contribute substantially to remyelination failure by preventing the maturation of OPCs that are recruited to demyelinating lesions...

Research Grants3

  1. Phytoestrogens as an alternative treatment for MS
    Bruce Bebo; Fiscal Year: 2005
    ....