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Species | George S BaileySummaryAffiliation: Oregon State University Country: USA Publications
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Publications
Nonlinear cancer response at ultralow dose: a 40800-animal ED(001) tumor and biomarker studyGeorge S Bailey
Department of Environmental and Molecular Toxicology, Marine and Freshwater Biomedical Sciences Center, Linus Pauling Institute, Environmental Health Sciences Center, Oregon State University, Corvallis, Oregon 97331, USA
Chem Res Toxicol 22:1264-76. 2009..They provide the first experimental estimation in any model of the degree of conservatism that may exist for the EPA default linear assumption for a genotoxic carcinogen...
Gene expression analysis during tumor enhancement by the dietary phytochemical, 3,3'-diindolylmethane, in rainbow troutSusan C Tilton
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
Carcinogenesis 28:1589-98. 2007..They confirm the importance of estrogenic signaling in the mechanism of promotion by dietary indoles in trout liver and indicate a possible dual effect that enhances tumor incidence and decreases potential for metastasis...- Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesisDavid J Castro
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
Carcinogenesis 30:315-20. 2009..005). This is the first demonstration that CHL can provide potent chemoprotection in a transplacental carcinogenesis model and support a mechanism involving complex-mediated reduction of carcinogen uptake... - Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyreneZhen Yu
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
Carcinogenesis 27:2116-23. 2006..Addition of chemoprotective agents to the maternal diet during pregnancy and nursing may be an effective new approach in reducing the incidence of cancers in children and young adults... - Toxicogenomic profiling of the hepatic tumor promoters indole-3-carbinol, 17beta-estradiol and beta-naphthoflavone in rainbow troutSusan C Tilton
Department of Environmental and Molecular Toxicology, Marine and Freshwater Biomedical Sciences Center and Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
Toxicol Sci 90:61-72. 2006..These data indicate I3C promotes hepatocarcinogenesis through estrogenic mechanisms in trout liver and suggest DIM may be an even more potent hepatic tumor promoter in this model... - Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation statusRong Wang
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Mutat Res 601:11-8. 2006..Thus, further studies are warranted on the mechanisms that upregulate beta-catenin at the transcriptional level in human and rodent colon cancers... - Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor studyTammie J McQuistan
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Food Chem Toxicol 50:341-52. 2012..This finding questions the human relevance of chemoprevention studies carried out at high carcinogen doses that are not proven to lie within a linear, or at least monotonic, endpoint dose-response range... - The importance of carcinogen dose in chemoprevention studies: quantitative interrelationships between, dibenzo[a,l]pyrene dose, chlorophyllin dose, target organ DNA adduct biomarkers and final tumor outcomeM Margaret Pratt
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97339, USA
Carcinogenesis 28:611-24. 2007.... - Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the ratMichael T Simonich
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Carcinogenesis 28:1294-302. 2007..0026) and 75% (P = 0.0004), respectively. These results show Chl and CHL provide potent chemoprotection against early biochemical and late pathophysiological biomarkers of AFB(1) carcinogenesis in the rat liver and colon... - Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow troutMichael T Simonich
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Food Chem Toxicol 46:1014-24. 2008..001). This is the first demonstration that dietary Chl can reduce tumorigenesis in any whole animal model, and that it may do so by a simple, species-independent mechanism... - Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the ratRong Wang
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Carcinogenesis 29:834-9. 2008..These findings are discussed in the context of epidemiological data which do not support an adverse effect of tea and coffee on colon tumor outcome-indeed, some such studies suggest a protective role for caffeinated beverages... - Rainbow trout (Oncorhynchus mykiss) and ultra-low dose cancer studiesDavid E Williams
Department of Environmental and Molecular Toxicology, Oregon State University, USA
Comp Biochem Physiol C Toxicol Pharmacol 149:175-81. 2009..0. Such studies demonstrate the statistical power of the trout cancer model and strengthen the case for incorporation of these data-sets into risk assessment for these environmental human carcinogens... - E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllinKorakod Chimploy
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
Int J Cancer 125:2086-94. 2009..We conclude that by inhibiting R1, R2, and p53R2, CHL has the potential to be effective in the clinical setting, when used alone or in combination with currently available cancer therapeutic agents... - The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cellsOrianna Carter
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
J Nutr 134:3441S-3444S. 2004.... 
MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinachMansi A Parasramka
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Mol Nutr Food Res 56:1259-69. 2012..A systems biology approach was used to examine, for the first time, miRNAs altered in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a heterocyclic amine carcinogen from cooked meat...- In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptorZhen Yu
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
Cancer Res 66:755-62. 2006.... - Use of a rainbow trout oligonucleotide microarray to determine transcriptional patterns in aflatoxin B1-induced hepatocellular carcinoma compared to adjacent liverSusan C Tilton
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, 97331, USA
Toxicol Sci 88:319-30. 2005.... - The rainbow trout (Oncorhynchus mykiss) tumor model: recent applications in low-dose exposures to tumor initiators and promotersDavid E William
Marine Freshwater Biomedical Sciences Center, Oregon State University, Corvallis, Oregon, USA
Toxicol Pathol 31:58-61. 2003..If these results can be confirmed with other carcinogens (genotoxic and perhaps nongenotoxic) and other targets, this could have a significant impact on the utilization of animal tumor data in human risk assessment... - Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of ratsGayle A Orner
Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
J Carcinog 5:6. 2006..The single concentration of CHL tested in this study (0.1% in the drinking water) had no significant effects on AFB1-induced foci of the liver and colons of rats... - Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signalingCarmen A Blum
Department of Environmental and Molecular Toxicology, Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331-6512, USA
Mutat Res 523:217-23. 2003....