George S Bailey

Summary

Affiliation: Oregon State University
Country: USA

Publications

  1. pmc Nonlinear cancer response at ultralow dose: a 40800-animal ED(001) tumor and biomarker study
    George S Bailey
    Department of Environmental and Molecular Toxicology, Marine and Freshwater Biomedical Sciences Center, Linus Pauling Institute, Environmental Health Sciences Center, Oregon State University, Corvallis, Oregon 97331, USA
    Chem Res Toxicol 22:1264-76. 2009
  2. ncbi request reprint Gene expression analysis during tumor enhancement by the dietary phytochemical, 3,3'-diindolylmethane, in rainbow trout
    Susan C Tilton
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 28:1589-98. 2007
  3. pmc Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis
    David J Castro
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
    Carcinogenesis 30:315-20. 2009
  4. ncbi request reprint Toxicogenomic profiling of the hepatic tumor promoters indole-3-carbinol, 17beta-estradiol and beta-naphthoflavone in rainbow trout
    Susan C Tilton
    Department of Environmental and Molecular Toxicology, Marine and Freshwater Biomedical Sciences Center and Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    Toxicol Sci 90:61-72. 2006
  5. ncbi request reprint Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene
    Zhen Yu
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
    Carcinogenesis 27:2116-23. 2006
  6. pmc Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status
    Rong Wang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Mutat Res 601:11-8. 2006
  7. pmc Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study
    Tammie J McQuistan
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Food Chem Toxicol 50:341-52. 2012
  8. pmc Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout
    Michael T Simonich
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Food Chem Toxicol 46:1014-24. 2008
  9. ncbi request reprint The importance of carcinogen dose in chemoprevention studies: quantitative interrelationships between, dibenzo[a,l]pyrene dose, chlorophyllin dose, target organ DNA adduct biomarkers and final tumor outcome
    M Margaret Pratt
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97339, USA
    Carcinogenesis 28:611-24. 2007
  10. pmc Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat
    Rong Wang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 29:834-9. 2008

Collaborators

Detail Information

Publications20

  1. pmc Nonlinear cancer response at ultralow dose: a 40800-animal ED(001) tumor and biomarker study
    George S Bailey
    Department of Environmental and Molecular Toxicology, Marine and Freshwater Biomedical Sciences Center, Linus Pauling Institute, Environmental Health Sciences Center, Oregon State University, Corvallis, Oregon 97331, USA
    Chem Res Toxicol 22:1264-76. 2009
    ..They provide the first experimental estimation in any model of the degree of conservatism that may exist for the EPA default linear assumption for a genotoxic carcinogen...
  2. ncbi request reprint Gene expression analysis during tumor enhancement by the dietary phytochemical, 3,3'-diindolylmethane, in rainbow trout
    Susan C Tilton
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 28:1589-98. 2007
    ..They confirm the importance of estrogenic signaling in the mechanism of promotion by dietary indoles in trout liver and indicate a possible dual effect that enhances tumor incidence and decreases potential for metastasis...
  3. pmc Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis
    David J Castro
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
    Carcinogenesis 30:315-20. 2009
    ..005). This is the first demonstration that CHL can provide potent chemoprotection in a transplacental carcinogenesis model and support a mechanism involving complex-mediated reduction of carcinogen uptake...
  4. ncbi request reprint Toxicogenomic profiling of the hepatic tumor promoters indole-3-carbinol, 17beta-estradiol and beta-naphthoflavone in rainbow trout
    Susan C Tilton
    Department of Environmental and Molecular Toxicology, Marine and Freshwater Biomedical Sciences Center and Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    Toxicol Sci 90:61-72. 2006
    ..These data indicate I3C promotes hepatocarcinogenesis through estrogenic mechanisms in trout liver and suggest DIM may be an even more potent hepatic tumor promoter in this model...
  5. ncbi request reprint Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene
    Zhen Yu
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
    Carcinogenesis 27:2116-23. 2006
    ..Addition of chemoprotective agents to the maternal diet during pregnancy and nursing may be an effective new approach in reducing the incidence of cancers in children and young adults...
  6. pmc Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status
    Rong Wang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Mutat Res 601:11-8. 2006
    ..Thus, further studies are warranted on the mechanisms that upregulate beta-catenin at the transcriptional level in human and rodent colon cancers...
  7. pmc Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study
    Tammie J McQuistan
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Food Chem Toxicol 50:341-52. 2012
    ..This finding questions the human relevance of chemoprevention studies carried out at high carcinogen doses that are not proven to lie within a linear, or at least monotonic, endpoint dose-response range...
  8. pmc Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout
    Michael T Simonich
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Food Chem Toxicol 46:1014-24. 2008
    ..001). This is the first demonstration that dietary Chl can reduce tumorigenesis in any whole animal model, and that it may do so by a simple, species-independent mechanism...
  9. ncbi request reprint The importance of carcinogen dose in chemoprevention studies: quantitative interrelationships between, dibenzo[a,l]pyrene dose, chlorophyllin dose, target organ DNA adduct biomarkers and final tumor outcome
    M Margaret Pratt
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97339, USA
    Carcinogenesis 28:611-24. 2007
    ....
  10. pmc Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat
    Rong Wang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 29:834-9. 2008
    ..These findings are discussed in the context of epidemiological data which do not support an adverse effect of tea and coffee on colon tumor outcome-indeed, some such studies suggest a protective role for caffeinated beverages...
  11. ncbi request reprint Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat
    Michael T Simonich
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 28:1294-302. 2007
    ..0026) and 75% (P = 0.0004), respectively. These results show Chl and CHL provide potent chemoprotection against early biochemical and late pathophysiological biomarkers of AFB(1) carcinogenesis in the rat liver and colon...
  12. pmc Rainbow trout (Oncorhynchus mykiss) and ultra-low dose cancer studies
    David E Williams
    Department of Environmental and Molecular Toxicology, Oregon State University, USA
    Comp Biochem Physiol C Toxicol Pharmacol 149:175-81. 2009
    ..0. Such studies demonstrate the statistical power of the trout cancer model and strengthen the case for incorporation of these data-sets into risk assessment for these environmental human carcinogens...
  13. pmc MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach
    Mansi A Parasramka
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Mol Nutr Food Res 56:1259-69. 2012
    ..A systems biology approach was used to examine, for the first time, miRNAs altered in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a heterocyclic amine carcinogen from cooked meat...
  14. pmc E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin
    Korakod Chimploy
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Int J Cancer 125:2086-94. 2009
    ..We conclude that by inhibiting R1, R2, and p53R2, CHL has the potential to be effective in the clinical setting, when used alone or in combination with currently available cancer therapeutic agents...
  15. pmc The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells
    Orianna Carter
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    J Nutr 134:3441S-3444S. 2004
    ....
  16. ncbi request reprint In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor
    Zhen Yu
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
    Cancer Res 66:755-62. 2006
    ....
  17. ncbi request reprint Use of a rainbow trout oligonucleotide microarray to determine transcriptional patterns in aflatoxin B1-induced hepatocellular carcinoma compared to adjacent liver
    Susan C Tilton
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, 97331, USA
    Toxicol Sci 88:319-30. 2005
    ....
  18. ncbi request reprint The rainbow trout (Oncorhynchus mykiss) tumor model: recent applications in low-dose exposures to tumor initiators and promoters
    David E William
    Marine Freshwater Biomedical Sciences Center, Oregon State University, Corvallis, Oregon, USA
    Toxicol Pathol 31:58-61. 2003
    ..If these results can be confirmed with other carcinogens (genotoxic and perhaps nongenotoxic) and other targets, this could have a significant impact on the utilization of animal tumor data in human risk assessment...
  19. pmc Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats
    Gayle A Orner
    Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
    J Carcinog 5:6. 2006
    ..The single concentration of CHL tested in this study (0.1% in the drinking water) had no significant effects on AFB1-induced foci of the liver and colons of rats...
  20. ncbi request reprint Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling
    Carmen A Blum
    Department of Environmental and Molecular Toxicology, Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512, USA
    Mutat Res 523:217-23. 2003
    ....