GROVER CARLTON BAGBY

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi The stem cell fitness landscape and pathways of molecular leukemogenesis
    Grover C Bagby
    Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Front Biosci (Schol Ed) 3:487-500. 2011
  2. ncbi Global rank-invariant set normalization (GRSN) to reduce systematic distortions in microarray data
    Carl R Pelz
    Department of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland, OR 97239 3098, USA
    BMC Bioinformatics 9:520. 2008
  3. ncbi Genetic basis of Fanconi anemia
    Grover C Bagby
    Oregon Health and Science University Cancer Institute, Department of Medicine, Oregon Health and Science University, Portland 97201, USA
    Curr Opin Hematol 10:68-76. 2003
  4. ncbi Myelodysplasia and acute leukemia as late complications of marrow failure: future prospects for leukemia prevention
    Grover C Bagby
    Department of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland, OR, USA
    Hematol Oncol Clin North Am 23:361-76. 2009
  5. ncbi Fanconi anemia
    Grover C Bagby
    OHSU Cancer Institute, Department of Medicine and Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR 97239, USA
    Semin Hematol 43:147-56. 2006
  6. ncbi Discovering early molecular determinants of leukemogenesis
    Grover C Bagby
    Department of Medicine and Molecular and Medical Genetics, Oregon Health and Sciences University, Oregon, USA
    J Clin Invest 118:847-50. 2008
  7. ncbi Human FANCC is hypomorphic in murine Fancc-deficient cells
    Laura E Hays
    Portland Veterans Administration Medical Center, Portland, OR 97239, USA
    Blood 116:2057-60. 2010
  8. ncbi TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells
    Scott M Vanderwerf
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239, USA
    Blood 114:5290-8. 2009
  9. ncbi Cytogenetic instability in ovarian epithelial cells from women at risk of ovarian cancer
    Tanja Pejovic
    Department of Obstetrics and Gynecology, Center for Women s Health, Oregon Health and Science University Cancer Institute, Portland, OR 97239, USA
    Cancer Res 66:9017-25. 2006
  10. ncbi Impaired type I IFN-induced Jak/STAT signaling in FA-C cells and abnormal CD4+ Th cell subsets in Fancc-/- mice
    Sara R Fagerlie
    Oregon Health and Science University Cancer Institute, Portland, OR, USA
    J Immunol 173:3863-70. 2004

Research Grants

  1. Microarray Program for NHLBI Investigators
    Grover Bagby; Fiscal Year: 2005
  2. HIV INDUCED BONE MARROW DYSFUNCTION
    Grover Bagby; Fiscal Year: 2003
  3. Eighteenth Annual Fanconi Anemia Research Symposium
    Grover Bagby; Fiscal Year: 2006

Collaborators

Detail Information

Publications16

  1. ncbi The stem cell fitness landscape and pathways of molecular leukemogenesis
    Grover C Bagby
    Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Front Biosci (Schol Ed) 3:487-500. 2011
    ....
  2. ncbi Global rank-invariant set normalization (GRSN) to reduce systematic distortions in microarray data
    Carl R Pelz
    Department of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland, OR 97239 3098, USA
    BMC Bioinformatics 9:520. 2008
    ..Therefore, methods to correct this kind of technical variation are critical. Here we consider a method to reduce this type of variation applied after three common procedures for processing microarray data: MAS 5.0, RMA, and dChip...
  3. ncbi Genetic basis of Fanconi anemia
    Grover C Bagby
    Oregon Health and Science University Cancer Institute, Department of Medicine, Oregon Health and Science University, Portland 97201, USA
    Curr Opin Hematol 10:68-76. 2003
    ....
  4. ncbi Myelodysplasia and acute leukemia as late complications of marrow failure: future prospects for leukemia prevention
    Grover C Bagby
    Department of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland, OR, USA
    Hematol Oncol Clin North Am 23:361-76. 2009
    ..This article reviews the evidence supporting a model of clonal selection, a paradigm that provides a reasonable expectation that these often fatal complications might be prevented in the future...
  5. ncbi Fanconi anemia
    Grover C Bagby
    OHSU Cancer Institute, Department of Medicine and Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR 97239, USA
    Semin Hematol 43:147-56. 2006
    ....
  6. ncbi Discovering early molecular determinants of leukemogenesis
    Grover C Bagby
    Department of Medicine and Molecular and Medical Genetics, Oregon Health and Sciences University, Oregon, USA
    J Clin Invest 118:847-50. 2008
    ....
  7. ncbi Human FANCC is hypomorphic in murine Fancc-deficient cells
    Laura E Hays
    Portland Veterans Administration Medical Center, Portland, OR 97239, USA
    Blood 116:2057-60. 2010
    ....
  8. ncbi TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells
    Scott M Vanderwerf
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239, USA
    Blood 114:5290-8. 2009
    ..In conclusion, FANCC suppresses TNF-alpha production in mononuclear phagocytes by suppressing TLR8 activity and this particular function of FANCC is independent of its function in protecting the genome from cross-linking agents...
  9. ncbi Cytogenetic instability in ovarian epithelial cells from women at risk of ovarian cancer
    Tanja Pejovic
    Department of Obstetrics and Gynecology, Center for Women s Health, Oregon Health and Science University Cancer Institute, Portland, OR 97239, USA
    Cancer Res 66:9017-25. 2006
    ..Inherited mutations that result in tissue-specific FANCD2 gene suppression may represent a cause of familial ovarian cancer...
  10. ncbi Impaired type I IFN-induced Jak/STAT signaling in FA-C cells and abnormal CD4+ Th cell subsets in Fancc-/- mice
    Sara R Fagerlie
    Oregon Health and Science University Cancer Institute, Portland, OR, USA
    J Immunol 173:3863-70. 2004
    ..We suggest that Fancc mutations result in a subtle immunological defect owing to the failure of FANCC to normally support Jak/STAT signaling...
  11. ncbi Fancd2-/- mice have hematopoietic defects that can be partially corrected by resveratrol
    Qing Shuo Zhang
    Oregon Stem Cell Center, Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA
    Blood 116:5140-8. 2010
    ..We conclude that Fancd2(-/-) mice have readily quantifiable hematopoietic defects, and that this model is well suited for pharmacologic screening studies...
  12. ncbi The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC
    Qishen Pang
    OHSU Cancer Institute, Department of Medicine and Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR 97201, USA
    J Biol Chem 277:49638-43. 2002
    ..We conclude that Hsp70 requires the cooperation of FANCC to suppress PKR activity and support survival of hematopoietic cells and that FANCC does not require the multimeric FA complex to exert this function...
  13. ncbi Constitutional marrow failure: Introduction
    Grover C Bagby
    OHSU Cancer Institute, Oregon Health and Science University, Portland, OR, USA
    Semin Hematol 43:145-6. 2006
  14. ncbi Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia
    M William Lensch
    OHSU Cancer Institute, CR145, Hatfield Research Center, 3181 SW Sam Jackson Park Rd, Portland, OR 97201, USA
    Blood 102:7-16. 2003
    ....
  15. ncbi Evaluation and lead optimization of anti-malarial acridones
    Rolf W Winter
    Medical Research Service, RD-33, VA Medical Center, 3710 SW U.S. Veterans Hospital Road, Portland, OR 97239, USA
    Exp Parasitol 114:47-56. 2006
    ..Haloalkoxyacridones represent an extraordinarily potent novel class of chemical compounds with the potential for development as therapeutic agents to treat or prevent malaria in humans...
  16. ncbi Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR
    Qishen Pang
    OHSU Cancer Institute, Schools of Medicine and Dentistry, Oregon Health Sciences University, Portland, OR 97201, USA
    J Biol Chem 278:41709-17. 2003
    ..Inhibition of PKR by NPM may be one mechanism by which neoplastic clones evolve in sporadic malignancies and in neoplastic cells arising in the context of the cancer predisposition syndrome, Fanconi anemia...

Research Grants15

  1. Microarray Program for NHLBI Investigators
    Grover Bagby; Fiscal Year: 2005
    ..abstract_text> ..
  2. HIV INDUCED BONE MARROW DYSFUNCTION
    Grover Bagby; Fiscal Year: 2003
    ..Results of these studies should clarify the molecular pathogenesis of regenerative granulopoietic failure in HIV-1 seropositive patients and may also reveal determinants of lymphoma progression in this clinical context. ..
  3. Eighteenth Annual Fanconi Anemia Research Symposium
    Grover Bagby; Fiscal Year: 2006
    ..This application seeks partial support for this meeting, scheduled to be held in Bethesda in October 2006. ..