Research Topics
| STEPHEN BACKSummaryAffiliation: Oregon Health and Science University Country: USA Publications
Research Grants
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Detail Information
Publications
The instrumented fetal sheep as a model of cerebral white matter injury in the premature infantStephen A Back
Department of Pediatrics, Oregon Health Sciences University, Portland, OR 97239, USA
Neurotherapeutics 9:359-70. 2012....- Differential susceptibility to axonopathy in necrotic and non-necrotic perinatal white matter injuryArt Riddle
Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
Stroke 43:178-84. 2012..We determined the burden of axonopathy in diffuse lesions... - An organotypic slice culture model of chronic white matter injury with maturation arrest of oligodendrocyte progenitorsJustin M Dean
Department of Pediatrics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
Mol Neurodegener 6:46. 2011..abstract:.. 
Maturation-dependent vulnerability of perinatal white matter in premature birthStephen A Back
Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
Stroke 38:724-30. 2007..The oligodendrocyte progenitor is a key target for preventive strategies to reduce ischemic cerebral white matter injury in premature infants...- Role of instrumented fetal sheep preparations in defining the pathogenesis of human periventricular white-matter injuryStephen A Back
Department of Pediatrics, Oregon Health and Science University, Portland 97239 3098, USA
J Child Neurol 21:582-9. 2006..We conclude with a review of the significant advantages of the instrumented fetal sheep to accelerate progress in the translation of preventive therapies for periventricular white-matter injury and cerebral palsy... - Perinatal white matter injury: the changing spectrum of pathology and emerging insights into pathogenetic mechanismsStephen A Back
Department of Pediatrics, Oregon Health and Sciences University, Portland, Oregon, USA
Ment Retard Dev Disabil Res Rev 12:129-40. 2006..As our understanding of the pathogenesis of PWMI improves, it is anticipated that new strategies for directly preventing brain injury in premature infants will develop... - Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injuryS A Back
Department of Pediatrics, Oregon Health Sciences University, Portland, Oregon 97201, USA
J Neurosci 21:1302-12. 2001.... - Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemiaStephen A Back
Department of Pediatrics, Oregon Health Sciences University, Portland, Oregon 97201, USA
J Neurosci 22:455-63. 2002..2001), maturation-dependent vulnerability of OL progenitors to hypoxia-ischemia may underlie the selective vulnerability to PVL of the white matter in the premature infant... - Selective vulnerability of preterm white matter to oxidative damage defined by F2-isoprostanesStephen A Back
Department of Pediatrics, Oregon Health and Science University, Portland OR 97239 3098, USA
Ann Neurol 58:108-20. 2005..Hence, the predilection of preterm infants for PWMI is related to selective lipid peroxidation-mediated injury of cerebral white matter and targeted death of oligodendrocyte progenitors... - Emerging concepts in periventricular white matter injuryStephen A Back
Department of Pediatrics, Oregon Health Science University, Portland, OR, USA
Semin Perinatol 28:405-14. 2004..As our understanding of the pathogenesis of PWMI improves, it is anticipated that new strategies for directly preventing brain injury in premature infants will evolve... - Protective effects of caffeine on chronic hypoxia-induced perinatal white matter injuryStephen A Back
Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA
Ann Neurol 60:696-705. 2006..INTERPRETATION: These observations support that hypoxia inhibits OL maturation and that caffeine administration during early postnatal development may have utility in the prevention of PWMI... - Spatial heterogeneity in oligodendrocyte lineage maturation and not cerebral blood flow predicts fetal ovine periventricular white matter injuryArt Riddle
Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239-3098, USA
J Neurosci 26:3045-55. 2006..These data support that although ischemia is necessary to generate PWMI, the presence of susceptible populations of oligodendrocyte progenitors underlies regional predilection to injury... - Quantitative analysis of perinatal rodent oligodendrocyte lineage progression and its correlation with humanAndrew Craig
Department of Pediatrics, Oregon Health and Science University, Portland 97201, USA
Exp Neurol 181:231-40. 2003..These studies support that the vulnerable period for white matter injury in the rodent is centered around P2 and should decline thereafter, coincident with the onset of myelination... - Hypoxia-ischemia preferentially triggers glutamate depletion from oligodendroglia and axons in perinatal cerebral white matterStephen A Back
Department of Pediatrics, Oregon Health and Sciences University, Portland, Oregon, USA
J Cereb Blood Flow Metab 27:334-47. 2007..97+/-0.08 counts/microm(2): P>0.001). The ependymal cells were damaged by the insult and represent a further potential source of glutamate during ischemia... - A 'GAG' reflex prevents repair of the damaged CNSLarry S Sherman
Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
Trends Neurosci 31:44-52. 2008..We propose that the balance between the synthesis and degradation of these molecules dictates, in part, how regeneration and recovery from CNS damage occurs... - Cerebral blood flow heterogeneity in preterm sheep: lack of physiologic support for vascular boundary zones in fetal cerebral white matterMelissa M McClure
Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, USA
J Cereb Blood Flow Metab 28:995-1008. 2008..Previously defined cellular maturational factors, thus, appear to have a greater influence on PVWM vulnerability to ischemic injury than the presence of immature vascular boundary zones... - Arrested oligodendrocyte lineage maturation in chronic perinatal white matter injuryKristen N Segovia
Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
Ann Neurol 63:520-30. 2008.... - Timing of appearance of late oligodendrocyte progenitors coincides with enhanced susceptibility of preterm rabbit cerebral white matter to hypoxia-ischemiaJoshua R Buser
Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
J Cereb Blood Flow Metab 30:1053-65. 2010..At E29, significant white matter atrophy developed after H-I at E25 but not E22. Thus, the timing of appearance of preOLs coincided with onset of a developmental window of enhanced white but not gray matter susceptibility to H-I... - Large-scale generation of highly enriched neural stem-cell-derived oligodendroglial cultures: maturation-dependent differences in insulin-like growth factor-mediated signal transductionSarah K Broughton
Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
J Neurochem 100:628-38. 2007.... - Preterm fetal hypoxia-ischemia causes hypertonia and motor deficits in the neonatal rabbit: a model for human cerebral palsy?Matthew Derrick
Department of Pediatrics, Northwestern University, and Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
J Neurosci 24:24-34. 2004..These findings provide a unique behavioral model to define mechanisms and sequelae of perinatal brain injury from antenatal hypoxia-ischemia... - Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturationStephen A Back
Department of Pediatrics, School of Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
Nat Med 11:966-72. 2005..HMW hyaluronan may therefore contribute substantially to remyelination failure by preventing the maturation of OPCs that are recruited to demyelinating lesions...
Research Grants
- Cellular Mechanisms of Fetal White Matter InjurySTEPHEN BACK; Fiscal Year: 2007..Our long-term objectives are to utilize this pre-clinical model to test new translational strategies to restore normal myelination and, potentially, neurological function in survivors of premature birth. ..
- Role of extracellular matrix in hypoxic-ischemic perinatal white matter injurySTEPHEN BACK; Fiscal Year: 2007....
- Cellular Mechanisms of Fetal White Matter InjurySTEPHEN BACK; Fiscal Year: 2006..Upon completion of this project, we hope to gain insight into strategies to prevent PVL by understanding intrinsic features of the OL progenitor which influence susceptibility to free radical-mediated injury from ischemia. ..
- Cellular Mechanisms of Perinatal White Matter InjurySTEPHEN BACK; Fiscal Year: 2005..Through this work we will gain fundamental new insights into the cellular and molecular mechanisms that underlie neonatal white matter injury and, thereby, develop new strategies to prevent PVL. ..
- Cellular Mechanisms of Preterm White Matter InjurySTEPHEN BACK; Fiscal Year: 2003....
- Role of extracellular matrix in hypoxic-ischemic perinatal white matter injurySTEPHEN BACK; Fiscal Year: 2009..abstract_text> ..