STEPHEN BACK

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Hemodynamic and metabolic correlates of perinatal white matter injury severity
    Art Riddle
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 8:e82940. 2013
  2. pmc Cerebral white and gray matter injury in newborns: new insights into pathophysiology and management
    Stephen A Back
    Neuroscience Section, Division of Pediatric Neuroscience, Department of Pediatrics, Papé Family Pediatric Research Institute, Oregon Health and Science University, Mail Code L481, Biomedical Research Building 317, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239 3098, USA Electronic address
    Clin Perinatol 41:1-24. 2014
  3. pmc The instrumented fetal sheep as a model of cerebral white matter injury in the premature infant
    Stephen A Back
    Department of Pediatrics, Oregon Health Sciences University, Portland, OR 97239, USA
    Neurotherapeutics 9:359-70. 2012
  4. pmc Differential susceptibility to axonopathy in necrotic and non-necrotic perinatal white matter injury
    Art Riddle
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Stroke 43:178-84. 2012
  5. pmc An organotypic slice culture model of chronic white matter injury with maturation arrest of oligodendrocyte progenitors
    Justin M Dean
    Department of Pediatrics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Mol Neurodegener 6:46. 2011
  6. ncbi request reprint Maturation-dependent vulnerability of perinatal white matter in premature birth
    Stephen A Back
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Stroke 38:724-30. 2007
  7. ncbi request reprint Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injury
    S A Back
    Department of Pediatrics, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Neurosci 21:1302-12. 2001
  8. ncbi request reprint Role of instrumented fetal sheep preparations in defining the pathogenesis of human periventricular white-matter injury
    Stephen A Back
    Department of Pediatrics, Oregon Health and Science University, Portland 97239 3098, USA
    J Child Neurol 21:582-9. 2006
  9. ncbi request reprint Perinatal white matter injury: the changing spectrum of pathology and emerging insights into pathogenetic mechanisms
    Stephen A Back
    Department of Pediatrics, Oregon Health and Sciences University, Portland, Oregon, USA
    Ment Retard Dev Disabil Res Rev 12:129-40. 2006
  10. ncbi request reprint Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia
    Stephen A Back
    Department of Pediatrics, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Neurosci 22:455-63. 2002

Collaborators

Detail Information

Publications23

  1. pmc Hemodynamic and metabolic correlates of perinatal white matter injury severity
    Art Riddle
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 8:e82940. 2013
    ..We hypothesized that the variability in WMI quantified by immunohistochemical markers of inflammation could be correlated with the severity of impaired blood oxygen, glucose and lactate...
  2. pmc Cerebral white and gray matter injury in newborns: new insights into pathophysiology and management
    Stephen A Back
    Neuroscience Section, Division of Pediatric Neuroscience, Department of Pediatrics, Papé Family Pediatric Research Institute, Oregon Health and Science University, Mail Code L481, Biomedical Research Building 317, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239 3098, USA Electronic address
    Clin Perinatol 41:1-24. 2014
    ..These recently recognized forms of cerebral gray and white matter dysmaturation suggest new therapeutic directions centered on reversal of the processes that promote dysmaturation. ..
  3. pmc The instrumented fetal sheep as a model of cerebral white matter injury in the premature infant
    Stephen A Back
    Department of Pediatrics, Oregon Health Sciences University, Portland, OR 97239, USA
    Neurotherapeutics 9:359-70. 2012
    ....
  4. pmc Differential susceptibility to axonopathy in necrotic and non-necrotic perinatal white matter injury
    Art Riddle
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Stroke 43:178-84. 2012
    ..We determined the burden of axonopathy in diffuse lesions...
  5. pmc An organotypic slice culture model of chronic white matter injury with maturation arrest of oligodendrocyte progenitors
    Justin M Dean
    Department of Pediatrics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Mol Neurodegener 6:46. 2011
    ..abstract:..
  6. ncbi request reprint Maturation-dependent vulnerability of perinatal white matter in premature birth
    Stephen A Back
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Stroke 38:724-30. 2007
    ..The oligodendrocyte progenitor is a key target for preventive strategies to reduce ischemic cerebral white matter injury in premature infants...
  7. ncbi request reprint Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injury
    S A Back
    Department of Pediatrics, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Neurosci 21:1302-12. 2001
    ....
  8. ncbi request reprint Role of instrumented fetal sheep preparations in defining the pathogenesis of human periventricular white-matter injury
    Stephen A Back
    Department of Pediatrics, Oregon Health and Science University, Portland 97239 3098, USA
    J Child Neurol 21:582-9. 2006
    ..We conclude with a review of the significant advantages of the instrumented fetal sheep to accelerate progress in the translation of preventive therapies for periventricular white-matter injury and cerebral palsy...
  9. ncbi request reprint Perinatal white matter injury: the changing spectrum of pathology and emerging insights into pathogenetic mechanisms
    Stephen A Back
    Department of Pediatrics, Oregon Health and Sciences University, Portland, Oregon, USA
    Ment Retard Dev Disabil Res Rev 12:129-40. 2006
    ..As our understanding of the pathogenesis of PWMI improves, it is anticipated that new strategies for directly preventing brain injury in premature infants will develop...
  10. ncbi request reprint Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia
    Stephen A Back
    Department of Pediatrics, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Neurosci 22:455-63. 2002
    ..2001), maturation-dependent vulnerability of OL progenitors to hypoxia-ischemia may underlie the selective vulnerability to PVL of the white matter in the premature infant...
  11. ncbi request reprint Selective vulnerability of preterm white matter to oxidative damage defined by F2-isoprostanes
    Stephen A Back
    Department of Pediatrics, Oregon Health and Science University, Portland OR 97239 3098, USA
    Ann Neurol 58:108-20. 2005
    ..Hence, the predilection of preterm infants for PWMI is related to selective lipid peroxidation-mediated injury of cerebral white matter and targeted death of oligodendrocyte progenitors...
  12. ncbi request reprint Emerging concepts in periventricular white matter injury
    Stephen A Back
    Department of Pediatrics, Oregon Health Science University, Portland, OR, USA
    Semin Perinatol 28:405-14. 2004
    ..As our understanding of the pathogenesis of PWMI improves, it is anticipated that new strategies for directly preventing brain injury in premature infants will evolve...
  13. ncbi request reprint Protective effects of caffeine on chronic hypoxia-induced perinatal white matter injury
    Stephen A Back
    Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA
    Ann Neurol 60:696-705. 2006
    ....
  14. ncbi request reprint Spatial heterogeneity in oligodendrocyte lineage maturation and not cerebral blood flow predicts fetal ovine periventricular white matter injury
    Art Riddle
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 26:3045-55. 2006
    ..These data support that although ischemia is necessary to generate PWMI, the presence of susceptible populations of oligodendrocyte progenitors underlies regional predilection to injury...
  15. ncbi request reprint Quantitative analysis of perinatal rodent oligodendrocyte lineage progression and its correlation with human
    Andrew Craig
    Department of Pediatrics, Oregon Health and Science University, Portland 97201, USA
    Exp Neurol 181:231-40. 2003
    ..These studies support that the vulnerable period for white matter injury in the rodent is centered around P2 and should decline thereafter, coincident with the onset of myelination...
  16. pmc Timing of appearance of late oligodendrocyte progenitors coincides with enhanced susceptibility of preterm rabbit cerebral white matter to hypoxia-ischemia
    Joshua R Buser
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Cereb Blood Flow Metab 30:1053-65. 2010
    ..At E29, significant white matter atrophy developed after H-I at E25 but not E22. Thus, the timing of appearance of preOLs coincided with onset of a developmental window of enhanced white but not gray matter susceptibility to H-I...
  17. pmc Arrested oligodendrocyte lineage maturation in chronic perinatal white matter injury
    Kristen N Segovia
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Ann Neurol 63:520-30. 2008
    ....
  18. pmc Cerebral blood flow heterogeneity in preterm sheep: lack of physiologic support for vascular boundary zones in fetal cerebral white matter
    Melissa M McClure
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, USA
    J Cereb Blood Flow Metab 28:995-1008. 2008
    ..Previously defined cellular maturational factors, thus, appear to have a greater influence on PVWM vulnerability to ischemic injury than the presence of immature vascular boundary zones...
  19. ncbi request reprint A 'GAG' reflex prevents repair of the damaged CNS
    Larry S Sherman
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Trends Neurosci 31:44-52. 2008
    ..We propose that the balance between the synthesis and degradation of these molecules dictates, in part, how regeneration and recovery from CNS damage occurs...
  20. ncbi request reprint Hypoxia-ischemia preferentially triggers glutamate depletion from oligodendroglia and axons in perinatal cerebral white matter
    Stephen A Back
    Department of Pediatrics, Oregon Health and Sciences University, Portland, Oregon, USA
    J Cereb Blood Flow Metab 27:334-47. 2007
    ..97+/-0.08 counts/microm(2): P>0.001). The ependymal cells were damaged by the insult and represent a further potential source of glutamate during ischemia...
  21. ncbi request reprint Large-scale generation of highly enriched neural stem-cell-derived oligodendroglial cultures: maturation-dependent differences in insulin-like growth factor-mediated signal transduction
    Sarah K Broughton
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
    J Neurochem 100:628-38. 2007
    ....
  22. ncbi request reprint Preterm fetal hypoxia-ischemia causes hypertonia and motor deficits in the neonatal rabbit: a model for human cerebral palsy?
    Matthew Derrick
    Department of Pediatrics, Northwestern University, and Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    J Neurosci 24:24-34. 2004
    ..These findings provide a unique behavioral model to define mechanisms and sequelae of perinatal brain injury from antenatal hypoxia-ischemia...
  23. ncbi request reprint Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation
    Stephen A Back
    Department of Pediatrics, School of Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Nat Med 11:966-72. 2005
    ..HMW hyaluronan may therefore contribute substantially to remyelination failure by preventing the maturation of OPCs that are recruited to demyelinating lesions...

Research Grants12

  1. Cellular Mechanisms of Fetal White Matter Injury
    STEPHEN BACK; Fiscal Year: 2003
    ..Upon completion of this project, we hope to gain insight into strategies to prevent PVL by understanding intrinsic features of the OL progenitor which influence susceptibility to free radical-mediated injury from ischemia. ..
  2. Cellular Mechanisms of Fetal White Matter Injury
    STEPHEN BACK; Fiscal Year: 2007
    ..Our long-term objectives are to utilize this pre-clinical model to test new translational strategies to restore normal myelination and, potentially, neurological function in survivors of premature birth. ..
  3. Role of extracellular matrix in hypoxic-ischemic perinatal white matter injury
    STEPHEN BACK; Fiscal Year: 2007
    ....
  4. Role of extracellular matrix in hypoxic-ischemic perinatal white matter injury
    STEPHEN BACK; Fiscal Year: 2006
    ....
  5. Cellular Mechanisms of Fetal White Matter Injury
    STEPHEN BACK; Fiscal Year: 2006
    ..Upon completion of this project, we hope to gain insight into strategies to prevent PVL by understanding intrinsic features of the OL progenitor which influence susceptibility to free radical-mediated injury from ischemia. ..
  6. Cellular Mechanisms of Perinatal White Matter Injury
    STEPHEN BACK; Fiscal Year: 2005
    ..Through this work we will gain fundamental new insights into the cellular and molecular mechanisms that underlie neonatal white matter injury and, thereby, develop new strategies to prevent PVL. ..
  7. Cellular Mechanisms of Fetal White Matter Injury
    STEPHEN BACK; Fiscal Year: 2005
    ..Upon completion of this project, we hope to gain insight into strategies to prevent PVL by understanding intrinsic features of the OL progenitor which influence susceptibility to free radical-mediated injury from ischemia. ..
  8. Cellular Mechanisms of Fetal White Matter Injury
    STEPHEN BACK; Fiscal Year: 2004
    ..Upon completion of this project, we hope to gain insight into strategies to prevent PVL by understanding intrinsic features of the OL progenitor which influence susceptibility to free radical-mediated injury from ischemia. ..
  9. Cellular Mechanisms of Preterm White Matter Injury
    STEPHEN BACK; Fiscal Year: 2003
    ....
  10. Role of extracellular matrix in hypoxic-ischemic perinatal white matter injury
    STEPHEN BACK; Fiscal Year: 2009
    ..abstract_text> ..