Susan G Amara

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi Neurotransmitter transporters as molecular targets for addictive drugs
    S G Amara
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Drug Alcohol Depend 51:87-96. 1998
  2. ncbi Excitatory amino acid transporters: keeping up with glutamate
    Susan G Amara
    Vollum Institute and Howard Hughes Medical Institute, Oregon Health Science University, L 474, 3181 SW Sam Jackson Park Road, 97201, Portland, OR, USA
    Neurochem Int 41:313-8. 2002
  3. ncbi Purification of a neuroprotective component of Parawixia bistriata spider venom that enhances glutamate uptake
    Andréia Cristina Karklin Fontana
    Laboratory of Neurochemistry, Department of Biochemistry and Immunology, Ribeirao Preto School of Medicine, University of Sao Paulo, Brazil
    Br J Pharmacol 139:1297-309. 2003
  4. ncbi Structural rearrangements at the translocation pore of the human glutamate transporter, EAAT1
    Barbara H Leighton
    Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Biol Chem 281:29788-96. 2006
  5. ncbi Effects of Tityus serrulatus scorpion venom and its toxin TsTX-V on neurotransmitter uptake in vitro
    Alessandra L Cecchini
    , , Av. do Caf, s/n, 14040-903, , Brazil
    Toxicol Appl Pharmacol 217:196-203. 2006
  6. ncbi Glutamate and monoamine transporters: new visions of form and function
    Gonzalo E Torres
    Department of Neurobiology, University of Pittsburgh School of Medicine, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
    Curr Opin Neurobiol 17:304-12. 2007
  7. ncbi Gain of function mutants reveal sites important for the interaction of the atypical inhibitors benztropine and bupropion with monoamine transporters
    Ole V Mortensen
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Neurochem 98:1531-40. 2006
  8. ncbi Differential regulation of GLAST immunoreactivity and activity by protein kinase C: evidence for modification of amino and carboxyl termini
    Bala T S Susarla
    Department of Pediatrics, University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    J Neurochem 91:1151-63. 2004
  9. ncbi Characterization of novel L-threo-beta-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters
    Keiko Shimamoto
    Suntory Institute for Bioorganic Research, 1 1 1, Wakayamadai, Shimamoto cho, Mishima gun, Osaka 618 8503, Japan
    Mol Pharmacol 65:1008-15. 2004
  10. ncbi The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter
    Ana M Carneiro
    Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 22:7045-54. 2002

Collaborators

  • M S Sonders
  • Andréia Cristina Karklin Fontana
  • N C Coimbra
  • Y Shigeri
  • K Shimamoto
  • Gonzalo E Torres
  • Barbara H Leighton
  • Alessandra L Cecchini
  • Ole V Mortensen
  • Rebecca P Seal
  • Bala T S Susarla
  • Ana M Carneiro
  • Mary O Skyba
  • Spencer D Watts
  • Eliane Candiani Arantes
  • John H Wolfe
  • Michael B Robinson
  • Deborah J Watson
  • Olga Zelenaia
  • Ava Sweeney
  • Susan L Ingram
  • Jean Martin Beaulieu
  • Marc G Caron
  • Jean-Martin Beaulieu
  • Sheila M Thomas

Detail Information

Publications11

  1. ncbi Neurotransmitter transporters as molecular targets for addictive drugs
    S G Amara
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Drug Alcohol Depend 51:87-96. 1998
    ....
  2. ncbi Excitatory amino acid transporters: keeping up with glutamate
    Susan G Amara
    Vollum Institute and Howard Hughes Medical Institute, Oregon Health Science University, L 474, 3181 SW Sam Jackson Park Road, 97201, Portland, OR, USA
    Neurochem Int 41:313-8. 2002
    ....
  3. ncbi Purification of a neuroprotective component of Parawixia bistriata spider venom that enhances glutamate uptake
    Andréia Cristina Karklin Fontana
    Laboratory of Neurochemistry, Department of Biochemistry and Immunology, Ribeirao Preto School of Medicine, University of Sao Paulo, Brazil
    Br J Pharmacol 139:1297-309. 2003
    ..5) This active spider venom component may serve as a basis for designing therapeutic drugs that increase glutamate clearance and limit neurodegeneration...
  4. ncbi Structural rearrangements at the translocation pore of the human glutamate transporter, EAAT1
    Barbara H Leighton
    Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Biol Chem 281:29788-96. 2006
    ..Such behavior likely reflects rearrangements in the tertiary structure of the translocation pore during transport and thus provides constraints for modeling the structural dynamics associated with transport...
  5. ncbi Effects of Tityus serrulatus scorpion venom and its toxin TsTX-V on neurotransmitter uptake in vitro
    Alessandra L Cecchini
    , , Av. do Caf, s/n, 14040-903, , Brazil
    Toxicol Appl Pharmacol 217:196-203. 2006
    ..Thus, TsTX-V causes a reduction of (3)H-GABA and (3)H-DA uptake in a Ca(2+)-dependent manner, not directly affecting GABA transporters, but, in consequence of depolarization, involving voltage-gated Na(+) channels...
  6. ncbi Glutamate and monoamine transporters: new visions of form and function
    Gonzalo E Torres
    Department of Neurobiology, University of Pittsburgh School of Medicine, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
    Curr Opin Neurobiol 17:304-12. 2007
    ..This review focuses on recent studies of glutamate and monoamine transporters as prototypes of the two carrier families...
  7. ncbi Gain of function mutants reveal sites important for the interaction of the atypical inhibitors benztropine and bupropion with monoamine transporters
    Ole V Mortensen
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Neurochem 98:1531-40. 2006
    ..Thus, these studies begin to identify residues that are important for the unique molecular interactions of benztropine and bupropion with the DAT, and that ultimately may contribute to the distinct behavioral actions of these drugs...
  8. ncbi Differential regulation of GLAST immunoreactivity and activity by protein kinase C: evidence for modification of amino and carboxyl termini
    Bala T S Susarla
    Department of Pediatrics, University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    J Neurochem 91:1151-63. 2004
    ....
  9. ncbi Characterization of novel L-threo-beta-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters
    Keiko Shimamoto
    Suntory Institute for Bioorganic Research, 1 1 1, Wakayamadai, Shimamoto cho, Mishima gun, Osaka 618 8503, Japan
    Mol Pharmacol 65:1008-15. 2004
    ..Taken together, these findings indicate that novel TBOA analogs, especially TFB-TBOA, should serve as useful tools for elucidating the physiological roles of the glutamate transporters...
  10. ncbi The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter
    Ana M Carneiro
    Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 22:7045-54. 2002
    ....
  11. ncbi Enhancing glutamate transport: mechanism of action of Parawixin1, a neuroprotective compound from Parawixia bistriata spider venom
    Andréia Cristina Karklin Fontana
    Department of Neurobiology, University of Pittsburgh, 6068 BST3, 3501 Fifth Ave, Pittsburgh, PA 15260, USA
    Mol Pharmacol 72:1228-37. 2007
    ....