HAROLD KIMELBERG

Summary

Affiliation: Ordway Research Institute
Country: USA

Publications

  1. pmc Supportive or information-processing functions of the mature protoplasmic astrocyte in the mammalian CNS? A critical appraisal
    Harold K Kimelberg
    Neural and Vascular Biology, Ordway Research Institute, Inc, 150 New Scotland Ave, Albany, NY 12208, USA
    Neuron Glia Biol 3:181-9. 2007
  2. pmc Functions of astrocytes and their potential as therapeutic targets
    Harold K Kimelberg
    Ordway Research Institute, 150 New Scotland Avenue, Albany, New York 12208, USA
    Neurotherapeutics 7:338-53. 2010
  3. ncbi Astrocytic swelling in cerebral ischemia as a possible cause of injury and target for therapy
    Harold K Kimelberg
    Neural and Vascular Biology, Ordway Research Institute, Albany, New York 12208, USA
    Glia 50:389-97. 2005
  4. ncbi Water homeostasis in the brain: basic concepts
    H K Kimelberg
    Neural and Vascular Biology Theme, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA
    Neuroscience 129:851-60. 2004
  5. ncbi The role of hypotheses in current research, illustrated by hypotheses on the possible role of astrocytes in energy metabolism and cerebral blood flow: from Newton to now
    Harold K Kimelberg
    Neural and Vascular Biology Theme, Ordway Research Institute, Albany, New York 12208, USA
    J Cereb Blood Flow Metab 24:1235-9. 2004
  6. ncbi Tamoxifen as a powerful neuroprotectant in experimental stroke and implications for human stroke therapy
    Harold K Kimelberg
    Neural and Vascular Biology, Ordway Research Institute, 150 New Scotland Ave, Albany, NY 12208, USA
    Recent Pat CNS Drug Discov 3:104-8. 2008
  7. ncbi Increased release of excitatory amino acids by the actions of ATP and peroxynitrite on volume-regulated anion channels (VRACs) in astrocytes
    Harold K Kimelberg
    Neural and Vascular Biology Theme, Ordway Research Institute, Inc, 150 New Scotland Ave, Albany, NY 12208, USA
    Neurochem Int 45:511-9. 2004
  8. ncbi The problem of astrocyte identity
    Harold K Kimelberg
    Neural and Vascular Biology Theme, Ordway Research Institute Inc, Center for Medical Science, 150 New Scotland Avenue, Albany, NY 12208, USA
    Neurochem Int 45:191-202. 2004
  9. ncbi Inhibition of release of taurine and excitatory amino acids in ischemia and neuroprotection
    Harold K Kimelberg
    Center for Neuropharmacology and Neuroscience and Division of Neurosurgery Albany Medical College, Albany, New York, USA
    Neurochem Res 29:267-74. 2004
  10. ncbi Volume activated anion channel and astrocytic cellular edema in traumatic brain injury and stroke
    Harold K Kimelberg
    Neural and Vascular Biology Theme, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA
    Adv Exp Med Biol 559:157-67. 2004

Research Grants

  1. MECHANISMS OF INCREASED EXCITATORY AMINOACID IN ISCHEMIA
    HAROLD KIMELBERG; Fiscal Year: 2000
  2. Excitatory Amino Acid Release in Ischemia
    HAROLD KIMELBERG; Fiscal Year: 2005

Collaborators

Detail Information

Publications32

  1. pmc Supportive or information-processing functions of the mature protoplasmic astrocyte in the mammalian CNS? A critical appraisal
    Harold K Kimelberg
    Neural and Vascular Biology, Ordway Research Institute, Inc, 150 New Scotland Ave, Albany, NY 12208, USA
    Neuron Glia Biol 3:181-9. 2007
    ....
  2. pmc Functions of astrocytes and their potential as therapeutic targets
    Harold K Kimelberg
    Ordway Research Institute, 150 New Scotland Avenue, Albany, New York 12208, USA
    Neurotherapeutics 7:338-53. 2010
    ....
  3. ncbi Astrocytic swelling in cerebral ischemia as a possible cause of injury and target for therapy
    Harold K Kimelberg
    Neural and Vascular Biology, Ordway Research Institute, Albany, New York 12208, USA
    Glia 50:389-97. 2005
    ..The question, however, of whether neuroprotection by tamoxifen can be solely attributed to VRAC inhibition in astrocytes has yet to be resolved...
  4. ncbi Water homeostasis in the brain: basic concepts
    H K Kimelberg
    Neural and Vascular Biology Theme, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA
    Neuroscience 129:851-60. 2004
    ..Finally, the mechanisms and roles of cellular and vasogenic edema in the CNS, especially in relation to aquaporins, are described...
  5. ncbi The role of hypotheses in current research, illustrated by hypotheses on the possible role of astrocytes in energy metabolism and cerebral blood flow: from Newton to now
    Harold K Kimelberg
    Neural and Vascular Biology Theme, Ordway Research Institute, Albany, New York 12208, USA
    J Cereb Blood Flow Metab 24:1235-9. 2004
  6. ncbi Tamoxifen as a powerful neuroprotectant in experimental stroke and implications for human stroke therapy
    Harold K Kimelberg
    Neural and Vascular Biology, Ordway Research Institute, 150 New Scotland Ave, Albany, NY 12208, USA
    Recent Pat CNS Drug Discov 3:104-8. 2008
    ..Differences that may make tamoxifen still desirable and the problem of predicting clinical efficacy from successful animal studies are discussed...
  7. ncbi Increased release of excitatory amino acids by the actions of ATP and peroxynitrite on volume-regulated anion channels (VRACs) in astrocytes
    Harold K Kimelberg
    Neural and Vascular Biology Theme, Ordway Research Institute, Inc, 150 New Scotland Ave, Albany, NY 12208, USA
    Neurochem Int 45:511-9. 2004
    ..Thus, the enhancement of cell volume-dependent release of excitatory amino acids from astrocytes can be physiological or pathological and its magnitude depends on the degree of the cell volume increase...
  8. ncbi The problem of astrocyte identity
    Harold K Kimelberg
    Neural and Vascular Biology Theme, Ordway Research Institute Inc, Center for Medical Science, 150 New Scotland Avenue, Albany, NY 12208, USA
    Neurochem Int 45:191-202. 2004
    ..This approach will no doubt be perfected with time but at present an acceptable, practical definition of what constitutes the class of astrocytes remains elusive...
  9. ncbi Inhibition of release of taurine and excitatory amino acids in ischemia and neuroprotection
    Harold K Kimelberg
    Center for Neuropharmacology and Neuroscience and Division of Neurosurgery Albany Medical College, Albany, New York, USA
    Neurochem Res 29:267-74. 2004
    ..Although tamoxifen cannot therefore be used as a test of the "VRAC-excitotxicity" hypothesis it may prove successful for translation of basic stroke research to the clinic because of its multiple targets...
  10. ncbi Volume activated anion channel and astrocytic cellular edema in traumatic brain injury and stroke
    Harold K Kimelberg
    Neural and Vascular Biology Theme, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA
    Adv Exp Med Biol 559:157-67. 2004
  11. doi Functions of mature mammalian astrocytes: a current view
    Harold K Kimelberg
    Ordway Research Institute, Albany, New York 12208, USA
    Neuroscientist 16:79-106. 2010
    ....
  12. ncbi Volume-regulated anion channels are the predominant contributors to release of excitatory amino acids in the ischemic cortical penumbra
    Paul J Feustel
    Center for Neuropharmacology and Neuroscience, MC136, Albany Medical College, Albany, New York, USA
    Stroke 35:1164-8. 2004
    ....
  13. ncbi Electrophysiologically "complex" glial cells freshly isolated from the hippocampus are immunopositive for the chondroitin sulfate proteoglycan NG2
    Gary P Schools
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Neurosci Res 73:765-77. 2003
    ....
  14. ncbi Peroxynitrite enhances astrocytic volume-sensitive excitatory amino acid release via a src tyrosine kinase-dependent mechanism
    Renée E Haskew
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Neurochem 82:903-12. 2002
    ..This modulation may contribute to EAA-mediated neuronal damage in ischemia and other pathological conditions favoring cell swelling and ONOO- production...
  15. pmc Pharmacological comparison of swelling-activated excitatory amino acid release and Cl- currents in cultured rat astrocytes
    Iskandar F Abdullaev
    Ordway Research Institute, Albany, NY 12208, USA
    J Physiol 572:677-89. 2006
    ..Taken together, our data suggest that (i) astrocytic volume-dependent EAA release is largely mediated by the VRAC, and (ii) the ClC-2, ClC-3, ClC-4, ClC-5, VDAC, CaCC, MDR-1 and CFTR gene products do not contribute to EAA permeability...
  16. ncbi ATP potently modulates anion channel-mediated excitatory amino acid release from cultured astrocytes
    Alexander A Mongin
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    Am J Physiol Cell Physiol 283:C569-78. 2002
    ..Moderate cell swelling and ATP may serve as two cooperative signals in bidirectional neuron-astrocyte communication in vivo...
  17. ncbi Development of GLAST(+) astrocytes and NG2(+) glia in rat hippocampus CA1: mature astrocytes are electrophysiologically passive
    Min Zhou
    Neural and Vascular Biology, Ordway Research Inst, 150 New Scotland Ave, Albany, NY 12208, USA
    J Neurophysiol 95:134-43. 2006
    ..While most glia in the NG2 lineage preserve a certain amount of voltage-gated ion conductances, mature GLAST(+) astrocytes are electrophysiologically passive...
  18. doi TWIK-1 and TREK-1 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slices
    Min Zhou
    Ordway Research Institute, Albany, New York 12208, USA
    J Neurosci 29:8551-64. 2009
    ..These results support TWIK-1 and TREK-1 as being the major components of the long-sought K(+) channels underlying the passive conductance of mature hippocampal astrocytes...
  19. ncbi Development of gap junctions in hippocampal astrocytes: evidence that whole cell electrophysiological phenotype is an intrinsic property of the individual cell
    Gary P Schools
    Neural and Vascular Biology Theme, Ordway Research Institute, Inc, Albany, NY 12208, USA
    J Neurophysiol 96:1383-92. 2006
    ....
  20. pmc Anion channels in astrocytes: biophysics, pharmacology, and function
    Harold K Kimelberg
    Neural and Vascular Biology Theme, Ordway Research Institute, Albany, New York 12208, USA
    Glia 54:747-57. 2006
    ..However, the identity of these channels in astrocytes, as in all other cells, remains elusive. The potential involvement of VRACs in pathological states such as stroke, metastasis, and spreading depression is also discussed...
  21. pmc Two distinct modes of hypoosmotic medium-induced release of excitatory amino acids and taurine in the rat brain in vivo
    RENEE E HASKEW-LAYTON
    Center of Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, USA
    PLoS ONE 3:e3543. 2008
    ..Taken together, our findings indicate that different transport mechanisms and/or distinct cellular sources mediate hypoosmotic medium-induced release of the excitatory amino acids and taurine in vivo...
  22. ncbi Oxygen and glucose deprivation-induced changes in astrocyte membrane potential and their underlying mechanisms in acute rat hippocampal slices
    Minjie Xie
    Department of Neural and Vascular Biology, Ordway Research Institute, Albany, NY 12208, USA
    J Cereb Blood Flow Metab 28:456-67. 2008
    ....
  23. pmc DCPIB, a specific inhibitor of volume regulated anion channels (VRACs), reduces infarct size in MCAo and the release of glutamate in the ischemic cortical penumbra
    Yonghua Zhang
    Neural and Vascular Biology Theme, Ordway Research Institute, Albany, New York 12208, USA
    Exp Neurol 210:514-20. 2008
    ..v. These experiments support the hypothesis that EAA released via VRACs contributes to later ischemic-induced damage...
  24. ncbi Neuroprotective activity of tamoxifen in permanent focal ischemia
    Harold K Kimelberg
    Center for Neuropharmacology and Neuroscience, and Division of Neurosurgery, Albany Medical College, Albany, New York 12208, USA
    J Neurosurg 99:138-42. 2003
    ..In this study the authors tested whether similar protective effects are found in a rat model of permanent focal ischemia (permanent middle cerebral artery [MCA] occlusion)...
  25. ncbi ATP regulates anion channel-mediated organic osmolyte release from cultured rat astrocytes via multiple Ca2+-sensitive mechanisms
    Alexander A Mongin
    Center for Neuropharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Am J Physiol Cell Physiol 288:C204-13. 2005
    ..Ca(2+)-dependent organic osmolyte release via VRACs may contribute to the physiological functions of these channels in the brain, including astrocyte-to-neuron intercellular communication...
  26. pmc Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivation
    Huaqiu Zhang
    Neural and Vascular Biology, Ordway Research Institute, Center for Medical Science, 150 New Scotland Avenue, Albany, NY 12208, USA
    Exp Neurol 212:44-52. 2008
    ....
  27. pmc Neuroprotection by tamoxifen in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activity
    Yonghua Zhang
    Neural and Vascular Biology Theme, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA
    Exp Neurol 204:819-27. 2007
    ..These data are consistent with at least part of tamoxifen's marked neuroprotection in focal cerebral ischemic injury being due to its antioxidant activity but not by an acute action on estrogen receptors (212 words)...
  28. ncbi Neuroprotection by pyrroloquinoline quinone (PQQ) in reversible middle cerebral artery occlusion in the adult rat
    Yonghua Zhang
    Neural and Vascular Biology, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA
    Brain Res 1094:200-6. 2006
    ..Thus, PQQ is neuroprotective when given as a single administration at least 3 h after initiation of rMCAo. These data indicate that PQQ may be a useful neuroprotectant in stroke therapy...
  29. ncbi Hydrogen peroxide potentiates volume-sensitive excitatory amino acid release via a mechanism involving Ca2+/calmodulin-dependent protein kinase II
    RENEE E HASKEW-LAYTON
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 280:3548-54. 2005
    ..These data demonstrate that H2O2 strongly up-regulates astrocytic volume-sensitive EAA release via a CaMKII-dependent mechanism and in this way may potently promote pathological EAA release and brain damage in ischemia...
  30. ncbi Behavioral and histological neuroprotection by tamoxifen after reversible focal cerebral ischemia
    Yonghua Zhang
    Neural and Vascular Biology Theme, Ordway Research Institute, Albany, NY 12208, USA
    Exp Neurol 196:41-6. 2005
    ..If these results are extrapolatable to human stroke, these data indicate that tamoxifen may be a useful neuroprotectant...
  31. ncbi Cellular expression of P2Y and beta-AR receptor mRNAs and proteins in freshly isolated astrocytes and tissue sections from the CA1 region of P8-12 rat hippocampus
    Yingzi Zhu
    Center for Neuropharmacology and Neuroscience, USA
    Brain Res Dev Brain Res 148:77-87. 2004
    ..These data show that astrocytes in situ express, and to a large extent likely co-express, beta-AR and P2Y receptors...
  32. ncbi Is autocrine ATP release required for activation of volume-sensitive chloride channels?
    Alexander A Mongin
    J Neurophysiol 90:2791-2; author reply 2792-3. 2003

Research Grants13

  1. MECHANISMS OF INCREASED EXCITATORY AMINOACID IN ISCHEMIA
    HAROLD KIMELBERG; Fiscal Year: 2000
    ....
  2. Excitatory Amino Acid Release in Ischemia
    HAROLD KIMELBERG; Fiscal Year: 2005
    ..The second half of the project that deals with neuroprotection has direct potential clinical implications, as TAM is known to be well tolerated in humans being widely used for breast cancer treatment. ..