Gennadi Glinsky

Summary

Affiliation: Ordway Research Institute
Country: USA

Publications

  1. ncbi request reprint Genomic analysis of pandemic (H1N1) 2009 reveals association of increasing disease severity with emergence of novel hemagglutinin mutations
    Gennadi V Glinsky
    Translational and Functional Genomics Laboratory, Department of Pathology and Laboratory Medicine, and Department of Surgery, Division of Urology, Albany Medical College, Ordway Cancer Center, Ordway Research Institute, Inc, Center for Medical Science, Albany, NY, USA
    Cell Cycle 9:958-70. 2010
  2. ncbi request reprint Death-from-cancer signatures and stem cell contribution to metastatic cancer
    Gennadi V Glinsky
    Ordway Cancer Center, Ordway Research Institute, Inc, Center for Medical Science, Division of Urology, Albany Medical College, Albany, New York 12208, USA
    Cell Cycle 4:1171-5. 2005
  3. ncbi request reprint Genomic models of metastatic cancer: functional analysis of death-from-cancer signature genes reveals aneuploid, anoikis-resistant, metastasis-enabling phenotype with altered cell cycle control and activated Polycomb Group (PcG) protein chromatin silencin
    Gennadi V Glinsky
    Functional Genomics Laboratory, Ordway Cancer Center, Ordway Research Institute, Inc, Center for Medical Sciences, Division of Urology, Albany Medical College, New York 12208 USA
    Cell Cycle 5:1208-16. 2006
  4. ncbi request reprint Integration of HapMap-based SNP pattern analysis and gene expression profiling reveals common SNP profiles for cancer therapy outcome predictor genes
    Gennadi V Glinsky
    Ordway Cancer Center, Ordway Research Institute, Inc, Albany, New York 12208, USA
    Cell Cycle 5:2613-25. 2006
  5. ncbi request reprint Stem cell origin of death-from-cancer phenotypes of human prostate and breast cancers
    Gennadi V Glinsky
    Translational and Functional Genomics Laboratory, Ordway Cancer Center, Ordway Research Institute, Albany, NY 12208, USA
    Stem Cell Rev 3:79-93. 2007
  6. ncbi request reprint Phenotype-defining functions of multiple non-coding RNA pathways
    Gennadi V Glinsky
    Translational and Functional Genomics Laboratory, Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York 12208, USA
    Cell Cycle 7:1630-9. 2008
  7. doi request reprint "Stemness" genomics law governs clinical behavior of human cancer: implications for decision making in disease management
    Gennadi V Glinsky
    Translational and Functional Genomics Laboratory, Ordway Research Institute, Ordway Cancer Center, Center for Medical Science, 150 New Scotland Ave, Albany, NY 12208, USA
    J Clin Oncol 26:2846-53. 2008
  8. ncbi request reprint Emerging genomic technologies and the concept of personalized medicine
    Victoria G Glinskii
    The School of Public Health, The University of California at Berkeley, Berkeley, California, USA
    Cell Cycle 7:2278-85. 2008
  9. ncbi request reprint An SNP-guided microRNA map of fifteen common human disorders identifies a consensus disease phenocode aiming at principal components of the nuclear import pathway
    Gennadi V Glinsky
    Department of Pathology and Laboratory Medicine, Division of Urology, Translational and Functional Genomics Laboratory, Albany Medical College, Albany, New York 12208, USA
    Cell Cycle 7:2570-83. 2008
  10. ncbi request reprint SNP-guided microRNA maps (MirMaps) of 16 common human disorders identify a clinically accessible therapy reversing transcriptional aberrations of nuclear import and inflammasome pathways
    Gennadi V Glinsky
    Translational and Functional Genomics Laboratory, Department of Pathology and Laboratory Medicine, Albany Medical College, New York 12208, USA
    Cell Cycle 7:3564-76. 2008

Research Grants

  1. TRANSCRIPTOME OF METASTATIC PROSTATE CANCER
    Gennadi Glinsky; Fiscal Year: 2004

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Genomic analysis of pandemic (H1N1) 2009 reveals association of increasing disease severity with emergence of novel hemagglutinin mutations
    Gennadi V Glinsky
    Translational and Functional Genomics Laboratory, Department of Pathology and Laboratory Medicine, and Department of Surgery, Division of Urology, Albany Medical College, Ordway Cancer Center, Ordway Research Institute, Inc, Center for Medical Science, Albany, NY, USA
    Cell Cycle 9:958-70. 2010
    ....
  2. ncbi request reprint Death-from-cancer signatures and stem cell contribution to metastatic cancer
    Gennadi V Glinsky
    Ordway Cancer Center, Ordway Research Institute, Inc, Center for Medical Science, Division of Urology, Albany Medical College, Albany, New York 12208, USA
    Cell Cycle 4:1171-5. 2005
    ....
  3. ncbi request reprint Genomic models of metastatic cancer: functional analysis of death-from-cancer signature genes reveals aneuploid, anoikis-resistant, metastasis-enabling phenotype with altered cell cycle control and activated Polycomb Group (PcG) protein chromatin silencin
    Gennadi V Glinsky
    Functional Genomics Laboratory, Ordway Cancer Center, Ordway Research Institute, Inc, Center for Medical Sciences, Division of Urology, Albany Medical College, New York 12208 USA
    Cell Cycle 5:1208-16. 2006
    ..A functionally complementary role of multiple cooperating oncogenic pathways and the essential role of Polycomb Group (PcG) protein chromatin silencing pathway in emergence of the stem cell cancer phenotype is highlighted...
  4. ncbi request reprint Integration of HapMap-based SNP pattern analysis and gene expression profiling reveals common SNP profiles for cancer therapy outcome predictor genes
    Gennadi V Glinsky
    Ordway Cancer Center, Ordway Research Institute, Inc, Albany, New York 12208, USA
    Cell Cycle 5:2613-25. 2006
    ..We propose that critical disease-causing combinations of SNP variants arise from SNPs regulating mRNA levels and determining genome-wide haplotype patterns of individual's disease susceptibility...
  5. ncbi request reprint Stem cell origin of death-from-cancer phenotypes of human prostate and breast cancers
    Gennadi V Glinsky
    Translational and Functional Genomics Laboratory, Ordway Cancer Center, Ordway Research Institute, Albany, NY 12208, USA
    Stem Cell Rev 3:79-93. 2007
    ..One of the major regulatory pathways manifesting distinct patterns of association with therapy-resistant and therapy-responsive cancer phenotypes is the Polycomb group proteins chromatin silencing pathway...
  6. ncbi request reprint Phenotype-defining functions of multiple non-coding RNA pathways
    Gennadi V Glinsky
    Translational and Functional Genomics Laboratory, Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York 12208, USA
    Cell Cycle 7:1630-9. 2008
    ....
  7. doi request reprint "Stemness" genomics law governs clinical behavior of human cancer: implications for decision making in disease management
    Gennadi V Glinsky
    Translational and Functional Genomics Laboratory, Ordway Research Institute, Ordway Cancer Center, Center for Medical Science, 150 New Scotland Ave, Albany, NY 12208, USA
    J Clin Oncol 26:2846-53. 2008
    ....
  8. ncbi request reprint Emerging genomic technologies and the concept of personalized medicine
    Victoria G Glinskii
    The School of Public Health, The University of California at Berkeley, Berkeley, California, USA
    Cell Cycle 7:2278-85. 2008
    ..We conclude by discussing how we can achieve a future of safe personalized medicine for the populous, which would require continuous productive interactions between policymakers and scientists...
  9. ncbi request reprint An SNP-guided microRNA map of fifteen common human disorders identifies a consensus disease phenocode aiming at principal components of the nuclear import pathway
    Gennadi V Glinsky
    Department of Pathology and Laboratory Medicine, Division of Urology, Translational and Functional Genomics Laboratory, Albany Medical College, Albany, New York 12208, USA
    Cell Cycle 7:2570-83. 2008
    ....
  10. ncbi request reprint SNP-guided microRNA maps (MirMaps) of 16 common human disorders identify a clinically accessible therapy reversing transcriptional aberrations of nuclear import and inflammasome pathways
    Gennadi V Glinsky
    Translational and Functional Genomics Laboratory, Department of Pathology and Laboratory Medicine, Albany Medical College, New York 12208, USA
    Cell Cycle 7:3564-76. 2008
    ..Prescription of chloroquine, an FDA-approved drug which is widely utilized for treatment of malaria, RA and systemic lupus erythematosus (SLE), may have a therapeutic value in clinical management of a large spectrum of human disorders...
  11. ncbi request reprint Disease phenocode analysis identifies SNP-guided microRNA maps (MirMaps) associated with human "master" disease genes
    Gennadi V Glinsky
    Department of Pathology and Laboratory Medicine, Albany Medical College, Ordway Cancer Center, Albany, New York 12208, USA
    Cell Cycle 7:3680-94. 2008
    ....
  12. ncbi request reprint Human genome connectivity code links disease-associated SNPs, microRNAs and pyknons
    Gennadi V Glinsky
    Department of Pathology, Laboratory Medicine, Division of Urology, Albany Medical College, Ordway Cancer Center, Ordway Research Institute, Inc, Center for Medical Science, Albany, NY 12208, USA
    Cell Cycle 8:925-30. 2009
    ....
  13. ncbi request reprint Dual-color-coded imaging of viable circulating prostate carcinoma cells reveals genetic exchange between tumor cells in vivo, contributing to highly metastatic phenotypes
    Gennadi V Glinsky
    Ordway Research Institute Cancer Center, Center for Medical Science, Albany, New York, USA
    Cell Cycle 5:191-7. 2006
    ..These results are consistent with the idea that spontaneous genetic exchange between tumor cells in vivo contributes to genomic instability and creation of highly metastatic cells...
  14. ncbi request reprint Essential role for activation of the Polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer
    Olga P Berezovska
    Translational and Functional Genomics Laboratory, Ordway Cancer Center, Ordway Research Institute, Inc, Center for Medical Sciences, Albany, New York 12208, USA
    Cell Cycle 5:1886-901. 2006
    ....
  15. ncbi request reprint Identification of intergenic trans-regulatory RNAs containing a disease-linked SNP sequence and targeting cell cycle progression/differentiation pathways in multiple common human disorders
    Anna B Glinskii
    Translational and Functional Genomics Laboratory, Department of Pathology and Laboratory Medicine, Division of Urology, Albany Medical College, Ordway Cancer Center, Ordway Research Institute, Inc, Center for Medical Science, Albany, NY, USA
    Cell Cycle 8:3925-42. 2009
    ..According to this model, random genetic variations which generate transRNAs asserting antagonistic phenotype-altering effects compared to ancestral alleles will be selected and retained as SNP variants...
  16. ncbi request reprint Modification of survival pathway gene expression in human breast cancer cells by tetraiodothyroacetic acid (tetrac)
    Anna B Glinskii
    Ordway Research Institute, Albany College of Pharmacy, Albany, NY, USA
    Cell Cycle 8:3554-62. 2009
    ..Nanoparticulate tetrac has coherent anti-cancer actions on expression of differentially-regulated genes important to survival of MDA-MB-231 cells...
  17. ncbi request reprint Identification of genes associated with tumor progression using microarrays
    Gerhard Gebauer
    Sidney Kimmel Cancer Center, San Diego, CA, USA
    Anticancer Res 25:1477-82. 2005
    ..Defining consistent changes in the gene expression pattern of cancer models may lead to detection of genes essential for tumor progression and may ultimately identify new targets for therapy...
  18. ncbi request reprint Intravascular metastatic cancer cell homotypic aggregation at the sites of primary attachment to the endothelium
    Vladislav V Glinsky
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
    Cancer Res 63:3805-11. 2003
    ....
  19. pmc Malignancy-associated regions of transcriptional activation: gene expression profiling identifies common chromosomal regions of a recurrent transcriptional activation in human prostate, breast, ovarian, and colon cancers
    Gennadi V Glinsky
    Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
    Neoplasia 5:218-28. 2003
    ....
  20. ncbi request reprint Viable circulating metastatic cells produced in orthotopic but not ectopic prostate cancer models
    Anna B Glinskii
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Cancer Res 63:4239-43. 2003
    ....
  21. ncbi request reprint Microarray analysis of xenograft-derived cancer cell lines representing multiple experimental models of human prostate cancer
    Gennadi V Glinsky
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Mol Carcinog 37:209-21. 2003
    ....
  22. ncbi request reprint Common malignancy-associated regions of transcriptional activation (MARTA) in human prostate, breast, ovarian, and colon cancers are targets for DNA amplification
    Gennadi V Glinsky
    Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
    Cancer Lett 201:67-77. 2003
    ..2-19 Mbp]; Xq28 [147-153 Mbp]). At least some of these cancer-associated MARTAs correspond well to the regions of recurrent amplification in human cancer and seemed to be targets for DNA amplifications in established cancer cell lines...
  23. pmc Gene expression profiling predicts clinical outcome of prostate cancer
    Gennadi V Glinsky
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    J Clin Invest 113:913-23. 2004
    ....
  24. ncbi request reprint Classification of human breast cancer using gene expression profiling as a component of the survival predictor algorithm
    Gennadi V Glinsky
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Clin Cancer Res 10:2272-83. 2004
    ....
  25. ncbi request reprint Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells
    Olga Berezovskaya
    The Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Cancer Res 65:2378-86. 2005
    ..We also provide initial preclinical data on the antimetastatic efficacy of recently discovered small-molecule antagonists of XIAP...
  26. ncbi request reprint Critical role for Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein in anoikis resistance and distant tumor formation
    Imtiaz A Mawji
    Ontario Cancer Institute, Princess Margaret Hospital, 610 University Ave, Toronto, ON, Canada, M5G 2M9
    J Natl Cancer Inst 99:811-22. 2007
    ..We hypothesized that c-Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein (FLIP), an endogenous inhibitor of death receptor signaling, may suppress anoikis...
  27. pmc Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer
    Gennadi V Glinsky
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    J Clin Invest 115:1503-21. 2005
    ....
  28. pmc Mechanical entrapment is insufficient and intercellular adhesion is essential for metastatic cell arrest in distant organs
    Olga V Glinskii
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
    Neoplasia 7:522-7. 2005
    ..Efficient blocking of beta-galactoside-mediated adhesion precludes malignant cell lodging in target organs...
  29. ncbi request reprint Regenerative medicine: evidence for remarkable healing power of adult (somatic) stem cells
    Gennadi V Glinsky
    Cell Cycle 7:1697. 2008
  30. ncbi request reprint MDA-MB-435 human breast carcinoma cell homo- and heterotypic adhesion under flow conditions is mediated in part by Thomsen-Friedenreich antigen-galectin-3 interactions
    Sophia K Khaldoyanidi
    Division of Vascular Biology, La Jolla Institute for Molecular Medicine, San Diego, California 92121, USA
    J Biol Chem 278:4127-34. 2003
    ....

Research Grants4

  1. TRANSCRIPTOME OF METASTATIC PROSTATE CANCER
    Gennadi Glinsky; Fiscal Year: 2004
    ..Subsequently the expression profile of these protein products will be studied in human prostate tumor samples by immunofluorescence analysis and immunohistochemistry to better correlate gene expression changes with phenotype. ..