R M Post

Summary

Affiliation: One DNA Way
Country: USA

Publications

  1. ncbi The health care crisis of childhood-onset bipolar illness: some recommendations for its amelioration
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health NIMH, National Institutes of Health NIH, Bldg 10, Rm 3S329, 10 Center Drive, Bethesda, MD 20892, USA
    J Clin Psychiatry 67:115-25. 2006
  2. ncbi Incidence of childhood-onset bipolar illness in the USA and Europe
    Robert M Post
    Department of Psychiatry, George Washington University, Washington, DC, USA
    Br J Psychiatry 192:150-1. 2008
  3. ncbi Promising avenues of therapeutics for bipolar illness
    Robert M Post
    George Washington University School of Medicine, USA
    Dialogues Clin Neurosci 10:193-201. 2008
  4. ncbi Complexity of pharmacologic treatment required for sustained improvement in outpatients with bipolar disorder
    Robert M Post
    Department of Psychiatry and Behavioral Sciences, George Washington University, Washington, DC, USA
    J Clin Psychiatry 71:1176-86; quiz 1252-3. 2010
  5. ncbi Role of childhood adversity in the development of medical co-morbidities associated with bipolar disorder
    Robert M Post
    Bipolar Collaborative Network, 5415 West Cedar Lane Suite 201B, Bethesda, MD 20814, USA
    J Affect Disord 147:288-94. 2013
  6. ncbi Bipolar disorder and substance misuse: pathological and therapeutic implications of their comorbidity and cross-sensitisation
    Robert M Post
    MD, Head, Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201 B, Bethesda, MD 20814, USA
    Br J Psychiatry 202:172-6. 2013
  7. ncbi Relationship of prior antidepressant exposure to long-term prospective outcome in bipolar I disorder outpatients
    Robert M Post
    Bipolar Collaborative Network, Bethesda, Maryland, USA
    J Clin Psychiatry 73:924-30. 2012
  8. ncbi Acquired lithium resistance revisited: discontinuation-induced refractoriness versus tolerance
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201B, Bethesda, MD 20814, United States
    J Affect Disord 140:6-13. 2012
  9. ncbi Neurobiological correlates of illness progression in the recurrent affective disorders
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201 B, Bethesda, MD 20814, United States
    J Psychiatr Res 46:561-73. 2012
  10. ncbi New findings from the Bipolar Collaborative Network: clinical implications for therapeutics
    Robert M Post
    Penn State College of Medicine, Hershey, PA, USA
    Curr Psychiatry Rep 8:489-97. 2006

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. ncbi The health care crisis of childhood-onset bipolar illness: some recommendations for its amelioration
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health NIMH, National Institutes of Health NIH, Bldg 10, Rm 3S329, 10 Center Drive, Bethesda, MD 20892, USA
    J Clin Psychiatry 67:115-25. 2006
    ..To describe new data on the incidence and impact of childhood- and adolescent-onset bipolar illness and make recommendations to help accelerate the acquisition of knowledge in this area...
  2. ncbi Incidence of childhood-onset bipolar illness in the USA and Europe
    Robert M Post
    Department of Psychiatry, George Washington University, Washington, DC, USA
    Br J Psychiatry 192:150-1. 2008
    ..In the USA there was also twice the incidence of childhood adversity and genetic/familial risk for affective disorder. The findings deserve replication and further exploration...
  3. ncbi Promising avenues of therapeutics for bipolar illness
    Robert M Post
    George Washington University School of Medicine, USA
    Dialogues Clin Neurosci 10:193-201. 2008
    ....
  4. ncbi Complexity of pharmacologic treatment required for sustained improvement in outpatients with bipolar disorder
    Robert M Post
    Department of Psychiatry and Behavioral Sciences, George Washington University, Washington, DC, USA
    J Clin Psychiatry 71:1176-86; quiz 1252-3. 2010
    ..To evaluate the clinical correlates of and types of naturalistic treatments associated with sustained improvement/remission for at least 6 months in outpatients with bipolar disorder...
  5. ncbi Role of childhood adversity in the development of medical co-morbidities associated with bipolar disorder
    Robert M Post
    Bipolar Collaborative Network, 5415 West Cedar Lane Suite 201B, Bethesda, MD 20814, USA
    J Affect Disord 147:288-94. 2013
    ....
  6. ncbi Bipolar disorder and substance misuse: pathological and therapeutic implications of their comorbidity and cross-sensitisation
    Robert M Post
    MD, Head, Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201 B, Bethesda, MD 20814, USA
    Br J Psychiatry 202:172-6. 2013
    ..Bipolar disorder has a high co-occurrence with substance use disorders, but the pathophysiological mechanisms have not been adequately explored...
  7. ncbi Relationship of prior antidepressant exposure to long-term prospective outcome in bipolar I disorder outpatients
    Robert M Post
    Bipolar Collaborative Network, Bethesda, Maryland, USA
    J Clin Psychiatry 73:924-30. 2012
    ..The long-term impact of prior antidepressant exposure on the subsequent course of bipolar illness remains controversial...
  8. ncbi Acquired lithium resistance revisited: discontinuation-induced refractoriness versus tolerance
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201B, Bethesda, MD 20814, United States
    J Affect Disord 140:6-13. 2012
    ..While some patients fail to respond to lithium from the outset, others are initially responsive and then develop treatment resistance. These acquired forms of lithium resistance have received relatively little clinical attention...
  9. ncbi Neurobiological correlates of illness progression in the recurrent affective disorders
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201 B, Bethesda, MD 20814, United States
    J Psychiatr Res 46:561-73. 2012
    ..As such, earlier and more sustained long-term prophylaxis to attempt to reduce these adverse outcomes is indicated...
  10. ncbi New findings from the Bipolar Collaborative Network: clinical implications for therapeutics
    Robert M Post
    Penn State College of Medicine, Hershey, PA, USA
    Curr Psychiatry Rep 8:489-97. 2006
    ..Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss...
  11. ncbi Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthood
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Bethesda, MD 20814, USA
    J Clin Psychiatry 71:864-72. 2010
    ..We examined the influence of age at onset of illness and the delay in time to first treatment on morbidity in adulthood...
  12. ncbi Tolerance to the prophylactic effects of carbamazepine and related mood stabilizers in the treatment of bipolar disorders
    Robert M Post
    Department of Psychiatry, George Washington University, Washington, DC, USA
    CNS Neurosci Ther 17:649-60. 2011
    ..Careful longitudinal monitoring of episode occurrence is essential to understanding tolerance development in the affective disorder and its treatment...
  13. ncbi Mechanisms of illness progression in the recurrent affective disorders
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201 B, Bethesda, MD 20814, USA
    Neurotox Res 18:256-71. 2010
    ....
  14. ncbi Kindling and sensitization as models for affective episode recurrence, cyclicity, and tolerance phenomena
    Robert M Post
    Penn State College of Medicine, 3502 Turner Lane, Chevy Chase, MD 20815, USA
    Neurosci Biobehav Rev 31:858-73. 2007
    ....
  15. ncbi Role of BDNF in bipolar and unipolar disorder: clinical and theoretical implications
    Robert M Post
    Penn State School of Medicine, Hershey, PA, USA
    J Psychiatr Res 41:979-90. 2007
    ....
  16. ncbi The role of psychosocial stress in the onset and progression of bipolar disorder and its comorbidities: the need for earlier and alternative modes of therapeutic intervention
    R M Post
    Penn State University School of Medicine, USA
    Dev Psychopathol 18:1181-211. 2006
    ..Without the mobilization of new clinical and public health approaches to earlier and more effective treatment and supportive interventions, bipolar illness will continue to have grave implications for many patients' long-term well being...
  17. ncbi Axis I psychiatric comorbidity and its relationship to historical illness variables in 288 patients with bipolar disorder
    S L McElroy
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Am J Psychiatry 158:420-6. 2001
    ..Therefore, the authors assessed comorbid lifetime and current axis I disorders in 288 patients with bipolar disorder and the relationships of these comorbid disorders to selected demographic and historical illness variables...
  18. ncbi The Stanley Foundation Bipolar Treatment Outcome Network. I. Longitudinal methodology
    G S Leverich
    Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1272, USA
    J Affect Disord 67:33-44. 2001
    ..This article describes the rationale for the Network, its guiding principles, methods, and study design to systematically assess the highly variable course of bipolar illness and its response to current and future treatments...
  19. ncbi The Stanley Foundation Bipolar Treatment Outcome Network. II. Demographics and illness characteristics of the first 261 patients
    T Suppes
    The Stanley Foundation Bipolar Network, 5430 Grosvenor Lane, Suite 200, Bethesda, MD 20814, USA
    J Affect Disord 67:45-59. 2001
    ..This report describes the demographics and course of illness characteristics of this study population...
  20. ncbi The Stanley Foundation Bipolar Network. I. Rationale and methods
    R M Post
    National Institute of Mental Health, Bethesda, Maryland, USA
    Br J Psychiatry Suppl 41:s169-76. 2001
    ..CONCLUSIONS: Well-characterised patients are followed in a detailed continuous longitudinal fashion in both opportunistic case series and double-blind, randomised controlled trials with reliable and validated measures...
  21. ncbi Understanding emotional prosody activates right hemisphere regions
    M S George
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Neurol 53:665-70. 1996
    ..The brain regions involved in recognition of emotional prosody in healthy subjects is less clear...
  22. ncbi Kindling: separate vs. shared mechanisms in affective disorders and epilepsy
    S R Weiss
    Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neuropsychobiology 38:167-80. 1998
    ..It is hoped that some of the lessons from the kindling model will provide useful and novel insights into aspects of treatment and mechanisms of psychiatric and neurologic illnesses...
  23. ncbi Rate of switch in bipolar patients prospectively treated with second-generation antidepressants as augmentation to mood stabilizers
    R M Post
    Biological Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892-1272, USA
    Bipolar Disord 3:259-65. 2001
    ..Individual data on each drug will be assessed in the next phase of the study after more subjects are recruited and the blind is broken...
  24. ncbi Clozapine in bipolar disorder: treatment implications for other atypical antipsychotics
    M A Frye
    National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD, USA
    J Affect Disord 48:91-104. 1998
    ..The foregoing agents and future drugs with atypical neuroleptic properties should come to play an increasingly important role, compared to the older classical neuroleptics, in the acute and long term management of bipolar disorder...
  25. ncbi Opposite effects of high and low frequency rTMS on mood in depressed patients: relationship to baseline cerebral activity on PET
    A M Speer
    Biological Psychiatry Branch, NIMH, NIH, Bethesda, Maryland, United States
    J Affect Disord 115:386-94. 2009
    ..Optimal parameters of rTMS for antidepressant efficacy in general, or within patients, have not been adequately delineated...
  26. ncbi Lack of adverse cognitive effects of 1 Hz and 20 Hz repetitive transcranial magnetic stimulation at 100% of motor threshold over left prefrontal cortex in depression
    A M Speer
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J ECT 17:259-63. 2001
    ..This study assesses the cognitive performance of depressed patients receiving high or low frequency rTMS for 10 days...
  27. ncbi Gabapentin does not alter single-dose lithium pharmacokinetics
    M A Frye
    Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Clin Psychopharmacol 18:461-4. 1998
    ....
  28. ncbi Blunted left cingulate activation in mood disorder subjects during a response interference task (the Stroop)
    M S George
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    J Neuropsychiatry Clin Neurosci 9:55-63. 1997
    ..This study supports theories of blunted limbic and paralimbic activation and abnormal cingulate activity in depression and adds to the growing knowledge of the functional neuroanatomy of depression...
  29. ncbi Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: a placebo-controlled crossover trial
    M S George
    Biological Psychiatry Branch, NIMH, Bethesda, MD 20892, USA
    Am J Psychiatry 154:1752-6. 1997
    ..Preliminary studies have indicated that daily left prefrontal repetitive transcranial magnetic stimulation might have antidepressant activity. The authors sought to confirm this finding by using a double-blind crossover design...
  30. ncbi Neurobiology of seizures and behavioral abnormalities
    R M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1272, USA
    Epilepsia 45:5-14. 2004
    ....
  31. ncbi MRI-based measurements of temporal lobe and ventricular structures in patients with bipolar I and bipolar II disorders
    P Hauser
    Department of Psychiatry, University of Maryland Medical Center and Psychiatry Service, Baltimore VA Medical Center, 10 North Greene Street, Baltimore, MD 21201, USA
    J Affect Disord 60:25-32. 2000
    ..Also there have been no quantitative MRI studies of bipolar II patients. The present study measured temporal lobe and ventricular structures in both bipolar I and bipolar II patients, as well as control subjects...
  32. ncbi Relationship between prior course of illness and neuropsychological functioning in patients with bipolar disorder
    K D Denicoff
    Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Affect Disord 56:67-73. 1999
    ..This study investigated the relationship between prior course of illness and neuropsychological deficits in relatively high functioning outpatients with bipolar disorder...
  33. ncbi Transcranial magnetic stimulation: a neuropsychiatric tool for the 21st century
    M S George
    Department of Psychiatry, Medical University of South Carolina, Charleston 29425, USA
    J Neuropsychiatry Clin Neurosci 8:373-82. 1996
    ..Preliminary investigations have also used rapid-rate TMS to improve motor speed in Parkinson's disease and mood in depression. TMS is likely to be an important future neuropsychiatric tool...
  34. ncbi Post-dexamethasone cortisol correlates with severity of depression before and during carbamazepine treatment in women but not men
    E A Osuch
    Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Acta Psychiatr Scand 104:397-401. 2001
    ..CONCLUSION: The pathophysiological implications of this selective positive relationship between severity of depression and post-DST cortisol in women, but not men, should be explored further...
  35. ncbi Amygdala-kindled seizures increase the expression of corticotropin-releasing factor (CRF) and CRF-binding protein in GABAergic interneurons of the dentate hilus
    M A Smith
    Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Brain Res 745:248-56. 1997
    ..These results suggest that CRF may contribute to the development of amygdala kindling. However, the compensatory induction of CRF-BP may serve to limit the excitatory effects of CRF in the dentate gyrus...
  36. ncbi Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers
    Gabriele S Leverich
    Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    Am J Psychiatry 163:232-9. 2006
    ..The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression...
  37. ncbi Mood switch in bipolar depression: comparison of adjunctive venlafaxine, bupropion and sertraline
    R M Post
    Department of Health and Human Services, National Institute of Mental Health, Bethesda, Maryland, USA
    Br J Psychiatry 189:124-31. 2006
    ..Few studies have examined the relative risks of switching into hypomania or mania associated with second-generation antidepressant drugs in bipolar depression...
  38. ncbi Lamotrigine reduces spontaneous and evoked GABAA receptor-mediated synaptic transmission in the basolateral amygdala: implications for its effects in seizure and affective disorders
    M F M Braga
    Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland, MD 20814, USA
    Neuropharmacology 42:522-9. 2002
    ..The modulation of inhibitory synaptic transmission may be an important mechanism underlying the psychotropic effects of LTG...
  39. ncbi Relationship between prior course of illness and neuroanatomic structures in bipolar disorder: a preliminary study
    S O Ali
    Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Neuropsychiatry Neuropsychol Behav Neurol 14:227-32. 2001
    ..CONCLUSIONS: Additional studies are needed to both replicate and further examine the association of prior course of illness and larger hippocampal and ventricular volumes in bipolar disorder...
  40. ncbi Development and validation of a screening instrument for bipolar spectrum disorder: the Mood Disorder Questionnaire
    R M Hirschfeld
    Department of Psychiatry and Behavioral Sciences, Medical Branch, the University of Texas at Galveston 77555 01888, USA
    Am J Psychiatry 157:1873-5. 2000
    ..This report describes the validation of a new brief self-report screening instrument for bipolar spectrum disorders called the Mood Disorder Questionnaire...
  41. ncbi A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorders
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 9:426-34. 2007
    ..The objective of this study was to compare sibutramine and topiramate as adjunctive treatments for psychotropic-associated weight gain in overweight or obese outpatients with BD...
  42. ncbi Treatment of rapid-cycling bipolar disorder
    Robert M Post
    Bipolar Collaborative Network, Chevy Chase, MD, USA
    CNS Spectr 9:1-11. 2004
  43. ncbi Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:370-4. 2005
    ..Given the effectiveness of a range of other anticonvulsants in bipolar disorder, we sought to evaluate levetiracetam in patients with treatment-resistant illness...
  44. ncbi Effects of thyroid alterations and carbamazepine on cortical beta-adrenergic receptors in the rat
    R T Joffe
    Biological Psychiatry Branch, NIMH, Bethesda, Maryland
    Neuropharmacology 27:171-4. 1988
    ....
  45. ncbi Effect of prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: a preliminary study
    B D Greenberg
    Laboratory of Clinical Science, NIMH, Bethesda, MD 20892 1264, USA
    Am J Psychiatry 154:867-9. 1997
    ..Prefrontal mechanisms are implicated in obsessive-compulsive disorder. The authors investigated whether prefrontal repetitive transcranial magnetic stimulation influenced obsessive-compulsive disorder symptoms...
  46. ncbi Comparative pharmacology of bipolar disorder and schizophrenia
    R M Post
    Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892 1272, USA
    Schizophr Res 39:153-8; discussion 163. 1999
    ....
  47. ncbi Apoptosis of hippocampal neurons after amygdala kindled seizures
    L X Zhang
    Biological Psychiatric Branch, NIMH, Bldg 10 Rm 3N212, Bethesda, MD 20982, USA
    Brain Res Mol Brain Res 55:198-208. 1998
    ....
  48. ncbi Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, PO Box 670559, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Clin Psychiatry 66:617-24. 2005
    ..The response of 62 outpatients with DSM-IV bipolar disorders to open-label adjunctive zonisamide was evaluated in a prospective 8-week acute trial, followed by a 48-week continuation trial, conducted from June 2001 through May 2002...
  49. ncbi A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network
    Robert M Post
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:396-406. 2003
    ..This paper reviews new data on: (1) depression in bipolar illness, (2) switch rates on ADs and (3) risks of AD discontinuation that are pertinent to the ongoing discussion and recommendations...
  50. ncbi Correlates of treatment-emergent mania associated with antidepressant treatment in bipolar depression
    Mark A Frye
    Department of Psychiatry, Mayo Mood Clinic and Research Program, Mayo Clinic, 200 First St, S W, Rochester, MN 55901, USA
    Am J Psychiatry 166:164-72. 2009
    ..This study examined the correlates associated with treatment-emergent mania in patients receiving adjunctive antidepressant treatment for bipolar depression...
  51. ncbi Convergences in course of illness and treatments of the epilepsies and recurrent affective disorders
    Robert M Post
    Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD, USA
    Clin EEG Neurosci 35:14-24. 2004
    ..Caveats in the use of this model and convergences and divergences in its predictive validity for seizures and affective disorders are noted...
  52. ncbi Low cerebrospinal fluid glutamate and glycine in refractory affective disorder
    Mark A Frye
    Department of Psychiatry, University of California Los Angeles Neuropsychiatric Institute, Los Angeles, CA, USA
    Biol Psychiatry 61:162-6. 2007
    ..Glutamatergic dysregulation has been documented in schizophrenia but has received less systematic study in affective illness...
  53. ncbi Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart method
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 12723, USA
    J Clin Psychiatry 64:680-90; quiz 738-9. 2003
    ..The detailed course and pattern of illness emerging despite comprehensive treatment with mood stabilizers and adjunctive agents have previously not been well delineated...
  54. ncbi Developmental vulnerabilities to the onset and course of bipolar disorder
    R M Post
    Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892-1272, USA
    Dev Psychopathol 13:581-98. 2001
    ....
  55. ncbi Input-specific LTP and depotentiation in the basolateral amygdala
    V Aroniadou-Anderjaska
    Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Neuroreport 12:635-40. 2001
    ..These synapse-specific, reversible changes in synaptic strength in the basolateral nucleus of the amygdala may be important to amygdala's role in emotional memory...
  56. ncbi Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment Network
    Trisha Suppes
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
    Int Clin Psychopharmacol 22:376-81. 2007
    ..No between-group differences in improvement were found. Adjunctive quetiapine may be useful as continuation treatment in bipolar populations with both pure depressive and cycling symptoms. Further controlled studies are warranted...
  57. ncbi Utility of the daily prospective National Institute of Mental Health Life-Chart Method (NIMH-LCM-p) ratings in clinical trials of bipolar disorder
    Kirk D Denicoff
    Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Depress Anxiety 15:1-9. 2002
    ....
  58. ncbi The impact of bipolar depression
    Robert M Post
    Bipolar Collaborative Network, Chevy Chase, MD, USA
    J Clin Psychiatry 66:5-10. 2005
    ..Early and accurate diagnosis, aggressive management, and earlier prophylactic treatment regimens are needed to overcome the impact of depressive episodes in patients with bipolar disorder...
  59. ncbi Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Clin Psychiatry 64:506-15. 2003
    ..We investigated demographic and course-of-illness variables to better understand the incidence and potential clinical correlates of serious suicide attempts in 648 outpatients with bipolar disorder...
  60. ncbi Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study
    Lori L Altshuler
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA, USA
    J Clin Psychiatry 67:1551-60. 2006
    ..Research examining this relationship in persons with bipolar disorder is rare. This study sought to evaluate the association between subsyndromal depressive symptoms and role functioning in subjects with bipolar disorder...
  61. ncbi Impact of antidepressant continuation after acute positive or partial treatment response for bipolar depression: a blinded, randomized study
    Lori L Altshuler
    Department of Psychiatry, Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Los Angeles, CA, USA
    J Clin Psychiatry 70:450-7. 2009
    ..To assess long-term outcome in bipolar disorder, subjects were prospectively followed after receiving acute treatment for bipolar depression...
  62. ncbi Regional cerebral blood flow correlated with flashback intensity in patients with posttraumatic stress disorder
    E A Osuch
    Uniformed Services University of the Health Sciences, Maryland, USA
    Biol Psychiatry 50:246-53. 2001
    ..CONCLUSIONS: This study correlated flashback intensity and rCBF in a group of patients with chronic PTSD suggesting involvement of brainstem, and areas associated with motor control, complex visual/spatial cues and memory...
  63. ncbi Specific amygdaloid nuclei are involved in suppression or propagation of epileptiform activity during transition stage between oral automatisms and generalized clonic seizures
    M Sitcoske O'Shea
    Biological Psychiatry Branch, National Institutes of Mental Health, Bethesda, MD 0892, USA
    Brain Res 873:1-17. 2000
    ..A neuroanatomical model of Am-induced seizure propagation is proposed suggesting that the Claust-Ins-PRh play a pivotal role during the transition between oral automatisms and generalized clonic convulsions...
  64. ncbi Tiagabine in treatment refractory bipolar disorder: a clinical case series
    Trisha Suppes
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Bipolar Disord 4:283-9. 2002
    ..We sought to evaluate the effectiveness of tiagabine added to ongoing medication regimens in patients with bipolar disorder inadequately responsive to or intolerant of usual treatments...
  65. ncbi Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine and the Mental Health Care Line, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 60:1020-2. 2006
    ..The results of pilot trials suggest that omega-3 fatty acids may have efficacy in the treatment of mood symptoms in bipolar disorder...
  66. ncbi Coadministration of gabapentin or MK-801 with lamotrigine slows tolerance to its anticonvulsant effects on kindled seizures
    Zhang Jin Zhang
    Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Pharmacol Biochem Behav 74:565-71. 2003
    ..These data indicate that cotreatment with either GBP or MK-801 slows tolerance development to the anticonvulsant effects of LTG on kindled seizures. Therapeutic implications of the present study remain to be explored...
  67. ncbi An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:310-9. 2003
    ..Selected recent findings of the Stanley Foundation Bipolar Network are briefly reviewed and their clinical implications discussed...
  68. ncbi Is there progression from irritability/dyscontrol to major depressive and manic symptoms? A retrospective community survey of parents of bipolar children
    Emily L Fergus
    Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    J Affect Disord 77:71-8. 2003
    ..The current study sought to trace parents' retrospective report of yearly occurrence of symptoms in a sample of children with and without a diagnosis of bipolar disorder in the community...
  69. ncbi Decreased expression of mineralocorticoid receptor mRNA in the prefrontal cortex in schizophrenia and bipolar disorder
    Guo Qiang Xing
    Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Int J Neuropsychopharmacol 7:143-53. 2004
    ..Whether these findings may be linked to the abnormal prefrontal function, HPA axis activation, or the deficits in SWS found in these major psychiatric illnesses remains to be further explored...
  70. ncbi Earliest symptoms discriminating juvenile-onset bipolar illness from ADHD
    David A Luckenbaugh
    Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD, USA
    Bipolar Disord 11:441-51. 2009
    ....
  71. ncbi Priority actions to improve the care of persons with co-occurring substance abuse and other mental disorders: a call to action
    Dennis S Charney
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104-6178, USA
    Biol Psychiatry 56:703-13. 2004
  72. ncbi Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenon
    Trisha Suppes
    Bipolar Disorder Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9121, USA
    Arch Gen Psychiatry 62:1089-96. 2005
    ..The prevalence of depressive symptoms co-occurring with hypomanic symptoms has not been quantified. Whether there is a greater likelihood for women to experience mixed symptoms has not been resolved...
  73. ncbi Thirty years of clinical experience with carbamazepine in the treatment of bipolar illness: principles and practice
    Robert M Post
    Bipolar Collaborative Network, Chevy Chase, Maryland, USA
    CNS Drugs 21:47-71. 2007
    ..More precise clinical and biological predictors and correlates of individual clinical responsiveness to carbamazepine and other mood stabilisers are eagerly awaited...
  74. ncbi Treatment of bipolar depression
    Robert M Post
    Bipolar Collaborative Network, Chevy Chase, Maryland, USA
    CNS Spectr 8:1-10; quiz 11. 2003
    ..Other adjuncts for treatment-refractory patients include monoamine oxidase inhibitors and electroconvulsive therapy...
  75. ncbi Principal components of the Beck Depression Inventory and regional cerebral metabolism in unipolar and bipolar depression
    Robert T Dunn
    Biological Psychiatry Branch, NIMH, NIH, Bethesda, Maryland 20892-1272, USA
    Biol Psychiatry 51:387-99. 2002
    ..Thus, different depressive symptom clusters may have different neural substrates in unipolars, but clusters and their substrates are convergent in bipolars...
  76. ncbi The poor prognosis of childhood-onset bipolar disorder
    Gabriele S Leverich
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Pediatr 150:485-90. 2007
    ..We examined age of onset of bipolar disorder as a potential course-of-illness modifier with the hypothesis that early onset will engender more severe illness...
  77. ncbi Clinical predictors of response to lamotrigine and gabapentin monotherapy in refractory affective disorders
    Gabriela V Obrocea
    National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, Maryland 20892, USA
    Biol Psychiatry 51:253-60. 2002
    ..These preliminary data in a treatment refractory subgroup may help in the further definition of the range of clinical utility of these widely used anticonvulsants...
  78. ncbi Unidirectional cross-tolerance from levetiracetam to carbamazepine in amygdala-kindled seizures
    Zhang Jin Zhang
    Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, U S A
    Epilepsia 44:1487-93. 2003
    ..The present study was designed to determine whether cross-tolerance occurs between levetiracetam (LEV) and carbamazepine (CBZ) in amygdala-kindled rats...
  79. ncbi Bupropion and venlafaxine responders differ in pretreatment regional cerebral metabolism in unipolar depression
    John T Little
    Division of Psychiatric Neuroimaging, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Biol Psychiatry 57:220-8. 2005
    ....
  80. ncbi Adjunctive strategies in the treatment of refractory bipolar depression: clinician options in the absence of a systematic database
    Robert M Post
    Biological Psychiatry Branch, National Institutes of Health, National Institute of Mental Health, Department of Health and Human Services, 10 Center Drive MSC 1272, Bldg 10, Room 3S239, Bethesda, MD 20892 1272, USA
    Expert Opin Pharmacother 6:531-46. 2005
    ....
  81. ncbi Psychosis in bipolar disorder: phenomenology and impact on morbidity and course of illness
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267-0559, USA
    Compr Psychiatry 44:263-9. 2003
    ..The lack of observable prognostic impact may have been, in part, due to the relatively high morbidity and poor functional outcome of a substantial portion of the total cohort...
  82. ncbi Psychological complexity: barriers to its integration into the neurobiology of major psychiatric disorders
    Robert M Post
    National Institute of Mental Health/BPB, Bethesda, MD 20892-1272, USA
    Dev Psychopathol 14:635-51. 2002
    ..This paper endorses renewed effort toward the multidisciplinary team approach under the leadership of a physician-scientist in order to better integrate many fields of study critical to ameliorating the effects of psychiatric illness...
  83. ncbi Preliminary findings of uncoupling of flow and metabolism in unipolar compared with bipolar affective illness and normal controls
    Robert T Dunn
    Biological Psychiatry Branch, National Institute of Mental Health, NIH, 10 Center Drive MSC 1272, Bethesda, MD 20892 1272, USA
    Psychiatry Res 140:181-98. 2005
    ....
  84. ncbi Early physical and sexual abuse associated with an adverse course of bipolar illness
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network and the Biological Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3S 239, Bethesda, MD 20892-1272, USA
    Biol Psychiatry 51:288-97. 2002
    ....
  85. ncbi Maternal deprivation increases cell death in the infant rat brain
    Li Xin Zhang
    Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Brain Res Dev Brain Res 133:1-11. 2002
    ....
  86. ncbi Correlates of overweight and obesity in 644 patients with bipolar disorder
    Susan L McElroy
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267-0559, USA
    J Clin Psychiatry 63:207-13. 2002
    ....
  87. ncbi Intensity-dependent regional cerebral blood flow during 1-Hz repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers studied with H215O positron emission tomography: II. Effects of prefrontal cortex rTMS
    Andrew M Speer
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10 Room 5N234, Bethesda, MD 20892-1430, USA
    Biol Psychiatry 54:826-32. 2003
    ....
  88. ncbi Left prefrontal-repetitive transcranial magnetic stimulation (rTMS) and regional cerebral glucose metabolism in normal volunteers
    Timothy A Kimbrell
    Biological Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Psychiatry Res 115:101-13. 2002
    ..While these results are in the predicted direction, further studies using other designs and higher intensities and frequencies of rTMS are indicated to better describe the local and distant changes induced by rTMS...
  89. ncbi Potential mechanisms of action of lamotrigine in the treatment of bipolar disorders
    Terence A Ketter
    Bipolar Disorders Clinic, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
    J Clin Psychopharmacol 23:484-95. 2003
    ..Although lamotrigine mechanisms overlap those of other mood-stabilizing anticonvulsants, important dissociations suggest candidate mechanisms, which could contribute to lamotrigine's distinctive psychotropic profile...
  90. ncbi Neurobiology of bipolar illness: implications for future study and therapeutics
    Robert M Post
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, Maryland 20892-1272, USA
    Ann Clin Psychiatry 15:85-94. 2003
    ..Further examination of the pathophysiology and neurobiology of bipolar illness should lead to both more effective treatments and, potentially, secondary and even primary episode prevention...
  91. ncbi The benzodiazepine partial inverse agonist Ro15-4513 alters anticonvulsant and lethal effects of carbamazepine in amygdala-kindled rats
    Zhang Jin Zhang
    Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Neurosci Lett 329:253-6. 2002
    ..The potential clinical implications for CBZ-induced toxicity and overdose remain to be explored...
  92. ncbi Antithyroid antibody-linked symptoms in borderline personality disorder
    Thomas D Geracioti
    Clinical Neuroendocrinology, National Institute of Mental Health, Bethesda, MD, USA
    Endocrine 21:153-8. 2003
    ..It will be of interest to determine the prevalence, pathophysiologic mechanisms, and treatment implications of this putative autoimmune- BPD link...
  93. ncbi Unique design issues in clinical trials of patients with bipolar affective disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bldg 10, Rm 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    J Psychiatr Res 37:61-73. 2003
    ..Acceptance of a wider variety of clinical trial designs may help facilitate the funding and accelerate the acquisition of new data on treatment of bipolar illness...
  94. ncbi Course of bipolar illness after history of childhood trauma
    Gabriele S Leverich
    Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892, USA
    Lancet 367:1040-2. 2006
  95. ncbi Are bipolar mood symptoms affected by the phase of the menstrual cycle?
    Geetha Shivakumar
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    J Womens Health (Larchmt) 17:473-8. 2008
    ..We sought to examine the relationship between bipolar disorder and menstrual cycle-related mood changes. To our knowledge, this is one of the largest samples in the literature addressing this issue...
  96. ncbi Prepubertal bipolar I disorder and bipolar disorder NOS are separable from ADHD
    Robert M Post
    J Clin Psychiatry 65:898-902. 2004
  97. ncbi Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, UCLA Bipolar Research Program, University of California Los Angeles School of Medicine, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:883-9. 2003
    ..This study examined gender-specific relationships between alcoholism and bipolar illness, which have previously received little systematic study...
  98. ncbi New designs for studies of the prophylaxis of bipolar disorder
    Robert M Post
    J Clin Psychopharmacol 22:1-3. 2002
  99. ncbi Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Bipolar Disord 9:531-5. 2007
    ..To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder...
  100. ncbi Open-label aripiprazole in the treatment of acute bipolar depression: a prospective pilot trial
    Susan L McElroy
    Psychopharmacology Research Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
    J Affect Disord 101:275-81. 2007
    ..Increasing evidence indicates that some second-generation antipsychotics are efficacious in bipolar depression, but there are few data on this illness for the novel agent aripiprazole...
  101. ncbi Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatients
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Tolsteegsingel 2A, 3582 AC Utrecht, Netherlands
    Am J Psychiatry 162:1273-80. 2005
    ..To detect risk factors for rapid cycling in bipolar disorder, the authors compared characteristics of rapid-cycling and non-rapid-cycling patients both from a categorical and a dimensional perspective...