Affiliation: One Innovation Drive
- Identification of a small-molecule entry inhibitor for filovirusesArnab Basu
Microbiotix, Inc, One Innovation Drive, Worcester, MA 01605, USA
J Virol 85:3106-19. 2011..In summary, we have identified a novel series of benzodiazepine compounds that are suitable for optimization as potential inhibitors of filoviral infection...
- High-throughput screening of viral entry inhibitors using pseudotyped virusArnab Basu
Microbiotix, Worcester, Massachusetts, USA
Curr Protoc Pharmacol . 2010..This unit includes protocols for preparing pseudotyped viruses using lentiviral vectors and use of pseudotyped viruses for high-throughput screening of viral entry inhibitors...
- Identification of HCV E1 an E2 InhibitorsArnab Basu; Fiscal Year: 2006..The most promising compound will advance to IND-enabling toxicology and pharmacology studies in two species (Phase III). ..
- Identification of Ebola Virus Entry InhibitorsArnab Basu; Fiscal Year: 2007..EBOV inhibitor confirmation; and 4. Prioritize screening hits based on spectrum, cytotoxicity and mechanism. The end result of Phase 1 work will be identification of hits specific for EBOV entry inhibition. ..
- Developing small molecule therapeutics for Ebola hemorrhagic fever virusArnab Basu; Fiscal Year: 2010..Identify EBOV inhibitors with in vitro ADME properties suitable for i.v. and oral dosing;and 5. Evaluate EBOV inhibitors in a guinea pig model of EBOV infection. ..