R A Towner

Summary

Affiliation: Oklahoma Medical Research Foundation
Country: USA

Publications

  1. doi request reprint A Feasibility Study to Determine Whether Clinical Contrast Enhanced Magnetic Resonance Imaging can Detect Increased Bladder Permeability in Patients with Interstitial Cystitis
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma Stephenson Cancer Center, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma Electronic address
    J Urol 195:631-8. 2016
  2. doi request reprint A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA
    BMC Cancer 15:522. 2015
  3. pmc Contrast enhanced magnetic resonance imaging as a diagnostic tool to assess bladder permeability and associated colon cross talk: preclinical studies in a rat model
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma Electronic address
    J Urol 193:1394-400. 2015
  4. pmc Experimental validation of 5 in-silico predicted glioma biomarkers
    Rheal A Towner
    Corresponding author Rheal A Towner, PhD, Director, Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, OK 73104 USA
    Neuro Oncol 15:1625-34. 2013
  5. doi request reprint In vivo detection of free radicals in mouse septic encephalopathy using molecular MRI and immuno-spin trapping
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA Electronic address
    Free Radic Biol Med 65:828-37. 2013
  6. doi request reprint Combined molecular MRI and immuno-spin-trapping for in vivo detection of free radicals in orthotopic mouse GL261 gliomas
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA Electronic address
    Biochim Biophys Acta 1832:2153-61. 2013
  7. doi request reprint In vivo detection of free radicals using molecular MRI and immuno-spin trapping in a mouse model for amyotrophic lateral sclerosis
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 63:351-60. 2013
  8. pmc Regression of glioma tumor growth in F98 and U87 rat glioma models by the Nitrone OKN-007
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104, USA
    Neuro Oncol 15:330-40. 2013
  9. pmc ELTD1, a potential new biomarker for gliomas
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Neurosurgery 72:77-90; discussion 91. 2013
  10. pmc In vivo imaging of immuno-spin trapped radicals with molecular magnetic resonance imaging in a diabetic mouse model
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Diabetes 61:2405-13. 2012

Detail Information

Publications20

  1. doi request reprint A Feasibility Study to Determine Whether Clinical Contrast Enhanced Magnetic Resonance Imaging can Detect Increased Bladder Permeability in Patients with Interstitial Cystitis
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma Stephenson Cancer Center, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma Electronic address
    J Urol 195:631-8. 2016
    ..This study establishes the feasibility of using contrast enhanced magnetic resonance imaging to quantify bladder permeability in patients with interstitial cystitis...
  2. doi request reprint A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA
    BMC Cancer 15:522. 2015
    ..Here we study the potential therapeutic agent AG119 in a pre-clinical model for gliomas. AG119 possesses both anti-angiogenic (RTK inhibition) and antimicrotubule cytotoxic activity in a single molecule...
  3. pmc Contrast enhanced magnetic resonance imaging as a diagnostic tool to assess bladder permeability and associated colon cross talk: preclinical studies in a rat model
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma Electronic address
    J Urol 193:1394-400. 2015
    ..It is usually diagnosed based on pain, urgency and frequency in the absence of other known causes. To our knowledge there is no diagnostic test to date...
  4. pmc Experimental validation of 5 in-silico predicted glioma biomarkers
    Rheal A Towner
    Corresponding author Rheal A Towner, PhD, Director, Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, OK 73104 USA
    Neuro Oncol 15:1625-34. 2013
    ....
  5. doi request reprint In vivo detection of free radicals in mouse septic encephalopathy using molecular MRI and immuno-spin trapping
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA Electronic address
    Free Radic Biol Med 65:828-37. 2013
    ..05 for both), were elevated in septic brains compared to shams. This is the first study that has reported on the detection of in vivo and in situ levels of free radicals in murine septic encephalopathy...
  6. doi request reprint Combined molecular MRI and immuno-spin-trapping for in vivo detection of free radicals in orthotopic mouse GL261 gliomas
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA Electronic address
    Biochim Biophys Acta 1832:2153-61. 2013
    ..Co-localization of the anti-DMPO probe with either 3-NT or 4-hydroxynonenal was also observed. This is the first report regarding the detection of in vivo levels of free radicals from a glioma model. ..
  7. doi request reprint In vivo detection of free radicals using molecular MRI and immuno-spin trapping in a mouse model for amyotrophic lateral sclerosis
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 63:351-60. 2013
    ..This novel, noninvasive, in vivo diagnostic method can be applied to investigate the involvement of free radical mechanisms in ALS rodent models...
  8. pmc Regression of glioma tumor growth in F98 and U87 rat glioma models by the Nitrone OKN-007
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104, USA
    Neuro Oncol 15:330-40. 2013
    ....
  9. pmc ELTD1, a potential new biomarker for gliomas
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Neurosurgery 72:77-90; discussion 91. 2013
    ..Glioblastoma multiforme (GBM), a high-grade glioma, is characterized by being diffuse, invasive, and highly angiogenic and has a very poor prognosis. Identification of new biomarkers could help in the further diagnosis of GBM...
  10. pmc In vivo imaging of immuno-spin trapped radicals with molecular magnetic resonance imaging in a diabetic mouse model
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Diabetes 61:2405-13. 2012
    ..This method can be specifically applied toward diabetes models for in vivo assessment of free radical levels, providing an avenue to more fully understand the role of free radicals in diabetes...
  11. pmc In vivo detection of c-Met expression in a rat C6 glioma model
    R A Towner
    Small Animal MRI Core Facility, Oklahoma City, OK, USA
    J Cell Mol Med 12:174-86. 2008
    ..Controls with no Ab or with a normal rat IgG attached to the contrast agent component indicated no non-specific binding to glioma tissue. This is the first successful visualization of in vivo overexpression of c-Met in gliomas...
  12. pmc Molecular magnetic resonance imaging approaches used to aid in the understanding of angiogenesis in vivo: implications for tissue engineering
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Tissue Eng Part A 16:357-64. 2010
    ..VEGF-R2 levels in tumor tissues were also confirmed in western blots and via immunohistochemistry. Based on our results, in vivo evaluation of tissue angiogenesis using molecular MRI is possible in tissue engineering applications...
  13. doi request reprint In vivo detection of inducible nitric oxide synthase in rodent gliomas
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 48:691-703. 2010
    ..In vivo assessment of iNOS levels associated with tumor development is quite feasible in heterogeneous tissues with mMRI...
  14. pmc Non-mammalian fat-1 gene prevents neoplasia when introduced to a mouse hepatocarcinogenesis model: Omega-3 fatty acids prevent liver neoplasia
    J Griffitts
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Biochim Biophys Acta 1801:1133-44. 2010
    ..Endogenous omega-3 fatty acids were found to prevent HCC development in mice...
  15. pmc In vivo MRS assessment of altered fatty acyl unsaturation in liver tumor formation of a TGF alpha/c-myc transgenic mouse model
    J Griffitts
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Lipid Res 50:611-22. 2009
    ....
  16. doi request reprint In vivo targeted molecular magnetic resonance imaging of free radicals in diabetic cardiomyopathy within mice
    R A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Free Radic Res 49:1140-6. 2015
    ..05 for both) in diabetic cardiac muscle compared to controls. It can be concluded that diabetic mice have more heterogeneously distributed radicals in cardiac tissue than non-diabetic mice. ..
  17. doi request reprint Assessment of colon and bladder crosstalk in an experimental colitis model using contrast-enhanced magnetic resonance imaging
    R A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Neurogastroenterol Motil 27:1571-9. 2015
    ..4 million Americans. 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis is a widely used model of experimental intestinal inflammation with characteristic transmural and segmental lesions that are similar to CD...
  18. ncbi request reprint Application of proton NMR spectroscopy in the study of lipid metabolites in a rat hepatocarcinogenesis model
    Y A Tesiram
    Oklahoma Medical Research Foundation, Free Radical Biology and Aging Research Program, 825 NE 13th St, Oklahoma City, OK 73104, USA
    Biochim Biophys Acta 1737:61-8. 2005
    ..The results of this study are in agreement with those previously published in the literature on other rat hepatocarcinogenesis models...
  19. ncbi request reprint In vivo detection of aflatoxin-induced lipid free radicals in rat bile
    R A Towner
    North Queensland Magnetic Resonance Centre and Department of Physiology and Pharmacology, School of Biomedical Sciences, Molecular Sciences Building, James Cook University, Townsville 4811 Queensland, Australia
    Biochim Biophys Acta 1573:55-62. 2002
    ..This indicates that oxidation of AFB1 generates free radical species via CYP metabolism and an iron-mediated redox mechanism...
  20. ncbi request reprint In vivo image-guided (1)H-magnetic resonance spectroscopy of the serial development of hepatocarcinogenesis in an experimental animal model
    L M Foley
    North Queensland Magnetic Resonance Centre, Department of Physiology and Pharmacology, James Cook University, Townsville, Australia
    Biochim Biophys Acta 1526:230-6. 2001
    ..It is anticipated that this model will precede the application of the same technology to the non-invasive diagnosis and grading of human hepatocellular carcinoma...