R A Towner

Summary

Affiliation: Oklahoma Medical Research Foundation
Country: USA

Publications

  1. ncbi Regression of glioma tumor growth in F98 and U87 rat glioma models by the Nitrone OKN-007
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104, USA
    Neuro Oncol 15:330-40. 2013
  2. ncbi ELTD1, a Potential New Biomarker for Gliomas
    Rheal A Towner
    Advanced Magnetic Resonance Center Cardiovascular Biology Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah The Methodist Hospital BV, The Methodist Neurological Institute, Houston, Texas
    Neurosurgery 72:77-91. 2013
  3. ncbi In vivo imaging of immuno-spin trapped radicals with molecular magnetic resonance imaging in a diabetic mouse model
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Diabetes 61:2405-13. 2012
  4. ncbi In vivo detection of inducible nitric oxide synthase in rodent gliomas
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 48:691-703. 2010
  5. ncbi Molecular magnetic resonance imaging approaches used to aid in the understanding of angiogenesis in vivo: implications for tissue engineering
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Tissue Eng Part A 16:357-64. 2010
  6. ncbi In vivo detection of c-Met expression in a rat C6 glioma model
    R A Towner
    Small Animal MRI Core Facility, Oklahoma City, OK, USA
    J Cell Mol Med 12:174-86. 2008
  7. ncbi Non-mammalian fat-1 gene prevents neoplasia when introduced to a mouse hepatocarcinogenesis model: Omega-3 fatty acids prevent liver neoplasia
    J Griffitts
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Biochim Biophys Acta 1801:1133-44. 2010
  8. ncbi In vivo MRS assessment of altered fatty acyl unsaturation in liver tumor formation of a TGF alpha/c-myc transgenic mouse model
    J Griffitts
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Lipid Res 50:611-22. 2009
  9. ncbi Application of proton NMR spectroscopy in the study of lipid metabolites in a rat hepatocarcinogenesis model
    Y A Tesiram
    Oklahoma Medical Research Foundation, Free Radical Biology and Aging Research Program, 825 NE 13th St, Oklahoma City, OK 73104, USA
    Biochim Biophys Acta 1737:61-8. 2005
  10. ncbi In vivo detection of aflatoxin-induced lipid free radicals in rat bile
    R A Towner
    North Queensland Magnetic Resonance Centre and Department of Physiology and Pharmacology, School of Biomedical Sciences, Molecular Sciences Building, James Cook University, Townsville 4811 Queensland, Australia
    Biochim Biophys Acta 1573:55-62. 2002

Collaborators

Detail Information

Publications11

  1. ncbi Regression of glioma tumor growth in F98 and U87 rat glioma models by the Nitrone OKN-007
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104, USA
    Neuro Oncol 15:330-40. 2013
    ....
  2. ncbi ELTD1, a Potential New Biomarker for Gliomas
    Rheal A Towner
    Advanced Magnetic Resonance Center Cardiovascular Biology Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah The Methodist Hospital BV, The Methodist Neurological Institute, Houston, Texas
    Neurosurgery 72:77-91. 2013
    ..Glioblastoma multiforme (GBM), a high-grade glioma, is characterized by being diffuse, invasive, and highly angiogenic and has a very poor prognosis. Identification of new biomarkers could help in the further diagnosis of GBM...
  3. ncbi In vivo imaging of immuno-spin trapped radicals with molecular magnetic resonance imaging in a diabetic mouse model
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Diabetes 61:2405-13. 2012
    ..This method can be specifically applied toward diabetes models for in vivo assessment of free radical levels, providing an avenue to more fully understand the role of free radicals in diabetes...
  4. ncbi In vivo detection of inducible nitric oxide synthase in rodent gliomas
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 48:691-703. 2010
    ..In vivo assessment of iNOS levels associated with tumor development is quite feasible in heterogeneous tissues with mMRI...
  5. ncbi Molecular magnetic resonance imaging approaches used to aid in the understanding of angiogenesis in vivo: implications for tissue engineering
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Tissue Eng Part A 16:357-64. 2010
    ..VEGF-R2 levels in tumor tissues were also confirmed in western blots and via immunohistochemistry. Based on our results, in vivo evaluation of tissue angiogenesis using molecular MRI is possible in tissue engineering applications...
  6. ncbi In vivo detection of c-Met expression in a rat C6 glioma model
    R A Towner
    Small Animal MRI Core Facility, Oklahoma City, OK, USA
    J Cell Mol Med 12:174-86. 2008
    ..Controls with no Ab or with a normal rat IgG attached to the contrast agent component indicated no non-specific binding to glioma tissue. This is the first successful visualization of in vivo overexpression of c-Met in gliomas...
  7. ncbi Non-mammalian fat-1 gene prevents neoplasia when introduced to a mouse hepatocarcinogenesis model: Omega-3 fatty acids prevent liver neoplasia
    J Griffitts
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Biochim Biophys Acta 1801:1133-44. 2010
    ..Endogenous omega-3 fatty acids were found to prevent HCC development in mice...
  8. ncbi In vivo MRS assessment of altered fatty acyl unsaturation in liver tumor formation of a TGF alpha/c-myc transgenic mouse model
    J Griffitts
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Lipid Res 50:611-22. 2009
    ....
  9. ncbi Application of proton NMR spectroscopy in the study of lipid metabolites in a rat hepatocarcinogenesis model
    Y A Tesiram
    Oklahoma Medical Research Foundation, Free Radical Biology and Aging Research Program, 825 NE 13th St, Oklahoma City, OK 73104, USA
    Biochim Biophys Acta 1737:61-8. 2005
    ..The results of this study are in agreement with those previously published in the literature on other rat hepatocarcinogenesis models...
  10. ncbi In vivo detection of aflatoxin-induced lipid free radicals in rat bile
    R A Towner
    North Queensland Magnetic Resonance Centre and Department of Physiology and Pharmacology, School of Biomedical Sciences, Molecular Sciences Building, James Cook University, Townsville 4811 Queensland, Australia
    Biochim Biophys Acta 1573:55-62. 2002
    ..This indicates that oxidation of AFB1 generates free radical species via CYP metabolism and an iron-mediated redox mechanism...
  11. ncbi In vivo image-guided (1)H-magnetic resonance spectroscopy of the serial development of hepatocarcinogenesis in an experimental animal model
    L M Foley
    North Queensland Magnetic Resonance Centre, Department of Physiology and Pharmacology, James Cook University, Townsville, Australia
    Biochim Biophys Acta 1526:230-6. 2001
    ..It is anticipated that this model will precede the application of the same technology to the non-invasive diagnosis and grading of human hepatocellular carcinoma...