L J Spicer

Summary

Affiliation: Oklahoma State University
Country: USA

Publications

  1. Pizzo F, Caloni F, Schreiber N, Schutz L, Totty M, Albonico M, et al. Direct effects of the algal toxin, domoic acid, on ovarian function: Bovine granulosa and theca cells as an in vitro model. Ecotoxicol Environ Saf. 2015;113:314-20 pubmed publisher
    ..10) on E2 production. Collectively, these results show for the first time that DA has direct effects on ovarian GC and TC steroidogenesis. Because DA inhibited E2 and P4 production, DA has the potential to be an endocrine disruptor. ..
  2. Zhang L, Feng T, Spicer L. The role of tight junction proteins in ovarian follicular development and ovarian cancer. Reproduction. 2018;155:R183-R198 pubmed publisher
  3. Bertero A, Moretti A, Spicer L, Caloni F. Fusarium Molds and Mycotoxins: Potential Species-Specific Effects. Toxins (Basel). 2018;10: pubmed publisher
    ..The aim of this review is to summarize the toxicological responses of the main species affected by Fusarium mycotoxins. ..
  4. Schutz L, Hurst R, Schreiber N, Spicer L. Transcriptome profiling of bovine ovarian theca cells treated with fibroblast growth factor 9. Domest Anim Endocrinol. 2018;63:48-58 pubmed publisher
    ..Overall, genes, pathways, and networks identified in this study painted a picture of how FGF9 may regulate folliculogenesis, providing novel candidate genes for further investigation of FGF9 functions in ovarian follicular development. ..
  5. Schutz L, Schreiber N, Gilliam J, Cortinovis C, Totty M, Caloni F, et al. Changes in fibroblast growth factor 9 mRNA in granulosa and theca cells during ovarian follicular growth in dairy cattle. J Dairy Sci. 2016;99:9143-9151 pubmed publisher
  6. request reprint
    Spicer L, Aad P. Insulin-like growth factor (IGF) 2 stimulates steroidogenesis and mitosis of bovine granulosa cells through the IGF1 receptor: role of follicle-stimulating hormone and IGF2 receptor. Biol Reprod. 2007;77:18-27 pubmed
    ..In particular, increased free IGF1 in developing follicles may decrease synthesis of IGF2R, thereby allowing for more IGF2 to be bioavailable (free) for induction of steroidogenesis and mitogenesis via the IGF1R. ..
  7. Spicer L, Sudo S, Aad P, Wang L, Chun S, Ben Shlomo I, et al. The hedgehog-patched signaling pathway and function in the mammalian ovary: a novel role for hedgehog proteins in stimulating proliferation and steroidogenesis of theca cells. Reproduction. 2009;138:329-39 pubmed publisher
    ..This study illustrates for the first time Hh activation of Gli1 transcriptional factor in theca cells and its stimulation of theca cell proliferation and androgen biosynthesis...
  8. Dentis J, Schreiber N, Gilliam J, Schutz L, Spicer L. Changes in brain ribonuclease (BRB) messenger RNA in granulosa cells (GCs) of dominant vs subordinate ovarian follicles of cattle and the regulation of BRB gene expression in bovine GCs. Domest Anim Endocrinol. 2016;55:32-40 pubmed publisher
    ..05) GCs numbers and E2 production. In conclusion, BRB is a hormonally and developmentally regulated gene in bovine GCs and may regulate E2 production during follicular growth in cattle. ..
  9. Totty M, Morrell B, Spicer L. Fibroblast growth factor 9 (FGF9) regulation of cyclin D1 and cyclin-dependent kinase-4 in ovarian granulosa and theca cells of cattle. Mol Cell Endocrinol. 2017;440:25-33 pubmed publisher
    ..For the first time we show that CCND1 mRNA expression is increased by FGF9 in bovine TC and GC, and that FGF9 likely uses the MAPK pathway to induce CCND1 mRNA production in bovine TC. ..

More Information

Publications12

  1. Spicer L, Schütz L, Williams J, Schreiber N, Evans J, Totty M, et al. G protein-coupled receptor 34 in ovarian granulosa cells of cattle: changes during follicular development and potential functional implications. Domest Anim Endocrinol. 2017;59:90-99 pubmed publisher
    ..In conclusion, GPR34 is a developmentally and hormonally regulated gene in GC, and its presumed ligands enhance IGF1-induced proliferation and steroidogenesis of bovine GC. ..
  2. Ervin J, Schutz L, Spicer L. Current status of the role of endothelins in regulating ovarian follicular function: A review. Anim Reprod Sci. 2017;186:1-10 pubmed publisher
  3. Feng T, Schutz L, Morrell B, Perego M, Spicer L. Effects of N-carbamylglutamate and L-arginine on steroidogenesis and gene expression in bovine granulosa cells. Anim Reprod Sci. 2018;188:85-92 pubmed publisher
    ..We conclude that NCG and ARG may act directly on GC and therefore may regulate ovarian function by slowing follicular differentiation via inhibiting IGF1 action, and steroid synthesis while stimulating GC proliferation in cattle. ..