L J Spicer
Affiliation: Oklahoma State University
Pizzo F, Caloni F, Schreiber N, Schutz L, Totty M, Albonico M, et al
. Direct effects of the algal toxin, domoic acid, on ovarian function: Bovine granulosa and theca cells as an in vitro model. Ecotoxicol Environ Saf. 2015;113:314-20 pubmed publisher
..10) on E2 production. Collectively, these results show for the first time that DA has direct effects on ovarian GC and TC steroidogenesis. Because DA inhibited E2 and P4 production, DA has the potential to be an endocrine disruptor. ..
Zhang L, Feng T, Spicer L. The role of tight junction proteins in ovarian follicular development and ovarian cancer. Reproduction. 2018;155:R183-R198 pubmed publisher
Bertero A, Moretti A, Spicer L, Caloni F. Fusarium Molds and Mycotoxins: Potential Species-Specific Effects. Toxins (Basel). 2018;10: pubmed publisher
..The aim of this review is to summarize the toxicological responses of the main species affected by Fusarium mycotoxins. ..
Schutz L, Hurst R, Schreiber N, Spicer L. Transcriptome profiling of bovine ovarian theca cells treated with fibroblast growth factor 9. Domest Anim Endocrinol. 2018;63:48-58 pubmed publisher
..Overall, genes, pathways, and networks identified in this study painted a picture of how FGF9 may regulate folliculogenesis, providing novel candidate genes for further investigation of FGF9 functions in ovarian follicular development. ..
Schutz L, Schreiber N, Gilliam J, Cortinovis C, Totty M, Caloni F, et al
. Changes in fibroblast growth factor 9 mRNA in granulosa and theca cells during ovarian follicular growth in dairy cattle. J Dairy Sci. 2016;99:9143-9151 pubmed publisher
Spicer L, Aad P. Insulin-like growth factor (IGF) 2 stimulates steroidogenesis and mitosis of bovine granulosa cells through the IGF1 receptor: role of follicle-stimulating hormone and IGF2 receptor. Biol Reprod. 2007;77:18-27 pubmed
..In particular, increased free IGF1 in developing follicles may decrease synthesis of IGF2R, thereby allowing for more IGF2 to be bioavailable (free) for induction of steroidogenesis and mitogenesis via the IGF1R. ..
Spicer L, Sudo S, Aad P, Wang L, Chun S, Ben Shlomo I, et al
. The hedgehog-patched signaling pathway and function in the mammalian ovary: a novel role for hedgehog proteins in stimulating proliferation and steroidogenesis of theca cells. Reproduction. 2009;138:329-39 pubmed publisher
..This study illustrates for the first time Hh activation of Gli1 transcriptional factor in theca cells and its stimulation of theca cell proliferation and androgen biosynthesis...
Dentis J, Schreiber N, Gilliam J, Schutz L, Spicer L. Changes in brain ribonuclease (BRB) messenger RNA in granulosa cells (GCs) of dominant vs subordinate ovarian follicles of cattle and the regulation of BRB gene expression in bovine GCs. Domest Anim Endocrinol. 2016;55:32-40 pubmed publisher
..05) GCs numbers and E2 production. In conclusion, BRB is a hormonally and developmentally regulated gene in bovine GCs and may regulate E2 production during follicular growth in cattle. ..
Totty M, Morrell B, Spicer L. Fibroblast growth factor 9 (FGF9) regulation of cyclin D1 and cyclin-dependent kinase-4 in ovarian granulosa and theca cells of cattle. Mol Cell Endocrinol. 2017;440:25-33 pubmed publisher
..For the first time we show that CCND1 mRNA expression is increased by FGF9 in bovine TC and GC, and that FGF9 likely uses the MAPK pathway to induce CCND1 mRNA production in bovine TC. ..