Swapan K Nath

Summary

Affiliation: Oklahoma Medical Research Foundation
Country: USA

Publications

  1. pmc Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    John B Harley
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:204-10. 2008
  2. pmc Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk
    Dharambir K Sanghera
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    BMC Med Genet 9:59. 2008
  3. pmc Admixture in Hispanic Americans: its impact on ITGAM association and implications for admixture mapping in SLE
    J E Molineros
    Genetic Epidemiology Unit, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Genes Immun 10:539-45. 2009
  4. doi request reprint A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus
    Swapan K Nath
    Genetic Epidemiology Unit, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:152-4. 2008
  5. pmc Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients
    Ryan Webb
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Ann Rheum Dis 70:151-6. 2011
  6. pmc Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE)
    Shizhong Han
    Genetic Epidemiology Unit, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Hum Mol Genet 18:1171-80. 2009
  7. pmc Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21
    Travis Hughes
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Arthritis Rheum 63:1689-97. 2011
  8. doi request reprint Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in Asian Sikhs
    Latonya F Been
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Obesity (Silver Spring) 18:425-9. 2010
  9. pmc Common variants within MECP2 confer risk of systemic lupus erythematosus
    Amr H Sawalha
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    PLoS ONE 3:e1727. 2008
  10. pmc High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups
    Bahram Namjou
    Oklahoma Medical Research Foundation, Oklahoma City, USA
    Arthritis Rheum 60:1085-95. 2009

Detail Information

Publications48

  1. pmc Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    John B Harley
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:204-10. 2008
    ..Our results show that numerous genes, some with known immune-related functions, predispose to SLE...
  2. pmc Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk
    Dharambir K Sanghera
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    BMC Med Genet 9:59. 2008
    ....
  3. pmc Admixture in Hispanic Americans: its impact on ITGAM association and implications for admixture mapping in SLE
    J E Molineros
    Genetic Epidemiology Unit, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Genes Immun 10:539-45. 2009
    ..We have shown that HA have great potential and are an appropriate population for admixture mapping. As expected, the case-only design is more powerful than case-control design, for any given admixture proportion or ancestry risk ratio...
  4. doi request reprint A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus
    Swapan K Nath
    Genetic Epidemiology Unit, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:152-4. 2008
    ..0002 and 0.003; overall meta-analysis P = 6.9 x 10(-22)). The genetic association between ITGAM and SLE implicates the alpha(M)beta2-integrin adhesion pathway in disease development...
  5. pmc Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients
    Ryan Webb
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Ann Rheum Dis 70:151-6. 2011
    ..Systemic lupus erythematosus (SLE) is a chronic, multiorgan, autoimmune disease that affects people of all ages and ethnicities...
  6. pmc Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE)
    Shizhong Han
    Genetic Epidemiology Unit, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Hum Mol Genet 18:1171-80. 2009
    ..Taken together along with our earlier findings, these results demonstrate that the coding variant, rs1143679, best explains the ITGAM-SLE association, especially in European- and African-derived populations, but not in Asian populations...
  7. pmc Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21
    Travis Hughes
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Arthritis Rheum 63:1689-97. 2011
    ..This study was undertaken to determine whether this genetic effect could be localized, using a very large cohort of lupus patients and controls...
  8. doi request reprint Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in Asian Sikhs
    Latonya F Been
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Obesity (Silver Spring) 18:425-9. 2010
    ..These observations demonstrate that the genetic variation in MC4R locus can have a moderate contribution in the regional fat deposition and development of central obesity in Asian Indians...
  9. pmc Common variants within MECP2 confer risk of systemic lupus erythematosus
    Amr H Sawalha
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    PLoS ONE 3:e1727. 2008
    ..These findings are potentially related to the overexpression of methylation-sensitive genes in SLE...
  10. pmc High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups
    Bahram Namjou
    Oklahoma Medical Research Foundation, Oklahoma City, USA
    Arthritis Rheum 60:1085-95. 2009
    ..STAT-1 and STAT-4 are transcription factors that play key roles in the interferon and Th1 signaling pathways, making them attractive candidates for involvement in SLE susceptibility...
  11. pmc Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
    Amit K Maiti
    Genetic Epidemiology Unit, Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Rheumatology (Oxford) 49:1239-44. 2010
    ..However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations...
  12. ncbi request reprint Linkage at 5q14.3-15 in multiplex systemic lupus erythematosus pedigrees stratified by autoimmune thyroid disease
    Bahram Namjou
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Arthritis Rheum 52:3646-50. 2005
    ..To identify genetic effects potentially shared between systemic lupus erythematosus (SLE) and autoimmune thyroiditis (AITD)...
  13. pmc ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry
    Xana Kim-Howard
    Genetic Epidemiology Unit, Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Ann Rheum Dis 69:1329-32. 2010
    ..It was hypothesised that the coding variant (R77H), rs1143679, within ITGAM could predict specific clinical manifestations associated with systemic lupus erythematosus (SLE)...
  14. pmc Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production
    Julio E Molineros
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
    PLoS Genet 9:e1003222. 2013
    ..Together with molecular modeling, our results establish a distinct role for IFIH1 in apoptosis, inflammation, and autoantibody production, and explain the molecular basis of these three risk alleles for SLE pathogenesis...
  15. pmc Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locus
    Amit K Maiti
    Oklahoma Medical Research Foundation, Oklahoma City, OK73104, USA
    Arthritis Rheum 62:323-9. 2010
    ....
  16. pmc A polymorphism within IL21R confers risk for systemic lupus erythematosus
    Ryan Webb
    Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Arthritis Rheum 60:2402-7. 2009
    ..The aim of this study was to examine the genetic association between single-nucleotide polymorphisms (SNPs) within IL21R and SLE...
  17. pmc Evidence for a susceptibility gene (SLEH1) on chromosome 11q14 for systemic lupus erythematosus (SLE) families with hemolytic anemia
    Jennifer A Kelly
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Proc Natl Acad Sci U S A 99:11766-71. 2002
    ..Thus, we show strong evidence for an SLE susceptibility gene, SLEH1, near D11S2002 in African-American pedigrees multiplex for SLE that have at least one SLE-affected patient with hemolytic anemia...
  18. ncbi request reprint Thrombocytopenia identifies a severe familial phenotype of systemic lupus erythematosus and reveals genetic linkages at 1q22 and 11p13
    R Hal Scofield
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
    Blood 101:992-7. 2003
    ....
  19. ncbi request reprint A candidate region on 11p13 for systemic lupus erythematosus: a linkage identified in African-American families
    Swapan K Nath
    Genetic Epidemiology Unit, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Investig Dermatol Symp Proc 9:64-7. 2004
    ....
  20. ncbi request reprint Stratification of pedigrees multiplex for systemic lupus erythematosus and for self-reported rheumatoid arthritis detects a systemic lupus erythematosus susceptibility gene (SLER1) at 5p15.3
    Bahram Namjou
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Arthritis Rheum 46:2937-45. 2002
    ..If this proved to be true, we would then use the increased genetic homogeneity to more easily reveal genetic linkage...
  21. pmc Osteopontin and systemic lupus erythematosus association: a probable gene-gender interaction
    Shizhong Han
    Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
    PLoS ONE 3:e0001757. 2008
    ..Our data suggest SPP1 is associated with SLE, and this association is especially stronger in males. To our knowledge, this report serves as the first association of a specific autosomal gene with human male lupus...
  22. pmc Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription
    Joel M Guthridge
    Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA Electronic address
    Am J Hum Genet 94:586-98. 2014
    ..Thus, our results demonstrated that both lupus-associated functional variants contribute to the autoimmune disease association by modulating transcription of BLK in B cells and thus potentially altering immune responses. ..
  23. pmc Linkage at 12q24 with systemic lupus erythematosus (SLE) is established and confirmed in Hispanic and European American families
    Swapan K Nath
    Arthritis and Immunology Research Program and Genetic Epidemiology Unit, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Am J Hum Genet 74:73-82. 2004
    ..11; P=.017). Therefore, our results have detected, established, and confirmed the existence of a novel SLE susceptibility locus at 12q24 (designated "SLEB4") that may cause lupus, especially in Hispanic and European American families...
  24. ncbi request reprint Genetic admixture of European FRDA genes is the cause of Friedreich ataxia in the Mexican population
    Mariluz Gomez
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, 975 NE, 10th Street, BRC458, Oklahoma City, OK 73104, USA
    Genomics 84:779-84. 2004
    ..This indicates that Friedreich ataxia in Mexican Mestizos is due to genetic admixture of European mutant FRDA genes in the Native American gene pool that existed prior to contact with Europeans...
  25. ncbi request reprint CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis
    Young Ho Lee
    Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, OK 73104, USA
    Hum Genet 116:361-7. 2005
    ..978, 95% CI=0.833-1.148, P=0.780). In conclusion, this meta-analysis supports the CTLA-4 exon-1 +49 (A/G) polymorphism influencing the risk for developing SLE, especially in Asians...
  26. ncbi request reprint Mapping the systematic lupus erythematosus susceptibility genes
    Swapan K Nath
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Methods Mol Med 102:11-29. 2004
    ..SLE is a complex clinical illness, and investigation of the genetics of the illness based on clinical manifestations revealed linkages not found without consideration of the phenotype of the disease...
  27. pmc Genome-wide association scan of Dupuytren's disease
    Joshua O Ojwang
    Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    J Hand Surg Am 35:2039-45. 2010
    ..The purpose of this study was to identify regions of the entire genome (chromosomes 1-23) associated with the disease by performing a genome-wide association scan on DD patients and controls...
  28. ncbi request reprint Systemic lupus erythematosus (SLE) and chromosome 16: confirmation of linkage to 16q12-13 and evidence for genetic heterogeneity
    Swapan K Nath
    Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Eur J Hum Genet 12:668-72. 2004
    ..Therefore, independent published reports, together with our initial linkage with Hispanics and followed by significant evidence from group-2, provide a strong and confirmed evidence for an SLE susceptibility locus at 16q12-13...
  29. pmc Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations
    Xana Kim-Howard
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Hum Mol Genet 23:1656-68. 2014
    ....
  30. pmc PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes
    Bahram Namjou
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
    PLoS ONE 8:e69404. 2013
    ..Additionally, rs1217414 and rs3765598 may be associated with SLE. Further studies are required to confirm the involvement of rs2476601 with aCL IgG...
  31. pmc Evaluation of 19 autoimmune disease-associated loci with rheumatoid arthritis in a Colombian population: evidence for replication and gene-gene interaction
    Harshal A Deshmukh
    Genetic Epidemiology Unit, Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    J Rheumatol 38:1866-70. 2011
    ....
  32. ncbi request reprint Polymorphisms of complement receptor 1 and interleukin-10 genes and systemic lupus erythematosus: a meta-analysis
    Swapan K Nath
    Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Hum Genet 118:225-34. 2005
    ..G11 allele and SLE in whole populations and the association between promoter -A1082G polymorphism and SLE in Asians...
  33. pmc Current status of lupus genetics
    Andrea L Sestak
    Oklahoma Medical Research Foundation, Arthritis and Immunology Research Program, 825 NE 13th St, Oklahoma City, Oklahoma 73104, USA
    Arthritis Res Ther 9:210. 2007
    ..In this review we will present what is known, what is disputed, and what remains to be discovered in the world of lupus genetics...
  34. ncbi request reprint Genetics of human systemic lupus erythematosus: the emerging picture
    Swapan K Nath
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Curr Opin Immunol 16:794-800. 2004
    ..Many of the susceptibility effects have been confirmed by independent studies...
  35. pmc Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM
    Amit K Maiti
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Hum Mol Genet 23:4161-76. 2014
    ..This two-pronged contribution (nucleic acid- and protein-level) of the rs1143679 risk allele to decreasing ITGAM activity provides insight into the molecular mechanisms of its potent association with SLE. ..
  36. pmc Detection of catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLE
    Anil D'Souza
    Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    BMC Med Genet 9:62. 2008
    ..Hence we investigated the effects of a genetic polymorphism of catalase on risk and severity of SLE in 48 pedigrees with African American ancestry...
  37. pmc Gene network analysis of small molecules with autoimmune disease associated genes predicts a novel strategy for drug efficacy
    Amit K Maiti
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, OK 73104, United States
    Autoimmun Rev 12:510-22. 2013
    ..Additionally, we have also identified several interlinking genes in the pathways that could be used for designing future association studies...
  38. ncbi request reprint SLEB3 in systemic lupus erythematosus (SLE) is strongly related to SLE families ascertained through neuropsychiatric manifestations
    Swapan K Nath
    Genetic Epidemiology Unit, Oklahoma Medical Research Foundation, Oklahoma City, USA
    Hum Genet 111:54-8. 2002
    ..The results demonstrated a significant increase of LOD score to detect SLEB3 when the families were further ascertained through NP, compared with the analysis of all EA SLE families together...
  39. pmc Multiple Autoantibodies Display Association with Lymphopenia, Proteinuria, and Cellular Casts in a Large, Ethnically Diverse SLE Patient Cohort
    Rufei Lu
    Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA Department of Medicine and Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Autoimmune Dis 2012:819634. 2012
    ....
  40. pmc Replication of recently identified associated single-nucleotide polymorphisms from six autoimmune diseases in Genetic Analysis Workshop 16 rheumatoid arthritis data
    Harshal Deshmukh
    Genetic Epidemiology Unit, Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, Oklahoma 73104 USA
    BMC Proc 3:S31. 2009
    ..Because multiple autoimmune diseases share common genetic origin, these could be areas of immense interest for further genetic and clinical association studies...
  41. ncbi request reprint Genetics of systemic lupus erythematosus: how far have we come?
    Andrea L Sestak
    Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73003, USA
    Rheum Dis Clin North Am 31:223-44, v. 2005
    ..These association studies are accumulating in greater numbers as the technology to determine the genotype at a given locus becomes more accessible. This article discusses the results of both types of studies...
  42. ncbi request reprint Segregation analysis of blood pressure and body mass index in a rural US community
    Swapan K Nath
    Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
    Hum Biol 74:11-23. 2002
    ..Our analysis results support the segregation of a major gene for BMI, but not for SBP or DBP. A recessive locus effect provided the best explanation for BMI where approximately 43% of the variance of BMI was due to this gene...
  43. ncbi request reprint Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility
    Young Ho Lee
    Division of Rheumatology, Korea University, Seoul, Korea
    Eur J Hum Genet 14:364-71. 2006
    ..8-2.3, P=0.2) or African (OR=1.2, CI=0.6-2.5, P=0.59) populations. In summary, this meta-analysis demonstrates that the TNF-alpha promoter -308 A/G polymorphism may confer susceptibility to SLE, especially in European-derived population...
  44. ncbi request reprint Systemic lupus erythematosus susceptibility loci defined by genome scan meta-analysis
    Young Ho Lee
    Division of Rheumatology, Korea University, Seou, Korea
    Hum Genet 118:434-43. 2005
    ..1-3q25.33 (Psumrnk=0.01376) may be an ethnicity-specific SLE linkage. In summary, the present GSMA have identified two statistically significant genomic regions that reconfirmed the SLE linkage at chromosomes 6 and 16...
  45. ncbi request reprint Ectrodactyly with aplasia of long bones (OMIM; 119100) in a large inbred Arab family with an apparent autosomal dominant inheritance and reduced penetrance: clinical and genetic analysis
    Mohammed Naveed
    Center for Arab Genomic Studies CAGS, Dubai, United Arab Emirates
    Am J Med Genet A 140:1440-6. 2006
    ..1. Two-point linkage and haplotype analyses did not show the involvement of the above regions in this family...
  46. pmc Genomewide linkage scan for split-hand/foot malformation with long-bone deficiency in a large Arab family identifies two novel susceptibility loci on chromosomes 1q42.2-q43 and 6q14.1
    Mohammed Naveed
    Center for Arab Genomic Studies CAGS, Dubai, United Arab Emirates
    Am J Hum Genet 80:105-11. 2007
    ..2-q43 and to a region of approximately 1.96 cM (4.1 Mb) between rs623155 and rs1547251 on 6q14.1. The study identified two novel loci for the SHFLD phenotype in this UAE family...
  47. pmc Genomewide scan for nonsyndromic cleft lip and palate in multigenerational Indian families reveals significant evidence of linkage at 13q33.1-34
    Uppala Radhakrishna
    Green Cross Blood Bank and Genetic Research Centre, Paldi, India
    Am J Hum Genet 79:580-5. 2006
    ..17 cM (7.42 Mb) between SNPs rs951095 and rs726455. Thus, we have identified a novel genomic region on 13q33.1-34 that harbors a high-risk variant for CL-P in these Indian families...