RODGER PAUL MCEVER
Affiliation: Oklahoma Medical Research Foundation
Yago T, Liu Z, Ahamed J, McEver R. Cooperative PSGL-1 and CXCR2 signaling in neutrophils promotes deep vein thrombosis in mice. Blood. 2018;: pubmed publisher
..Our results demonstrate that neutrophils cooperatively signal through PSGL-1 and CXCR2 to promote DVT. ..
Wang Y, Yago T, Zhang N, Abdisalaam S, Alexandrakis G, Rodgers W, et al
. Cytoskeletal regulation of CD44 membrane organization and interactions with E-selectin. J Biol Chem. 2014;289:35159-71 pubmed publisher
..These data demonstrate that spectrin and actin networks regulate CD44 clustering and suggest that ankyrin enhances CD44-mediated neutrophil rolling and signaling. ..
McEver R. Selectins: initiators of leucocyte adhesion and signalling at the vascular wall. Cardiovasc Res. 2015;107:331-9 pubmed publisher
..In vivo, selectin-mediated adhesion and signalling likely contributes to atherosclerosis, arterial and deep vein thrombosis, ischaemia-reperfusion injury, and other cardiovascular diseases. ..
Yago T, Petrich B, Zhang N, Liu Z, Shao B, Ginsberg M, et al
. Blocking neutrophil integrin activation prevents ischemia-reperfusion injury. J Exp Med. 2015;212:1267-81 pubmed publisher
..They further show that neutrophil arrest requires talin recruitment to and activation of integrins. However, although neutrophil slow rolling requires talin recruitment to integrins, talin-mediated integrin activation is dispensable. ..
Liu Z, Zhang N, Shao B, Panicker S, Fu J, McEver R. Replacing the Promoter of the Murine Gene Encoding P-selectin with the Human Promoter Confers Human-like Basal and Inducible Expression in Mice. J Biol Chem. 2016;291:1441-7 pubmed publisher
..Therefore, divergent sequences in a short promoter mediate most of the functionally significant differences in expression of human and murine P-selectin in vivo. ..
Zhang N, Liu Z, Yao L, Mehta D souza P, McEver R. P-Selectin Expressed by a Human SELP Transgene Is Atherogenic in Apolipoprotein E-Deficient Mice. Arterioscler Thromb Vasc Biol. 2016;36:1114-21 pubmed publisher
..P-selectin expressed by human SELP is atherogenic in Apoe(-/-) mice, suggesting that P-selectin contributes to atherogenesis in humans. ..
Shao B, Yago T, Setiadi H, Wang Y, Mehta D souza P, Fu J, et al
. O-glycans direct selectin ligands to lipid rafts on leukocytes. Proc Natl Acad Sci U S A. 2015;112:8661-6 pubmed publisher
..Preassociation of these glycoproteins with rafts is required for signaling but not for movement to uropods. ..
Mehta D souza P, Klopocki A, Oganesyan V, Terzyan S, Mather T, Li Z, et al
. Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force. J Biol Chem. 2017;292:2510-2518 pubmed publisher
..Cells expressing E-selectinE88D rolled but detached faster. Our data support a two-state model for selectins in which Glu-88 must engage ligand to trigger allostery that stabilizes the high affinity state under force. ..