Michelle L Joachims

Summary

Affiliation: Oklahoma Medical Research Foundation
Country: USA

Publications

  1. pmc Inhibition of deoxynucleoside kinases in human thymocytes prevents dATP accumulation and induction of apoptosis
    Michelle L Joachims
    Department of Immunobiology and Cancer, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Nucleosides Nucleotides Nucleic Acids 27:816-20. 2008
  2. pmc Restoration of adenosine deaminase-deficient human thymocyte development in vitro by inhibition of deoxynucleoside kinases
    Michelle L Joachims
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Immunol 181:8153-61. 2008
  3. pmc Further differentiation of murine double-positive thymocytes is inhibited in adenosine deaminase-deficient murine fetal thymic organ culture
    C Justin Van De Wiele
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA
    J Immunol 176:5925-33. 2006
  4. pmc CD73-generated adenosine restricts lymphocyte migration into draining lymph nodes
    Masahide Takedachi
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA
    J Immunol 180:6288-96. 2008
  5. pmc Human alpha beta and gamma delta thymocyte development: TCR gene rearrangements, intracellular TCR beta expression, and gamma delta developmental potential--differences between men and mice
    Michelle L Joachims
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Immunol 176:1543-52. 2006
  6. pmc Individual antibody and T cell responses to vaccination and infection with the 2009 pandemic swine-origin H1N1 influenza virus
    Gillian M Air
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    J Clin Immunol 31:900-12. 2011

Collaborators

Detail Information

Publications6

  1. pmc Inhibition of deoxynucleoside kinases in human thymocytes prevents dATP accumulation and induction of apoptosis
    Michelle L Joachims
    Department of Immunobiology and Cancer, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Nucleosides Nucleotides Nucleic Acids 27:816-20. 2008
    ..Thus, both deoxynucleoside kinases are involved in this model of ADA deficiency...
  2. pmc Restoration of adenosine deaminase-deficient human thymocyte development in vitro by inhibition of deoxynucleoside kinases
    Michelle L Joachims
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Immunol 181:8153-61. 2008
    ..Our work reveals that multiple deoxynucleoside kinases are involved in the phosphorylation of deoxyadenosine when ADA is absent, and suggests an alternate therapeutic strategy for treatment of ADA-deficient patients...
  3. pmc Further differentiation of murine double-positive thymocytes is inhibited in adenosine deaminase-deficient murine fetal thymic organ culture
    C Justin Van De Wiele
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA
    J Immunol 176:5925-33. 2006
    ..These data suggest that ADA deficiency leads to the induction of mitochondria-dependent apoptosis as a consequence of the accumulation of dATP derived from thymocytes failing the positive/negative selection checkpoint...
  4. pmc CD73-generated adenosine restricts lymphocyte migration into draining lymph nodes
    Masahide Takedachi
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA
    J Immunol 180:6288-96. 2008
    ..Adenosine receptor signaling to restrict lymphocyte migration across HEV may be an important mechanism to control the magnitude of an inflammatory response...
  5. pmc Human alpha beta and gamma delta thymocyte development: TCR gene rearrangements, intracellular TCR beta expression, and gamma delta developmental potential--differences between men and mice
    Michelle L Joachims
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Immunol 176:1543-52. 2006
    ..Aspects that differ from the mouse are the status of TCR gene rearrangements at the nonexpressed loci, the timing of beta selection, and maintenance of gammadelta potential through the early double positive stage of development...
  6. pmc Individual antibody and T cell responses to vaccination and infection with the 2009 pandemic swine-origin H1N1 influenza virus
    Gillian M Air
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    J Clin Immunol 31:900-12. 2011
    ....