Timothy M Griffin

Summary

Affiliation: Oklahoma Medical Research Foundation
Country: USA

Publications

  1. pmc Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice
    Timothy M Griffin
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Arthritis Res Ther 12:R130. 2010
  2. pmc Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen
    Kyle D Allen
    Duke University Medical Center and Duke University, Durham, NC 27710, USA
    Arthritis Rheum 60:2684-93. 2009
  3. pmc Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis
    Timothy M Griffin
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 60:2935-44. 2009
  4. pmc Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise
    Timothy M Griffin
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 64:443-53. 2012
  5. pmc Why is obesity associated with osteoarthritis? Insights from mouse models of obesity
    Timothy M Griffin
    Department of Surgery and Biomedical Engineering, Duke University Medical Center, Durham, NC 27710, USA
    Biorheology 45:387-98. 2008
  6. pmc Locomotor activity and gait in aged mice deficient for type IX collagen
    Kerry E Costello
    Department of Surgery, Duke University Medical Center, Durham, Durham, NC 27710, USA
    J Appl Physiol (1985) 109:211-8. 2010
  7. pmc Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet
    Christopher J O'Conor
    Department of Orthopaedic Surgery, Duke University Medical Center, 375 MSRB, Box 3093, Durham, NC 27710, USA
    Ann Rheum Dis 72:300-4. 2013
  8. ncbi request reprint The role of mechanical loading in the onset and progression of osteoarthritis
    Timothy M Griffin
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Exerc Sport Sci Rev 33:195-200. 2005

Collaborators

Detail Information

Publications9

  1. pmc Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice
    Timothy M Griffin
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Arthritis Res Ther 12:R130. 2010
    ..In this study, we examined biomechanical, neurobehavioral, inflammatory, and osteoarthritic changes in C57BL/6J mice fed a high-fat diet...
  2. pmc Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen
    Kyle D Allen
    Duke University Medical Center and Duke University, Durham, NC 27710, USA
    Arthritis Rheum 60:2684-93. 2009
    ..The aim of this study was to investigate Col9a1(-/-) mice for functional and symptomatic changes that may be associated with these pathologies...
  3. pmc Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis
    Timothy M Griffin
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 60:2935-44. 2009
    ..To test the hypothesis that obesity resulting from deletion of the leptin gene or the leptin receptor gene results in increased knee osteoarthritis (OA), systemic inflammation, and altered subchondral bone morphology...
  4. pmc Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise
    Timothy M Griffin
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 64:443-53. 2012
    ....
  5. pmc Why is obesity associated with osteoarthritis? Insights from mouse models of obesity
    Timothy M Griffin
    Department of Surgery and Biomedical Engineering, Duke University Medical Center, Durham, NC 27710, USA
    Biorheology 45:387-98. 2008
    ..The ability to control these factors, together with the development of methods to conduct more intricate measures of local biomechanical factors, make mouse models an excellent system to study obesity and osteoarthritis...
  6. pmc Locomotor activity and gait in aged mice deficient for type IX collagen
    Kerry E Costello
    Department of Surgery, Duke University Medical Center, Durham, Durham, NC 27710, USA
    J Appl Physiol (1985) 109:211-8. 2010
    ..These results support the concept that current disease status, rather than age of disease onset, is the primary determinant of impaired locomotor activity with aging...
  7. pmc Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet
    Christopher J O'Conor
    Department of Orthopaedic Surgery, Duke University Medical Center, 375 MSRB, Box 3093, Durham, NC 27710, USA
    Ann Rheum Dis 72:300-4. 2013
    ....
  8. ncbi request reprint The role of mechanical loading in the onset and progression of osteoarthritis
    Timothy M Griffin
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Exerc Sport Sci Rev 33:195-200. 2005
    ..Obesity-induced osteoarthritis and the benefits of physical activity may be mediated by systemic levels of proinflammatory mediators as well as local biomechanical factors in the joint...