Charles T Esmon

Summary

Affiliation: Oklahoma Medical Research Foundation
Country: USA

Publications

  1. pmc The APCs of neuroprotection
    Charles T Esmon
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, and Howard Hughes Medical Institute, Oklahoma City, Oklahoma 73104, USA
    J Clin Invest 119:3205-7. 2009
  2. pmc Basic mechanisms and pathogenesis of venous thrombosis
    Charles T Esmon
    Oklahoma Medical Research Foundation, Howard Hughes Medical Institute, and Departments of Pathology and Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States
    Blood Rev 23:225-9. 2009
  3. pmc Effects of membrane and soluble EPCR on the hemostatic balance and endotoxemia in mice
    Xunzhen Zheng
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, The Howard Hughes Medical Institute, Oklahoma City 73104, USA
    Blood 109:1003-9. 2007
  4. doi request reprint Molecular circuits in thrombosis and inflammation
    Charles T Esmon
    Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Howard Hughes Medical Institute, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Thromb Haemost 109:416-20. 2013
  5. ncbi request reprint The impact of the inflammatory response on coagulation
    Charles T Esmon
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, OK, USA
    Thromb Res 114:321-7. 2004
  6. doi request reprint The link between vascular features and thrombosis
    Charles T Esmon
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, 73104, USA
    Annu Rev Physiol 73:503-14. 2011
  7. pmc Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4
    Fabrizio Semeraro
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Blood 118:1952-61. 2011
  8. pmc Extraembryonic expression of EPCR is essential for embryonic viability
    Weihong Li
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Blood 106:2716-22. 2005
  9. ncbi request reprint Inflammation and the activated protein C anticoagulant pathway
    Charles T Esmon
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Semin Thromb Hemost 32:49-60. 2006
  10. pmc Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury
    Jun Xu
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Immunol 187:2626-31. 2011

Research Grants

  1. Post-Translational Modifications in Host Defense
    Charles Esmon; Fiscal Year: 2005

Collaborators

Detail Information

Publications27

  1. pmc The APCs of neuroprotection
    Charles T Esmon
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, and Howard Hughes Medical Institute, Oklahoma City, Oklahoma 73104, USA
    J Clin Invest 119:3205-7. 2009
    ..Here we discuss the potential importance of these data and possible relevance to human neurodegenerative diseases...
  2. pmc Basic mechanisms and pathogenesis of venous thrombosis
    Charles T Esmon
    Oklahoma Medical Research Foundation, Howard Hughes Medical Institute, and Departments of Pathology and Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States
    Blood Rev 23:225-9. 2009
    ....
  3. pmc Effects of membrane and soluble EPCR on the hemostatic balance and endotoxemia in mice
    Xunzhen Zheng
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, The Howard Hughes Medical Institute, Oklahoma City 73104, USA
    Blood 109:1003-9. 2007
    ..In conclusion, mEPCR, but not physiologically elevated sEPCR, regulated protein C activation. Procr heterozygosity results in a mild increase of thrombosis tendency and little influence on the response to endotoxin...
  4. doi request reprint Molecular circuits in thrombosis and inflammation
    Charles T Esmon
    Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Howard Hughes Medical Institute, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Thromb Haemost 109:416-20. 2013
    ..Blocking this histone-mediated cascade has the potential to impact a variety of clinical conditions including sepsis, trauma, chemical toxicity, transplant injury and reperfusion injury...
  5. ncbi request reprint The impact of the inflammatory response on coagulation
    Charles T Esmon
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, OK, USA
    Thromb Res 114:321-7. 2004
    ..Inflammatory mediators like interleukin 6 can increase both platelet count and their responsiveness to agonists like thrombin. All of these events tend to shift the hemostatic balance in favor of clot formation...
  6. doi request reprint The link between vascular features and thrombosis
    Charles T Esmon
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, 73104, USA
    Annu Rev Physiol 73:503-14. 2011
    ..Surgery and trauma, two major risk factors for thrombosis, result in the release of a variety of cellular components that trigger coagulation through separate mechanisms...
  7. pmc Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4
    Fabrizio Semeraro
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Blood 118:1952-61. 2011
    ..These data show that histone-activated platelets possess a procoagulant phenotype that drives plasma thrombin generation and suggest that TLR2 and TLR4 mediate the activation process...
  8. pmc Extraembryonic expression of EPCR is essential for embryonic viability
    Weihong Li
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Blood 106:2716-22. 2005
    ..Spontaneous thrombin formation in the deficient animals increases with age. These findings show that extraembryonic EPCR expression is critical for embryo development...
  9. ncbi request reprint Inflammation and the activated protein C anticoagulant pathway
    Charles T Esmon
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Semin Thromb Hemost 32:49-60. 2006
    ..Overall this pathway is critical to both regulation of the blood coagulation process, and control of the innate inflammatory response and some of its associated downstream pathologies...
  10. pmc Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury
    Jun Xu
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Immunol 187:2626-31. 2011
    ..TLR2- or TLR4-null mice were also protected. These studies imply that histone release contributes to death in inflammatory injury and in chemical-induced cellular injury, both of which are mediated in part through the TLRs...
  11. ncbi request reprint Protein C pathway in sepsis
    Charles T Esmon
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Ann Med 34:598-605. 2002
    ..This reduction may be due to both the anticoagulant effects as demonstrated by a reduction in D-dimer and inflammatory effects as demonstrated by a reduction in interleukin 6...
  12. ncbi request reprint The interactions between inflammation and coagulation
    Charles T Esmon
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Br J Haematol 131:417-30. 2005
    ..When the inflammation-coagulation interactions overwhelm the natural defence systems, catastrophic events occur, such as manifested in severe sepsis or inflammatory bowel disease...
  13. pmc Platelet endothelial cell adhesion molecule targeted oxidant-resistant mutant thrombomodulin fusion protein with enhanced potency in vitro and in vivo
    Ronald Carnemolla
    Department of Pharmacology and Center for Targeted Therapeutics and Translational Nanomedicine of the Institute for Translational Medicine and Therapeutics R C, C F G, A M C, S Z, and V R M and Department of Radiology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania A M C Department of Molecular Medicine, Boston University School of Medicine, Boston, Massachusetts K R P Department of Genetic Medicine, Weill Cornell Medical College, New York, New York B S D Departments of Pathology and Biochemistry Molecular Biology, Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, and Howard Hughes Medical Institute, Oklahoma City, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma C T E
    J Pharmacol Exp Ther 347:339-45. 2013
    ..Therefore, oxidant resistant mutant anti-PECAM scFv/TM M388L is a preferable targeted biotherapeutic to compensate for loss of antithrombotic and anti-inflammatory TM functions in the context of vascular oxidative stress. ..
  14. pmc What did we learn from new oral anticoagulant treatment?
    Charles T Esmon
    Howard Hughes Medical Institute, Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Thromb Res 130:S41-3. 2012
    ..Patients with renal insufficiency have delayed clearance and hence may have elevated levels of the drug leading to increased risk of bleeding...
  15. pmc Inhibition of APC anticoagulant activity on oxidized phospholipid by anti-{beta}2-glycoprotein I monoclonal antibodies
    Omid Safa
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104, USA
    Blood 106:1629-35. 2005
    ..We conclude that antibodies to beta(2)-GPI inhibit APC function specifically and contribute to a hypercoaguable state by disrupting specific protein-protein interactions induced by oxidation of PE-containing membranes...
  16. ncbi request reprint The endothelial protein C receptor
    Charles T Esmon
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma, USA
    Curr Opin Hematol 13:382-5. 2006
    ..This review covers the most recent evidence that relatively common genetic and acquired abnormalities of endothelial cell protein C receptor do contribute to pathophysiological disease processes...
  17. pmc Protein C anticoagulant system--anti-inflammatory effects
    Charles T Esmon
    Laboratory of Coagulation Biology, Oklahoma Medical Research Foundation, Oklahoma, OK 73104, USA
    Semin Immunopathol 34:127-32. 2012
    ..In addition to EPCR orchestrating these changes, CD11b is also capable of supporting APC signaling. Selective control of these pathways offers potential in new therapeutic approaches to disease...
  18. pmc Extracellular histones are major mediators of death in sepsis
    Jun Xu
    Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Nat Med 15:1318-21. 2009
    ..We conclude that extracellular histones are potential molecular targets for therapeutics for sepsis and other inflammatory diseases...
  19. ncbi request reprint Crosstalk between inflammation and thrombosis
    Charles T Esmon
    Department of Pathology, University of Oklahoma Health Sciences Center, Howard Hughes Medical Institute, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Maturitas 47:305-14. 2004
    ....
  20. ncbi request reprint Coagulation and inflammation
    Charles T Esmon
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    J Endotoxin Res 9:192-8. 2003
    ....
  21. pmc New mechanisms for vascular control of inflammation mediated by natural anticoagulant proteins
    Charles T Esmon
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Department of Pathology, University of Oklahoma Health Sciences Center, and Howard Hughes Medical Institute, Oklahoma City, OK 73104, USA
    J Exp Med 196:561-4. 2002
  22. ncbi request reprint The protein C pathway
    Charles T Esmon
    Howard Hughes Medical Institute, Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Chest 124:26S-32S. 2003
    ..APC has been shown clinically to protect patients with severe sepsis. Protein C and thrombomodulin are in early stage clinical trials for this disease, and each has distinct potential advantages and disadvantages relative to APC...
  23. ncbi request reprint Why do animal models (sometimes) fail to mimic human sepsis?
    Charles T Esmon
    Departments of Pathology and Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Crit Care Med 32:S219-22. 2004
    ..To describe potential mechanisms that may account for the observation that drugs that work in treating sepsis in animal models often fail in sepsis trials in patients...
  24. ncbi request reprint Interactions between the innate immune and blood coagulation systems
    Charles T Esmon
    Oklahoma Medical Research Foundation, Dept of Pathology, University of Oklahoma Health Sciences Center, and Howard Hughes Medical Institute, Oklahoma City 73104, USA
    Trends Immunol 25:536-42. 2004
    ..This Review will summarize our current understanding of the mechanisms involved in the crosstalk between these two important systems...
  25. pmc Extracellular histone release in response to traumatic injury: implications for a compensatory role of activated protein C
    Matthew E Kutcher
    Department of Surgery at San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA
    J Trauma Acute Care Surg 73:1389-94. 2012
    ..We hypothesized that extracellular histone levels would be increased and associated with poor outcomes after traumatic injury...
  26. ncbi request reprint Structure and functions of the endothelial cell protein C receptor
    Charles T Esmon
    Department of Pathology, University of Oklahoma Health Sciences Center, Howard Hughes Medical Institute, Oklahoma City, OK, USA
    Crit Care Med 32:S298-301. 2004
    ..Thus, available data suggest a potential role of EPCR in hematopoiesis, autoimmunity, and the control of both the coagulation and inflammation responses to infection and trauma...
  27. ncbi request reprint The crystal structure of the endothelial protein C receptor and a bound phospholipid
    Vaheh Oganesyan
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    J Biol Chem 277:24851-4. 2002
    ..The EPCR structure is a model for how CD1d binds lipids and further suggests additional potential functions for EPCR in immune regulation, possibly including the anti-phospholipid syndrome...

Research Grants2

  1. Post-Translational Modifications in Host Defense
    Charles Esmon; Fiscal Year: 2005
    ..The success of these junior investigators will enlarge the critical mass of talent in overlapping scientific areas, a synergistic method to expand the biomedical research infrastructure in Oklahoma. ..