Junpeng Deng

Summary

Affiliation: Oklahoma State University
Country: USA

Publications

  1. ncbi Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
    Junpeng Deng
    Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA
    Proc Natl Acad Sci U S A 105:1499-504. 2008
  2. ncbi The R1441C mutation alters the folding properties of the ROC domain of LRRK2
    Yongchao Li
    Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA
    Biochim Biophys Acta 1792:1194-7. 2009
  3. ncbi Crystal structure of Manduca sexta prophenoloxidase provides insights into the mechanism of type 3 copper enzymes
    Yongchao Li
    Department of Biochemistry, Oklahoma State University, Stillwater, OK 74078, USA
    Proc Natl Acad Sci U S A 106:17002-6. 2009
  4. ncbi A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein
    Brian Krumm
    Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma, United States of America
    PLoS Pathog 8:e1002876. 2012
  5. ncbi Structure of an RNA dodecamer containing a fragment from SRP domain IV of Escherichia coli
    Junpeng Deng
    Department of Chemistry, The Ohio State University, 200 Johnston Laboratory, 176 West 19th Avenue, Columbus, Ohio 43210, USA
    Acta Crystallogr D Biol Crystallogr 59:1004-11. 2003
  6. ncbi High resolution crystal structure of a key editosome enzyme from Trypanosoma brucei: RNA editing ligase 1
    Junpeng Deng
    Howard Hughes Medical Institute, University of Washington, Seattle WA 98195, USA
    J Mol Biol 343:601-13. 2004

Research Grants

  1. Structure-function studies on IL-18, IL-18 binding proteins and receptors
    Junpeng Deng; Fiscal Year: 2010

Collaborators

Detail Information

Publications6

  1. ncbi Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
    Junpeng Deng
    Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA
    Proc Natl Acad Sci U S A 105:1499-504. 2008
    ..The structure of the LRRK2 ROC domain also represents a signature from a previously undescribed class of GTPases from complex proteins and results may provide a unique molecular target for therapeutics in PD...
  2. ncbi The R1441C mutation alters the folding properties of the ROC domain of LRRK2
    Yongchao Li
    Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA
    Biochim Biophys Acta 1792:1194-7. 2009
    ..These data suggest a mechanism whereby the R1441C mutation can reduce the GTPase activity of LRRK2, and highlights the possibility of targeting the stability of the ROC domain as a therapeutic avenue in LRRK2 disease...
  3. ncbi Crystal structure of Manduca sexta prophenoloxidase provides insights into the mechanism of type 3 copper enzymes
    Yongchao Li
    Department of Biochemistry, Oklahoma State University, Stillwater, OK 74078, USA
    Proc Natl Acad Sci U S A 106:17002-6. 2009
    ..A drastic change in electrostatic surface induced on cleavage at Arg-51 allows us to propose a model for localized PPO activation in insects...
  4. ncbi A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein
    Brian Krumm
    Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma, United States of America
    PLoS Pathog 8:e1002876. 2012
    ..However, despite this extensive divergence, YLDV-IL18BP binds to the same surface of IL18 used by other IL18BPs, suggesting that all IL18BPs use a conserved inhibitory mechanism by blocking a putative receptor-binding site on IL18...
  5. ncbi Structure of an RNA dodecamer containing a fragment from SRP domain IV of Escherichia coli
    Junpeng Deng
    Department of Chemistry, The Ohio State University, 200 Johnston Laboratory, 176 West 19th Avenue, Columbus, Ohio 43210, USA
    Acta Crystallogr D Biol Crystallogr 59:1004-11. 2003
    ..Comparison with other crystal structures of fragments of 4.5S RNA indicates that the conformation of the symmetric loop is independent of the asymmetrical loop in domain IV...
  6. ncbi High resolution crystal structure of a key editosome enzyme from Trypanosoma brucei: RNA editing ligase 1
    Junpeng Deng
    Howard Hughes Medical Institute, University of Washington, Seattle WA 98195, USA
    J Mol Biol 343:601-13. 2004
    ....

Research Grants2

  1. Structure-function studies on IL-18, IL-18 binding proteins and receptors
    Junpeng Deng; Fiscal Year: 2010
    ..It may benefit efforts in developing treatments against some autoimmune and inflammatory diseases, in developing immunotherapies against other infectious diseases and cancer and in combating bioterrorism. ..