Darlene E Berryman

Summary

Affiliation: Ohio University
Country: USA

Publications

  1. pmc Growth hormone and adipose tissue: beyond the adipocyte
    Darlene E Berryman
    School of Applied Health Sciences and Wellness College of Health Sciences and Human Performance, Ohio University, Athens, OH 45701, United States
    Growth Horm IGF Res 21:113-23. 2011
  2. ncbi request reprint A dwarf mouse model with decreased GH/IGF-1 activity that does not experience life-span extension: potential impact of increased adiposity, leptin, and insulin with advancing age
    Darlene E Berryman
    Rd, LD, E338 Grover Center, School of Applied Health Sciences and Wellness, Ohio University, Athens, OH 45701
    J Gerontol A Biol Sci Med Sci 69:131-41. 2014
  3. ncbi request reprint Effect of growth hormone on susceptibility to diet-induced obesity
    Darlene E Berryman
    School of Human and Consumer Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701, USA
    Endocrinology 147:2801-8. 2006
  4. ncbi request reprint Dietetics students possess negative attitudes toward obesity similar to nondietetics students
    Darlene E Berryman
    School of Human and Consumer Sciences, Ohio University, Athens, OH 45701, USA
    J Am Diet Assoc 106:1678-82. 2006
  5. pmc Two-year body composition analyses of long-lived GHR null mice
    Darlene E Berryman
    School of Human and Consumer Sciences, College of Health and Human Services, Ohio University, Athens, OH 45701, USA
    J Gerontol A Biol Sci Med Sci 65:31-40. 2010
  6. pmc The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice
    Edward O List
    Edison Biotechnology Institute, Athens, OH 45701, USA
    Mol Endocrinol 27:524-35. 2013
  7. pmc Age-related changes in body composition of bovine growth hormone transgenic mice
    Amanda J Palmer
    School of Human and Consumer Sciences, College of Health and Human Services, Edison Biotechnology Institute, Ohio University, Athens, Ohio 45701, USA
    Endocrinology 150:1353-60. 2009
  8. pmc Decreased insulin sensitivity and increased oxidative damage in wasting adipose tissue depots of wild-type mice
    Lucila Sackmann-Sala
    Edison Biotechnology Institute, Ohio University, 1 Water Tower Dr, The Ridges, Athens, OH 45701, USA
    Age (Dordr) 34:1225-37. 2012
  9. pmc Age-related and depot-specific changes in white adipose tissue of growth hormone receptor-null mice
    Lucila Sackmann-Sala
    Edison Biotechnology Institute, Ohio University, 1 Water Tower Dr, The Ridges, Athens, OH 45701
    J Gerontol A Biol Sci Med Sci 69:34-43. 2014
  10. doi request reprint Elevated systolic blood pressure in male GH transgenic mice is age dependent
    Adam Jara
    Edison Biotechnology Institute A J, C M B, D S, X L, E O L, L A H, D E B, J J K Ohio University, Athens, Ohio 45701 Department of Biomedical Sciences A J, D E B, J J K and Department of Specialty Medicine E O L, Heritage College of Osteopathic Medicine, Athens, Ohio 45701 School of Applied Health Sciences and Wellness C M B, X L, D E B College of Health Sciences and Professions, Ohio University, Athens, Ohio 45701 and Department of Biological Sciences A J, J J K and Department of Social and Public Health D S, Ohio University, Athens, Ohio 45701
    Endocrinology 155:975-86. 2014

Research Grants

  1. The impact of growth hormone on adipose tissue
    Darlene Berryman; Fiscal Year: 2006

Collaborators

Detail Information

Publications25

  1. pmc Growth hormone and adipose tissue: beyond the adipocyte
    Darlene E Berryman
    School of Applied Health Sciences and Wellness College of Health Sciences and Human Performance, Ohio University, Athens, OH 45701, United States
    Growth Horm IGF Res 21:113-23. 2011
    ....
  2. ncbi request reprint A dwarf mouse model with decreased GH/IGF-1 activity that does not experience life-span extension: potential impact of increased adiposity, leptin, and insulin with advancing age
    Darlene E Berryman
    Rd, LD, E338 Grover Center, School of Applied Health Sciences and Wellness, Ohio University, Athens, OH 45701
    J Gerontol A Biol Sci Med Sci 69:131-41. 2014
    ....
  3. ncbi request reprint Effect of growth hormone on susceptibility to diet-induced obesity
    Darlene E Berryman
    School of Human and Consumer Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701, USA
    Endocrinology 147:2801-8. 2006
    ..More importantly, because there were genotype-specific effects of diet, these data stress the importance of diet selection and sampling multiple adipose depots in studies with these mouse models...
  4. ncbi request reprint Dietetics students possess negative attitudes toward obesity similar to nondietetics students
    Darlene E Berryman
    School of Human and Consumer Sciences, Ohio University, Athens, OH 45701, USA
    J Am Diet Assoc 106:1678-82. 2006
    ..Together, these results suggest that dietetics students are no more or less susceptible to negative attitudes toward obesity than their peers...
  5. pmc Two-year body composition analyses of long-lived GHR null mice
    Darlene E Berryman
    School of Human and Consumer Sciences, College of Health and Human Services, Ohio University, Athens, OH 45701, USA
    J Gerontol A Biol Sci Med Sci 65:31-40. 2010
    ..Along with previously published data, these results suggest a consistent and intriguing protective effect of excess fat mass in the subcutaneous region...
  6. pmc The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice
    Edward O List
    Edison Biotechnology Institute, Athens, OH 45701, USA
    Mol Endocrinol 27:524-35. 2013
    ..However, removal of GHR in adipose tissue alone is not sufficient to increase levels of resistin or adiponectin and does not alter glucose metabolism...
  7. pmc Age-related changes in body composition of bovine growth hormone transgenic mice
    Amanda J Palmer
    School of Human and Consumer Sciences, College of Health and Human Services, Edison Biotechnology Institute, Ohio University, Athens, Ohio 45701, USA
    Endocrinology 150:1353-60. 2009
    ....
  8. pmc Decreased insulin sensitivity and increased oxidative damage in wasting adipose tissue depots of wild-type mice
    Lucila Sackmann-Sala
    Edison Biotechnology Institute, Ohio University, 1 Water Tower Dr, The Ridges, Athens, OH 45701, USA
    Age (Dordr) 34:1225-37. 2012
    ..In conclusion, features of wasting WAT were similar in the four depots, including decreased adipocyte sizes and alterations in protein expression profiles that indicated decreased insulin sensitivity and increased lipid peroxidation...
  9. pmc Age-related and depot-specific changes in white adipose tissue of growth hormone receptor-null mice
    Lucila Sackmann-Sala
    Edison Biotechnology Institute, Ohio University, 1 Water Tower Dr, The Ridges, Athens, OH 45701
    J Gerontol A Biol Sci Med Sci 69:34-43. 2014
    ..Overall, the protein changes detected in this study offer new insights into possible mechanisms contributing to enhanced insulin sensitivity and extended life span in GHR(-) (/-) mice. ..
  10. doi request reprint Elevated systolic blood pressure in male GH transgenic mice is age dependent
    Adam Jara
    Edison Biotechnology Institute A J, C M B, D S, X L, E O L, L A H, D E B, J J K Ohio University, Athens, Ohio 45701 Department of Biomedical Sciences A J, D E B, J J K and Department of Specialty Medicine E O L, Heritage College of Osteopathic Medicine, Athens, Ohio 45701 School of Applied Health Sciences and Wellness C M B, X L, D E B College of Health Sciences and Professions, Ohio University, Athens, Ohio 45701 and Department of Biological Sciences A J, J J K and Department of Social and Public Health D S, Ohio University, Athens, Ohio 45701
    Endocrinology 155:975-86. 2014
    ..These results indicate that elevated SBP in bGH mice is dependent on age, independent of insulin resistance, and related to alterations in both the natriuretic peptide and renin-angiotensin systems. ..
  11. pmc Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity?
    Ellen R Lubbers
    Edison Biotechnology Institute, College of Health Sciences and Professions, E338 Grover Center, Ohio University, Athens, Ohio 45701, USA
    J Endocrinol 216:363-74. 2013
    ..Taken together, these results fill important gaps in the literature related to GH and adiponectin and question the frequently reported associations of total and HMW adiponectin with insulin sensitivity and longevity...
  12. pmc Plasma proteomic profiles of bovine growth hormone transgenic mice as they age
    Juan Ding
    Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA
    Transgenic Res 20:1305-20. 2011
    ..Also, these newly discovered plasma proteins may be indicative or 'biomarkers' of a shortened lifespan...
  13. ncbi request reprint Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles
    Edward O List
    Edison Biotechnology Institute E O L, D E B, K F, A J, B K, E A J, W Z, J J K, Department of Specialty Medicine, Heritage College of Osteopathic Medicine E O L, School of Applied Health Sciences and Wellness D E B, Department of Biomedical Sciences, Heritage College of Osteopathic Medicine D E B, A J, J J K, Ohio University, Athens, Ohio 45701 2942 Department of Internal Medicine F W, A B, Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9628 Robert and Arlene Kogod Center on Aging M B S, T A W, N K L, T P, T T, J L K, Mayo Clinic, Rochester, Minnesota 55905 0002 College of Medicine, Burnett School of Biomedical Sciences X Z, M M M, University of Central Florida, Orlando, Division of Respiratory Medicine
    Endocrinology 155:1793-805. 2014
    ..Furthermore, our data suggest that novel GH-dependent cross talk between liver and adipose is important for regulation of adipokines in vivo. ..
  14. ncbi request reprint Comparing adiposity profiles in three mouse models with altered GH signaling
    Darlene E Berryman
    School of Human and Consumer Sciences, Ohio University, Athens, OH, USA
    Growth Horm IGF Res 14:309-18. 2004
    ..Thus, adiponectin levels were negatively correlated with GH function suggesting a role for adiponectin in GH-induced insulin resistance...
  15. pmc Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse
    Edward O List
    The Edison Biotechnology Institute, Ohio University, Athens, Ohio 45701, USA
    Endocr Rev 32:356-86. 2011
    ..We have attempted to present the findings in the context of current knowledge regarding GH action and, where applicable, to discuss how these mice compare to GH insensitivity syndrome in humans...
  16. ncbi request reprint CIDE-A gene expression is decreased in white adipose tissue of growth hormone receptor/binding protein gene disrupted mice and with high-fat feeding of normal mice
    Bruce Kelder
    Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA
    Growth Horm IGF Res 17:346-51. 2007
    ..These data demonstrate that CIDE-A levels are reduced in two different mouse models of obesity and this reduction may contribute to altered lipid metabolism...
  17. ncbi request reprint Analysis of mouse skin reveals proteins that are altered in a diet-induced diabetic state: a new method for detection of type 2 diabetes
    Edward O List
    Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA
    Proteomics 7:1140-9. 2007
    ....
  18. pmc Age- and sex-associated plasma proteomic changes in growth hormone receptor gene-disrupted mice
    Juan Ding
    Edison Biotechnology Institute, 1 Water Tower Drive, The Ridges, Ohio University, Athens, OH 45701, USA
    J Gerontol A Biol Sci Med Sci 67:830-40. 2012
    ..In conclusion, we find plasma proteomic changes in GHR-/- mice that favor a longer life span as well as sex differences indicative of an improved health span in female mice...
  19. doi request reprint The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations
    Darlene E Berryman
    Edison Biotechnology Institute, Ohio University, 1 Water Tower Drive, The Ridges, Athens, OH 45701, USA
    Nat Rev Endocrinol 9:346-56. 2013
    ..This Review provides an introduction to the role of GH in obesity and summarizes clinical and preclinical data that describe how GH can influence the obese state...
  20. pmc Heterogeneity among white adipose tissue depots in male C57BL/6J mice
    Lucila Sackmann-Sala
    Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA
    Obesity (Silver Spring) 20:101-11. 2012
    ..The observed WAT depot-specific differences provide clues as to the mechanisms leading to these depots' respective diverse functions...
  21. ncbi request reprint The GH/IGF-1 axis in ageing and longevity
    Riia K Junnila
    Edison Biotechnology Institute, Ohio University, 1 Water Tower Drive, The Ridges, Athens, OH 45701, USA
    Nat Rev Endocrinol 9:366-76. 2013
    ..The outcome of corresponding or similar mutations in humans is described, as well as the potential mechanisms underlying increased longevity and the therapeutic benefits and risks of medical disruption of the GH/IGF-1 axis in humans...
  22. doi request reprint Evaluation of growth hormone (GH) action in mice: discovery of GH receptor antagonists and clinical indications
    John J Kopchick
    Edison Biotechnology Institute, Ohio University, Athens, OH 45701, United States Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, United States Electronic address
    Mol Cell Endocrinol 386:34-45. 2014
    ..Additionally, we will describe experiments in which the GHA was discovered, review results of pegvisomant's preclinical and clinical trials, and provide data suggesting pegvisomant's therapeutic value in selected types of cancer. ..
  23. ncbi request reprint Discovery and uses of pegvisomant: a growth hormone antagonist
    Darlene E Berryman
    School of Huma and Consumer Sciences, Ohio University, Athens, OH, USA
    Endokrynol Pol 58:322-9. 2007
    ..In addition, we discuss the discovery and development of an effective GH receptor antagonist, pegvisomant, and summarise potential therapeutic uses of this drug...
  24. pmc Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models
    Darlene E Berryman
    School of Human and Consumer Sciences, College of Health and Human Services, Ohio University, Athens, OH 45701, United States
    Growth Horm IGF Res 18:455-71. 2008
    ....

Research Grants1

  1. The impact of growth hormone on adipose tissue
    Darlene Berryman; Fiscal Year: 2006
    ..Accomplishment of this research will provide me with exceptional training in a new research area with untapped potential, as well as open multiple avenues of inquiry for the writing of competitive research proposals. ..