Research Topics
| Darlene E BerrymanSummaryAffiliation: Ohio University Country: USA Publications
Research Grants
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Detail Information
Publications
Growth hormone and adipose tissue: beyond the adipocyteDarlene E Berryman
School of Applied Health Sciences and Wellness College of Health Sciences and Human Performance, Ohio University, Athens, OH 45701, United States
Growth Horm IGF Res 21:113-23. 2011....
Two-year body composition analyses of long-lived GHR null miceDarlene E Berryman
School of Human and Consumer Sciences, College of Health and Human Services, Ohio University, Athens, OH 45701, USA
J Gerontol A Biol Sci Med Sci 65:31-40. 2010..Along with previously published data, these results suggest a consistent and intriguing protective effect of excess fat mass in the subcutaneous region...
Effect of growth hormone on susceptibility to diet-induced obesityDarlene E Berryman
School of Human and Consumer Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701, USA
Endocrinology 147:2801-8. 2006..More importantly, because there were genotype-specific effects of diet, these data stress the importance of diet selection and sampling multiple adipose depots in studies with these mouse models...
Dietetics students possess negative attitudes toward obesity similar to nondietetics studentsDarlene E Berryman
School of Human and Consumer Sciences, Ohio University, Athens, OH 45701, USA
J Am Diet Assoc 106:1678-82. 2006..Together, these results suggest that dietetics students are no more or less susceptible to negative attitudes toward obesity than their peers...
Age-related changes in body composition of bovine growth hormone transgenic miceAmanda J Palmer
School of Human and Consumer Sciences, College of Health and Human Services, Edison Biotechnology Institute, Ohio University, Athens, Ohio 45701, USA
Endocrinology 150:1353-60. 2009....
Decreased insulin sensitivity and increased oxidative damage in wasting adipose tissue depots of wild-type miceLucila Sackmann-Sala
Edison Biotechnology Institute, Ohio University, 1 Water Tower Dr, The Ridges, Athens, OH 45701, USA
Age (Dordr) 34:1225-37. 2012..In conclusion, features of wasting WAT were similar in the four depots, including decreased adipocyte sizes and alterations in protein expression profiles that indicated decreased insulin sensitivity and increased lipid peroxidation...
Plasma proteomic profiles of bovine growth hormone transgenic mice as they ageJuan Ding
Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA
Transgenic Res 20:1305-20. 2011..Also, these newly discovered plasma proteins may be indicative or 'biomarkers' of a shortened lifespan...
CIDE-A gene expression is decreased in white adipose tissue of growth hormone receptor/binding protein gene disrupted mice and with high-fat feeding of normal miceBruce Kelder
Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA
Growth Horm IGF Res 17:346-51. 2007..These data demonstrate that CIDE-A levels are reduced in two different mouse models of obesity and this reduction may contribute to altered lipid metabolism...
Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouseEdward O List
The Edison Biotechnology Institute, Ohio University, Athens, Ohio 45701, USA
Endocr Rev 32:356-86. 2011..We have attempted to present the findings in the context of current knowledge regarding GH action and, where applicable, to discuss how these mice compare to GH insensitivity syndrome in humans...
Comparing adiposity profiles in three mouse models with altered GH signalingDarlene E Berryman
School of Human and Consumer Sciences, Ohio University, Athens, OH, USA
Growth Horm IGF Res 14:309-18. 2004..Thus, adiponectin levels were negatively correlated with GH function suggesting a role for adiponectin in GH-induced insulin resistance...
Analysis of mouse skin reveals proteins that are altered in a diet-induced diabetic state: a new method for detection of type 2 diabetesEdward O List
Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA
Proteomics 7:1140-9. 2007....
Age- and sex-associated plasma proteomic changes in growth hormone receptor gene-disrupted miceJuan Ding
Edison Biotechnology Institute, 1 Water Tower Drive, The Ridges, Ohio University, Athens, OH 45701, USA
J Gerontol A Biol Sci Med Sci 67:830-40. 2012..In conclusion, we find plasma proteomic changes in GHR-/- mice that favor a longer life span as well as sex differences indicative of an improved health span in female mice...
The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted miceEdward O List
Edison Biotechnology Institute, Athens, OH 45701, USA
Mol Endocrinol 27:524-35. 2013..However, removal of GHR in adipose tissue alone is not sufficient to increase levels of resistin or adiponectin and does not alter glucose metabolism...
Heterogeneity among white adipose tissue depots in male C57BL/6J miceLucila Sackmann-Sala
Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA
Obesity (Silver Spring) 20:101-11. 2012..The observed WAT depot-specific differences provide clues as to the mechanisms leading to these depots' respective diverse functions...
Discovery and uses of pegvisomant: a growth hormone antagonistDarlene E Berryman
School of Huma and Consumer Sciences, Ohio University, Athens, OH, USA
Endokrynol Pol 58:322-9. 2007..In addition, we discuss the discovery and development of an effective GH receptor antagonist, pegvisomant, and summarise potential therapeutic uses of this drug...
Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity?Ellen R Lubbers
Edison Biotechnology Institute, College of Health Sciences and Professions, E338 Grover Center, Ohio University, Athens, Ohio 45701, USA
J Endocrinol 216:363-74. 2013..Taken together, these results fill important gaps in the literature related to GH and adiponectin and question the frequently reported associations of total and HMW adiponectin with insulin sensitivity and longevity...
Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal modelsDarlene E Berryman
School of Human and Consumer Sciences, College of Health and Human Services, Ohio University, Athens, OH 45701, United States
Growth Horm IGF Res 18:455-71. 2008....
Research Grants
- The impact of growth hormone on adipose tissueDarlene Berryman; Fiscal Year: 2006..Accomplishment of this research will provide me with exceptional training in a new research area with untapped potential, as well as open multiple avenues of inquiry for the writing of competitive research proposals. ..
