R N Re

Summary

Affiliation: Ochsner Clinic Foundation
Country: USA

Publications

  1. ncbi The origins of intracrine hormone action
    Richard N Re
    Division of Research, Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121, USA
    Am J Med Sci 323:43-8. 2002
  2. ncbi Intracellular renin and the nature of intracrine enzymes
    Richard N Re
    Research Division, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Hypertension 42:117-22. 2003
  3. ncbi Nuclear accumulation of the AT1 receptor in a rat vascular smooth muscle cell line: effects upon signal transduction and cellular proliferation
    Julia L Cook
    Ochsner Clinic Foundation, Division of Research, New Orleans, LA 70121, USA
    J Mol Cell Cardiol 40:696-707. 2006
  4. ncbi Intracellular renin-angiotensin system: the tip of the intracrine physiology iceberg
    Richard Re
    Research Division, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Am J Physiol Heart Circ Physiol 293:H905-6. 2007
  5. ncbi Mechanisms of disease: Intracrine physiology in the cardiovascular system
    Richard N Re
    Research Division, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Nat Clin Pract Cardiovasc Med 4:549-57. 2007
  6. ncbi The mitochondrial component of intracrine action
    Richard N Re
    Ochsner Clinic Foundation, 1514 Jefferson Hwy, New Orleans, LA 70121, USA
    Am J Physiol Heart Circ Physiol 299:H577-83. 2010
  7. ncbi Tissue renin angiotensin systems
    Richard N Re
    Research Division, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Med Clin North Am 88:19-38. 2004
  8. ncbi The inhibition of tumor growth by triplex-forming oligonucleotides
    Richard N Re
    Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Cancer Lett 209:51-3. 2004
  9. ncbi A proposal regarding the biology of memory: participation of intracrine peptide networks
    Richard N Re
    Research Division, Ochsner Clinic Foundation, 511 Brent House, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Med Hypotheses 63:887-94. 2004
  10. ncbi The intracrine hypothesis: an update
    Richard N Re
    Research Division, Ochsner Clinic Foundation, 1516 Jefferson Highway, New Orleans, LA 70121, USA
    Regul Pept 133:1-9. 2006

Detail Information

Publications41

  1. ncbi The origins of intracrine hormone action
    Richard N Re
    Division of Research, Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121, USA
    Am J Med Sci 323:43-8. 2002
    ..It is here argued that intracrine action is the modern analogue of a biologically ancient mechanism for regulating message translation and ribosome synthesis. The implications of this view for research and therapeutics are discussed...
  2. ncbi Intracellular renin and the nature of intracrine enzymes
    Richard N Re
    Research Division, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Hypertension 42:117-22. 2003
    ..The relation of prorenin/renin to other intracrine enzymes, and to intracrines in general, is discussed...
  3. ncbi Nuclear accumulation of the AT1 receptor in a rat vascular smooth muscle cell line: effects upon signal transduction and cellular proliferation
    Julia L Cook
    Ochsner Clinic Foundation, Division of Research, New Orleans, LA 70121, USA
    J Mol Cell Cardiol 40:696-707. 2006
    ..Extracellular AII also stimulates a unique pathway, apparently reflecting interaction with plasma membrane-associated AT(1)R...
  4. ncbi Intracellular renin-angiotensin system: the tip of the intracrine physiology iceberg
    Richard Re
    Research Division, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Am J Physiol Heart Circ Physiol 293:H905-6. 2007
  5. ncbi Mechanisms of disease: Intracrine physiology in the cardiovascular system
    Richard N Re
    Research Division, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Nat Clin Pract Cardiovasc Med 4:549-57. 2007
    ....
  6. ncbi The mitochondrial component of intracrine action
    Richard N Re
    Ochsner Clinic Foundation, 1514 Jefferson Hwy, New Orleans, LA 70121, USA
    Am J Physiol Heart Circ Physiol 299:H577-83. 2010
    ..The implications of this mitochondrial intracrine biology are discussed...
  7. ncbi Tissue renin angiotensin systems
    Richard N Re
    Research Division, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Med Clin North Am 88:19-38. 2004
    ..It is to be expected that with enhanced understanding of the biology of the multiple RASs, new suggestions for therapeutic interventions will be forthcoming...
  8. ncbi The inhibition of tumor growth by triplex-forming oligonucleotides
    Richard N Re
    Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Cancer Lett 209:51-3. 2004
    ..05). A triplex forming oligonucleotide directed at a p53 consensus binding site reduces tumor growth suggesting a novel method of tumor inhibition...
  9. ncbi A proposal regarding the biology of memory: participation of intracrine peptide networks
    Richard N Re
    Research Division, Ochsner Clinic Foundation, 511 Brent House, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Med Hypotheses 63:887-94. 2004
    ..In addition, intracrine networks provide a previously unappreciated dynamic substrate for the integration of information and ultimately for the formation of the associations that underlay consciousness...
  10. ncbi The intracrine hypothesis: an update
    Richard N Re
    Research Division, Ochsner Clinic Foundation, 1516 Jefferson Highway, New Orleans, LA 70121, USA
    Regul Pept 133:1-9. 2006
    ..Here the intracrine hypothesis is briefly described and then recent experimental findings which bear on predictions made earlier on the basis of the theory are discussed. These findings provide new support for the intracrine hypothesis...
  11. ncbi Mechanisms of disease: local renin-angiotensin-aldosterone systems and the pathogenesis and treatment of cardiovascular disease
    Richard N Re
    Research Division, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Nat Clin Pract Cardiovasc Med 1:42-7. 2004
    ....
  12. ncbi An intracrine view of angiogenesis
    Richard N Re
    Research Division, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Bioessays 28:943-53. 2006
    ..Collectively, these explorations lead to testable hypotheses regarding the regulation of normal and pathological angiogenesis, and point to similarities between tumor-induced angiogenesis and tissue differentiation...
  13. ncbi Potential therapeutic implications of intracrine angiogenesis
    Richard N Re
    Research Division, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, United States
    Med Hypotheses 69:414-21. 2007
    ..Here the participation and regulation of intracrines in angiogenesis is explored, as are the actions of various anti-angiogenic factors...
  14. ncbi The basis of an intracrine pharmacology
    Richard N Re
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    J Clin Pharmacol 48:344-50. 2008
    ..The intracrine pharmacology of the renin-angiotensin system, angiogenesis, and stem cell development is discussed...
  15. ncbi The physiological basis of intracrine stem cell regulation
    Richard N Re
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Am J Physiol Heart Circ Physiol 295:H447-53. 2008
    ..The reprogramming of cells to restore the pleuripotent phenotype and the possible role of stem/progenitor cells in neoplasia are also discussed...
  16. ncbi Senescence, apoptosis, and stem cell biology: the rationale for an expanded view of intracrine action
    Richard N Re
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Am J Physiol Heart Circ Physiol 297:H893-901. 2009
    ..These notions have potentially important therapeutic implications, including implications for the therapy of cardiovascular disease...
  17. ncbi New insights into target organ involvement in hypertension
    Richard N Re
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Med Clin North Am 93:559-67. 2009
    ..While this review is not exhaustive, it does serve to point out the varied nature of the biologic processes that must be taken into account and it points to new avenues for the development of therapeutic agents...
  18. ncbi The clinical implication of tissue renin angiotensin systems
    R N Re
    Research Division, Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121, USA
    Curr Opin Cardiol 16:317-27. 2001
    ..Finally, tissue angiotensin systems outside the cardiovascular system also appear to be physiologically relevant...
  19. ncbi The intracrine hypothesis and intracellular peptide hormone action
    Richard N Re
    Research Division, Ochsner Clinic Foundation, 99 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Bioessays 25:401-9. 2003
    ..The intracellular/intracrine renin-angiotensin system (iRAS) is reviewed to illustrate the intracrine analogue of a well-established physiological system. The role of intracrine action in metazoan development is also considered...
  20. ncbi Toward a theory of intracrine hormone action
    Richard N Re
    Research Division, Ochsner Clinic Foundation, 1516 Jefferson Highway, New Orleans, LA 70121, USA
    Regul Pept 106:1-6. 2002
    ..Possible implications for cellular differentiation, cellular memory and hormonal responsiveness, as well as for the assumption of novel functions by intracellular regulatory proteins are discussed...
  21. ncbi Noncanonical intracrine action
    Richard N Re
    Ochsner Clinic Foundation, New Orleans, LA, USA
    J Am Soc Hypertens 5:435-48. 2011
    ..Moreover, an appreciation of noncanonical intracrine functionality informs our understanding of the major effector protein of the renin-angiotensin system, angiotensin II, as well as other hormones operative in cardiovascular biology...
  22. ncbi Patient and physician satisfaction in a clinical study of telemedicine in a hypertensive patient population
    M A Krousel-Wood
    Division of Research, Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121, USA
    J Telemed Telecare 7:206-11. 2001
    ..Patients reported high satisfaction scores for both telemedicine and in-person visits...
  23. ncbi In vitro evidence for an intracellular site of angiotensin action
    J L Cook
    Division of Research, Ochsner Clinic Foundation, New Orleans, LA, USA
    Circ Res 89:1138-46. 2001
    ....
  24. ncbi The cellular biology of angiotensin: paracrine, autocrine and intracrine actions in cardiovascular tissues
    R N Re
    Alton Ochsner Medical Foundation, New Orleans, LA 70121
    J Mol Cell Cardiol 21:63-9. 1989
    ..In these multiple actions, angiotensin may provide a paradigm for other peptide growth factors and hormones...
  25. ncbi C-terminal processing of GABARAP is not required for trafficking of the angiotensin II type 1A receptor
    Jawed Alam
    Laboratory of Molecular Genetics, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Regul Pept 159:78-86. 2010
    ....
  26. ncbi Transgenic mice expressing an intracellular fluorescent fusion of angiotensin II demonstrate renal thrombotic microangiopathy and elevated blood pressure
    K M Redding
    Department of Molecular Genetics, Ochsner Clinic Foundation, 1514 Jefferson Highway, Biomedical Research Bldg, New Orleans, LA 70121, USA
    Am J Physiol Heart Circ Physiol 298:H1807-18. 2010
    ..This transgenic model may be useful to further explore the intracellular renin-angiotensin system and its implication in abnormal kidney function and hypertension...
  27. ncbi Suppression of cellular proliferation using p53 DNA recognition site-related oligonucleotides
    R N Re
    Alton Ochsner Medical Foundation, Division of Research, New Orleans, Louisiana, USA
    Am J Med Sci 311:65-72. 1996
    ..On the basis of these studies, p53 analogues may be used therapeutically to selectively modify proliferation of transformed cells...
  28. ncbi New medication adherence scale versus pharmacy fill rates in seniors with hypertension
    Marie Krousel-Wood
    Center for Health Research, Ochsner Clinic Foundation, 1514 Jefferson Hwy, New Orleans, LA 70121, USA
    Am J Manag Care 15:59-66. 2009
    ..To evaluate the association and concordance of the new 8-item self-report Morisky Medication Adherence Scale (MMAS) with pharmacy fill data in a sample of community-dwelling seniors with hypertension...
  29. ncbi Medication adherence in older clinic patients with hypertension after Hurricane Katrina: implications for clinical practice and disaster management
    Marie A Krousel-Wood
    Center for Health Research, Ochsner Clinic Foundation, New Orleans, Louisiana, USA
    Am J Med Sci 336:99-104. 2008
    ..In post-disaster situations, additional barriers may reduce antihypertensive medication adherence...
  30. ncbi The trafficking protein GABARAP binds to and enhances plasma membrane expression and function of the angiotensin II type 1 receptor
    Julia L Cook
    Division of Research, Ochsner Clinic Foundation, Ochsner Health System, 1514 Jefferson Hwy, New Orleans, LA 70121, USA
    Circ Res 102:1539-47. 2008
    ..Immunoblot analyses confirmed the quantitative image data. We conclude that GABARAP binds to and promotes trafficking of the AT(1)R to the plasma membrane...
  31. ncbi Intracellular angiotensin II increases the long isoform of PDGF mRNA in rat hepatoma cells
    Julia L Cook
    Division of Research, Ochsner Clinic Foundation, 1516 Jefferson Hwy, New Orleans, LA 70121, USA
    J Mol Cell Cardiol 34:1525-37. 2002
    ....
  32. ncbi Application of the combined quality improvement ratio in the evaluation of a quality improvement activity in a managed care organization
    Marie A Krousel-Wood
    Ochsner Clinic Foundation, Division of Research, New Orleans, LA 70121, USA
    Am J Med Qual 18:117-21. 2003
    ..92 [CP] versus 0.38 [RP] and 0.82 [MP]) and a decrease in the confidence interval range (0.97 [CP] versus 2.06 [RP] and 1.14 [MP]). The CQuIR uses a statistically valid approach to increase the data available for the evaluation of QIAs...
  33. ncbi Reliability of a medication adherence measure in an outpatient setting
    Marie Krousel-Wood
    Research Division, Ochsner Clinic Foundation, Department of Epidemiology, Tulane University Health Sciences Center, School of Public Health and Tropical Medicine, New Orleans, Louisiana 70121, USA
    Am J Med Sci 330:128-33. 2005
    ..The objective of the current study was to determine the reliability of the Hill-Bone Compliance Scale among elderly hypertensive patients...
  34. ncbi Cleavage of the angiotensin II type 1 receptor and nuclear accumulation of the cytoplasmic carboxy-terminal fragment
    Julia L Cook
    Ochsner Clinic Foundation, Ochsner Health System, 1516 Jefferson Hwy, New Orleans, LA 70121, USA
    Am J Physiol Cell Physiol 292:C1313-22. 2007
    ..Overexpressed native AT(1)R (nonfusion) is also cleaved; the intracellular 6-kDa cytoplasmic domain product accumulates to a significantly higher level with ANG II treatment...
  35. ncbi Growth factors and cardiovascular structure. Implications for calcium antagonist therapy
    R N Re
    Alton Ochsner Medical Foundation, New Orleans, LA 70121
    Am J Hypertens 4:460S-465S. 1991
    ....
  36. ncbi The effect of education on patients' willingness to participate in a telemedicine study
    M A Krousel-Wood
    Division of Research, Alton Ochsner Medical Foundation, 1516 Jefferson Highway, New Orleans, LA 70121, USA
    J Telemed Telecare 7:281-7. 2001
    ..6 (95% confidence interval 1.9-7.0). Educational status should be carefully considered when designing, implementing and interpreting telemedicine studies...
  37. ncbi Do we need yet another blocker of the renin-angiotensin system?
    Franz H Messerli
    J Am Coll Cardiol 49:1164-5. 2007
  38. ncbi Implications of intracrine hormone action for physiology and medicine
    Richard N Re
    Am J Physiol Heart Circ Physiol 284:H751-7. 2003
  39. ncbi Cardiac angiotensin II: an intracrine hormone?
    Richard N Re
    Am J Hypertens 16:426-7. 2003
  40. ncbi Accuracy of telemedicine in detecting uncontrolled hypertension and its impact on patient management
    Ahmed A Abdoh
    Clinical Epidemiology, Department of Surgery, University of Manitoba, Winnipeg, Canada
    Telemed J E Health 9:315-23. 2003
    ..Meanwhile, there was no difference in ordering diagnostic tests or therapeutics detectable between the two encounter types. Telemedicine proved to be a valid means for detecting uncontrolled BP among hypertensive patients...
  41. ncbi Renin excess after renin inhibition: malefactor or innocent bystander?
    Richard N Re
    Int J Clin Pract 61:1427-9. 2007