E D Frohlich

Summary

Affiliation: Ochsner Clinic Foundation
Country: USA

Publications

  1. doi request reprint Pressure overload
    Edward D Frohlich
    Hypertension Research Laboratory, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Heart Fail Clin 8:21-32. 2012
  2. ncbi request reprint The role of salt in hypertension: the complexity seems to become clearer
    Edward D Frohlich
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Nat Clin Pract Cardiovasc Med 5:2-3. 2008
  3. ncbi request reprint Blood pressure, large arteries and atherosclerosis
    Edward D Frohlich
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Adv Cardiol 44:117-24. 2007
  4. ncbi request reprint Isolated systolic hypertension in elderly WKY is reversed with L-arginine and ACE inhibition
    D Susic
    Alton Ochsner Medical Foundation, New Orleans, LA 70121, USA
    Hypertension 38:1422-6. 2001
  5. ncbi request reprint The salt conundrum: a hypothesis
    Edward D Frohlich
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Hypertension 50:161-6. 2007
  6. doi request reprint Role of beta-adrenergic receptor blocking agents in hypertensive diseases: personal thoughts as the controversy persists
    Edward D Frohlich
    Ochsner Clinic Foundation, New Orleans, LA, USA
    Ther Adv Cardiovasc Dis 3:455-64. 2009
  7. doi request reprint Current challenges and unresolved problems in hypertensive disease
    Edward D Frohlich
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Med Clin North Am 93:527-40, Table of Contents. 2009
  8. ncbi request reprint Sodium directly impairs target organ function in hypertension
    Edward D Frohlich
    Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Curr Opin Cardiol 20:424-9. 2005
  9. ncbi request reprint Clinical implications of local renin-angiotensin-aldosterone systems
    Edward D Frohlich
    Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Curr Cardiol Rep 5:247-8. 2003
  10. ncbi request reprint Robert P. Grant, MD
    Edward D Frohlich
    Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Am J Cardiol 91:646-8. 2003

Detail Information

Publications80

  1. doi request reprint Pressure overload
    Edward D Frohlich
    Hypertension Research Laboratory, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Heart Fail Clin 8:21-32. 2012
    ..Particular emphasis is placed on molecular mechanisms that govern the development of hypertrophy and that may lead to maladaptive structural changes resulting in adverse cardiac events...
  2. ncbi request reprint The role of salt in hypertension: the complexity seems to become clearer
    Edward D Frohlich
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Nat Clin Pract Cardiovasc Med 5:2-3. 2008
  3. ncbi request reprint Blood pressure, large arteries and atherosclerosis
    Edward D Frohlich
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Adv Cardiol 44:117-24. 2007
    ....
  4. ncbi request reprint Isolated systolic hypertension in elderly WKY is reversed with L-arginine and ACE inhibition
    D Susic
    Alton Ochsner Medical Foundation, New Orleans, LA 70121, USA
    Hypertension 38:1422-6. 2001
    ..The results suggest that different mechanisms may be responsible for the hypertension- and age-related cardiovascular changes, although they may appear to be similar...
  5. ncbi request reprint The salt conundrum: a hypothesis
    Edward D Frohlich
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Hypertension 50:161-6. 2007
  6. doi request reprint Role of beta-adrenergic receptor blocking agents in hypertensive diseases: personal thoughts as the controversy persists
    Edward D Frohlich
    Ochsner Clinic Foundation, New Orleans, LA, USA
    Ther Adv Cardiovasc Dis 3:455-64. 2009
    ..Personally, I disagree; and, no doubt, controversy will continue...
  7. doi request reprint Current challenges and unresolved problems in hypertensive disease
    Edward D Frohlich
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Med Clin North Am 93:527-40, Table of Contents. 2009
    ..What remains of utmost importance is for members of the academic community with a wide spectrum of experience and points of view to continue to work with the fundamental problems and mechanisms of the diseases...
  8. ncbi request reprint Sodium directly impairs target organ function in hypertension
    Edward D Frohlich
    Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Curr Opin Cardiol 20:424-9. 2005
    ....
  9. ncbi request reprint Clinical implications of local renin-angiotensin-aldosterone systems
    Edward D Frohlich
    Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Curr Cardiol Rep 5:247-8. 2003
  10. ncbi request reprint Robert P. Grant, MD
    Edward D Frohlich
    Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Am J Cardiol 91:646-8. 2003
  11. ncbi request reprint Mechanisms underlying obesity associated with systemic and renal hemodynamics in essential hypertension
    Edward D Frohlich
    Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Curr Hypertens Rep 10:151-5. 2008
    ..Although recently postulated pathophysiologic mechanisms have been associated with obesity, none has yet been related to the hemodynamic alterations associated with obesity that coexist in patients with essential hypertension...
  12. ncbi request reprint Target organ involvement in hypertension: a realistic promise of prevention and reversal
    Edward D Frohlich
    Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Med Clin North Am 88:209-21. 2004
    ....
  13. ncbi request reprint Management of diabetic and hypertensive cardiovascular disease
    Edward D Frohlich
    Ochsner Clinic Foundation, 1516 Jefferson Highway, New Orleans, LA 70121, USA
    Curr Hypertens Rep 5:309-15. 2003
    ..Inherent in this concept is the promise of retarding the development of the cardiovascular and renal morbid events and also reducing their associated mortal endpoints...
  14. ncbi request reprint Uric acid: its relationship to renal hemodynamics and the renal renin-angiotensin system
    Xiaoyan Zhou
    Alton Ochsner Distinguished Scientist, Ochsner Clinic Foundation, 1516 Jefferson Highway, New Orleans, LA 70121, USA
    Curr Hypertens Rep 8:120-4. 2006
    ..Additionally, there are no available data on the effects of lowering uric acid on pressure control and organ protection...
  15. ncbi request reprint Recent advances in hypertension, stroke, and cardiorenal disease
    Edward D Frohlich
    Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Curr Opin Cardiol 20:258-63. 2005
  16. ncbi request reprint The role of sodium in hypertension is more complex than simply elevating arterial pressure
    Edward D Frohlich
    Oschner Clinic Foundation, New Orleans, LA 70121, USA
    Nat Clin Pract Cardiovasc Med 1:24-30. 2004
    ....
  17. ncbi request reprint Seasonal variations in blood pressure
    Edward D Frohlich
    Ochsner Clinic Foundation, 1516 Jefferson Highway, New Orleans, LA 70121, USA
    Am J Geriatr Cardiol 13:274-5. 2004
  18. ncbi request reprint Low-dose ACE with alpha- or beta-adrenergic receptor inhibitors have beneficial SHR cardiovascular effects
    J Varagic
    Hypertension Research Laboratory, Alton Ochsner Medical Foundation, New Orleans, LA 70121, USA
    J Cardiovasc Pharmacol Ther 6:57-63. 2001
    ..CONCLUSION: These data show that the low subdepressor dose ACE inhibitor with an alpha- or beta-adrenergic receptor antagonist provides beneficial cardiovascular effects in SHR...
  19. ncbi request reprint Coronary hemodynamic and ventricular responses to angiotensin type 1 receptor inhibition in SHR: interaction with angiotensin type 2 receptors
    J Varagic
    Hypertension Research Laboratory, Alton Ochsner Medical Foundation, New Orleans, LA70121, USA
    Hypertension 37:1399-403. 2001
    ..These data suggest that AT(2) receptors contribute to the hypotensive and antifibrotic effects but not the coronary hemodynamic improvement or reduced left ventricular mass of AT(1) receptor inhibition in these adult SHR...
  20. ncbi request reprint Abnormal renal vascular responses to dipyridamole-induced vasodilation in spontaneously hypertensive rats
    D Susic
    Hypertension Research Laboratory, Alton Ochsner Medical Foundation, New Orleans, LA 70121, USA
    Hypertension 37:894-7. 2001
    ..These findings may be of importance in identifying the earliest hemodynamic evidence of developing hypertensive nephrosclerosis...
  21. ncbi request reprint Cardiovascular mass and ventricular function after celiprolol in Wistar-Kyoto and spontaneously hypertensive rats
    S Horinaka
    Alton Ochsner Medical Foundation, New Orleans, LA 70121
    Cardiovasc Res 26:396-400. 1992
    ....
  22. ncbi request reprint Angiotensin type 1 receptor antagonism and ACE inhibition produce similar renoprotection in N(omega)-nitro-L>-arginine methyl ester/spontaneously hypertensive rats
    Y Nakamura
    Hypertension Research Laboratories, Alton Ochsner Medical Foundation, New Orleans, LA 70121, USA
    Hypertension 37:1262-7. 2001
    ....
  23. ncbi request reprint Local hemodynamic changes in hypertension: insights for therapeutic preservation of target organs
    E D Frohlich
    Alton Ochsner Medical Foundation, New Orleans, LA 70121, USA
    Hypertension 38:1388-94. 2001
    ..To this end, we look forward to the results of ongoing, well-controlled, and prospectively conducted multicenter clinical studies designed to demonstrate prevention of cardiac and renal failure...
  24. ncbi request reprint Vasodilatory beta-blockers: systemic and regional hemodynamic effects
    E D Frohlich
    Alton Ochsner Medical Foundation, New Orleans, LA 70121
    Am Heart J 121:1012-6; discussion 1016-7. 1991
    ..Recent beta-blockers, such as celiprolol, provide an improved physiologic response by instantly reducing arterial pressure and total peripheral resistance without reducing heart rate or cardiac output or expanding intravascular volume...
  25. ncbi request reprint Hemodynamic effects of celiprolol in essential hypertension
    E D Frohlich
    Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121
    Am J Cardiol 68:509-14. 1991
    ..These effects may be explained by celiprolol's cardiac beta-1 receptor inhibitory and peripheral beta-2 receptor agonistic effects...
  26. ncbi request reprint Fibrosis and ischemia: the real risks in hypertensive heart disease
    E D Frohlich
    Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121, USA
    Am J Hypertens 14:194S-199S. 2001
    ....
  27. ncbi request reprint Calcium antagonists. Their physiological differences
    E D Frohlich
    Alton Ochsner Medical Foundation, New Orleans, LA 70121
    Am J Hypertens 4:430S-433S. 1991
    ..Thus, the calcium antagonists are far more heterogeneous than other classes of antihypertensive agents in their physiological and clinical actions.(ABSTRACT TRUNCATED AT 250 WORDS)..
  28. ncbi request reprint Renin-angiotensin system inhibition improves coronary flow reserve in hypertension
    E D Frohlich
    Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121, USA
    J Cardiovasc Pharmacol 37:S35-9. 2001
    ..These findings suggest the potential merits for clinical studies employing the combination of ACE inhibitor and angiotensin receptor blocker therapy in patients with hypertension and hypertensive heart disease...
  29. ncbi request reprint Angiotensin converting enzyme inhibitors. Disparities in the mechanism of their antihypertensive effect
    G E Garavaglia
    Department of Internal Medicine, Ochsner Clinic, New Orleans, LA 70121
    Am J Hypertens 1:214S-216S. 1988
    ..These findings suggest that systemic and renal hemodynamic effects may be drug specific and not uniform for all ACE inhibitors...
  30. ncbi request reprint Apoptosis and glomerular injury after prolonged nitric oxide synthase inhibition in spontaneously hypertensive rats
    H Ono
    Hypertension Research Laboratory, Alton Ochsner Medical Foundation, New Orleans, LA 70121, USA
    Hypertension 38:1300-6. 2001
    ..These results indicate that angiotensin II activation, induced by L-NAME, was related to glomerular cell deletion and apoptosis together with the pathophysiological changes of severe nephrosclerosis and impaired renal dynamics...
  31. ncbi request reprint AT1 receptors: coronary flow and flow reserve
    E D Frohlich
    Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121, USA
    Am J Hypertens 13:39S-44S. 2000
    ..This finding suggests a possible advantage of combination angiotensin converting enzyme inhibitors and angiotensin II receptor blocker therapy in patients with hypertension and hypertensive heart disease...
  32. ncbi request reprint Sympathectomy fails to reveal prominent vasodilation by atrial natriuretic factor
    R W Barbee
    Division of Research, Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121
    Hypertension 15:888-93. 1990
    ..Furthermore, atrial natriuretic factor decreased cardiac output, central venous pressure, and plasma volume independent of the sympathetic nervous system...
  33. ncbi request reprint Effects of calcium entry blockers on distribution of blood volume
    S Oren
    Department of Internal Medicine, Ochsner Clinic, New Orleans, Louisiana, USA
    Am J Hypertens 9:628-32. 1996
    ..These results suggest that the effect of CEBs varies in order of venodilatory effect from verapamil to isradipine to diltiazem, with verapamil having the greatest effect...
  34. ncbi request reprint Hypertensive renal vascular disease and cardiovascular endpoints
    Luis C Matavelli
    Hypertension Research Laboratories, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Curr Opin Cardiol 21:305-9. 2006
    ..We discuss the coexistence of cardiorenal disease as a manifestation of vascular involvement in hypertension, and the relationship of biomarkers of renal vascular involvement in hypertension with cardiovascular endpoints...
  35. ncbi request reprint Overview for the hypertension issue of Current Opinion in Cardiology
    Edward D Frohlich
    Curr Opin Cardiol 21:265-7. 2006
  36. ncbi request reprint Cardiovascular effects of nonproteolytic activation of prorenin
    Dinko Susic
    Hypertension 48:e113; author reply e114. 2006
  37. ncbi request reprint Myocardial fibrosis, impaired coronary hemodynamics, and biventricular dysfunction in salt-loaded SHR
    Jasmina Varagic
    Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Am J Physiol Heart Circ Physiol 290:H1503-9. 2006
    ..These findings point to the conclusion that the concept of "salt sensitivity" in hypertension is far more complex than simply its effects on arterial pressure or the LV...
  38. ncbi request reprint Hurricane Katrina. Aftershocks
    Edward D Frohlich
    Ochsner Clinic Foundation, New Orleans, USA
    N Engl J Med 353:1545. 2005
  39. doi request reprint Optimal treatment of hypertension with diastolic heart failure
    Dinko Susic
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Heart Fail Clin 4:117-24. 2008
    ..Lifestyle changes may also be helpful...
  40. ncbi request reprint Long-term mineralocorticoid receptor blockade reduces fibrosis and improves cardiac performance and coronary hemodynamics in elderly SHR
    Dinko Susic
    Division of Research, Ochsner Clinic Foundation, 1520 Jefferson Hwy, New Orleans, LA 70121, USA
    Am J Physiol Heart Circ Physiol 292:H175-9. 2007
    ..Thus reduction in myocardial fibrosis, paralleled by improvements in left ventricular function and coronary hemodynamics, was observed in eplerenone-treated SHR...
  41. ncbi request reprint Salt loading produces severe renal hemodynamic dysfunction independent of arterial pressure in spontaneously hypertensive rats
    Luis C Matavelli
    Hypertension Research Laboratory, Division of Research, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Am J Physiol Heart Circ Physiol 292:H814-9. 2007
    ..These findings support the concept of a strong independent causal relationship between salt excess and cardiovascular and renal injury...
  42. ncbi request reprint Partial adherence to antihypertensive therapy fails to achieve full cardiovascular benefits in hypertensive rats
    Dinko Susic
    Division of Research, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Am J Med Sci 335:420-5. 2008
    ..We quantitatively evaluated cardiovascular risk inherent in partial therapy adherence in spontaneously hypertensive rats with accelerated hypertension...
  43. ncbi request reprint AT1 receptor antagonism attenuates target organ effects of salt excess in SHRs without affecting pressure
    Jasmina Varagic
    Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, Louisiana, USA
    Am J Physiol Heart Circ Physiol 294:H853-8. 2008
    ..These data clearly demonstrated that angiotensin II (via AT(1) receptors), at least in part, participated importantly in the pressure-independent effects of salt excess on target organ damage of hypertension...
  44. doi request reprint Cardiovascular effects of prorenin blockade in genetically spontaneously hypertensive rats on normal and high-salt diet
    Dinko Susic
    Hypertension Research Laboratory, Ochsner Clinic Foundation, 1520 Jefferson Hwy, New Orleans, LA 70121, USA
    Am J Physiol Heart Circ Physiol 295:H1117-H1121. 2008
    ....
  45. pmc Medication adherence in older clinic patients with hypertension after Hurricane Katrina: implications for clinical practice and disaster management
    Marie A Krousel-Wood
    Center for Health Research, Ochsner Clinic Foundation, New Orleans, Louisiana, USA
    Am J Med Sci 336:99-104. 2008
    ..In post-disaster situations, additional barriers may reduce antihypertensive medication adherence...
  46. doi request reprint The aging hypertensive heart: a brief update
    Dinko Susic
    Division of Research, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Nat Clin Pract Cardiovasc Med 5:104-10. 2008
    ..In this report we briefly summarize the primary pathophysiology of cardiovascular aging and hypertension and describe the clinical and therapeutic impact that hypertension and aging combined have on the cardiovascular system...
  47. ncbi request reprint The metabolic syndrome: there's little that's new under the sun!
    Edward D Frohlich
    J Cardiometab Syndr 1:293-4. 2006
  48. ncbi request reprint Improvements in clinical outcomes with the use of angiotensin-converting enzyme inhibitors: cross-fertilization between clinical and basic investigation
    Marc A Pfeffer
    Am J Physiol Heart Circ Physiol 291:H2021-5. 2006
    ....
  49. ncbi request reprint Analogy of cardiac and renal complications in essential hypertension and aged SHR or L-NAME/SHR
    Xiaoyan Zhou
    Ochsner Clinic Foundation, 1516 Jefferson Highway, New Orleans, LA 70121, USA
    Med Chem 3:61-5. 2007
    ..The latter hypertensive rat model with induced endothelial dysfunction is recommended enthusiastically for its foregoing as well as time-saving and economic values...
  50. ncbi request reprint Beneficial cardiovascular actions of eplerenone in the spontaneously hypertensive rat
    Dinko Susic
    Hypertension Research Laboratory, Division of Research, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    J Cardiovasc Pharmacol Ther 10:197-203. 2005
    ....
  51. ncbi request reprint Omapatrilat induces profound renal vasodilation but does not affect coronary hemodynamics
    Jasmina Varagic
    Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    J Cardiovasc Pharmacol Ther 8:167-74. 2003
    ..The contribution of endogenous bradykinin on the cardiovascular actions of omapatrilat in this genetic model of hypertension was also investigated...
  52. ncbi request reprint Physiologic evidence of renoprotection by antihypertensive therapy
    Xiaoyan Zhou
    Hypertension Research Laboratories, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Curr Opin Cardiol 20:290-5. 2005
    ..This review summarizes the latest data demonstrating the physiologic evidence of renoprotection by antihypertensive therapy...
  53. ncbi request reprint Long-term left ventricular echocardiographic follow-up of SHR and WKY rats: effects of hypertension and age
    Michel Slama
    Unite de Reanimation, Service de Nephrologie, CHU, Sud Amiens 80054 cedex 1, France
    Am J Physiol Heart Circ Physiol 286:H181-5. 2004
    ..In contrast, relaxation and SF were only slightly altered in old WKY rats, suggesting that pressure-related changes in LV function were the dominant features in the SHR...
  54. ncbi request reprint Ageing, hypertension and the kidney: new data on an old problem
    Xiaoyan Zhou
    Nephrol Dial Transplant 18:1442-5. 2003
  55. ncbi request reprint Renoprotective effects of omapatrilat are mediated partially by bradykinin
    Xiaoyan Zhou
    Hypertension Research Laboratories, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Am J Nephrol 23:214-21. 2003
    ..05). Icatibant partially inhibited these beneficial effects of omapatrilat. CONCLUSION: Omapatrilat provided potent antihypertensive and renoprotective actions, which were mediated, in part, by bradykinin...
  56. ncbi request reprint Treating hypertension - what are we to believe?
    Edward D Frohlich
    N Engl J Med 348:639-41. 2003
  57. ncbi request reprint Edward D. Frohlich, MD. A conversation about hypertension: from bedside to bench and return. Interview by Hector O. Ventura
    Edward D Frohlich
    Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Congest Heart Fail 8:321-30. 2002
  58. ncbi request reprint Local cardiac renin-angiotensin system: hypertension and cardiac failure
    Jasmina Varagic
    Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    J Mol Cell Cardiol 34:1435-42. 2002
    ..This paper reviews evidence that supports the concept that the cardiac RAS participate importantly in the development and risk of HHD...
  59. ncbi request reprint Prevention of hypertension
    Michel Slama
    Hypertension Research Laboratories, Division of Research, Oschner Clinic Foundation, New Orleans, LA 70121, USA
    Curr Opin Cardiol 17:531-6. 2002
    ....
  60. ncbi request reprint High rate of ventricular septal defects in WKY rats
    Michel Slama
    Hypertension Research Laboratories, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Hypertension 40:175-8. 2002
    ....
  61. ncbi request reprint Diastolic dysfunction in hypertension
    Michel Slama
    Hypertension Research Laboratories, Division of Research, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Curr Opin Cardiol 17:368-73. 2002
    ..Furthermore, it has been made clear recently that myocardial ischemia and fibrosis are two important factors associated with diastolic dysfunction in hypertension...
  62. ncbi request reprint Clinical management of the obese hypertensive patient
    Edward D Frohlich
    Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121, USA
    Cardiol Rev 10:127-38. 2002
    ..Each of the lifestyle modifications and seven classes of antihypertensive therapy that is discussed herein is done in light of the coexistent hypertension and comorbid diseases...
  63. ncbi request reprint N- and L-type calcium channel antagonist improves glomerular dynamics, reverses severe nephrosclerosis, and inhibits apoptosis and proliferation in an l-NAME/SHR model
    Xiaoyan Zhou
    Hypertension Research Laboratories, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    J Hypertens 20:993-1000. 2002
    ....
  64. ncbi request reprint Beneficial pleiotropic vascular effects of rosuvastatin in two hypertensive models
    Dinko Susic
    Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    J Am Coll Cardiol 42:1091-7. 2003
    ..The goal of this research was to study the effects of rosuvastatin on systemic and regional hemodynamics in two hypertensive rat models, one genetic, the other induced with inhibition of nitric oxide synthesis...
  65. ncbi request reprint Insulin and insulin resistance: impact on blood pressure and cardiovascular disease
    James R Sowers
    Division of Endocrinology, Diabetes and Hypertension, SUNY Downstate and VAMC, 450 Clarkson Avenue, Box 1205, Brooklyn, NY 11203, USA
    Med Clin North Am 88:63-82. 2004
    ..Additional therapeutic agents are currently being developed specifically to improve INS sensitivity and other CVD risk factors that are components of the cardiometabolic syndrome...
  66. ncbi request reprint Superiority of combination of thiazide with angiotensin-converting enzyme inhibitor or AT1-receptor blocker over thiazide alone on renoprotection in L-NAME/SHR
    Xiaoyan Zhou
    Alton Ochsner Distinguished Scientist, Ochsner Clinic Foundation, 1516 Jefferson Highway, New Orleans, LA 70121, USA
    Am J Physiol Renal Physiol 289:F871-9. 2005
    ....
  67. ncbi request reprint Validation of echocardiographic and Doppler indexes of left ventricular relaxation in adult hypertensive and normotensive rats
    Michel Slama
    Unite de Reanimation, Service de Nephrologie, CHU Sud Amiens 80054 Cedex 1, France
    Am J Physiol Heart Circ Physiol 289:H1131-6. 2005
    ..In conclusion, LV relaxation can be assessed reliably using echocardiographic and Doppler techniques, and, using these indexes, impaired relaxation was demonstrated in SHR...
  68. ncbi request reprint Differential effects of antihypertensive drugs on renal and glomerular hemodynamics and injury in the chronic nitric-oxide-suppressed rat
    Xiaoyan Zhou
    Hypertension Research Laboratories, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Am J Nephrol 25:138-52. 2005
    ....
  69. ncbi request reprint Crosslink breakers: a new approach to cardiovascular therapy
    Dinko Susic
    Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Curr Opin Cardiol 19:336-40. 2004
    ..This review summarizes the latest evidence that breaking collagen crosslinks may be an efficient new therapeutic approach to the adverse cardiovascular and renal consequences of aging and diabetes...
  70. ncbi request reprint Cilnidipine improves spontaneously hypertensive rat coronary hemodynamics without altering cardiovascular mass and collagen
    Jasmina Varagic
    Hypertension Research Laboratory, Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121, USA
    J Hypertens 20:317-22. 2002
    ....
  71. ncbi request reprint Left ventricular hypertrophy: a "factor of risk": mass is reversible, but is the risk?
    Edward D Frohlich
    J Am Coll Cardiol 43:2216-8. 2004
  72. ncbi request reprint Obesity and suppressed B-type natriuretic peptide levels in heart failure
    Mandeep R Mehra
    Department of Cardiovascular Medicine, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    J Am Coll Cardiol 43:1590-5. 2004
    ..This investigation evaluated the relationship between obesity and B-type natriuretic peptide (BNP) in heart failure...
  73. ncbi request reprint Cardiovascular and renal effects of a collagen cross-link breaker (ALT 711) in adult and aged spontaneously hypertensive rats
    Dinko Susic
    Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Am J Hypertens 17:328-33. 2004
    ..This study reports our initial inquires into the cardiovascular and renal effects of a cross-link breaker (ALT-711) in aged spontaneously hypertensive rats (SHR)...
  74. ncbi request reprint Cardiac structural and functional responses to salt loading in SHR
    Jwari Ahn
    Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Am J Physiol Heart Circ Physiol 287:H767-72. 2004
    ..Moreover, the SHR are more susceptible to cardiac damage when high dietary salt is introduced earlier in life...
  75. ncbi request reprint Collagen cross-link breakers: a beginning of a new era in the treatment of cardiovascular changes associated with aging, diabetes, and hypertension
    Dinko Susic
    Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Curr Drug Targets Cardiovasc Haematol Disord 4:97-101. 2004
    ..This report briefly summarizes age related changes in cardiovascular structure and function and describes results of experimental and clinical studies involving collagen cross-link breakers...
  76. ncbi request reprint Aldosterone antagonism ameliorates proteinuria and nephrosclerosis independent of glomerular dynamics in L-NAME/SHR model
    Xiaoyan Zhou
    Hypertension Research Laboratories, Ochsner Clinic Foundation, New Orleans, LA, USA
    Am J Nephrol 24:242-9. 2004
    ....
  77. doi request reprint An appeal for reimbursement for innovative prevention measures in patient cardiovascular education
    Edward D Frohlich
    Nat Clin Pract Cardiovasc Med 5:175. 2008
  78. doi request reprint Excitement of clinical investigation: new basic mechanisms of action after drug introduction
    Edward D Frohlich
    Hypertension 52:465-6. 2008
  79. ncbi request reprint Guidelines on hypertension in 2005: a commentary
    Edward D Frohlich
    Nat Clin Pract Cardiovasc Med 2:269. 2005
  80. ncbi request reprint Echocardiographic measurement of cardiac output in rats
    Michel Slama
    Laboratoire de Pharmacologie et de Physiopathologie Cardiovasculaire, Faculte de Medecine, Université de Picardie Jules Vernes, 80054 Amiens, France
    Am J Physiol Heart Circ Physiol 284:H691-7. 2003
    ..This annulus was demonstrated to remain stable, but pulmonary annulus, thoracic aorta, mitral valve, and left ventricular diameters were found to be more modifiable during volumic changes...