Research Topics
| L BlondeSummaryAffiliation: Ochsner Clinic Foundation Country: USA Publications
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Publications
Current challenges in diabetes managementLawrence Blonde
Ochsner Clinical Research Unit, Section of Endocrinology, Department of Internal Medicine Ochsner Clinic Foundation New Orleans, Louisiana 70115, USA
Clin Cornerstone 7:S6-17. 2005....
Improving care for patients with type 2 diabetes: applying management guidelines and algorithms, and a review of new evidence for incretin agents and lifestyle interventionLawrence Blonde
Ochsner Medical Center, Department of Endocrinology, 1514 Jefferson Hwy, New Orleans, LA, USA
Am J Manag Care 17:S368-76. 2011..In addition, the feasibility of matching patients to appropriate lifestyle intervention, for both diabetes and diabetes prevention, is increasing...
Fixed-dose combinations for treatment of type 2 diabetes mellitusLawrence Blonde
Department of Endocrinology, Diabetes and Metabolic Diseases, Ochsner Medical Center, New Orleans, LA 70121, USA
Adv Ther 29:1-13. 2012..Although several fixed-dose combinations (FDCs) are available, representing standard types of combination therapy in T2DM, use of these products has been limited...
Benefits and risks for intensive glycemic control in patients with diabetes mellitusLawrence Blonde
Department of Endocrinology, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
Am J Med Sci 343:17-20. 2012..Writing groups convened by these organizations have also developed treatment algorithms to help clinicians appropriately use both lifestyle and pharmacotherapy interventions to safely achieve glycemic targets...
Long-term outcomes in patients with type 2 diabetes receiving glimepiride combined with liraglutide or rosiglitazoneSean D Sullivan
Pharmaceutical, Outcomes Research and Policy Program, University of Washington, Seattle, USA
Cardiovasc Diabetol 8:12. 2009..Studies of new diabetes treatments are rarely designed to assess mortality, complication rates and costs. We sought to estimate the long-term consequences of liraglutide and rosiglitazone both added to glimepiride...
What are incretins, and how will they influence the management of type 2 diabetes?Lawrence Blonde
Ochsner Diabeed Clinical Research Unit, Department of Internal Medicine, Ochsner Clinic Foundation, 1514 Jefferson Hwy, New Orleans, LA 70121, USA
J Manag Care Pharm 12:S2-12; quiz S14-6. 2006..Novel incretin-based therapies currently available, and in late-stage development, are among those showing the greatest promise for addressing the unmet needs of traditional therapies...
Current antihyperglycemic treatment guidelines and algorithms for patients with type 2 diabetes mellitusLawrence Blonde
Ochsner Diabetes Clinical Research Unit, Department of Endocrinology, Diabetes and Metabolism, Ochsner Medical Center, New Orleans, Louisiana 70121, USA
Am J Med 123:S12-8. 2010..Virtually all recognize that type 2 diabetes is a multifaceted disease, necessitating an integrated yet individualized approach to patient care...
Reducing cardiovascular disease risk in patients with diabetes: a message from the National Diabetes Education ProgramLawrence Blonde
Ochsner Diabetes Clinical Research Unit, Section on Endocrinology, Diabetes and Metabolic Diseases, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
J Am Acad Nurse Pract 18:524-33. 2006..To provide nurse practitioners (NPs) a review of current practice guidelines that help clinicians' efforts to reduce the morbidity and mortality associated with diabetes and its major macrovascular complications...
Sildenafil citrate for erectile dysfunction in men with diabetes and cardiovascular risk factors: a retrospective analysis of pooled data from placebo-controlled trialsLawrence Blonde
Ochsner Clinic Foundation, New Orleans, LA 70121, USA
Curr Med Res Opin 22:2111-20. 2006..e., hypertension, dyslipidemia, and smoking)...
State of diabetes care in the United StatesLawrence Blonde
Ochsner Diabetes Clinical Research Unit, Ochsner Clinic Foundation, 1514 Jefferson Hwy, New Orleans, LA 70121, USA
Am J Manag Care 13:S36-40. 2007..With the advent of new incretin-related therapies, some of these concerns may be addressed. Diabetes is of growing concern, and better knowledge of treatment options and goals should be a priority for all healthcare professionals...
Easing the transition to insulin therapy in people with type 2 diabetesLawrence Blonde
Diabetes Clinical Research Unit, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
Diabetes Educ 33:232S-240S. 2007
Patient-directed titration for achieving glycaemic goals using a once-daily basal insulin analogue: an assessment of two different fasting plasma glucose targets - the TITRATE studyL Blonde
Ochsner Diabetes Clinical Research Unit, Department of Endocrinology, Diabetes and Metabolic Diseases, Ochsner Medical Center, New Orleans, LA, USA
Diabetes Obes Metab 11:623-31. 2009..9-5.0 mmol/l (70-90 mg/dl)] using a patient-directed, treat-to-target algorithm for once-daily basal insulin in insulin-naïve subjects with type 2 diabetes suboptimally treated with oral antidiabetes drugs (OADs)...
Comparison of vildagliptin and thiazolidinedione as add-on therapy in patients inadequately controlled with metformin: results of the GALIANT trial--a primary care, type 2 diabetes studyL Blonde
Department of Endocrinology, Diabetes and Metabolism, Ochsner Medical Center, New Orleans, LA 70121, USA
Diabetes Obes Metab 11:978-86. 2009..To assess the efficacy and tolerability of vildagliptin compared with thiazolidinediones (TZDs) as an add on to metformin treatment in a primary care patient population with type 2 diabetes...
The safety and efficacy of liraglutide with or without oral antidiabetic drug therapy in type 2 diabetes: an overview of the LEAD 1-5 studiesL Blonde
Ochsner Diabetes Clinical Research Unit, Department of Endocrinology, Ochsner Medical Center, New Orleans, LA, USA
Diabetes Obes Metab 11:26-34. 2009..Liraglutide was associated with a low risk of hypoglycaemia and was generally well tolerated. The majority of adverse effects were gastrointestinal, the most frequent of which was nausea...
Current antihyperglycemic treatment strategies for patients with type 2 diabetes mellitusLawrence Blonde
Ochsner Diabetes Clinical Research Unit, Department of Endocrinology, Diabetes and Metabolism, Ochsner Medical Center, New Orleans, LA 70121, USA
Cleve Clin J Med 76:S4-11. 2009..Both classes have been shown to significantly reduce hyperglycemia. GLP-1 receptor agonists also promote significant weight loss and have potentially beneficial effects on cardiovascular risk markers...
Current evidence regarding the value of self-monitored blood glucose testingLawrence Blonde
Ochsner Diabetes Clinical Research Unit, Section on Endocrinology, Diabetes and Metabolic Diseases, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
Am J Med 118:20S-26S. 2005..Although additional work is needed to establish optimal frequency and timing of SMBG, these studies can serve as a basis for conservative recommendations to guide patients and their healthcare providers...
Defining and measuring quality of diabetes careL Blonde
Department of Internal Medicine, Section on Endocrinology, Ochsner Clinic and Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121, USA
Prim Care 26:841-55. 1999..This article defines the components of quality of diabetes care provision and discusses approaches to their measurement individually and globally...
Glyburide/metformin combination product is safe and efficacious in patients with type 2 diabetes failing sulphonylurea therapyL Blonde
Ochsner Clinic Foundation, New Orleans, LA 70121, USA
Diabetes Obes Metab 4:368-75. 2002..To compare the efficacy, safety and tolerability of a fixed combination glyburide/metformin preparation with those of glyburide or metformin alone in patients with type 2 diabetes inadequately controlled by sulphonylurea, diet and exercise...
Greater reductions in A1C in type 2 diabetic patients new to therapy with glyburide/metformin tablets as compared to glyburide co-administered with metforminL Blonde
Ochsner Clinic Foundation, New Orleans, LA 70121, USA
Diabetes Obes Metab 5:424-31. 2003..A cohort of patients with type 2 diabetes, prescribed glyburide/metformin tablets, experienced significantly greater improvements in glycaemic control compared to patients receiving glyburide co-administered with metformin...
Durable efficacy of metformin/glibenclamide combination tablets (Glucovance) during 52 weeks of open-label treatment in type 2 diabetic patients with hyperglycaemia despite previous sulphonylurea monotherapyL Blonde
Ochsner Clinic Foundation, New Orleans, LA 70121, USA
Int J Clin Pract 58:820-6. 2004..No patient withdrew or required pharmacologic intervention for hypoglycaemia. Metformin-glibenclamide combination tablets are an effective and well-tolerated therapeutic option for intensifying oral anti-diabetic therapy...
Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetesL Blonde
Ochsner Clinic Foundation, New Orleans, LA, USA
Diabetes Obes Metab 8:436-47. 2006....
Comparison of liraglutide versus other incretin-related anti-hyperglycaemic agentsL Blonde
Ochsner Diabetes Clinical Research Unit, Department of Endocrinology, Diabetes and Metabolism, Ochsner Medical Center, New Orleans, LA, USA
Diabetes Obes Metab 14:20-32. 2012..In clinical trials, liraglutide has shown efficacy and tolerability and resulted in certain significant benefits when compared with exenatide and sitagliptin...
Predicted risk of diabetes and coronary heart disease in patients with schizophrenia: aripiprazole versus standard of careLawrence Blonde
Ochsner Clinic Foundation, New Orleans, LA, USA
J Clin Psychiatry 69:741-8. 2008....
The effect of the availability of inhaled insulin on glycaemic control in patients with Type 2 diabetes failing on oral therapy: the evaluation of Exubera as a therapeutic option on insulin initiation and improvement in glycaemic control in clinical practS Del Prato
Ochsner Health System, New Orleans, LO, USA
Diabet Med 25:662-70. 2008..To examine the impact of inhaled human insulin (Exubera, EXU) on patient or physician willingness to adopt insulin after oral glucose-lowering agent failure...
Thiazolidinediones in the treatment of managed care patients with type 2 diabetesRam Pathak
Department of Internal Medicine, Ochsner Clinic Foundation, New Orleans, Louisiana, USA
Am J Manag Care 8:S483-94. 2002..A number of studies have shown that a strategy of aggressive use of pharmacologic agents to achieve glycemic control is associated with cost benefits...
Does home-based exercise improve body mass index in patients with type 2 diabetes? Results of a feasibility trialM A Krousel-Wood
Ochsner Clinic Foundation, Center for Health Research, New Orleans, LA 70121, United States
Diabetes Res Clin Pract 79:230-6. 2008..This feasibility trial evaluated the use, safety, and short-term benefits of a home-based exercise intervention designed to increase physical activity among adults with diabetes...
Internet resources to improve health care for patients with diabetesLawrence Blonde
Ochsner Diabetes Clinical Research Unit, Section on Endocrinology, Diabetes, and Metabolic Diseases, Ochsner Clinic Foundation, New Orleans, Louisiana, USA
Endocr Pract 12:131-7. 2006....
Liraglutide, a once-daily human glucagon-like peptide 1 analogue, provides sustained improvements in glycaemic control and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetesA Garber
Department of Medicine and the Division of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, 1709 Dryden Road, Houston, TX 77030, USA
Diabetes Obes Metab 13:348-56. 2011..Most treatments for type 2 diabetes fail over time, necessitating combination therapy. We investigated the safety, tolerability and efficacy of liraglutide monotherapy compared with glimepiride monotherapy over 2 years...
Case presentation: a patient with type 2 diabetesLawrence Blonde
Department of Endocrinology, Diabetes and Metabolic Diseases, Ochsner Clinic Foundation, New Orleans, LA, USA
Diabetes Educ 33:114S-6S; quiz 117S. 2007
Classification of diabetes mellitusA A Kazi
Department of Ophthalmology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
Clin Lab Med 21:1-13. 2001....
The road ahead in diabetes managementLawrence Blonde
Ochsner Diabetes Clinical Research Unit, Ochsner Clinic Foundation, New Orleans, LA, USA
Am J Manag Care 11:S167-9. 2005
Best practices in diabetes management: getting more patients to goalLawrence Blonde
Ochsner Diabetes Clinical Research Unit, Ochsner Clinic Foundation, New Orleans, LA, USA
Am J Manag Care 11:S186-8. 2005
Gastrointestinal tolerability of extended-release metformin tablets compared to immediate-release metformin tablets: results of a retrospective cohort studyLawrence Blonde
Department of Internal Medicine, Oschner Clinic Foundation, New Orleans, LA, USA
Curr Med Res Opin 20:565-72. 2004..This retrospective chart review examined the overall gastrointestinal (GI) tolerability of both formulations...
Availability of inhaled insulin promotes greater perceived acceptance of insulin therapy in patients with type 2 diabetesNick Freemantle
Department of Primary Care and General Practice, Primary Care Clinical Sciences Building, University of Birmingham Edgbaston, Birmingham B15 2TT UK
Diabetes Care 28:427-8. 2005
The Hurricane Katrina aftermath and its impact on diabetes care: observations from "ground zero": lessons in disaster preparedness of people with diabetesWilliam T Cefalu
Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, Louisiana 70808, USA
Diabetes Care 29:158-60. 2006
Road maps to achieve glycemic control in type 2 diabetes mellitus: ACE/AACE Diabetes Road Map Task ForcePaul S Jellinger
Endocr Pract 13:260-8. 2007
Frequency of blood glucose monitoring in relation to glycemic control in patients with type 2 diabetesLawrence Blonde
Diabetes Care 25:245-6. 2002
Efficacy and safety of inhaled insulin (exubera) compared with subcutaneous insulin therapy in patients with type 2 diabetes: results of a 6-month, randomized, comparative trialPriscilla A Hollander
Baylor University Medical Center, Endocrinology Center, 3600 Gaston Ave, Wadley Tower, Dallas, TX 75246, USA
Diabetes Care 27:2356-62. 2004....
Metabolic issues in patients with severe mental illnessLeslie Citrome
New York University School of Medicine, Department of Psychiatry, and the Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY, USA
South Med J 98:714-20. 2005..Collaborative treatment between a psychiatrist and an endocrinologist is encouraged. The primary care physician may be required to fulfill both roles...
ACE/AACE consensus conference on the implementation of outpatient management of diabetes mellitus: consensus conference recommendationsHarold E Lebovitz
Endocr Pract 12:6-12. 2006
New directions for type 2 diabetes mellitus managementLawrence Blonde
Am J Manag Care 8:S437-40. 2002
Thalidomide-associated hyperglycemia and diabetes: case report and review of literatureRam D Pathak
Diabetes Care 26:1322-3. 2003
Glucose-insulin-potassium infusion and mortality in the CREATE-ECLA trialJayant Dey
JAMA 293:2597-8; author reply 2598. 2005
Adiposopathy: how do diet, exercise and weight loss drug therapies improve metabolic disease in overweight patients?Harold Bays
L MARC Research Center, Medical Director President, 3288 Illinois Avenue, Louisville, KY 40213, USA
Expert Rev Cardiovasc Ther 4:871-95. 2006..This review describes how adiposopathy interventions may affect fat function, and thus improve EFRMD...
