Y Xia

Summary

Affiliation: Oakland University
Country: USA

Publications

  1. ncbi request reprint Averaged and depth-dependent anisotropy of articular cartilage by microscopic imaging
    Yang Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    Semin Arthritis Rheum 37:317-27. 2008
  2. pmc MRI of articular cartilage at microscopic resolution
    Y Xia
    Oakland University, 276 Hannah Hall, Department of Physics, Rochester, Michigan 48309, USA
    Bone Joint Res 2:9-17. 2013
  3. pmc Chemical visualization of individual chondrocytes in articular cartilage by attenuated-total-reflection Fourier Transform Infrared Microimaging
    Jianhua Yin
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
    Biomed Opt Express 2:937-45. 2011
  4. pmc Anisotropic properties of bovine nasal cartilage
    Yang Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    Microsc Res Tech 75:300-6. 2012
  5. doi request reprint Depth-dependent profiles of glycosaminoglycans in articular cartilage by microMRI and histochemistry
    Yang Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
    J Magn Reson Imaging 28:151-7. 2008
  6. pmc Molecular and morphological adaptations in compressed articular cartilage by polarized light microscopy and Fourier-transform infrared imaging
    Y Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
    J Struct Biol 164:88-95. 2008
  7. pmc Reversed laminar appearance of articular cartilage by T1-weighting in 3D fat-suppressed spoiled gradient recalled echo (SPGR) imaging
    Yang Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    J Magn Reson Imaging 32:733-7. 2010
  8. pmc Depth-dependent anisotropies of amides and sugar in perpendicular and parallel sections of articular cartilage by Fourier transform infrared imaging
    Yang Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    Microsc Res Tech 74:122-32. 2011
  9. pmc Strain-dependent T1 relaxation profiles in articular cartilage by MRI at microscopic resolutions
    Yang Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    Magn Reson Med 65:1733-7. 2011
  10. pmc The depth-dependent anisotropy of articular cartilage by Fourier-transform infrared imaging (FTIRI)
    Y Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
    Osteoarthritis Cartilage 15:780-8. 2007

Collaborators

  • P T Callaghan
  • Matthew Szarko
  • Jiani Hu
  • M Lu
  • Quan Jiang
  • Jun Li
  • J R Matyas
  • Shaokuan Zheng
  • Hisham A Alhadlaq
  • Nagarajan Ramakrishnan
  • Aruna Bidthanapally
  • Jianhua Yin
  • S Zheng
  • Janci L Chunn
  • Jonathan B Moody
  • H A Alhadlaq
  • Nick Duvoisin
  • Itamar Ilsar
  • Farid Badar
  • Fay M Hansen
  • George Lust
  • Clifford M Les
  • Jose G Molina
  • Michael R Blackburn
  • Tiejuan Mi
  • Rodney E Kellems
  • J B Moody

Detail Information

Publications39

  1. ncbi request reprint Averaged and depth-dependent anisotropy of articular cartilage by microscopic imaging
    Yang Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    Semin Arthritis Rheum 37:317-27. 2008
    ..The imaging techniques involved include microscopic magnetic resonance imaging (microMRI), polarized light microscopy (PLM), Fourier-transform infrared imaging (FTIRI), and transmission electron microscopy (TEM)...
  2. pmc MRI of articular cartilage at microscopic resolution
    Y Xia
    Oakland University, 276 Hannah Hall, Department of Physics, Rochester, Michigan 48309, USA
    Bone Joint Res 2:9-17. 2013
    ..Rather than an exhaustive review to capture all activities in the literature, the studies cited in this review are merely illustrative...
  3. pmc Chemical visualization of individual chondrocytes in articular cartilage by attenuated-total-reflection Fourier Transform Infrared Microimaging
    Jianhua Yin
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
    Biomed Opt Express 2:937-45. 2011
    ..One can also study the territorial matrix of fine collagen fibrils surrounding the individual chondrocytes by the polarization experiments using the absorption ratio of amide I to amide II bands...
  4. pmc Anisotropic properties of bovine nasal cartilage
    Yang Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    Microsc Res Tech 75:300-6. 2012
    ..Collectively, the results in this project coherently indicate a marked structural anisotropy in cartilage from the nasal septum, where the long axis of the collagen fibrils is oriented in parallel with the medial axis...
  5. doi request reprint Depth-dependent profiles of glycosaminoglycans in articular cartilage by microMRI and histochemistry
    Yang Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
    J Magn Reson Imaging 28:151-7. 2008
    ....
  6. pmc Molecular and morphological adaptations in compressed articular cartilage by polarized light microscopy and Fourier-transform infrared imaging
    Y Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
    J Struct Biol 164:88-95. 2008
    ..These depth-dependent adaptations to static loading in cartilage's morphological structure and chemical distribution could be useful in the future studies of the early diseased cartilage...
  7. pmc Reversed laminar appearance of articular cartilage by T1-weighting in 3D fat-suppressed spoiled gradient recalled echo (SPGR) imaging
    Yang Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    J Magn Reson Imaging 32:733-7. 2010
    ..To investigate the reversed intensity pattern in the laminar appearance of articular cartilage by 3D fat-suppressed spoiled gradient recalled echo (FS-SPGR) imaging in magnetic resonance imaging (MRI)...
  8. pmc Depth-dependent anisotropies of amides and sugar in perpendicular and parallel sections of articular cartilage by Fourier transform infrared imaging
    Yang Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    Microsc Res Tech 74:122-32. 2011
    ..Being sensitive to the orientation of the macromolecular structure in healthy articular cartilage aids the prospect of detecting the early onset of the tissue degradation that may lead to pathological conditions such as osteoarthritis...
  9. pmc Strain-dependent T1 relaxation profiles in articular cartilage by MRI at microscopic resolutions
    Yang Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    Magn Reson Med 65:1733-7. 2011
    ..This finding has potential implications in the use of gadolinium contrast agent in clinical magnetic resonance imaging of cartilage (the dGEMRIC procedure), when the loading or loading history of patients is considered...
  10. pmc The depth-dependent anisotropy of articular cartilage by Fourier-transform infrared imaging (FTIRI)
    Y Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
    Osteoarthritis Cartilage 15:780-8. 2007
    ..To study the anisotropic characteristics of individual histological zones in articular cartilage using Fourier-transform infrared imaging (FTIRI) at 6.25microm pixel resolution...
  11. ncbi request reprint Quantitative in situ correlation between microscopic MRI and polarized light microscopy studies of articular cartilage
    Y Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    Osteoarthritis Cartilage 9:393-406. 2001
    ..7 microm), and based on the same piece of tissue (articular cartilage from canine shoulder joint)...
  12. ncbi request reprint Heterogeneity of cartilage laminae in MR imaging
    Y Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    J Magn Reson Imaging 11:686-93. 2000
    ..The ability to visualize such structural heterogeneity is important because of the direct connection between collagen structure and the mechanical characteristics of cartilage...
  13. ncbi request reprint Orientational dependence of T2 relaxation in articular cartilage: A microscopic MRI (microMRI) study
    Yang Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    Magn Reson Med 48:460-9. 2002
    ..Each has the same peak value of T(2), but the angular dependence of one is shifted in phase by 90 degrees relative to the other by virtue of the fact that each is associated with groups of mutually perpendicular fibrils...
  14. ncbi request reprint Imaging the physical and morphological properties of a multi-zone young articular cartilage at microscopic resolution
    Yang Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    J Magn Reson Imaging 17:365-74. 2003
    ....
  15. ncbi request reprint Magic-angle effect in magnetic resonance imaging of articular cartilage: a review
    Y Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    Invest Radiol 35:602-21. 2000
    ..The laminar appearance is associated with the magic-angle effect in the MR imaging (MRI) of articular cartilage...
  16. ncbi request reprint Characteristics of topographical heterogeneity of articular cartilage over the joint surface of a humeral head
    Y Xia
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    Osteoarthritis Cartilage 10:370-80. 2002
    ..To investigate the topographical variations among the morphological and physical properties of articular cartilage over a canine humeral head...
  17. ncbi request reprint Imaging the velocity profiles in tubeless siphon flow by NMR microscopy
    Y Xia
    Department of Physics, Oakland University, 190 Science and Engineering Building, Rochester, MI 48309, USA
    J Magn Reson 164:365-8. 2003
    ....
  18. ncbi request reprint Quantification of the graphical details of collagen fibrils in transmission electron micrographs
    Y Xia
    Department of Physics, Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
    J Microsc 204:3-16. 2001
    ....
  19. ncbi request reprint Origin of cartilage laminae in MRI
    Y Xia
    Department of Physics, Oakland University, Rochester, MI 48309, USA
    J Magn Reson Imaging 7:887-94. 1997
    ..The results show that the T2 anisotropy provides an indirect but sensitive indicator for the orientation of macromolecular structures in cartilage. The clinical implications of this anisotropy are discussed...
  20. pmc The collagen fibril structure in the superficial zone of articular cartilage by microMRI
    S Zheng
    Department of Physics, Oakland University, Rochester, MI 48309, USA
    Osteoarthritis Cartilage 17:1519-28. 2009
    ..To investigate the fibril architecture of the collagen matrix in the superficial zone (SZ) of articular cartilage non-destructively by microscopic magnetic resonance imaging (microMRI) T(2) anisotropy...
  21. pmc Detecting structural changes in early experimental osteoarthritis of tibial cartilage by microscopic magnetic resonance imaging and polarised light microscopy
    H A Alhadlaq
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
    Ann Rheum Dis 63:709-17. 2004
    ..To detect changes in the collagen fibril network in articular cartilage in a canine experimental model of early osteoarthritis (OA) using microscopic magnetic resonance imaging (microMRI) and polarised light microscopy (PLM)...
  22. ncbi request reprint Morphological changes in articular cartilage due to static compression: polarized light microscopy study
    Hisham A Alhadlaq
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    Connect Tissue Res 48:76-84. 2007
    ..We concluded that this novel compression procedure can be used effectively to study the altered architecture of the collagen matrix in compressed cartilage...
  23. pmc Multi-components of T2 relaxation in ex vivo cartilage and tendon
    Shaokuan Zheng
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
    J Magn Reson 198:188-96. 2009
    ..81-20.52% increase in T2 relaxation in articular cartilage, depending upon the angle at which the tissue specimen was oriented in the magnetic field...
  24. pmc Damages to the extracellular matrix in articular cartilage due to cryopreservation by microscopic magnetic resonance imaging and biochemistry
    Shaokuan Zheng
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
    Magn Reson Imaging 27:648-55. 2009
    ..These imaging results were verified by the biochemical analysis...
  25. doi request reprint Effect of phosphate electrolyte buffer on the dynamics of water in tendon and cartilage
    Shaokuan Zheng
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
    NMR Biomed 22:158-64. 2009
    ....
  26. ncbi request reprint The structural adaptations in compressed articular cartilage by microscopic MRI (microMRI) T(2) anisotropy
    Hisham A Alhadlaq
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
    Osteoarthritis Cartilage 12:887-94. 2004
    ..To detect structural adaptations of collagen fiber matrix in compressed articular cartilage in individual sub-tissue zones by microscopic magnetic resonance imaging (microMRI) at 23 microm in-depth resolution...
  27. ncbi request reprint Determination of zonal boundaries in articular cartilage using infrared dichroism
    Nagarajan Ramakrishnan
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    Appl Spectrosc 61:1404-9. 2007
    ....
  28. ncbi request reprint Modifications of orientational dependence of microscopic magnetic resonance imaging T(2) anisotropy in compressed articular cartilage
    Hisham A Alhadlaq
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    J Magn Reson Imaging 22:665-73. 2005
    ..To investigate the compression-induced changes in the orientational characteristics in T(2) anisotropy of articular cartilage using microscopic magnetic resonance imaging (microMRI)...
  29. ncbi request reprint Polarized IR microscopic imaging of articular cartilage
    Nagarajan Ramakrishnan
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
    Phys Med Biol 52:4601-14. 2007
    ..Cross-polarization experiment indicates the resolution of overlapping peaks of collagen triple helix and/or proteoglycan in articular cartilage...
  30. pmc The impact of the relaxivity definition on the quantitative measurement of glycosaminoglycans in cartilage by the MRI dGEMRIC method
    Shaokuan Zheng
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, Michigan 48309, USA
    Magn Reson Med 63:25-32. 2010
    ....
  31. pmc On the measurement of multi-component T2 relaxation in cartilage by MR spectroscopy and imaging
    Shaokuan Zheng
    Department of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
    Magn Reson Imaging 28:537-45. 2010
    ....
  32. doi request reprint Nanoparticle-reinforced resin-based dental composites
    Yang Xia
    Institute of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing 210029, People s Republic of China
    J Dent 36:450-5. 2008
    ..TiO(2) nanoparticles treated with the organosilane allyltriethoxysilane (ATES) are used to improve the mechanical properties of dental resin-based composites (RBCs, Z100, 3M ESPE)...
  33. ncbi request reprint Analysis of multi-exponential relaxation data with very short components using linear regularization
    Jonathan B Moody
    Department of Physics, Oakland University, 190 Science and Engineering Building, Rochester, MI 48309 4487, USA
    J Magn Reson 167:36-41. 2004
    ....
  34. ncbi request reprint Rapidly growing collagenomas in multiple endocrine neoplasia type I
    Yang Xia
    Department of Dermatology at National Capital Consortium, Walter Reed Army Medical Center, Washington, DC, USA
    J Am Acad Dermatol 56:877-80. 2007
    ..Rapid growth of protuberant collagenomas appears to be unusual in MEN-I, but we suggest that MEN-I be considered in patients with apparent eruptive collagenoma...
  35. ncbi request reprint What is your diagnosis? Aquagenic syringeal acrokeratoderma (ASA)
    Yang Xia
    School of Medicine, Uniform Services University of the Health Sciences, Bethesda, Maryland, USA
    Cutis 78:304, 317-9. 2006
  36. ncbi request reprint Adenosine-dependent pulmonary fibrosis in adenosine deaminase-deficient mice
    Janci L Chunn
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Medical School, Houston, TX 77030, USA
    J Immunol 175:1937-46. 2005
    ..These findings demonstrate that chronic adenosine elevations are associated with pulmonary fibrosis in ADA-deficient mice and suggest that the adenosine functions as a profibrotic signal in the lung...
  37. ncbi request reprint Orientational dependence of trimethyl ammonium signal in human muscles by (1)H magnetic resonance spectroscopic imaging
    Jiani Hu
    Department of Radiology, Wayne State University, Detroit, MI 48201, USA
    Magn Reson Imaging 23:97-104. 2005
    ..62, P<.001). In vivo (1)H MRSI has the potential to simultaneously evaluate the orientation of muscle fibers and biochemical changes induced by a disease process or physiological activity...
  38. ncbi request reprint Significant differences in proton trimethyl ammonium signals between human gastrocnemius and soleus muscle
    Jiani Hu
    Department of Radiology, Wayne State University, Detroit, Michigan, USA
    J Magn Reson Imaging 19:617-22. 2004
    ....
  39. ncbi request reprint Spectral pattern of total creatine and trimethyl ammonium in multiple sclerosis
    Jiani Hu
    Department of Radiology, Wayne State University, Detroit, MI 48201, USA
    Magn Reson Imaging 22:427-9. 2004
    ....

Research Grants11

  1. Adaptability of Articular Cartilage to External Loading by Microscopic Imaging
    Yang Xia; Fiscal Year: 2010
    ..This project aims to detect the early changes in the in situ molecular architecture of diseased cartilage using a set of multidisciplinary microscopic imaging techniques. ..
  2. MICROSCOPIC MRI T2 ANISOTROPY IN ARTICULAR CARTILAGE
    Yang Xia; Fiscal Year: 2001
    ..We can now examine the tissue properties in individual histological zones in cartilage non-invasively and at microscopic resolution, thus contributing to the understanding, and ultimately, prevention of arthritic disease. ..
  3. MICROSCOPIC MRI T2 ANISOTROPY IN ARTICULAR CARTILAGE
    Yang Xia; Fiscal Year: 2002
    ..We can now examine the tissue properties in individual histological zones in cartilage non-invasively and at microscopic resolution, thus contributing to the understanding, and ultimately, prevention of arthritic disease. ..
  4. MICROSCOPIC MRI T2 ANISOTROPY IN ARTICULAR CARTILAGE
    Yang Xia; Fiscal Year: 2003
    ..We can now examine the tissue properties in individual histological zones in cartilage non-invasively and at microscopic resolution, thus contributing to the understanding, and ultimately, prevention of arthritic disease. ..
  5. Quantitative molecular imaging in articular cartilage
    Yang Xia; Fiscal Year: 2006
    ....
  6. Adaptability of Articular Cartilage to External Loading by Microscopic Imaging
    Yang Xia; Fiscal Year: 2009
    ..This project aims to detect the early changes in the in situ molecular architecture of diseased cartilage using a set of multidisciplinary microscopic imaging techniques. ..
  7. Quantitative molecular imaging in articular cartilage
    Yang Xia; Fiscal Year: 2009
    ....
  8. Quantitative molecular imaging in articular cartilage
    Yang Xia; Fiscal Year: 2007
    ....
  9. MICROSCOPIC MRI T2 ANISOTROPY IN ARTICULAR CARTILAGE
    Yang Xia; Fiscal Year: 2000
    ..We can now examine the tissue properties in individual histological zones in cartilage non-invasively and at microscopic resolution, thus contributing to the understanding, and ultimately, prevention of arthritic disease. ..