B S Shastry

Summary

Affiliation: Oakland University
Country: USA

Publications

  1. ncbi request reprint Pharmacogenomics in ophthalmology
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Discov Med 12:159-67. 2011
  2. ncbi request reprint Genetic susceptibility to primary angle closure glaucoma (PACG)
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Discov Med 15:17-22. 2013
  3. ncbi request reprint Lack of association of the VEGF gene promoter (-634 G-->C and -460 C-->T) polymorphism and the risk of advanced retinopathy of prematurity
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI, USA
    Graefes Arch Clin Exp Ophthalmol 245:741-3. 2007
  4. ncbi request reprint Neurodegenerative disorders of protein aggregation
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Neurochem Int 43:1-7. 2003
  5. ncbi request reprint Further support for the common variants in complement factor H (Y402H) and LOC387715 (A69S) genes as major risk factors for the exudative age-related macular degeneration
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309 4401, USA
    Ophthalmologica 220:291-5. 2006
  6. ncbi request reprint Molecular genetics of autism spectrum disorders
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 48:495-501. 2003
  7. ncbi request reprint Cosegregation of two unlinked mutant alleles in some cases of autosomal dominant familial exudative vitreoretinopathy
    B S Shastry
    Department of Biological Sciences, Oakland University Rochester, MI 48309, USA
    Eur J Hum Genet 12:79-82. 2004
  8. ncbi request reprint Overproduction and partial purification of the Norrie disease gene product, norrin, from a recombinant baculovirus
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Biochem Biophys Res Commun 312:229-34. 2003
  9. ncbi request reprint Molecular genetics of attention-deficit hyperactivity disorder (ADHD): an update
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Neurochem Int 44:469-74. 2004
  10. ncbi request reprint Developmental dyslexia: an update
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 52:104-9. 2007

Collaborators

  • J Fielding Hejtmancik
  • Michael R Hayden
  • Mark E Samuels
  • M Hiraoka
  • M T Trese
  • Xiaodong Jiao
  • Sarah Kleinberg
  • Michael T Trese
  • Johane Robitaille
  • Valerio Ventruto
  • Scott Garrant
  • Terri Tillen
  • Roshni R Singaraja
  • Ajamete Kaykas
  • Jutta Zeisler
  • Lin Hua Zhang
  • Marie Pierre Dube
  • Randall T Moon
  • Ann Hoskin-Mott
  • Duane L Guernsey
  • Simon N Pimstone
  • Laird C Sheldahl
  • Marcia L E MacDonald
  • Lee F Siebert
  • Y Paul Goldberg
  • Binyou Zheng
  • F Rossi
  • D M Berinstein

Detail Information

Publications42

  1. ncbi request reprint Pharmacogenomics in ophthalmology
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Discov Med 12:159-67. 2011
    ..In this article an attempt has been made to summarize some of the recent small-scale pharmacogenetic studies on two major eye disorders, age-related macular degeneration (AMD) and glaucoma...
  2. ncbi request reprint Genetic susceptibility to primary angle closure glaucoma (PACG)
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Discov Med 15:17-22. 2013
    ..This article summarizes the current status of genetic investigations on PACG which is the most common cause of blindness worldwide...
  3. ncbi request reprint Lack of association of the VEGF gene promoter (-634 G-->C and -460 C-->T) polymorphism and the risk of advanced retinopathy of prematurity
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI, USA
    Graefes Arch Clin Exp Ophthalmol 245:741-3. 2007
    ..In order to evaluate its general applicability as a screening procedure in clinics and to replicate the above result, we have undertaken the following study...
  4. ncbi request reprint Neurodegenerative disorders of protein aggregation
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Neurochem Int 43:1-7. 2003
    ....
  5. ncbi request reprint Further support for the common variants in complement factor H (Y402H) and LOC387715 (A69S) genes as major risk factors for the exudative age-related macular degeneration
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309 4401, USA
    Ophthalmologica 220:291-5. 2006
    ..These results further support the notion that CFH and LOC387715 genes are the major risk factors for ARMD...
  6. ncbi request reprint Molecular genetics of autism spectrum disorders
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 48:495-501. 2003
    ..These may alleviate some behavioral problems. The identification of autism genes, an understanding of the neurobiology of the condition, and additional clinical studies may help to develop pharmacological interventions in the future...
  7. ncbi request reprint Cosegregation of two unlinked mutant alleles in some cases of autosomal dominant familial exudative vitreoretinopathy
    B S Shastry
    Department of Biological Sciences, Oakland University Rochester, MI 48309, USA
    Eur J Hum Genet 12:79-82. 2004
    ....
  8. ncbi request reprint Overproduction and partial purification of the Norrie disease gene product, norrin, from a recombinant baculovirus
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Biochem Biophys Res Commun 312:229-34. 2003
    ..The protein was partially purified by the process of immobilized metal affinity chromatography and the use of ion exchange chromatography..
  9. ncbi request reprint Molecular genetics of attention-deficit hyperactivity disorder (ADHD): an update
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Neurochem Int 44:469-74. 2004
    ..This may lead to an effective new treatment strategy...
  10. ncbi request reprint Developmental dyslexia: an update
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 52:104-9. 2007
    ..Interestingly, in spite of genetic heterogeneity, the pathology appears to involve common phonological coding deficits. The condition can be managed by a highly structured educational training exercise...
  11. ncbi request reprint Evaluation of the ABCR and glutathione peroxidase-3 genes in familial and sporadic cases of exudative age-related macular degeneration
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Int J Mol Med 14:753-7. 2004
    ..However, it may be associated with other additive factors as might be expected for a complex disorder...
  12. ncbi request reprint Bipolar disorder: an update
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, 316 DHE, Rochester, MI 48309, USA
    Neurochem Int 46:273-9. 2005
    ..Identification of risk genes in the future may provide a better understanding of the nature of pathogenesis that may lead to a better therapeutic target...
  13. ncbi request reprint Genetic diversity and new therapeutic concepts
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 50:321-8. 2005
    ..Despite these limitations, translation of pharmacogenomic data into clinical practice would certainly provide better opportunities to increase the safety and efficacy of medicine in the future...
  14. ncbi request reprint SNPs in disease gene mapping, medicinal drug development and evolution
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI, USA
    J Hum Genet 52:871-80. 2007
    ..Therefore, it is possible that disease-associated SNPs (or pathology) and evolution can be related to one another...
  15. ncbi request reprint Assessment of the contribution of the LOC387715 gene polymorphism in a family with exudative age-related macular degeneration and heterozygous CFH variant (Y402H)
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI, USA
    J Hum Genet 52:384-7. 2007
    ..Further studies on these and other susceptibility genes may provide clues on variable phenotypes, new preventive strategies and treatment options for AMD...
  16. ncbi request reprint Assessment of the contribution of insulin-like growth factor I receptor 3174 G-->A polymorphism to the progression of advanced retinopathy of prematurity
    B S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Eur J Ophthalmol 17:950-3. 2007
    ....
  17. doi request reprint Copy number variation and susceptibility to human disorders (Review)
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI, USA
    Mol Med Report 2:143-7. 2009
    ....
  18. doi request reprint Genetic diversity and medicinal drug response in eye care
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI, USA
    Graefes Arch Clin Exp Ophthalmol 248:1057-61. 2010
    ..Much has been published in the literature in recent years about the potential of pharmacogenetic testing and individualized medicine. The development of personalized medicine is truly an exciting area of research...
  19. doi request reprint Common polymorphisms of the CFH, LOC 387715/ARMS2 and HTRA1 genes may not influence the intra-familial variability of X-linked juvenile retinoschisis
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Mol Med Report 3:469-71. 2010
    ....
  20. pmc Genetic susceptibility to advanced retinopathy of prematurity (ROP)
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI, USA
    J Biomed Sci 17:69. 2010
    ..Future studies involving genomics, bioinformatics and proteomics may provide a better understanding of the pathophysiology and management of ROP...
  21. doi request reprint Persistent hyperplastic primary vitreous: congenital malformation of the eye
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Clin Experiment Ophthalmol 37:884-90. 2009
    ..Identification of other candidate genes in the future may provide a better understanding of the pathogenesis of the condition that may lead to a better therapeutic approach and better management...
  22. ncbi request reprint Evaluation of the common variants of the ABCA4 gene in families with Stargardt disease and autosomal recessive retinitis pigmentosa
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Int J Mol Med 21:715-20. 2008
    ....
  23. ncbi request reprint Pharmacogenetics and the concept of individualized medicine
    B S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Pharmacogenomics J 6:16-21. 2006
    ..If it becomes a reality, it delivers benefits to improve public health and allow genetically subgroup diseases thereby avoiding adverse drug reactions (by knowing in advance who should be treated with what drug and how)...
  24. ncbi request reprint Evaluation of RP2 and RP3 genes in an X-linked RP family manifesting loss of central vision and preserved peripheral function
    M Hiraoka
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 46:241-3. 2001
    ..Further identification of the X-linked genes may facilitate the elucidation of the molecular basis of the disorder in the family analyzed...
  25. ncbi request reprint Identification of novel missense mutations in the Norrie disease gene associated with one X-linked and four sporadic cases of familial exudative vitreoretinopathy
    B S Shastry
    Eye Research Institute, Oakland University, Rochester, Michigan 48309 4401, USA
    Hum Mutat 9:396-401. 1997
    ..It also demonstrates that it may be beneficial for clinical diagnosis to screen for mutations in the Norrie disease gene in sporadic FEVR cases...
  26. ncbi request reprint Recurrent missense (R197C) and nonsense (Y89X) mutations in the XLRS1 gene in families with X-linked retinoschisis
    B S Shastry
    Eye Research Institute, Oakland University, Rochester, Michigan 48309 4410, USA
    Biochem Biophys Res Commun 256:317-9. 1999
    ..These mutations, which are transmitted through three generations, cosegregated with the disease, and are not found in the unaffected family members and 150 normal X-chromosomes, are likely to be pathogenic in these families...
  27. ncbi request reprint Insertion and deletion mutations in the dinucleotide repeat region of the Norrie disease gene in patients with advanced retinopathy of prematurity
    M Hiraoka
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 46:178-81. 2001
    ..Although the ND gene is not frequently involved in advanced ROP, the present large-scale study further supports the hypothesis that genetic influences may play an important role in the development of severe ROP in some premature infants...
  28. ncbi request reprint Factor V Leiden mutation (R506Q) and the risk of advanced retinopathy of prematurity
    Sarah Kleinberg
    Department of Biological Sciences, Oakland University, Rochester, MI 48309 4401, USA
    Int J Mol Med 12:469-72. 2003
    ..4%). Therefore, statistically factor V mutation on its own is not a major risk factor for the above two disorders. However, it may be associated with other additive factors as might be expected for a complex genetic trait...
  29. ncbi request reprint X-linked juvenile retinoschisis: mutations at the retinoschisis and Norrie disease gene loci?
    M Hiraoka
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 46:53-6. 2001
    ..If this proves to be a widespread problem, it will complicate the strategies used to identify the genes involved in diseases and to develop methods for intervention...
  30. ncbi request reprint Molecular and cell biological aspects of Alzheimer disease
    B S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 46:609-18. 2001
    ..Although we are still lacking the molecular basis and order of events involved in the disease process, the future for AD research, as well as for AD patients, is more promising than ever before...
  31. doi request reprint SNPs: impact on gene function and phenotype
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI, USA
    Methods Mol Biol 578:3-22. 2009
    ....
  32. ncbi request reprint Molecular genetics of Rett syndrome
    B S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Neurochem Int 38:503-8. 2001
    ..Since the encoded protein was previously shown to be a global transcriptional repressor, undesired expression of yet unidentified genes that are normally repressed is considered to be pathogenic in Rett syndrome...
  33. ncbi request reprint Parkinson disease: etiology, pathogenesis and future of gene therapy
    B S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Neurosci Res 41:5-12. 2001
    ....
  34. ncbi request reprint SNP alleles in human disease and evolution
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 47:561-6. 2002
    ..Nevertheless, these variants may provide a starting point for further inquiry...
  35. ncbi request reprint SNPs and haplotypes: genetic markers for disease and drug response (review)
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Int J Mol Med 11:379-82. 2003
    ..This newly developed toxicogenomic or pharmacogenomic field is rapidly advancing and may change the practice of medicine in the future, providing personalized medicine for each individual...
  36. ncbi request reprint Recent progress in the genetics of incontinentia pigmenti (Bloch-Sulzberger syndrome)
    B S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 45:323-6. 2000
    ..These maps could be invaluable tools in the identification of genes in the near future...
  37. ncbi request reprint Linkage and candidate gene analysis of X-linked familial exudative vitreoretinopathy
    B S Shastry
    Eye Research Institute, Oakland University, Rochester, Michigan 48309, USA
    Genomics 27:341-4. 1995
    ..Additionally, a polymorphic missense mutation (H127R) was detected in a severely affected patient...
  38. ncbi request reprint Therapeutic options for Parkinson's disease
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, Michigan 48309, USA
    Drugs Today (Barc) 38:445-51. 2002
    ..This understanding may lead to predicting drug response and ultimately to developing preventive medicine at the individual level in the future...
  39. ncbi request reprint Schizophrenia: a genetic perspective (review)
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Int J Mol Med 9:207-12. 2002
    ..Meanwhile, treatment with newly developed anti-psychotic drugs combined with educational and cognitive rehabilitation procedure may help the patients to cope with the illness...
  40. ncbi request reprint Ophthalmic genetics: complexity in paediatric vitreoretinopathies
    Barkur S Shastry
    Clin Experiment Ophthalmol 34:633-4. 2006
  41. ncbi request reprint Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy
    Johane Robitaille
    Department of Ophthalmology, Izaak Walton Killam IWK Health Centre, Dalhousie University, Halifax, Nova Scotia B3H 2Y9, Canada
    Nat Genet 32:326-30. 2002
    ..In one of the mutants, altered subcellular trafficking led to defective signaling. These findings support a function for frizzled-4 in retinal angiogenesis and establish the first association between a Wnt receptor and human disease...
  42. pmc Autosomal recessive familial exudative vitreoretinopathy is associated with mutations in LRP5
    Xiaodong Jiao
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 75:878-84. 2004
    ..Sequencing of LRP5 shows, in all three families, homozygous mutations R570Q, R752G, and E1367K. This suggests that mutations in this gene can cause autosomal recessive as well as autosomal dominant FEVR...