Chhabi K Govind

Summary

Affiliation: Oakland University
Country: USA

Publications

  1. ncbi request reprint Gcn5 promotes acetylation, eviction, and methylation of nucleosomes in transcribed coding regions
    Chhabi K Govind
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Mol Cell 25:31-42. 2007
  2. pmc Phosphorylated Pol II CTD recruits multiple HDACs, including Rpd3C(S), for methylation-dependent deacetylation of ORF nucleosomes
    Chhabi K Govind
    Laboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Mol Cell 39:234-46. 2010
  3. pmc Measuring dynamic changes in histone modifications and nucleosome density during activated transcription in budding yeast
    Chhabi K Govind
    Department of Biological Sciences, Oakland University, Rochester, MI, USA
    Methods Mol Biol 833:15-27. 2012
  4. pmc Simultaneous recruitment of coactivators by Gcn4p stimulates multiple steps of transcription in vivo
    Chhabi K Govind
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Mol Cell Biol 25:5626-38. 2005
  5. pmc Activator Gcn4p and Cyc8p/Tup1p are interdependent for promoter occupancy at ARG1 in vivo
    Soon ja Kim
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Mol Cell Biol 25:11171-83. 2005
  6. pmc NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5
    Daniel S Ginsburg
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Mol Cell Biol 29:6473-87. 2009
  7. pmc Recruitment of the ArgR/Mcm1p repressor is stimulated by the activator Gcn4p: a self-checking activation mechanism
    Sungpil Yoon
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:11713-8. 2004

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Gcn5 promotes acetylation, eviction, and methylation of nucleosomes in transcribed coding regions
    Chhabi K Govind
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Mol Cell 25:31-42. 2007
    ..Gcn5p also enhances H3-K4 trimethylation in the ARG1 ORF and bulk histones. Thus, Gcn5p, most likely in SAGA, stimulates modification and eviction of nucleosomes in transcribed coding sequences and promotes Pol II elongation...
  2. pmc Phosphorylated Pol II CTD recruits multiple HDACs, including Rpd3C(S), for methylation-dependent deacetylation of ORF nucleosomes
    Chhabi K Govind
    Laboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Mol Cell 39:234-46. 2010
    ..A strong correlation between increased acetylation and lower histone occupancy in HDA mutants implies that histone acetylation is important for nucleosome eviction...
  3. pmc Measuring dynamic changes in histone modifications and nucleosome density during activated transcription in budding yeast
    Chhabi K Govind
    Department of Biological Sciences, Oakland University, Rochester, MI, USA
    Methods Mol Biol 833:15-27. 2012
    ..In this paper, we describe a detailed methodology to determine changes in histone modifications in budding yeast that takes into account reductions in nucleosome...
  4. pmc Simultaneous recruitment of coactivators by Gcn4p stimulates multiple steps of transcription in vivo
    Chhabi K Govind
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Mol Cell Biol 25:5626-38. 2005
    ..Our findings reveal a program of coactivator recruitment and PIC assembly that distinguishes Gcn4p from other yeast activators studied thus far...
  5. pmc Activator Gcn4p and Cyc8p/Tup1p are interdependent for promoter occupancy at ARG1 in vivo
    Soon ja Kim
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Mol Cell Biol 25:11171-83. 2005
    ..Our findings reveal a novel coactivator function for Cyc8p/Tup1p at the level of activator binding and suggest that Gcn4p may enhance its own binding to the UAS by recruiting Cyc8p/Tup1p...
  6. pmc NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5
    Daniel S Ginsburg
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Mol Cell Biol 29:6473-87. 2009
    ..Our findings delineate a pathway for acetylation-mediated nucleosome remodeling and eviction in coding sequences that stimulates transcription elongation by Pol II in vivo...
  7. pmc Recruitment of the ArgR/Mcm1p repressor is stimulated by the activator Gcn4p: a self-checking activation mechanism
    Sungpil Yoon
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:11713-8. 2004
    ..By recruiting an arginine-regulated repressor, Gcn4p can precisely modulate its activation function at ARG1 according to the availability of arginine...