Mark Frederick McCarty


Affiliation: NutriGuard Research
Country: USA


  1. McCarty M. AMPK activation as a strategy for reversing the endothelial lipotoxicity underlying the increased vascular risk associated with insulin resistance syndrome. Med Hypotheses. 2005;64:1211-5 pubmed
    ..More generally, metformin - or, preferably, better tolerated activators of AMPK - may have considerable potential for promoting vascular health in the large proportion of the adult population afflicted with insulin resistance syndrome. ..
  2. McCarty M, Block K. Toward a core nutraceutical program for cancer management. Integr Cancer Ther. 2006;5:150-71 pubmed
    ..It would be of interest to test this program in nude mouse xenograft models...
  3. McCarty M. Dietary saturate/unsaturate ratio as a determinant of adiposity. Med Hypotheses. 2010;75:14-6 pubmed publisher
  4. McCarty M. Poor vitamin D status may contribute to high risk for insulin resistance, obesity, and cardiovascular disease in Asian Indians. Med Hypotheses. 2009;72:647-51 pubmed publisher
  5. McCarty M. Rationale for a novel nutraceutical complex 'K-water': potassium taurine bicarbonate (PTB). Med Hypotheses. 2006;67:65-70 pubmed
  6. McCarty M. Practical prevention of cardiac remodeling and atrial fibrillation with full-spectrum antioxidant therapy and ancillary strategies. Med Hypotheses. 2010;75:141-7 pubmed publisher
  7. McCarty M. Does bitter melon contain an activator of AMP-activated kinase?. Med Hypotheses. 2004;63:340-3 pubmed
  8. McCarty M. A taurine-supplemented vegan diet may blunt the contribution of neutrophil activation to acute coronary events. Med Hypotheses. 2004;63:419-25 pubmed
    ..Moderate alcohol consumption, the well-tolerated drug pentoxifylline, and 5-lipoxygenase inhibitors--zileuton, boswellic acids, fish oil--may also have potential in this regard. ..
  9. McCarty M. Potential utility of natural polyphenols for reversing fat-induced insulin resistance. Med Hypotheses. 2005;64:628-35 pubmed

More Information


  1. McCarty M. Induction of heat shock proteins may combat insulin resistance. Med Hypotheses. 2006;66:527-34 pubmed
    ..The possible complementarity of bimoclomol and lipoic acid for heat shock protein induction should be assessed, and further efforts to identify well-tolerated agents active in this regard are warranted. ..
  2. McCarty M, Barroso Aranda J, Contreras F. Practical strategies for suppressing hypoxia-inducible factor activity in cancer therapy. Med Hypotheses. 2010;74:789-97 pubmed publisher
    ..Comprehensive strategies for suppressing HIF-1 activity can be expected to complement the efficacy of cancer chemotherapy and of effective anti-angiogenic regimens. ..
  3. McCarty M, Barroso Aranda J, Contreras F. Oxidative stress therapy for solid tumors - a proposal. Med Hypotheses. 2010;74:1052-4 pubmed publisher
    ..Cell culture studies could be employed to devise effective protocols that could be tested in xenografted rodents and, ultimately, in exploratory clinical trials. ..
  4. McCarty M. Up-regulation of PPARgamma coactivator-1alpha as a strategy for preventing and reversing insulin resistance and obesity. Med Hypotheses. 2005;64:399-407 pubmed
    ..Phytanic acid, a branched-chain fatty acid found in omnivore diets, can also activate PPARdelta, and thus should be examined with respect to its impact on mitochondrial biogenesis and insulin sensitivity. ..
  5. McCarty M. A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk. Med Hypotheses. 2005;64:848-53 pubmed
  6. McCarty M. Hyperinsulinemia may boost both hematocrit and iron absorption by up-regulating activity of hypoxia-inducible factor-1alpha. Med Hypotheses. 2003;61:567-73 pubmed
    ..People who are insulin resistant can minimize any health risk associated with iron overload by avoiding heme-rich flesh foods and donating blood regularly. ..
  7. McCarty M, Barroso Aranda J, Contreras F. The "rejuvenatory" impact of lipoic acid on mitochondrial function in aging rats may reflect induction and activation of PPAR-gamma coactivator-1alpha. Med Hypotheses. 2009;72:29-33 pubmed publisher
    ..g. glutathione and heme oxygenase-1), but also induction of various proteins that function expressly to protect mitochondria from self-generated oxidant stress. Further research is required to evaluate this model. ..