Mark Frederick McCarty

Summary

Affiliation: NutriGuard Research
Country: USA

Publications

  1. ncbi AMPK activation as a strategy for reversing the endothelial lipotoxicity underlying the increased vascular risk associated with insulin resistance syndrome
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:1211-5. 2005
  2. ncbi Toward a core nutraceutical program for cancer management
    Mark F McCarty
    Block Center for Integrative Cancer Care, Evanston, IL 60201, USA
    Integr Cancer Ther 5:150-71. 2006
  3. doi Dietary saturate/unsaturate ratio as a determinant of adiposity
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States
    Med Hypotheses 75:14-6. 2010
  4. ncbi Gamma-tocopherol may promote effective no synthase function by protecting tetrahydrobiopterin from peroxynitrite
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States
    Med Hypotheses 69:1367-70. 2007
  5. ncbi ''Iatrogenic Gilbert syndrome''--a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin
    Mark F McCarty
    Oasis of Hope Hospital, Tijuana, Mexico
    Med Hypotheses 69:974-94. 2007
  6. ncbi PPAR gamma agonists can be expected to potentiate the efficacy of metronomic chemotherapy through CD36 up-regulation
    Mark F McCarty
    Oasis of Hope Hospital, Tijuana, Mexico
    Med Hypotheses 70:419-23. 2008
  7. ncbi A two-phase strategy for treatment of oxidant-dependent cancers
    Mark F McCarty
    Oasis of Hope Hospital, Tijuana, Mexico
    Med Hypotheses 69:489-96. 2007
  8. ncbi Exenatide and biotin in conjunction with a protein-sparing fast for normalization of beta cell function in type 2 diabetics
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Dr, San Marcos, CA 92078, USA
    Med Hypotheses 69:928-32. 2007
  9. ncbi Oster rediscovered--mega-dose folate for symptomatic atherosclerosis
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, United States
    Med Hypotheses 69:325-32. 2007
  10. ncbi Neuroprotective potential of the Bahadori leanness program: a "mini-fast with exercise" strategy
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Dr, San Marcos, CA 92078, United States
    Med Hypotheses 68:935-40. 2007

Collaborators

Detail Information

Publications75

  1. ncbi AMPK activation as a strategy for reversing the endothelial lipotoxicity underlying the increased vascular risk associated with insulin resistance syndrome
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:1211-5. 2005
    ..More generally, metformin - or, preferably, better tolerated activators of AMPK - may have considerable potential for promoting vascular health in the large proportion of the adult population afflicted with insulin resistance syndrome...
  2. ncbi Toward a core nutraceutical program for cancer management
    Mark F McCarty
    Block Center for Integrative Cancer Care, Evanston, IL 60201, USA
    Integr Cancer Ther 5:150-71. 2006
    ..It would be of interest to test this program in nude mouse xenograft models...
  3. doi Dietary saturate/unsaturate ratio as a determinant of adiposity
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States
    Med Hypotheses 75:14-6. 2010
    ....
  4. ncbi Gamma-tocopherol may promote effective no synthase function by protecting tetrahydrobiopterin from peroxynitrite
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States
    Med Hypotheses 69:1367-70. 2007
    ..The impact of supplemental gamma-tocopherol on compromised endothelium-dependent vasodilation in various disorders merits examination...
  5. ncbi ''Iatrogenic Gilbert syndrome''--a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin
    Mark F McCarty
    Oasis of Hope Hospital, Tijuana, Mexico
    Med Hypotheses 69:974-94. 2007
    ..Phycobilins, algal biliverdin metabolites that are good substrates for biliverdin reductase, may prove to have clinical antioxidant potential comparable to that of bilirubin...
  6. ncbi PPAR gamma agonists can be expected to potentiate the efficacy of metronomic chemotherapy through CD36 up-regulation
    Mark F McCarty
    Oasis of Hope Hospital, Tijuana, Mexico
    Med Hypotheses 70:419-23. 2008
    ....
  7. ncbi A two-phase strategy for treatment of oxidant-dependent cancers
    Mark F McCarty
    Oasis of Hope Hospital, Tijuana, Mexico
    Med Hypotheses 69:489-96. 2007
    ....
  8. ncbi Exenatide and biotin in conjunction with a protein-sparing fast for normalization of beta cell function in type 2 diabetics
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Dr, San Marcos, CA 92078, USA
    Med Hypotheses 69:928-32. 2007
    ....
  9. ncbi Oster rediscovered--mega-dose folate for symptomatic atherosclerosis
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, United States
    Med Hypotheses 69:325-32. 2007
    ..In light of these new findings, a properly controlled assessment of Oster's mega-dose folate therapy is warranted...
  10. ncbi Neuroprotective potential of the Bahadori leanness program: a "mini-fast with exercise" strategy
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Dr, San Marcos, CA 92078, United States
    Med Hypotheses 68:935-40. 2007
    ..Thus, it is conceivable that BLP will provide a range of health benefits extending beyond those attributable to its favorable impact on body composition...
  11. ncbi Rationale for a novel nutraceutical complex 'K-water': potassium taurine bicarbonate (PTB)
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Dr, San Marcos, CA 92078, United States
    Med Hypotheses 67:65-70. 2006
    ....
  12. ncbi Isoflavones made simple - genistein's agonist activity for the beta-type estrogen receptor mediates their health benefits
    Mark Frederick McCarty
    Natural Alternatives International, San Marcos, CA 92078, USA
    Med Hypotheses 66:1093-114. 2006
    ....
  13. ncbi Down-regulation of microglial activation may represent a practical strategy for combating neurodegenerative disorders
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Dr, San Marcos, CA 92078, USA
    Med Hypotheses 67:251-69. 2006
    ..To achieve optimal clinical outcomes, regimens which down-regulate microglial activation could be used in conjunction with complementary measures which address other aspects of excitotoxicity...
  14. ncbi Induction of heat shock proteins may combat insulin resistance
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Dr, San Marcos, CA 92078, USA
    Med Hypotheses 66:527-34. 2006
    ..The possible complementarity of bimoclomol and lipoic acid for heat shock protein induction should be assessed, and further efforts to identify well-tolerated agents active in this regard are warranted...
  15. ncbi PKC-mediated modulation of L-type calcium channels may contribute to fat-induced insulin resistance
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Dr, San Marcos, CA 92078, USA
    Med Hypotheses 66:824-31. 2006
    ..A report that chromium picolinate can induce the plasmalemmal Ca2+-ATPase in smooth muscle cells, raises the possibility that modulation of calcium transport might play a role in the insulin-sensitizing efficacy of bioactive chromium...
  16. ncbi Multifocal angiostatic therapy: an update
    Mark F McCarty
    Block Center for Integrative Cancer Care, Evanston, Illinois 60201, USA
    Integr Cancer Ther 4:301-14. 2005
    ..The potential complementary of the components of MAT should be assessed in nude mouse xenograft models...
  17. ncbi Chromium picolinate may favorably influence the vascular risk associated with smoking by combating cortisol-induced insulin resistance
    Mark F McCarty
    NutriGuard Research, 1054 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:1220-4. 2005
    ..The impact of chromium picolinate on smoking- or nicotine-induced insulin resistance merits study...
  18. ncbi Scavenging of peroxynitrite-derived radicals by flavonoids may support endothelial NO synthase activity, contributing to the vascular protection associated with high fruit and vegetable intakes
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Dr, San Marcos, CA 92078, United States
    Med Hypotheses 70:170-81. 2008
    ....
  19. ncbi Clinical potential of Spirulina as a source of phycocyanobilin
    Mark F McCarty
    NutriGuard Research, Encinitas, CA 92024, USA
    J Med Food 10:566-70. 2007
    ..Such a regimen should be evaluated in clinical syndromes characterized and in part mediated by NADPH oxidase overactivity in affected tissues...
  20. doi Genistein and phycocyanobilin may prevent hepatic fibrosis by suppressing proliferation and activation of hepatic stellate cells
    Mark F McCarty
    Oasis of Hope Hospital, Tijuana, Mexico
    Med Hypotheses 72:330-2. 2009
    ..Joint administration of soy isoflavones and PCB in appropriate doses might have considerable potential for prevention of hepatic fibrosis in at-risk subjects...
  21. doi Practical strategies for suppressing hypoxia-inducible factor activity in cancer therapy
    Mark F McCarty
    Oasis of Hope Hospital, Paseo Playas 19, Playas de Tijuana, Tijuana, B C, Mexico
    Med Hypotheses 74:789-97. 2010
    ..Comprehensive strategies for suppressing HIF-1 activity can be expected to complement the efficacy of cancer chemotherapy and of effective anti-angiogenic regimens...
  22. doi Oxidative stress therapy for solid tumors - a proposal
    Mark F McCarty
    Oasis of Hope Hospital, Playas de Tijuana, Tijuana, B C 22504, Mexico
    Med Hypotheses 74:1052-4. 2010
    ..Cell culture studies could be employed to devise effective protocols that could be tested in xenografted rodents and, ultimately, in exploratory clinical trials...
  23. doi Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease
    Mark F McCarty
    NutriGuard Research, Encinitas CA 92024, USA
    Med Hypotheses 74:1055-8. 2010
    ....
  24. doi Practical prevention of cardiac remodeling and atrial fibrillation with full-spectrum antioxidant therapy and ancillary strategies
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 75:141-7. 2010
    ....
  25. doi Salsalate may have broad utility in the prevention and treatment of vascular disorders and the metabolic syndrome
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, 811 B Nahant Ct, San Diego, CA 92024, USA
    Med Hypotheses 75:276-81. 2010
    ..Appropriate rodent studies should pave the way for clinical trials with salsalate in patients at vascular risk...
  26. doi Potential complementarity of high-flavanol cocoa powder and spirulina for health protection
    Mark F McCarty
    Oasis of Hope Hospital, Tijuana, Mexico
    Med Hypotheses 74:370-3. 2010
    ..Thus, food products featuring ample amounts of both high-flavanol cocoa powder and spirulina may have considerable potential for health promotion, and merit evaluation in rodent studies and clinical trials...
  27. doi Oral phycocyanobilin may diminish the pathogenicity of activated brain microglia in neurodegenerative disorders
    Mark F McCarty
    Oasis of Hope Hospital, Paseo Playas 19, Playas de Tijuana, BC 22504, Tijuana, Mexico
    Med Hypotheses 74:601-5. 2010
    ....
  28. doi Activation of AMP-activated kinase as a strategy for managing autosomal dominant polycystic kidney disease
    Mark F McCarty
    Oasis of Hope Hospital, 92078 Tijuana, Mexico
    Med Hypotheses 73:1008-10. 2009
    ..The traditional use of berberine in diarrhea associated with bacterial infections may reflect, in part, the inhibitory impact of AMPK on chloride extrusion by small intestinal enterocytes...
  29. doi High-dose folate and dietary purines promote scavenging of peroxynitrite-derived radicals--clinical potential in inflammatory disorders
    Mark F McCarty
    Oasis of Hope Hospital, 92078 Tijuana, Mexico
    Med Hypotheses 73:824-34. 2009
    ....
  30. doi The hyperpolarizing impact of glycine on endothelial cells may be anti-atherogenic
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Road, San Marcos, CA 92078, USA
    Med Hypotheses 73:263-4. 2009
    ..Administration of large daily doses of glycine would appear to be practical and safe, and has already been shown to inhibit protein glycation in human diabetics...
  31. doi Poor vitamin D status may contribute to high risk for insulin resistance, obesity, and cardiovascular disease in Asian Indians
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Dr, San Marcos, CA 92078, USA
    Med Hypotheses 72:647-51. 2009
    ....
  32. doi Can moderate elevations of parathyroid hormone acutely increase risk for ischemic cardiac arrhythmias?
    Mark F McCarty
    Oasis of Hope Hospital, Tijuana, Mexico
    Med Hypotheses 72:581-3. 2009
    ..The extent to which this effect can be evoked by the high-normal PTH levels prevalent in many elderly subjects, can be assessed in epidemiological studies...
  33. doi AMP-activated kinase may suppress NADPH oxidase activation in vascular tissues
    Mark F McCarty
    Oasis of Hope Hospital, Tijuana, Mexico
    Med Hypotheses 72:468-70. 2009
    ....
  34. doi The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy
    Mark F McCarty
    Oasis of Hope Hospital, Tijuana, Mexico
    Med Hypotheses 72:125-8. 2009
    ....
  35. doi The "rejuvenatory" impact of lipoic acid on mitochondrial function in aging rats may reflect induction and activation of PPAR-gamma coactivator-1alpha
    Mark F McCarty
    Oasis of Hope Hospital, Tijuana, Mexico
    Med Hypotheses 72:29-33. 2009
    ..g. glutathione and heme oxygenase-1), but also induction of various proteins that function expressly to protect mitochondria from self-generated oxidant stress. Further research is required to evaluate this model...
  36. ncbi High mitochondrial redox potential may promote induction and activation of UCP2 in hepatocytes during hepatothermic therapy
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:1216-9. 2005
    ..Under these conditions, high mitochondrial redox potential would be expected, and induction of UCP2's uncoupling activity would represent a homeostatically appropriate antioxidant response...
  37. ncbi Acid-base balance may influence risk for insulin resistance syndrome by modulating cortisol output
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:380-4. 2005
    ..Future prospective epidemiology should assess whether the estimated acid-base balance of habitual diets - calculated from the ratio of dietary protein and potassium - correlates with risk for insulin resistance syndrome and diabetes...
  38. ncbi Nutraceutical resources for diabetes prevention--an update
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:151-8. 2005
    ..Nutraceuticals featuring meaningful doses of combinations of these agents would likely have substantial diabetes-preventive efficacy, and presumably could be marketed legally as aids to good glucose tolerance and insulin sensitivity...
  39. ncbi Targeting multiple signaling pathways as a strategy for managing prostate cancer: multifocal signal modulation therapy
    Mark F McCarty
    NutriGuard Research, Encinitas, California 92024, USA
    Integr Cancer Ther 3:349-80. 2004
    ..When MSMTs fail to raise the spontaneous apoptosis rate sufficiently to achieve tumor stasis or regression, incorporation of appropriate cytotoxic agents into the regimen may improve the clinical outcome...
  40. ncbi A taurine-supplemented vegan diet may blunt the contribution of neutrophil activation to acute coronary events
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 63:419-25. 2004
    ..Moderate alcohol consumption, the well-tolerated drug pentoxifylline, and 5-lipoxygenase inhibitors--zileuton, boswellic acids, fish oil--may also have potential in this regard...
  41. ncbi Supplementary taurine may stabilize atheromatous plaque by antagonizing the activation of metalloproteinases by hypochlorous acid
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 63:414-8. 2004
    ....
  42. ncbi Does bitter melon contain an activator of AMP-activated kinase?
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 63:340-3. 2004
    ....
  43. ncbi Chronic activation of AMP-activated kinase as a strategy for slowing aging
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 63:334-9. 2004
    ....
  44. ncbi AMPK activation may suppress hepatic production of C-reactive protein by stimulating nitric oxide synthase
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 63:328-33. 2004
    ..Although the impact of metformin on plasma IL-6 levels has not been reported, the possibility that AMPK activation could influence adipocyte secretion of this cytokine also merits scrutiny...
  45. ncbi A shift in myocardial substrate, improved endothelial function, and diminished sympathetic activity may contribute to the anti-anginal impact of very-low-fat diets
    M F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, California 92109, USA
    Med Hypotheses 62:62-71. 2004
    ..These safe and relatively inexpensive nutritional strategies for coping with angina deserve far more attention than orthodox medical practice has thus far accorded them...
  46. ncbi Hyperinsulinemia may boost both hematocrit and iron absorption by up-regulating activity of hypoxia-inducible factor-1alpha
    M F McCarty
    Pantox Laboratories, San Diego, California 92109, USA
    Med Hypotheses 61:567-73. 2003
    ..People who are insulin resistant can minimize any health risk associated with iron overload by avoiding heme-rich flesh foods and donating blood regularly...
  47. ncbi Iatrogenic lipodystrophy in HIV patients - the need for very-low-fat diets
    M F McCarty
    Pantox Laboratories, San Diego, CA 92109, USA
    Med Hypotheses 61:561-6. 2003
    ..Despite perceptions to the contrary, very-low-fat diets can meet with good compliance in well-motivated subjects given appropriate instruction...
  48. ncbi A moderately low phosphate intake may provide health benefits analogous to those conferred by UV light - a further advantage of vegan diets
    M F McCarty
    Pantox Laboratories, San Diego, CA 92109, USA
    Med Hypotheses 61:543-60. 2003
    ....
  49. ncbi PTH excess may promote weight gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium, vitamin D, and alcohol on body weight
    M F McCarty
    Pantox Laboratories, San Diego, CA 92109, USA
    Med Hypotheses 61:535-42. 2003
    ....
  50. ncbi Turning an 'Achilles' Heel' into an asset--activation of HIF-1alpha during angiostatic therapy will increase tumor sensitivity to iron-catalyzed oxidative damage
    M F McCarty
    Pantox Laboratories, San Diego, California 92109, USA
    Med Hypotheses 61:509-11. 2003
    ..Thus, it can be anticipated that many tumors which evolve relative resistance to angiostatic therapy will be selectively susceptible to attack by the iron-loading/artemisinin strategy...
  51. ncbi The A54T polymorphism of fatty acid-binding protein 2 may entail a reduction in fat-stimulated secretion of GIP that potentiates the adverse impact of fatty diets on insulin sensitivity
    M F McCarty
    Pantox Laboratories, San Diego, CA 92109, USA
    Med Hypotheses 61:458-62. 2003
    ..If this thesis proves to be correct, it will help to clarify the importance of appropriate GIP secretion to maintenance of insulin sensitivity in the context of fatty diets...
  52. ncbi Low-insulin-response diets may decrease plasma C-reactive protein by influencing adipocyte function
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 64:385-7. 2005
    ..These considerations suggest that it may be possible to achieve worthwhile reductions in CRP by avoiding high-insulin-response starchy foods and by ingesting more soluble fiber, in foods or as a meal-time supplement...
  53. ncbi De novo synthesis of diacylglycerol in endothelium may mediate the association between PAI-1 and the insulin resistance syndrome
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 64:388-93. 2005
    ..g., metformin), which can be expected to lessen tissue DAG synthesis...
  54. ncbi Supplemental arginine and high-dose folate may promote bone health by supporting the activity of endothelial-type nitric oxide synthase in bone
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 64:1030-3. 2005
    ..These considerations suggest that supplementation with arginine as well as high-dose folate might aid maintenance of bone density by helping to preserve optimal NO synthase activity in bone cells...
  55. ncbi Marinobufagenin may mediate the adverse impact of salty diets on renal calcium retention by impairing the efficiency of renal tubular sodium-calcium exchange
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe Street, San Diego, CA 92109, USA
    Med Hypotheses 64:1027-9. 2005
    ..Thus, it is postulated that MBG mediates the impact of salt loading on renal calcium retention...
  56. ncbi Secondary hyperparathyroidism promotes the acute phase response -- a rationale for supplemental vitamin D in prevention of vascular events in the elderly
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 64:1022-6. 2005
    ....
  57. ncbi Nutritional modulation of parathyroid hormone secretion may influence risk for left ventricular hypertrophy
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:1015-21. 2005
    ..Whether these nutritional measures do indeed influence LVH risk could be examined in prospective studies targeting patients at high risk, such as hypertensives...
  58. ncbi Marinobufagenin may mediate the impact of salty diets on left ventricular hypertrophy by disrupting the protective function of coronary microvascular endothelium
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe Street, San Diego, CA 92109, USA
    Med Hypotheses 64:854-63. 2005
    ....
  59. ncbi Toward prevention of Alzheimers disease--potential nutraceutical strategies for suppressing the production of amyloid beta peptides
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Dr, San Marcos, CA 92078, United States
    Med Hypotheses 67:682-97. 2006
    ..The impact of these measures on Abeta production in rodent models of AD should be evaluated, with the intent of defining practical strategies for AD prevention...
  60. ncbi An ezetimibe-policosanol combination has the potential to be an OTC agent that could dramatically lower LDL cholesterol without side effects
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:636-45. 2005
    ....
  61. ncbi Potential utility of natural polyphenols for reversing fat-induced insulin resistance
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 64:628-35. 2005
    ....
  62. ncbi Up-regulation of PPARgamma coactivator-1alpha as a strategy for preventing and reversing insulin resistance and obesity
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 64:399-407. 2005
    ..Phytanic acid, a branched-chain fatty acid found in omnivore diets, can also activate PPARdelta, and thus should be examined with respect to its impact on mitochondrial biogenesis and insulin sensitivity...
  63. ncbi Optimizing endothelial nitric oxide activity may slow endothelial aging
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 63:719-23. 2004
    ..The impact of lifelong caloric restriction on endothelial aging requires further study, preferably in primates...
  64. ncbi Coping with endothelial superoxide: potential complementarity of arginine and high-dose folate
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 63:709-18. 2004
    ....
  65. ncbi Up-regulatory impact of boron on vitamin D function -- does it reflect inhibition of 24-hydroxylase?
    Dusan Miljkovic
    FutureCeuticals Inc, 5080 Shoreham Plaza, San Diego, CA 92122, USA
    Med Hypotheses 63:1054-6. 2004
    ....
  66. ncbi Marinobufagenin may mediate the impact of salty diets on left ventricular hypertrophy by disrupting the protective function of coronary microvascular endothelium
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe Street, San Diego, CA 92109, USA
    Med Hypotheses 62:993-1002. 2004
    ....
  67. ncbi cGMP may have trophic effects on beta cell function comparable to those of cAMP, implying a role for high-dose biotin in prevention/treatment of diabetes
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 66:323-8. 2006
    ....
  68. ncbi A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:848-53. 2005
    ....
  69. ncbi Vascular endothelium is the organ chiefly responsible for the catabolism of plasma asymmetric dimethylarginine--an explanation for the elevation of plasma ADMA in disorders characterized by endothelial dysfunction
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe Street, San Diego, CA 92109, USA
    Med Hypotheses 63:699-708. 2004
    ..Whether or not ADMA plays an important pathogenic role, it seems likely to emerge as a potent risk factor for adverse vascular events, since it may be viewed as a barometer of endothelial health...
  70. ncbi A low-fat, whole-food vegan diet, as well as other strategies that down-regulate IGF-I activity, may slow the human aging process
    Mark F McCarty
    Pantox Laboratories, San Diego, California 92109, USA
    Med Hypotheses 60:784-92. 2003
    ....
  71. doi Practical strategies for targeting NF-kappaB and NADPH oxidase may improve survival during lethal influenza epidemics
    Mark F McCarty
    Oasis of Hope Hospital, Tijuana, Mexico
    Med Hypotheses 74:18-20. 2010
    ....
  72. ncbi Adjuvant strategies for prevention of glomerulosclerosis
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 67:1277-96. 2006
    ..Most of these measures may likewise reduce risk for left ventricular hypertrophy in hypertensives, inasmuch as the signaling mechanisms which mediate this disorder appear similar to those involved in glomerulosclerosis...
  73. ncbi The low-AGE content of low-fat vegan diets could benefit diabetics - though concurrent taurine supplementation may be needed to minimize endogenous AGE production
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:394-8. 2005
    ..Thus, a taurine supplemented low-fat vegan diet may be recommended as a strategy for minimizing AGE-mediated complications in diabetics and in patients with renal failure...
  74. ncbi High-dose folate may improve platelet function in acute coronary syndrome and other pathologies associated with increased platelet oxidative stress
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Road, San Marcos, CA 92078, USA
    Med Hypotheses 69:12-9. 2007
    ..As a complement to the proven benefits of low-dose aspirin, a supplemental regimen emphasizing these nutrients in appropriate doses may act directly on platelets to further diminish risk for thrombotic episodes...
  75. ncbi Magnesium may mediate the favorable impact of whole grains on insulin sensitivity by acting as a mild calcium antagonist
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe Street, San Diego, CA 92109, USA
    Med Hypotheses 64:619-27. 2005
    ..These considerations, however, should not detract from efforts to better inform the public regarding the strong desirability of choosing whole grain products in preference to refined grains...