Wei Qin Zhao

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi request reprint Expression of annexin A2 in GABAergic interneurons in the normal rat brain
    Wei Qin Zhao
    Blanchette Rockefeller Neurosciences Institute, Rockville, Maryland, USA
    J Neurochem 100:1211-23. 2007
  2. ncbi request reprint Amyloid beta oligomers induce impairment of neuronal insulin receptors
    Wei Qin Zhao
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Dr, Hogan 5 110, Evanston, IL 60280, USA
    FASEB J 22:246-60. 2008
  3. pmc Insulin receptor signaling in long-term memory consolidation following spatial learning
    Jing Tao Dou
    Blanchette Rockefeller Neurosciences Institute, Rockville, Maryland 20850, USA
    Learn Mem 12:646-55. 2005
  4. pmc Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}
    Wei Qin Zhao
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 284:18742-53. 2009
  5. pmc Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers
    Fernanda G De Felice
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 106:1971-6. 2009
  6. ncbi request reprint Gene expression of alpha-endosulfine in the rat brain: correlative changes with aging, learning and stress
    Jingtao Dou
    Blanchette Rockefeller Neurosciences Institute, 9601 Medical Center Drive, Rockville, MD 20850 3332, USA
    J Neurochem 87:1086-100. 2003
  7. ncbi request reprint c-Src protein tyrosine kinase activity is required for muscarinic receptor-mediated DNA synthesis and neurogenesis via ERK1/2 and c-AMP-responsive element-binding protein signaling in neural precursor cells
    Wei Qin Zhao
    Blanchette Rockefeller Neurosciences Institute, Rockville, Maryland 20850, USA
    J Neurosci Res 72:334-42. 2003
  8. ncbi request reprint Specific localization of the annexin II heterotetramer in brain lipid raft fractions and its changes in spatial learning
    Wei Qin Zhao
    Blanchette Rockefeller Neurosciences Institute, Rockville, Maryland 20850 3332, USA
    J Neurochem 90:609-20. 2004
  9. ncbi request reprint Insulin and the insulin receptor in experimental models of learning and memory
    Wei Qin Zhao
    Blanchette Rockefeller Neurosciences Institute, 3rd Floor, Academic and Research Building, 9601 Medical Center Drive, Rockville, MD 20850, USA
    Eur J Pharmacol 490:71-81. 2004
  10. ncbi request reprint Impairment of phosphatase 2A contributes to the prolonged MAP kinase phosphorylation in Alzheimer's disease fibroblasts
    Wei Qin Zhao
    Blanchette Rockefeller Neurosciences Institutes, Rockville, MD 20850, USA
    Neurobiol Dis 14:458-69. 2003

Detail Information

Publications14

  1. ncbi request reprint Expression of annexin A2 in GABAergic interneurons in the normal rat brain
    Wei Qin Zhao
    Blanchette Rockefeller Neurosciences Institute, Rockville, Maryland, USA
    J Neurochem 100:1211-23. 2007
    ..These results may have implications in the function and regulatory mechanism of ANX2 in the normal brain...
  2. ncbi request reprint Amyloid beta oligomers induce impairment of neuronal insulin receptors
    Wei Qin Zhao
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Dr, Hogan 5 110, Evanston, IL 60280, USA
    FASEB J 22:246-60. 2008
    ....
  3. pmc Insulin receptor signaling in long-term memory consolidation following spatial learning
    Jing Tao Dou
    Blanchette Rockefeller Neurosciences Institute, Rockville, Maryland 20850, USA
    Learn Mem 12:646-55. 2005
    ..Our results suggest that insulin/IR signaling plays a modulatory role in learning and memory processing, which may be compensated for by alternative pathways in the brain when an insulin deficit occurs...
  4. pmc Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}
    Wei Qin Zhao
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 284:18742-53. 2009
    ..Our results suggest that dysfunctions of brain insulin and IGF-1 receptors contribute to Abeta aggregation and subsequent synaptic loss...
  5. pmc Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers
    Fernanda G De Felice
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 106:1971-6. 2009
    ..The finding that synapse vulnerability to ADDLs can be mitigated by insulin suggests that bolstering brain insulin signaling, which can decline with aging and diabetes, could have significant potential to slow or deter AD pathogenesis...
  6. ncbi request reprint Gene expression of alpha-endosulfine in the rat brain: correlative changes with aging, learning and stress
    Jingtao Dou
    Blanchette Rockefeller Neurosciences Institute, 9601 Medical Center Drive, Rockville, MD 20850 3332, USA
    J Neurochem 87:1086-100. 2003
    ..These results suggest that alpha-EDSF gene expression is differentially regulated by distinct brain processes involving excitatory neuronal activities...
  7. ncbi request reprint c-Src protein tyrosine kinase activity is required for muscarinic receptor-mediated DNA synthesis and neurogenesis via ERK1/2 and c-AMP-responsive element-binding protein signaling in neural precursor cells
    Wei Qin Zhao
    Blanchette Rockefeller Neurosciences Institute, Rockville, Maryland 20850, USA
    J Neurosci Res 72:334-42. 2003
    ..These results suggest that c-src activity is essential for the muscarinic receptor-mediated proliferation and neurogenesis in neural precursor cells via Erk1/2 and CREB signaling pathways...
  8. ncbi request reprint Specific localization of the annexin II heterotetramer in brain lipid raft fractions and its changes in spatial learning
    Wei Qin Zhao
    Blanchette Rockefeller Neurosciences Institute, Rockville, Maryland 20850 3332, USA
    J Neurochem 90:609-20. 2004
    ..This probably involves focal adhesion and interactions with actin that are associated with brain development and memory consolidation...
  9. ncbi request reprint Insulin and the insulin receptor in experimental models of learning and memory
    Wei Qin Zhao
    Blanchette Rockefeller Neurosciences Institute, 3rd Floor, Academic and Research Building, 9601 Medical Center Drive, Rockville, MD 20850, USA
    Eur J Pharmacol 490:71-81. 2004
    ..Furthermore, deterioration of insulin receptor signaling appears to be associated with aging-related brain degeneration such as the Alzheimer's dementia and cognitive impairment in aged subjects suffering type 2 diabetes mellitus...
  10. ncbi request reprint Impairment of phosphatase 2A contributes to the prolonged MAP kinase phosphorylation in Alzheimer's disease fibroblasts
    Wei Qin Zhao
    Blanchette Rockefeller Neurosciences Institutes, Rockville, MD 20850, USA
    Neurobiol Dis 14:458-69. 2003
    ..These results suggest that the delayed dephosphorylation of Erk1/2 in AD cells following its BK-stimulated activation may be due to deficits of PP2A activity and impaired nuclear translocation of phosphorylated Erk1/2...
  11. ncbi request reprint Secretion of Annexin II via activation of insulin receptor and insulin-like growth factor receptor
    Wei Qin Zhao
    Laboratory of Adaptive Systems, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:4205-15. 2003
    ..These results suggest that the insulin receptor and its signaling pathways may participate in molecular mechanisms mediating annexin II secretion...
  12. pmc Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency
    Min Chen
    Metabolic Diseases Branch, NIDDK, NIH, Bethesda, Maryland 20892 1752, USA
    J Clin Invest 115:3217-27. 2005
    ..Our results define novel roles for hepatic G(s)-signaling pathways in glucose and lipid regulation, which may prove useful in designing new therapeutic targets for diabetes and obesity...
  13. ncbi request reprint MAP kinase signaling cascade dysfunction specific to Alzheimer's disease in fibroblasts
    Wei Qin Zhao
    Laboratory of Adaptive Systems, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Neurobiol Dis 11:166-83. 2002
    ..Moreover, detection of AD-specific differences in MAP kinase in peripheral tissues may provide an efficient means for early diagnosis of AD as well as help us to identify therapeutic targets for drug discovery...
  14. ncbi request reprint [Expression of human cytomegalovirus immediate early gene in the intracranial artery walls of atherosclerosis]
    Li Yi
    Beijing Friendship Hospital, Capital University of Medical Science, Beijing 100050, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 18:66-8. 2004
    ..The aim of this study was to confirm the presence of HCMV IE gene DNA in intracranial artery walls and the association of the virus with the development of atherosclerosis...