Qiang Zhang

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. doi request reprint Nuclear factor-kappaB-mediated transforming growth factor-beta-induced expression of vimentin is an independent predictor of biochemical recurrence after radical prostatectomy
    Qiang Zhang
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Clin Cancer Res 15:3557-67. 2009
  2. ncbi request reprint Insensitivity to transforming growth factor-beta results from promoter methylation of cognate receptors in human prostate cancer cells (LNCaP)
    Qiang Zhang
    Department of Urology, Northwestern University Feinberg School of Medicine, 303E, Chicago Avenue, Tarry 16 726, Chicago, Illinois 60611, USA
    Mol Endocrinol 19:2390-9. 2005
  3. pmc TGF-β regulates DNA methyltransferase expression in prostate cancer, correlates with aggressive capabilities, and predicts disease recurrence
    Qiang Zhang
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 6:e25168. 2011
  4. ncbi request reprint Infiltration of tumor-reactive transforming growth factor-beta insensitive CD8+ T cells into the tumor parenchyma is associated with apoptosis and rejection of tumor cells
    Qiang Zhang
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA, and Institute of Urology, The First Hospital, Peking University, Beijing, China
    Prostate 66:235-47. 2006
  5. ncbi request reprint Blockade of transforming growth factor-{beta} signaling in tumor-reactive CD8(+) T cells activates the antitumor immune response cycle
    Qiang Zhang
    Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Tarry 16 733, Chicago, IL 60611, USA
    Mol Cancer Ther 5:1733-43. 2006
  6. doi request reprint Treatment of transforming growth factor-beta-insensitive mouse Renca tumor by transforming growth factor-beta elimination
    Kent Perry
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Urology 72:225-9. 2008
  7. pmc Overexpression of transforming growth factor β1 in malignant prostate cells is partly caused by a runaway of TGF-β1 auto-induction mediated through a defective recruitment of protein phosphatase 2A by TGF-β type I receptor
    Nengwang Yu
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Urology 76:1519.e8-13. 2010
  8. ncbi request reprint Tumor evasion of the immune system by converting CD4+CD25- T cells into CD4+CD25+ T regulatory cells: role of tumor-derived TGF-beta
    Victoria C Liu
    Department of Urology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Immunol 178:2883-92. 2007
  9. ncbi request reprint The leader sequence triggers and enhances several functions of clusterin and is instrumental in the progression of human prostate cancer in vivo and in vitro
    Qiang Zhang
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    BJU Int 98:452-60. 2006
  10. ncbi request reprint Adoptive transfer of tumor-reactive transforming growth factor-beta-insensitive CD8+ T cells: eradication of autologous mouse prostate cancer
    Qiang Zhang
    Department of Urology, Northwestern University s Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Cancer Res 65:1761-9. 2005

Collaborators

Detail Information

Publications34

  1. doi request reprint Nuclear factor-kappaB-mediated transforming growth factor-beta-induced expression of vimentin is an independent predictor of biochemical recurrence after radical prostatectomy
    Qiang Zhang
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Clin Cancer Res 15:3557-67. 2009
    ..In this study, we elucidated TGF-beta-mediated EMT as a predictor of disease recurrence after therapy for prostate cancer, which has not been reported before...
  2. ncbi request reprint Insensitivity to transforming growth factor-beta results from promoter methylation of cognate receptors in human prostate cancer cells (LNCaP)
    Qiang Zhang
    Department of Urology, Northwestern University Feinberg School of Medicine, 303E, Chicago Avenue, Tarry 16 726, Chicago, Illinois 60611, USA
    Mol Endocrinol 19:2390-9. 2005
    ..These results demonstrate that insensitivity to TGF-beta in some prostate cancer cells is due to promoter methylation in TbetaRs...
  3. pmc TGF-β regulates DNA methyltransferase expression in prostate cancer, correlates with aggressive capabilities, and predicts disease recurrence
    Qiang Zhang
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 6:e25168. 2011
    ..The specific mechanisms of DNMT's role in CaP remain undetermined. In this study, we describe the mechanism of TGF-β-mediated DNMT in CaP and its association with clinical outcomes following radical prostatectomy...
  4. ncbi request reprint Infiltration of tumor-reactive transforming growth factor-beta insensitive CD8+ T cells into the tumor parenchyma is associated with apoptosis and rejection of tumor cells
    Qiang Zhang
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA, and Institute of Urology, The First Hospital, Peking University, Beijing, China
    Prostate 66:235-47. 2006
    ..In the present study, we report a distinct ability of tumor reactive, TGF-beta-insensitive CD8+ T cells to infiltrate into established tumors, secrete relevant cytokines, and induce apoptosis of tumor cells...
  5. ncbi request reprint Blockade of transforming growth factor-{beta} signaling in tumor-reactive CD8(+) T cells activates the antitumor immune response cycle
    Qiang Zhang
    Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Tarry 16 733, Chicago, IL 60611, USA
    Mol Cancer Ther 5:1733-43. 2006
    ..Based on these results, we postulated a concept of antitumor immune response cycle in tumor immunology...
  6. doi request reprint Treatment of transforming growth factor-beta-insensitive mouse Renca tumor by transforming growth factor-beta elimination
    Kent Perry
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Urology 72:225-9. 2008
    ..The present study was conducted to determine whether removal of TGF-beta from these tumor cells would inhibit tumor progression in vivo...
  7. pmc Overexpression of transforming growth factor β1 in malignant prostate cells is partly caused by a runaway of TGF-β1 auto-induction mediated through a defective recruitment of protein phosphatase 2A by TGF-β type I receptor
    Nengwang Yu
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Urology 76:1519.e8-13. 2010
    ..To elucidate the mechanism of transforming growth factor (TGF)-β1 overexpression in prostate cancer cells...
  8. ncbi request reprint Tumor evasion of the immune system by converting CD4+CD25- T cells into CD4+CD25+ T regulatory cells: role of tumor-derived TGF-beta
    Victoria C Liu
    Department of Urology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Immunol 178:2883-92. 2007
    ..In summary, we have demonstrated that tumor cells directly convert CD4+CD25- T cells to T(reg) cells through production of high levels of TGF-beta, suggesting a possible mechanism through which tumor cells evade the immune system...
  9. ncbi request reprint The leader sequence triggers and enhances several functions of clusterin and is instrumental in the progression of human prostate cancer in vivo and in vitro
    Qiang Zhang
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    BJU Int 98:452-60. 2006
    ....
  10. ncbi request reprint Adoptive transfer of tumor-reactive transforming growth factor-beta-insensitive CD8+ T cells: eradication of autologous mouse prostate cancer
    Qiang Zhang
    Department of Urology, Northwestern University s Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Cancer Res 65:1761-9. 2005
    ..These results suggest that adoptive transfer of tumor-reactive TGF-beta-insensitive CD8+ T cells may warrant consideration for cancer therapy...
  11. ncbi request reprint The toll-like receptor pathway: a novel mechanism of infection-induced carcinogenesis of prostate epithelial cells
    Shilajit D Kundu
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Prostate 68:223-9. 2008
    ..Inflammation and infection have been linked to the pathogenesis of many cancers including prostate cancer. Components of bacteria and viruses have been identified within pathological specimens of men with prostate cancer...
  12. ncbi request reprint Restoration of expression of transforming growth factor-beta type II receptor in murine renal cell carcinoma (renca) cells by 5-Aza-2'-deoxycytidine
    Qiang Zhang
    Department of Urology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue Tarry 16 733, Chicago, IL, 60611, USA
    Life Sci 76:1159-66. 2005
    ..Levels of TGF-beta1 were similar before and after 5-Aza treatment. Results of the present study indicated that, in Renca cells, the loss of sensitivity to TGF-beta is likely due to a promoter hypermethylation in the TbetaR-II gene...
  13. ncbi request reprint Cutting edge: TGF-beta-induced expression of Foxp3 in T cells is mediated through inactivation of ERK
    Xunrong Luo
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Immunol 180:2757-61. 2008
    ..These results indicate that the epigenetic regulation of TGF-beta-induced expression of Foxp3 may be mediated through the inactivation of ERK...
  14. doi request reprint 17Beta-estradiol at low concentrations acts through distinct pathways in normal versus benign prostatic hyperplasia-derived prostate stromal cells
    Irwin I Park
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Endocrinology 150:4594-605. 2009
    ..This may provide the basis for new insights into the causes of, and possible treatments for, BPH...
  15. ncbi request reprint Natural products and transforming growth factor-beta (TGF-β) signaling in cancer development and progression
    Chung Lee
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Curr Cancer Drug Targets 13:500-5. 2013
    ..Finally, the third category of herbal products has no impact on TGF-β signaling, such as lycopene. ..
  16. pmc The use and interpretation of competing risks regression models
    James J Dignam
    Department of Health Studies, The University of Chicago, Chicago, Illinois 60637, USA
    Clin Cancer Res 18:2301-8. 2012
    ..With competing risks, several modeling approaches are available to evaluate the relationship of covariates to cause-specific failures. We discuss the use and interpretation of commonly used competing risks regression models...
  17. doi request reprint Vaccination with transforming growth factor-beta insensitive dendritic cells suppresses pulmonary metastases of renal carcinoma in mice
    Feng Tian
    Department of Urology, Xijing Hospital, Fourth Military Medical University, 15 Chang Le West Road, Xi an, Shaanxi Province 710032, China
    Cancer Lett 271:333-41. 2008
    ..These results suggest TGF-beta-insensitive TP-DC vaccine can be used to enhance the antitumor efficacy of DC vaccine...
  18. pmc Predictive value of MTT assay as an in vitro chemosensitivity testing for gastric cancer: one institution's experience
    Bin Wu
    Department of Gastroenterology, Shanghai Sixth Hospital Affiliated to Shanghai Jiaotong University, Yishang Road 600, Shanghai 200223, China
    World J Gastroenterol 14:3064-8. 2008
    ..To investigate the predictive clinical value of in vitro 3-(4,5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay for directing chemosensitivity in patients with gastric cancer...
  19. doi request reprint Enhanced therapeutic effects on the multi-drug resistant human leukemia cells in vitro and xenograft in mice using the stealthy liposomal vincristine plus quinacrine
    Gong Wen Liang
    State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Fundam Clin Pharmacol 22:429-37. 2008
    ..The stealthy liposomal encapsulation of vincristine plus quinacrine could be a potential therapeutic approach for resistant human leukemia...
  20. doi request reprint Myostatin induces p300 degradation to silence cyclin D1 expression through the PI3K/PTEN/Akt pathway
    Ming Ji
    National Laboratory of Medical Molecular Biology and Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, 5 Dong Dan San Tiao, Beijing 100005, PR China
    Cell Signal 20:1452-8. 2008
    ..Results presented in this study uncovered an epigenetic control of genes expression in response to myostatin...
  21. doi request reprint Adoptive transfer of tumor-reactive transforming growth factor-beta-insensitive cytolytic T cells for treatment of established mouse Renca tumors
    Weijun Qin
    Department of Urology, Xijing Hospital, The Fourth Military Medical University, Xi an, Shanxi Province, China
    Urology 72:943-7. 2008
    ..To test, using a mouse renal cancer, Renca, whether adoptive transfer of tumor-reactive transforming growth factor (TGF)-beta-insensitive cytolytic T cells can inhibit tumor progression...
  22. ncbi request reprint FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy
    Jianwei Ye
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, PR China
    Gene 404:53-60. 2007
    ..All our data suggest that FBXO40 may function as a regulator involved in the postnatal myogenesis...
  23. ncbi request reprint Rac1 and superoxide are required for the expression of cell adhesion molecules induced by tumor necrosis factor-alpha in endothelial cells
    Xi Lin Chen
    Discovery Research, AtheroGenics, Inc, 8995 Westside Parkway, Alpharetta, GA 30004, USA
    J Pharmacol Exp Ther 305:573-80. 2003
    ..These data suggest that Rac1 and superoxide play crucial roles in the regulation of expression of cell adhesion molecules in endothelial cells...
  24. ncbi request reprint hSGT interacts with the N-terminal region of myostatin
    Haixia Wang
    Molecular and Cellular Developmental Biology Laboratory, Harbin Institute of Technology, 150001, Harbin, PR China
    Biochem Biophys Res Commun 311:877-83. 2003
    ..Recent studies indicate that hSGT probably functions as a molecular chaperone involved in protein folding and processing. These findings suggest that hSGT may play a role in the regulation of myostatin secretion and activation...
  25. ncbi request reprint Transport of proteins and peptides across human cultured alveolar A549 cell monolayer
    Zhiying Wang
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, PR China
    Int J Pharm 269:451-6. 2004
    ..These findings suggest that the hydrophilic peptides and proteins used in this study, sCT, INS, rHAV2, and rhGH, appear to cross the A549 cell monolayers via a paracellular pathway by a passive diffusion mechanism...
  26. ncbi request reprint Modulation of P-glycoprotein function and reversal of multidrug resistance by (-)-epigallocatechin gallate in human cancer cells
    Feng Qian
    State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, PR China
    Biomed Pharmacother 59:64-9. 2005
    ..Thus, these results suggest that EGCG modulated the function of P-gp and reversed P-gp mediated multidrug resistance in human cancer cells...
  27. ncbi request reprint [The in vitro cytotoxicity and in vivo toxicity of doxorubicin antiresistant stealth liposomes]
    Jian Cheng Wang
    Department of Pharmaceutics, Peking University, Beijing 100083, China
    Yao Xue Xue Bao 40:475-80. 2005
    ..Multidrug resistance ( MDR) as a major obstacle to successful clinical cancer chemotherapy, searching a novel effective antiresistant drug would be necessary...
  28. ncbi request reprint New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding
    Qiang Zhang
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, One Gustave L Levy Place, New York, NY 10029, USA
    J Mol Biol 354:777-88. 2005
    ..These results suggest that Arg294 and Arg295 play an important role in PAC-1 catalytic activation induced by ERK2 binding...
  29. ncbi request reprint [Expression of early growth response gene-1 and its correlative genes in autogenous vein graft and significance thereof: an experiment with rats]
    Cheng Wei Liu
    Department of Vascular Surgery, First Affiliated Hospital, China Medical University, Shenyang 110001, China
    Zhonghua Yi Xue Za Zhi 85:3414-8. 2005
    ....
  30. pmc Discovery of novel triazole-based opioid receptor antagonists
    Qiang Zhang
    Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey and UMDNJ Informatics Institute, Piscataway, New Jersey 08854, USA
    J Med Chem 49:4044-7. 2006
    ..Among those delta antagonists sharing this core structure, 8 exhibited strong binding affinity (K(i) = 50 nM) for the DOR and appreciable selectivity for delta over mu and kappa opioid receptors (delta/mu = 80; delta/kappa > 200)...
  31. pmc CFTR Expression in human neutrophils and the phagolysosomal chlorination defect in cystic fibrosis
    Richard G Painter
    Gene Therapy Program, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Biochemistry 45:10260-9. 2006
    ..This report provides evidence which suggests that CFTR channel expression in neutrophils and its dysfunction affect neutrophil chlorination of phagocytosed bacteria...
  32. ncbi request reprint TGF-beta insensitive dendritic cells: an efficient vaccine for murine prostate cancer
    Fu Li Wang
    Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi, China
    Cancer Immunol Immunother 56:1785-93. 2007
    ..Furthermore, complete tumor regression occurred in two vaccinated mice. These results demonstrate that blocking TGF-beta signals in DC enhances the efficacy of DC-based vaccines...
  33. pmc The chemokine receptor CCR7 mediates corneal antigen-presenting cell trafficking
    Yiping Jin
    Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Mol Vis 13:626-34. 2007
    ..However, very little is known about the molecular regulation of this pathway. We investigated the expression and function of the chemokine receptor CCR7 in mediating corneal APC migration in inflammation...
  34. ncbi request reprint Renal cell carcinoma related novel gene, GYLZ-RCC18: cloning and functional studies
    Qiang Zhang
    Department of Urology and Institute of Urology, The First Affiliated Hospital, Peking University, Beijing 100034, China
    Chin Med J (Engl) 115:746-9. 2002
    ..To clone the full length of renal cell carcinoma (RCC) related novel gene GYLZ-RCC18 and study its function...