Guang Yu Yang

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Overexpression and oncogenic function of aldo-keto reductase family 1B10 (AKR1B10) in pancreatic carcinoma
    Yeon Tae Chung
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    Mod Pathol 25:758-66. 2012
  2. pmc Soluble epoxide hydrolase deficiency inhibits dextran sulfate sodium-induced colitis and carcinogenesis in mice
    Wanying Zhang
    Northwestern University, Feinberg School of Medicine 303 E Chicago Avenue, Chicago, IL 60611, U S A Tel 1 3125030645
    Anticancer Res 33:5261-71. 2013
  3. pmc Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis
    Goo Lee
    Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Gastroenterology 139:869-81, 881.e1-9. 2010
  4. pmc Atorvastatin inhibits pancreatic carcinogenesis and increases survival in LSL-KrasG12D-LSL-Trp53R172H-Pdx1-Cre mice
    Jie Liao
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Carcinog 52:739-50. 2013
  5. pmc Soluble epoxide hydrolase gene deficiency or inhibition attenuates chronic active inflammatory bowel disease in IL-10(-/-) mice
    Wanying Zhang
    Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Dig Dis Sci 57:2580-91. 2012
  6. pmc Sulindac inhibits pancreatic carcinogenesis in LSL-KrasG12D-LSL-Trp53R172H-Pdx-1-Cre mice via suppressing aldo-keto reductase family 1B10 (AKR1B10)
    Haonan Li
    Department of Pathology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Ward 6 118, Chicago, IL 60611
    Carcinogenesis 34:2090-8. 2013
  7. pmc Reduction of inflammatory bowel disease-induced tumor development in IL-10 knockout mice with soluble epoxide hydrolase gene deficiency
    Wanying Zhang
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Carcinog 52:726-38. 2013
  8. pmc Aldoketoreductase family 1B10 (AKR1B10) as a biomarker to distinguish hepatocellular carcinoma from benign liver lesions
    Kristina A Matkowskyj
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, WI 53792, USA
    Hum Pathol 45:834-43. 2014
  9. pmc Quantitative multiparametric PROPELLER MRI of diethylnitrosamine-induced hepatocarcinogenesis in wister rat model
    Jie Deng
    Department of Radiology, Northwestern University, Chicago, Illinois, USA
    J Magn Reson Imaging 31:1242-51. 2010
  10. pmc Intra-voxel incoherent motion MRI in rodent model of diethylnitrosamine-induced liver fibrosis
    Yue Zhang
    Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA
    Magn Reson Imaging 31:1017-21. 2013

Collaborators

Detail Information

Publications35

  1. pmc Overexpression and oncogenic function of aldo-keto reductase family 1B10 (AKR1B10) in pancreatic carcinoma
    Yeon Tae Chung
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    Mod Pathol 25:758-66. 2012
    ..Our findings provide first time evidence that AKR1B10 is a unique enzyme involved in pancreatic carcinogenesis possibly via modulation of cell apoptosis and protein prenylation...
  2. pmc Soluble epoxide hydrolase deficiency inhibits dextran sulfate sodium-induced colitis and carcinogenesis in mice
    Wanying Zhang
    Northwestern University, Feinberg School of Medicine 303 E Chicago Avenue, Chicago, IL 60611, U S A Tel 1 3125030645
    Anticancer Res 33:5261-71. 2013
    ..These results indicate that sEH plays an important role in the development of colitis and in inducing carcinogenesis. ..
  3. pmc Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis
    Goo Lee
    Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Gastroenterology 139:869-81, 881.e1-9. 2010
    ..We investigated whether phosphoinositide 3-kinase (PI3K) is required for Akt-mediated activation of beta-catenin during intestinal inflammation...
  4. pmc Atorvastatin inhibits pancreatic carcinogenesis and increases survival in LSL-KrasG12D-LSL-Trp53R172H-Pdx1-Cre mice
    Jie Liao
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Carcinog 52:739-50. 2013
    ..This study indicates that atorvastatin has the potential to serve as a chemopreventive agent against pancreatic carcinogenesis...
  5. pmc Soluble epoxide hydrolase gene deficiency or inhibition attenuates chronic active inflammatory bowel disease in IL-10(-/-) mice
    Wanying Zhang
    Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Dig Dis Sci 57:2580-91. 2012
    ..Soluble epoxide hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids (EETs) into their much less active dihydroxy derivatives dihydroxyeicosatrienoic acids. Thus, targeting sEH would be important for inflammation...
  6. pmc Sulindac inhibits pancreatic carcinogenesis in LSL-KrasG12D-LSL-Trp53R172H-Pdx-1-Cre mice via suppressing aldo-keto reductase family 1B10 (AKR1B10)
    Haonan Li
    Department of Pathology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Ward 6 118, Chicago, IL 60611
    Carcinogenesis 34:2090-8. 2013
    ..Our results demonstrate that sulindac inhibits pancreatic carcinogenesis by the inhibition of Kras protein prenylation by targeting AKR1B10...
  7. pmc Reduction of inflammatory bowel disease-induced tumor development in IL-10 knockout mice with soluble epoxide hydrolase gene deficiency
    Wanying Zhang
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Carcinog 52:726-38. 2013
    ..These results indicate that sEH plays an important role in IBD and its-induced carcinogenesis and could serve as a highly potential target of chemoprevention and treatment for IBD...
  8. pmc Aldoketoreductase family 1B10 (AKR1B10) as a biomarker to distinguish hepatocellular carcinoma from benign liver lesions
    Kristina A Matkowskyj
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, WI 53792, USA
    Hum Pathol 45:834-43. 2014
    ....
  9. pmc Quantitative multiparametric PROPELLER MRI of diethylnitrosamine-induced hepatocarcinogenesis in wister rat model
    Jie Deng
    Department of Radiology, Northwestern University, Chicago, Illinois, USA
    J Magn Reson Imaging 31:1242-51. 2010
    ....
  10. pmc Intra-voxel incoherent motion MRI in rodent model of diethylnitrosamine-induced liver fibrosis
    Yue Zhang
    Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA
    Magn Reson Imaging 31:1017-21. 2013
    ..To compare the apparent diffusion coefficient (ADC) and the perfusion fraction measured by intra-voxel incoherent motion (IVIM) Magnetic Resonance Imaging (MRI) with liver fibrosis degrees in a rodent model...
  11. pmc Inhibition of chronic pancreatitis and pancreatic intraepithelial neoplasia (PanIN) by capsaicin in LSL-KrasG12D/Pdx1-Cre mice
    Han Bai
    Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Ward 6 118, Chicago, IL 60611, USA
    Carcinogenesis 32:1689-96. 2011
    ..These results indicate that capsaicin could be a promising agent for the chemoprevention of pancreatic carcinogenesis, possibly via inhibiting pancreatitis and mutant Kras-led ERK activation...
  12. ncbi request reprint Inhibition of chronic ulcerative colitis associated adenocarcinoma development in mice by inositol compounds
    Jie Liao
    Department of Pathology, Northwestern University, Feinberg School of Medicine 303 East Chicago Avenue, Chicago, IL 60611, USA
    Carcinogenesis 28:446-54. 2007
    ..This study indicates that inositol compounds may have the potential to serve as preventive agents for chronic inflammation-carcinogenesis...
  13. ncbi request reprint Cytologic features and histologic correlations of microacinar and microtrabecular types of well-differentiated hepatocellular carcinoma in fine-needle aspiration biopsy
    Grace C H Yang
    Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    Cancer 102:27-33. 2004
    ..The objective of this study was to characterize the cytologic features of this pattern with histologic correlations...
  14. pmc Irreversible electroporation in the liver: contrast-enhanced inversion-recovery MR imaging approaches to differentiate reversibly electroporated penumbra from irreversibly electroporated ablation zones
    Yang Guo
    Department of Radiology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 737 N Michigan Ave, 16th Floor, Chicago, IL 60611, USA
    Radiology 258:461-8. 2011
    ....
  15. pmc Gas challenge-blood oxygen level-dependent (GC-BOLD) MRI in the rat Novikoff hepatoma model
    Yang Guo
    Department of Radiology, Northwestern University, Chicago, IL 60611, USA
    Magn Reson Imaging 30:133-8. 2012
    ..The purpose of the study was to investigate the relationship between gas challenge-blood oxygen level-dependent (GC-BOLD) response angiogenesis and tumor size in rat Novikoff hepatoma model...
  16. pmc Magnetization transfer MRI in pancreatic cancer xenograft models
    Weiguo Li
    Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Magn Reson Med 68:1291-7. 2012
    ..69, P=0.01). Results indicated that MTR measurements offer the potential to serve as a valuable in vivo biomarker of desmoplasia in pancreatic ductal adenocarcinoma...
  17. pmc MR imaging to assess immediate response to irreversible electroporation for targeted ablation of liver tissues: preclinical feasibility studies in a rodent model
    Yue Zhang
    Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA
    Radiology 256:424-32. 2010
    ..To test the hypothesis that magnetic resonance (MR) imaging measurements can be used to immediately detect treated tissue regions after irreversible electroporation (IRE) ablation procedures in rodent liver tissues...
  18. pmc Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis
    Jeffrey B Brown
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children s Memorial Hospital, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Gastroenterology 138:595-605, 605.e1-3. 2010
    ..The present study addressed the possibility that mesalamine reduces beta-catenin-associated progenitor cell activation, Akt-phosphorylated beta-catenin(Ser552) (P-beta-catenin), and colitis-induced dysplasia (CID)...
  19. ncbi request reprint Parietal cell carcinoma of gastric cardia: immunophenotype and ultrastructure
    Guang Yu Yang
    Department of Pathology, NYU Medical Center, and New York Harbor Healthcare Center, New York University School of Medicine, New York, New York 10010, USA
    Ultrastruct Pathol 27:87-94. 2003
    ..Immunohistochemically, there was positive staining of tumor cells for the parietal cell specific antibodies to H/K-ATPase and human milk fat globule-2 (HMFG-2)...
  20. pmc Functional magnetic resonance imaging in an animal model of pancreatic cancer
    Robert J Lewandowski
    Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    World J Gastroenterol 16:3292-8. 2010
    ..To test the hypotheses that diffusion weighed (DW)- and transcatheter intraarterial perfusion (TRIP)-magnetic resonance imaging (MRI) can each be used to assess regional differences in tumor function in an animal pancreatic cancer model...
  21. pmc Mucinous nonneoplastic cyst of the pancreas: apomucin phenotype distinguishes this entity from intraductal papillary mucinous neoplasm
    Wenqing Cao
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Hum Pathol 41:513-21. 2010
    ..For the first time, using HUMARA assay, we demonstrate the nonneoplastic nature of these cysts and further characterize morphologic and immunophenotypic properties that allow differentiation from intraductal papillary mucinous neooplasm...
  22. doi request reprint Carbogen gas-challenge BOLD MR imaging in a rat model of diethylnitrosamine-induced liver fibrosis
    Ning Jin
    Department of Radiology, Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611, USA
    Radiology 254:129-37. 2010
    ..To investigate the relationship between gas-challenge blood oxygen level-dependent (BOLD) magnetic resonance (MR) imaging measurements and hepatic disease progression in a rat model of diethylnitrosamine (DEN)-induced liver fibrosis...
  23. pmc Quantitative magnetization transfer MRI of desmoplasia in pancreatic ductal adenocarcinoma xenografts
    Weiguo Li
    Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    NMR Biomed 26:1688-95. 2013
    ..77, P < 0.01). Our results indicate that qMT measurements offer the potential to noninvasively quantify fibrosis levels in PDAC mouse xenograft models and thus serve as a valuable in vivo biomarker of desmoplasia in PDAC...
  24. pmc Unique morphologic and clinical features of liver predominant/primary small cell carcinoma--autopsy and biopsy case series
    Amy A Lo
    Department of Pathology, Northwestern University, Chicago, IL 60611
    Ann Diagn Pathol 18:151-6. 2014
    ....
  25. pmc MRI-guided biopsy to correlate tissue specimens with MR elastography stiffness readings in liver transplants
    Ryan B Perumpail
    Department of Radiology, Northwestern University, Chicago, IL 60611, USA
    Acad Radiol 19:1121-6. 2012
    ..In this study, the ability of real-time MRI to guide biopsies of segments of the liver with different MRE stiffness values in the same post-transplant patient was assessed...
  26. ncbi request reprint Dysplastic lesions in inflammatory bowel disease: molecular pathogenesis to morphology
    Kristina A Matkowskyj
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Arch Pathol Lab Med 137:338-50. 2013
    ..With better screening modalities and detection/characterization of dysplastic lesions, IBD-associated serrated lesions, and "field cancerization," we will improve our understanding of and approach to risk stratification...
  27. pmc Systemic immunoregulatory and proteogenomic effects of tacrolimus to sirolimus conversion in liver transplant recipients
    Josh Levitsky
    Division of Gastroenterology and Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Hepatology 57:239-48. 2013
    ..Finally, 289 novel genes and 22 proteins, several important in immunoregulatory pathways, were expressed after conversion...
  28. pmc Irreversible electroporation therapy in the liver: longitudinal efficacy studies in a rat model of hepatocellular carcinoma
    Yang Guo
    Department of Radiology, Northwestern University, Chicago, Illinois 60611, USA
    Cancer Res 70:1555-63. 2010
    ..Our findings suggest that IRE can be an effective strategy for targeted ablation of liver tumors, prompting its further evaluation for HCC therapy...
  29. ncbi request reprint Expression of glypican 3 in hepatoblastoma: an immunohistochemical study of 65 cases
    Debra L Zynger
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Hum Pathol 39:224-30. 2008
    ..The high GPC3 expression consistently demonstrated in this study suggests that GPC3 may play a role in the tumorigenesis of hepatoblastoma...
  30. pmc Increased susceptibility of chronic ulcerative colitis-induced carcinoma development in DNA repair enzyme Ogg1 deficient mice
    Jie Liao
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Mol Carcinog 47:638-46. 2008
    ..These results provide important evidence on the relationship between inflammation-caused oxidative stress, DNA repair enzyme Ogg1, and carcinogenesis...
  31. pmc CAAX-box protein, prenylation process and carcinogenesis
    Juehua Gao
    Department of Pathology, Northwestern University, Feinberg School of Medicine 303 East Chicago Avenue, Chicago, Illinois, USA
    Am J Transl Res 1:312-25. 2009
    ..Here, we mainly focus on the prenylation process of the clinically important CAAX box proteins, and their potential as a biomarker or preventive/therapeutic target in carcinogenesis...
  32. pmc Somatic acquisition of TGFBR1*6A by epithelial and stromal cells during head and neck and colon cancer development
    Yansong Bian
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Northwestern University, Chicago, IL 60611, USA
    Hum Mol Genet 16:3128-35. 2007
    ..They also represent the first human report of somatically acquired altered stromal TGF-beta signaling during oncogenesis and the first report of a concordant mutation in the stromal and epithelial compartments in colon cancer...
  33. ncbi request reprint Clear cell carcinoma of the pancreas: histopathologic features and a unique biomarker: hepatocyte nuclear factor-1beta
    Lisa Kim
    Department of Pathology and Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Mod Pathol 21:1075-83. 2008
    ..Hepatocyte nuclear factor-1beta is a useful marker to identify these clear cell carcinomas, and its overexpression may aid in stratifying survival rate...
  34. ncbi request reprint Downregulation of missing in metastasis gene (MIM) is associated with the progression of bladder transitional carcinomas
    Ying Wang
    Department of Pathology, University of Maryland, Marlene Stewart Greenebaum Cancer Center, Baltimore, Maryland 21201, USA
    Cancer Invest 25:79-86. 2007
    ..This finding indicates that downegulation of MIM expression may correlate with the transition of tumor cells from distinct epithelium-like morphology to less differentiated carcinomas...
  35. ncbi request reprint Distinguishing well-differentiated hepatocellular carcinoma from benign liver by the physical features of fine-needle aspirates
    Grace C H Yang
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Mod Pathol 17:798-802. 2004
    ..This physical characteristic can be used as the first clue to distinguish malignant and benign liver aspirates prior to microscopic examination...

Research Grants9

  1. Ulcerative colitis-associated cancer and its prevention
    Guang Yu Yang; Fiscal Year: 2005
    ..This concept will be investigated using our UC-Ca model as well as using Ogg1 knockout mice. ..
  2. Ulcerative colitis-associated cancer and its prevention
    Guang Yu Yang; Fiscal Year: 2006
    ..This concept will be investigated using our UC-Ca model as well as using Ogg1 knockout mice. ..
  3. HMG-CoA reductase inhibitor, tea polyphenols and pancreatic cancer prevention
    Guang Yu Yang; Fiscal Year: 2007
    ....
  4. Soluble epoxide hydrolase as a novel target of colitis-induced carcinogenesis
    Guang Yu Yang; Fiscal Year: 2009
    ....
  5. Soluble epoxide hydrolase as a novel target of colitis-induced carcinogenesis
    Guang Yu Yang; Fiscal Year: 2010
    ....
  6. Ulcerative colitis-associated cancer and its prevention
    Guang Yu Yang; Fiscal Year: 2004
    ..This concept will be investigated using our UC-Ca model as well as using Ogg1 knockout mice. ..
  7. Ulcerative colitis-associated cancer and its prevention
    Guang Yu Yang; Fiscal Year: 2007
    ..This concept will be investigated using our UC-Ca model as well as using Ogg1 knockout mice. ..