Research Topics
Species | Richard G WunderinkSummaryAffiliation: Northwestern University Country: USA Publications
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Publications
Clinical cure and survival in Gram-positive ventilator-associated pneumonia: retrospective analysis of two double-blind studies comparing linezolid with vancomycinMarin H Kollef
Pulmonary and Critical Care Division, Department of Internal Medicine, School of Medicine, Washington University, 660 South Euclid Avenue, St Louis, MO 63110, USA
Intensive Care Med 30:388-94. 2004..To assess the effect of baseline variables, including treatment, on clinical cure and survival rates in patients with Gram-positive, ventilator-associated pneumonia (VAP)...- Methicillin-Resistant S. aureus Ventilator-Associated Pneumonia: Strategies to Prevent and TreatAnna P Lam
Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Semin Respir Crit Care Med 27:92-103. 2006..Treatment with linezolid, which penetrates well into the lung, is associated with higher cure and survival rates. Further data are needed to evaluate the efficacy of new antibiotics in MRSA VAP... 
How Important is Methicillin-Resistant Staphylococcus aureus as a Cause of Community-Acquired Pneumonia and What is Best Antimicrobial Therapy?Richard G Wunderink
Pulmonary and Critical Care Division, Northwestern University Feinberg School of Medicine, 676 North Saint Clair Street, Arkes 14 044, Chicago, IL 60611, USA Electronic address
Infect Dis Clin North Am 27:177-88. 2013..The consistent trend toward better outcomes for documented MRSA pneumonia suggests that linezolid be considered the drug of choice for documented MRSA CAP, especially for CA-MRSA...- Adjunctive therapy in community-acquired pneumoniaRichard G Wunderink
Department of Medicine, Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 North St Clair, Chicago, IL 60611, USA
Semin Respir Crit Care Med 33:311-8. 2012..Other therapies have theoretical benefit but are not yet in the stage of clinical trials... - Rapid response team-triggered procalcitonin measurement predicts infectious intensive care unit transfers*Richard G Wunderink
Department of Medicine, Pulmonary and Critical Care Division, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Crit Care Med 40:2090-5. 2012..Determine if procalcitonin at the time of initial rapid response team activation identifies patients who are likely to need subsequent intensive care unit transfer... - Linezolid in methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled studyRichard G Wunderink
Department of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Clin Infect Dis 54:621-9. 2012..This study prospectively assessed efficacy and safety of linezolid, compared with a dose-optimized vancomycin regimen, for treatment of MRSA nosocomial pneumonia... 
A clinical evaluation committee assessment of recombinant human tissue factor pathway inhibitor (tifacogin) in patients with severe community-acquired pneumoniaPierre Francois Laterre
St Luc University Hospital, Universite Catholique de Louvain, Avenue Hippocrate 10, 1200 Brussels, Belgium
Crit Care 13:R36. 2009....- Genetics of community-acquired pneumoniaRichard G Wunderink
Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Semin Respir Crit Care Med 26:553-62. 2005..The real value of these genetic studies in CAP and other severe infections will be when the management of an individual patient can be optimized by therapy based on the individual's genotype for molecules important in outcome... - Influenza and bacterial pneumonia--constant companionsRichard G Wunderink
Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, 676 North St, Clair Street, Suite 14 044, Chicago, IL 60611, USA
Crit Care 14:150. 2010..Given the frequency of viral pneumonia and diagnostic limitations, empirical antivirals may be underutilized in community-acquired pneumonia. Thankfully, increasingly effective vaccines appear to disrupt this synergistic relationship... - Community-acquired pneumonia: pathophysiology and host factors with focus on possible new approaches to management of lower respiratory tract infectionsRichard G Wunderink
Northwestern University Feinberg School of Medicine, 676 North St Clair, Suite 14 044, Chicago, IL 60611, USA
Infect Dis Clin North Am 18:743-59, vii. 2004..This article reviews genetic variation in the molecules involved in the known patho-genic mechanisms of CAP, including cough, bacterial recognition, inflammation and the compensatory anti-inflammatory response,and organ dysfunction... - Recombinant tissue factor pathway inhibitor in severe community-acquired pneumonia: a randomized trialRichard G Wunderink
Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Am J Respir Crit Care Med 183:1561-8. 2011..A systemic inhibitor of coagulation, tifacogin (recombinant human tissue factor pathway inhibitor) seemed to provide mortality benefit in the sCAP subgroup of a previous sepsis trial... - Scenario 2: community-acquired pneumonia requiring hospitalization but not requiring admission to an intensive care unitRichard G Wunderink
Pulmonary and Critical Care Division, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Clin Infect Dis 47:S186-8. 2008..The patient is a 65-year-old woman with community-acquired pneumonia of sufficient severity to require hospitalization. Factors important for consideration in clinical trials are illustrated... - [Assessment of patients with poor resolution of HAP]Richard G Wunderink
Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine Chicago, Illinois, USA
Enferm Infecc Microbiol Clin 23:52-7. 2005..Biochemical markers may be more accurate than clinical but still don't discriminate between causes. The appropriate diagnostic strategy and treatment algorithms have not been fully addressed and more research is clearly needed... - Adjunctive therapy in community-acquired pneumoniaRichard G Wunderink
Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Semin Respir Crit Care Med 30:146-53. 2009..Other therapies have theoretical benefit but are not yet in the stage of clinical trials... - Nosocomial pneumonia, including ventilator-associated pneumoniaRichard G Wunderink
Pulmonary and Critical Care Division, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 North St Clair, Suite 14 044, Chicago, IL 60611, USA
Proc Am Thorac Soc 2:440-4. 2005..Adequate treatment of an initial infection is required for reversal of the temporary immunoparalysis, whereas specific immunomodulatory therapies can reverse the markers of immunoparalysis and may decrease the risk of infection... - Early microbiological response to linezolid vs vancomycin in ventilator-associated pneumonia due to methicillin-resistant Staphylococcus aureusRichard G Wunderink
Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Chest 134:1200-7. 2008..This prospective, open-label, multicenter clinical trial compared the early microbiological efficacy of linezolid (LZD) therapy with that of vancomycin (VAN) therapy in patients with MRSA VAP... - Expanded clinical presentation of community-acquired methicillin-resistant Staphylococcus aureus pneumoniaL Jason Lobo
Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Chest 138:130-6. 2010..The frequency of occurrence, risk factors, and optimal treatment of CA-MRSA CAP are unclear... - Empiric antibiotic, mechanical ventilation, and central venous catheter duration as potential factors mediating the effect of a checklist prompting intervention on mortality: an exploratory analysisCurtis H Weiss
Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Suite 1400 676 N, St, Clair, Chicago, IL 60611, USA
BMC Health Serv Res 12:198. 2012..We sought to examine the degree to which these process of care improvements explained the observed difference in hospital mortality between the group that received prompting and an unprompted control group... - The role of MRSA in healthcare-associated pneumoniaAnna P Lam
Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Semin Respir Crit Care Med 30:52-60. 2009..The limitations of vancomycin and evidence for superior outcomes with linezolid are reviewed. Alternatives for community-acquired strains and future options are mentioned... - The effect of rosuvastatin in a murine model of influenza A infectionKathryn A Radigan
Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
PLoS ONE 7:e35788. 2012..We hypothesized that rosuvastatin would decrease viral replication, attenuate lung injury, and improve mortality following influenza A infection in mice... - Surrogate markers and microbiologic end pointsRichard G Wunderink
Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Clin Infect Dis 51:S126-30. 2010..A decreasing or low procalcitonin level after initiation of antibiotic treatment correlates well with bacterial eradication... - Management of community-acquired pneumonia in adultsGrant W Waterer
University of Western Australia, Perth, Australia
Am J Respir Crit Care Med 183:157-64. 2011.... - Potential impact of vancomycin pulmonary distribution on treatment outcomes in patients with methicillin-resistant Staphylococcus aureus pneumoniaMarc H Scheetz
Department of Pharmacy, Northwestern Memorial Hospital, Chicago, Illinois 60611, USA
Pharmacotherapy 26:539-50. 2006..The possibility of increased serum vancomycin concentrations as a method to optimize current treatment outcomes is also explored... - Bronchoalveolar lavage amylase is associated with risk factors for aspiration and predicts bacterial pneumonia*Curtis H Weiss
1 Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 2 Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 3 Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL
Crit Care Med 41:765-73. 2013.... - Comparative in vitro stimulation with lipopolysaccharide to study TNFalpha gene expression in fresh whole blood, fresh and frozen peripheral blood mononuclear cellsJiwang Chen
Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
J Immunol Methods 357:33-7. 2010..Our results strongly suggest that fresh whole blood is the best choice for in vitro stimulation studies... - Severe pseudomonal infectionsGokhan M Mutlu
Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Curr Opin Crit Care 12:458-63. 2006..To review the most recent data on severe Pseudomonas aeruginosa infections. The focus will be on clinical studies with an emphasis on the critically ill... - Derivation of a triage algorithm for chest radiography of community-acquired pneumonia patients in the emergency departmentDemetrios N Kyriacou
Department of Emergency Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Acad Emerg Med 15:40-4. 2008..Community-acquired pneumonia (CAP) accounts for 1.5 million emergency department (ED) patient visits in the United States each year... - Prompting physicians to address a daily checklist and process of care and clinical outcomes: a single-site studyCurtis H Weiss
Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Am J Respir Crit Care Med 184:680-6. 2011..Checklists may reduce errors of omission for critically ill patients... - Use and limitations of clinical and radiologic diagnosis of pneumoniaMatthew Mabie
Research Department, Methodist-University Hospital, Memphis, TN, USA
Semin Respir Infect 18:72-9. 2003..An accurate assessment of the normal, expected response of pneumonia to antibiotic therapy is therefore crucial. A discussion of the clinical response to treatment concludes the article... - Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsisSachin Yende
The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Am J Respir Crit Care Med 177:1242-7. 2008..Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown... - Evaluation of ICU admission criteria and diagnostic methods for patients with severe community-acquired pneumonia: current practice surveyMarcos I Restrepo
Chest 133:828-9. 2008 - There is no "cap" on the importance of community-acquired pneumonia in the ICUAndrew F Shorr
Chest 133:590-2. 2008 - 4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumoniaSachin Yende
CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Respir Crit Care Med 176:1129-37. 2007..Whether variation within the PAI-1 gene is associated with increased susceptibility to infection is unknown... - Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adultsLionel A Mandell
McMaster University Medical School, Hamilton, Ontario, Canada
Clin Infect Dis 44:S27-72. 2007 - Tumor necrosis factor gene polymorphisms and the variable presentation and outcome of community-acquired pneumoniaRichard G Wunderink
Methodist Le Bonheur Healthcare Foundation, University of Tennessee, Memphis, TN, USA
Chest 121:87S. 2002 - Association of tumor necrosis factor gene polymorphisms and prolonged mechanical ventilation after coronary artery bypass surgerySachin Yende
Methodist Healthcare University Hospital, Memphis, TN, USA
Crit Care Med 31:133-40. 2003.... - Heat shock protein 70-2+1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumoniaGrant W Waterer
Department of Medicine, University of Western Australia
Crit Care Med 31:1367-72. 2003.... - Continuation of a randomized, double-blind, multicenter study of linezolid versus vancomycin in the treatment of patients with nosocomial pneumoniaRichard G Wunderink
Methodist Healthcare Memphis and the University of Tennessee, Memphis, Tennessee 38104 3499, USA
Clin Ther 25:980-92. 2003.... - Genetics of sepsis and pneumoniaRichard G Wunderink
Research Department, Methodist LeBonheur Healthcare, Memphis, Tennessee, USA
Curr Opin Crit Care 9:384-9. 2003..Recent association studies in pneumonia and sepsis will be reviewed... - Impact of cytokine gene polymorphisms on outcomes of coronary artery bypass graft surgerySachin Yende
Methodist Healthcare and University of Tennessee, Memphis, TN 38104, USA
Chest 121:86S. 2002 - Intracellular adhesion molecule Gly241Arg polymorphism has no impact on ARDS or septic shock in community-acquired pneumoniaMichael W Quasney
Department of Pediatrics, Crippled Children's Foundation Research Center, University of Tennessee, Memphis, 38103, USA
Chest 121:85S-86S. 2002 - Clinical relevance of angiotensin-converting enzyme gene polymorphisms to predict risk of mechanical ventilation after coronary artery bypass graft surgerySachin Yende
Physician Research Network SY, Methodist Healthcare Memphis, Memphis, TN, USA
Crit Care Med 32:922-7. 2004..Therefore, we examined interactions between these polymorphisms... - A long and winding roadRichard G Wunderink
Crit Care Med 32:1077-9. 2004 - Association between surfactant protein B + 1580 polymorphism and the risk of respiratory failure in adults with community-acquired pneumoniaMichael W Quasney
Division of Critical Care, Department of Pediatrics, University of Tennessee, Memphis, Children s Foundation Research Center of Memphis, Le Bonheur Children s Medical Center, 50 N Dunlap, Memphis, TN 38103, USA
Crit Care Med 32:1115-9. 2004..The objective was to determine whether the SP-B + 1580 CC genotype is associated with an increased risk of respiratory failure and ARDS in adults with community-acquired pneumonia... - Healthcare-associated bacteremia: Stirring the mudRichard G Wunderink
Crit Care Med 34:2685-6. 2006 - Slow response times: is it the pneumonia or the physician?Richard G Wunderink
Crit Care Med 33:1429-30. 2005 - Genetic polymorphisms that predict outcome and need for treatment in cardiovascular diseaseSachin Yende
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Curr Opin Crit Care 12:420-5. 2006..SUMMARY: A familial risk of cardiovascular disease is well known. The specific genotypes at risk are increasingly being discovered. The science has progressed to the point that genotype-specific interventions are increasingly feasible... - Delayed administration of antibiotics and atypical presentation in community-acquired pneumoniaGrant W Waterer
University of Western Australia, School of Medicine and Pharmacology, 4th Floor MRF Building, Royal Perth Hospital, GPO Box X2213, Perth, WA, Australia 6847
Chest 130:11-5. 2006..We investigated the factors that predict a prolonged TFAD and their association with mortality... - Pharmaceutical industry research and cost savings in community-acquired pneumoniaLori A Kessler
Physicians Research Network, Methodist Le Bonheur Healthcare Foundation, Memphis, Tenn 38104, USA
Am J Manag Care 8:798-800. 2002..To provide financial justification for continuing pharmaceutical research in an environment that has met with increasing resistance from insurance carriers to paying for the care of patients enrolled in research studies... - Dollars and sense in the intensive care unit: the costs of ventilator-associated pneumoniaAndrew F Shorr
Crit Care Med 31:1582-3. 2003 - A CAP on antibiotic durationRichard G Wunderink
Am J Respir Crit Care Med 174:3-5. 2006 - High-dose, short-course levofloxacin for community-acquired pneumonia: a new treatment paradigmLala M Dunbar
Louisiana State University Medical Center, New Orleans, Louisiana, USA
Clin Infect Dis 37:752-60. 2003..2% and 92.4% in the 750-mg and 500-mg groups, respectively. These data demonstrate that 750 mg of levofloxacin per day for 5 days is at least as effective as 500 mg per day for 10 days for treatment of mild-to-severe CAP... - " 'Tis a gift to be simple..."Richard G Wunderink
Chest 124:777-8. 2003 - Health care-associated infection (HAI): a critical appraisal of the emerging threat-proceedings of the HAI SummitMarin H Kollef
Washington University School of Medicine, St Louis, Missouri 63110, USA
Clin Infect Dis 47:S55-99; quiz S100-1. 2008.... - Linezolid vs vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumoniaRichard G Wunderink
Methodist Healthcare Memphis and the University of Tennessee, Memphis, TN 38104 3499, USA
Chest 124:1789-97. 2003..To assess the effect of baseline variables, including treatment, on outcome in patients with nosocomial pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA)... - Genetic susceptibility to pneumoniaGrant W Waterer
School of Medicine and Pharmacology, University of Western Australia, Royal Perth Hospital, GP0 Box X2213, Perth, Western Australia
Clin Chest Med 26:29-38. 2005..IL-10 and IL-1 receptor antagonist polymorphisms have an important role in the anti-inflammatory response. Specific organ dysfunction, such as ARDS or DIC, may be related to polymorphisms in specific effector genes... - Medium-term survival after hospitalization with community-acquired pneumoniaGrant W Waterer
Department of Medicine, University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia
Am J Respir Crit Care Med 169:910-4. 2004....