L D Wilsbacher

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi request reprint Circadian rhythms: molecular basis of the clock
    L D Wilsbacher
    Department of Neurobiology and Physiology, Northwestern University, 2153 N Campus Drive, Evanston, Illinois 60208, USA
    Curr Opin Genet Dev 8:595-602. 1998
  2. pmc Functional identification of the mouse circadian Clock gene by transgenic BAC rescue
    M P Antoch
    National Science Foundation Center for Biological Timing, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Cell 89:655-67. 1997
  3. pmc The mouse Clock locus: sequence and comparative analysis of 204 kb from mouse chromosome 5
    L D Wilsbacher
    Howard Hughes Medical Institute, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Genome Res 10:1928-40. 2000
  4. ncbi request reprint Positional cloning of the mouse circadian clock gene
    D P King
    National Science Foundation Center for Biological Timing, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Cell 89:641-53. 1997
  5. ncbi request reprint Role of the CLOCK protein in the mammalian circadian mechanism
    N Gekakis
    Department of Neurobiology, Harvard Medical School, Boston MA 02115, USA 02115, USA
    Science 280:1564-9. 1998
  6. pmc Mop3 is an essential component of the master circadian pacemaker in mammals
    M K Bunger
    The McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, WI 53706, USA
    Cell 103:1009-17. 2000

Collaborators

  • Y Zhao
  • M Tanaka
  • P L Lowrey
  • L H Pinto
  • J S Takahashi
  • D P King
  • M P Antoch
  • M K Bunger
  • N Gekakis
  • M H Vitaterna
  • A M Sangoram
  • L A Radcliffe
  • C A Bradfield
  • C Clendenin
  • S M Moran
  • J B Hogenesch
  • M C Simon
  • H B Nguyen
  • F C Davis
  • D Staknis
  • C J Weitz
  • J M Kornhauser
  • A M Chang
  • T D Steeves
  • F W Turek
  • E J Song

Detail Information

Publications6

  1. ncbi request reprint Circadian rhythms: molecular basis of the clock
    L D Wilsbacher
    Department of Neurobiology and Physiology, Northwestern University, 2153 N Campus Drive, Evanston, Illinois 60208, USA
    Curr Opin Genet Dev 8:595-602. 1998
    ..In addition, the discovery of brain-independent clocks promises to revolutionize the study of circadian biology...
  2. pmc Functional identification of the mouse circadian Clock gene by transgenic BAC rescue
    M P Antoch
    National Science Foundation Center for Biological Timing, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Cell 89:655-67. 1997
    ..Taken together, these results provide a proof of principle that "cloning by rescue" is an efficient and definitive method in mice...
  3. pmc The mouse Clock locus: sequence and comparative analysis of 204 kb from mouse chromosome 5
    L D Wilsbacher
    Howard Hughes Medical Institute, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Genome Res 10:1928-40. 2000
    ..Finally, a new BAC transgenic line indicates that the genomic region that is sufficient for rescue of the Clock mutant phenotype is no greater than 120 kb and tightly flanks the 3' end of the Clock gene...
  4. ncbi request reprint Positional cloning of the mouse circadian clock gene
    D P King
    National Science Foundation Center for Biological Timing, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Cell 89:641-53. 1997
    ..CLOCK represents the second example of a PAS domain-containing clock protein (besides Drosophila PERIOD), which suggests that this motif may define an evolutionarily conserved feature of the circadian clock mechanism...
  5. ncbi request reprint Role of the CLOCK protein in the mammalian circadian mechanism
    N Gekakis
    Department of Neurobiology, Harvard Medical School, Boston MA 02115, USA 02115, USA
    Science 280:1564-9. 1998
    ..Thus, CLOCK-BMAL1 heterodimers appear to drive the positive component of per transcriptional oscillations, which are thought to underlie circadian rhythmicity...
  6. pmc Mop3 is an essential component of the master circadian pacemaker in mammals
    M K Bunger
    The McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, WI 53706, USA
    Cell 103:1009-17. 2000
    ..These results provide genetic evidence that MOP3 is the bona fide heterodimeric partner of mCLOCK. Furthermore, these data demonstrate that MOP3 is a nonredundant and essential component of the circadian pacemaker in mammals...