Jian Jun Wei

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. doi request reprint miR-106a represses the Rb tumor suppressor p130 to regulate cellular proliferation and differentiation in high-grade serous ovarian carcinoma
    Zhaojian Liu
    Department of Pathology, Northwestern University School of Medicine, Feinberg 7 334, 251 East Huron Street, Chicago, IL 60611
    Mol Cancer Res 11:1314-25. 2013
  2. doi request reprint Endometriosis and ovarian cancer: a review of clinical, pathologic, and molecular aspects
    Jian Jun Wei
    Department of Pathology, Division of Reproductive Biology Research, Northwestern University Feinberg School of Medicine, 251 E Huron St, Chicago, IL, 60611, USA
    Int J Gynecol Pathol 30:553-68. 2011
  3. doi request reprint HMGA2: a potential biomarker complement to P53 for detection of early-stage high-grade papillary serous carcinoma in fallopian tubes
    Jian Jun Wei
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Am J Surg Pathol 34:18-26. 2010
  4. doi request reprint MicroRNA: a new tool for biomedical risk assessment and target identification in human uterine leiomyomas
    Jian Jun Wei
    Department of Pathology, Northwestern University, Chicago, Illinois 60611, USA
    Semin Reprod Med 26:515-21. 2008
  5. doi request reprint MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma
    Zhaojian Liu
    Department of Pathology, Northwestern University School of Medicine, Chicago, IL 60611, USA
    J Pathol 228:204-15. 2012
  6. doi request reprint Let-7 repression leads to HMGA2 overexpression in uterine leiomyosarcoma
    Guizhi Shi
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    J Cell Mol Med 13:3898-905. 2009
  7. doi request reprint Antiproliferative effects by Let-7 repression of high-mobility group A2 in uterine leiomyoma
    Yi Peng
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Mol Cancer Res 6:663-73. 2008
  8. doi request reprint HMGA2: a biomarker significantly overexpressed in high-grade ovarian serous carcinoma
    Aparna Mahajan
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    Mod Pathol 23:673-81. 2010
  9. ncbi request reprint Ethnic differences in expression of the dysregulated proteins in uterine leiomyomata
    Jian Jun Wei
    Department of Pathology, New York University School of Medicine, Bellevue Hospital, 560 First Avenue, New York, NY 10016, USA
    Hum Reprod 21:57-67. 2006
  10. pmc Regulation of HMGA1 expression by microRNA-296 affects prostate cancer growth and invasion
    Jian Jun Wei
    Department of Pathology, Northwestern University, Feinberg Medical School, Chicago, Illinois, USA
    Clin Cancer Res 17:1297-305. 2011

Collaborators

Detail Information

Publications21

  1. doi request reprint miR-106a represses the Rb tumor suppressor p130 to regulate cellular proliferation and differentiation in high-grade serous ovarian carcinoma
    Zhaojian Liu
    Department of Pathology, Northwestern University School of Medicine, Feinberg 7 334, 251 East Huron Street, Chicago, IL 60611
    Mol Cancer Res 11:1314-25. 2013
    ..Implications: The current study suggests that the RB tumor suppressor pathway is a critical regulator of growth and differentiation in HGSOC...
  2. doi request reprint Endometriosis and ovarian cancer: a review of clinical, pathologic, and molecular aspects
    Jian Jun Wei
    Department of Pathology, Division of Reproductive Biology Research, Northwestern University Feinberg School of Medicine, 251 E Huron St, Chicago, IL, 60611, USA
    Int J Gynecol Pathol 30:553-68. 2011
    ..This study is a review of the natural history of endometriosis and the role of microenvironments that favor the accumulation of genetic alterations and endometriosis-associated ovarian cancer progression...
  3. doi request reprint HMGA2: a potential biomarker complement to P53 for detection of early-stage high-grade papillary serous carcinoma in fallopian tubes
    Jian Jun Wei
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Am J Surg Pathol 34:18-26. 2010
    ..45), indicating the role of HMGA2 in p53 mediated tumor progression. Our findings of immunoreactivity for HMGA2 may lead to a novel, useful biomarker to complement p53 in the detection of early-stage serous carcinoma...
  4. doi request reprint MicroRNA: a new tool for biomedical risk assessment and target identification in human uterine leiomyomas
    Jian Jun Wei
    Department of Pathology, Northwestern University, Chicago, Illinois 60611, USA
    Semin Reprod Med 26:515-21. 2008
    ..Among the most highly dysregulated miRNAs, let-7 miRNAs seem to play a critical role in tumorigenesis of ULMs through negative regulation of some key target oncogenes, including high mobility group 2...
  5. doi request reprint MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma
    Zhaojian Liu
    Department of Pathology, Northwestern University School of Medicine, Chicago, IL 60611, USA
    J Pathol 228:204-15. 2012
    ..Our findings suggest that miR-182 dysregulation confers powerful oncogenic potential in the tumourigenesis of HG-SOC. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd...
  6. doi request reprint Let-7 repression leads to HMGA2 overexpression in uterine leiomyosarcoma
    Guizhi Shi
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    J Cell Mol Med 13:3898-905. 2009
    ..We found that overexpression of HMGA2 and let-7-mediated HMGA2 repression is a relevant molecular alteration in ULMS. Disrupting the control of HMGA2 and let-7 pairs promotes ULMS cell growth in vitro...
  7. doi request reprint Antiproliferative effects by Let-7 repression of high-mobility group A2 in uterine leiomyoma
    Yi Peng
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Mol Cancer Res 6:663-73. 2008
    ..Our findings suggest that the Let-7-mediated repression of HMGA2 mechanism can be an important molecular event in leiomyoma growth...
  8. doi request reprint HMGA2: a biomarker significantly overexpressed in high-grade ovarian serous carcinoma
    Aparna Mahajan
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    Mod Pathol 23:673-81. 2010
    ..Our findings suggest that HMGA2 is an important molecular change significantly related to high-grade papillary serous carcinoma and is less common in other histological types of ovarian cancer...
  9. ncbi request reprint Ethnic differences in expression of the dysregulated proteins in uterine leiomyomata
    Jian Jun Wei
    Department of Pathology, New York University School of Medicine, Bellevue Hospital, 560 First Avenue, New York, NY 10016, USA
    Hum Reprod 21:57-67. 2006
    ..Black ethnicity is one of the risk factors for uterine leiomyomata (ULM). Little is known about the ethnic differences in leiomyoma-associated gene products in women with uterine leiomyomata...
  10. pmc Regulation of HMGA1 expression by microRNA-296 affects prostate cancer growth and invasion
    Jian Jun Wei
    Department of Pathology, Northwestern University, Feinberg Medical School, Chicago, Illinois, USA
    Clin Cancer Res 17:1297-305. 2011
    ..However, regulation of HMGA1 expression is not well understood. Identification of microRNA-mediated HMGA1 regulation will provide a promising therapeutic target in treating PC...
  11. doi request reprint Cellular senescence in usual type uterine leiomyoma
    Jordan Laser
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    Fertil Steril 93:2020-6. 2010
    ..To evaluate the role of senescence in symptomatic patients with multifibroids...
  12. ncbi request reprint Spatial differences in biologic activity of large uterine leiomyomata
    Jian Jun Wei
    Department of Pathology, Bellevue Hospital, New York, New York, USA
    Fertil Steril 85:179-87. 2006
    ..To evaluate the growth pattern of the large uterine leiomyomata (ULM), we examined the spatial gene distributions, vessel density, proliferative activity, and hyaline degeneration...
  13. doi request reprint Expression analysis of MIR182 and its associated target genes in advanced ovarian carcinoma
    Brian D McMillen
    Department of Pathology, Northwestern University, Feinberg Medical School, Chicago, IL, USA
    Mod Pathol 25:1644-53. 2012
    ..02). FOXO3 expression was associated with lower-stage disease (P=0.04) and solid growth pattern (P=0.03). MIR182 expression is significantly higher in high-grade serous ovarian carcinoma than in fallopian tubes...
  14. pmc Genome-wide DNA methylation indicates silencing of tumor suppressor genes in uterine leiomyoma
    Antonia Navarro
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 7:e33284. 2012
    ..Epigenetic dysregulation of individual genes has been demonstrated in leiomyoma cells; however, the in vivo genome-wide distribution of such epigenetic abnormalities remains unknown...
  15. ncbi request reprint Expression profile of the tumorigenic factors associated with tumor size and sex steroid hormone status in uterine leiomyomata
    Jian Jun Wei
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    Fertil Steril 84:474-84. 2005
    ..To use tissue microarray in combination with dendrogram cluster analysis to characterize some potential tumorigenic factors in association with tumor size and sex steroid hormone status in uterine leiomyomata...
  16. pmc Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling
    Maria V Guijarro
    Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    Am J Pathol 182:2015-27. 2013
    ..Our results highlight the importance of molecularly subclassifying patients with high-grade sarcoma for targeted treatments...
  17. doi request reprint Down-Regulation of miR-29b Is Essential for Pathogenesis of Uterine Leiomyoma
    Wenan Qiang
    Division of Reproductive Science in Medicine W Q, V A S, S A D, Y L, M E F, T K, Department of Obstetrics and Gynecology, Center of Genetic Medicine Department of Pathology Z L, J J W Robert H Lurie Comprehensive Cancer Center W Q, J J W, T K, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611
    Endocrinology 155:663-9. 2014
    ..Thus, we conclude that ECM production in LMs is regulated by steroid hormones via down-regulation of miR-29b, which is one of the mechanisms underlying the excessive accumulation of ECM. ..
  18. ncbi request reprint Differential expression of selected gene products in uterine leiomyomata and adenomyosis
    Mary Levy
    Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    Fertil Steril 88:220-3. 2007
    ..With appropriate internal controls, there were significant differences in gene expression between adenomyosis and leiomyomata...
  19. doi request reprint Histologic and immunohistochemical analyses of endometrial carcinomas: experiences from endometrial biopsies in 358 consultation cases
    Jian Jun Wei
    From the Department of Pathology, Feinberg Medical School, Northwestern University, Chicago, Illinois
    Arch Pathol Lab Med 137:1574-83. 2013
    ....
  20. doi request reprint Expression of insulin-like growth factors (IGFs) and IGF signaling: molecular complexity in uterine leiomyomas
    Lan Peng
    Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    Fertil Steril 91:2664-75. 2009
    ..To study whether dysregulation of insulin-like growth factors (IGFs) and IGF signaling are common molecular changes in symptomatic leiomyomas (fibroids) and whether IGFs are associated with large fibroids...
  21. pmc MK-2206, an AKT inhibitor, promotes caspase-independent cell death and inhibits leiomyoma growth
    Elizabeth C Sefton
    PhD, Department of Obstetrics and Gynecology, Division of Reproductive Biology Research, Northwestern University Feinberg School of Medicine, 303 East Superior Street, Lurie 4 117, Chicago, Illinois 60611
    Endocrinology 154:4046-57. 2013
    ..Our data provide molecular evidence for the involvement of AKT in UL cell survival and suggest that AKT inhibition by MK-2206 may be a viable option to consider for the treatment of ULs. ..