Jian Jun Wei

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Expression and function of androgen receptor coactivator p44/Mep50/WDR77 in ovarian cancer
    Martin Ligr
    Department of Pathology, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 6:e26250. 2011
  2. pmc miR-106a represses the Rb tumor suppressor p130 to regulate cellular proliferation and differentiation in high-grade serous ovarian carcinoma
    Zhaojian Liu
    Department of Pathology, Northwestern University School of Medicine, Feinberg 7 334, 251 East Huron Street, Chicago, IL 60611
    Mol Cancer Res 11:1314-25. 2013
  3. doi request reprint HMGA2: a potential biomarker complement to P53 for detection of early-stage high-grade papillary serous carcinoma in fallopian tubes
    Jian Jun Wei
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Am J Surg Pathol 34:18-26. 2010
  4. ncbi request reprint Endometriosis and ovarian cancer: a review of clinical, pathologic, and molecular aspects
    Jian Jun Wei
    Department of Pathology, Division of Reproductive Biology Research, Northwestern University Feinberg School of Medicine, 251 E Huron St, Chicago, IL, 60611, USA
    Int J Gynecol Pathol 30:553-68. 2011
  5. ncbi request reprint MicroRNA: a new tool for biomedical risk assessment and target identification in human uterine leiomyomas
    Jian Jun Wei
    Department of Pathology, Northwestern University, Chicago, Illinois 60611, USA
    Semin Reprod Med 26:515-21. 2008
  6. doi request reprint MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma
    Zhaojian Liu
    Department of Pathology, Northwestern University School of Medicine, Chicago, IL 60611, USA
    J Pathol 228:204-15. 2012
  7. doi request reprint Antiproliferative effects by Let-7 repression of high-mobility group A2 in uterine leiomyoma
    Yi Peng
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Mol Cancer Res 6:663-73. 2008
  8. pmc Profiling and functional analyses of microRNAs and their target gene products in human uterine leiomyomas
    Jiri Zavadil
    Department of Pathology, School of Medicine, New York University, New York, New York, United States of America
    PLoS ONE 5:e12362. 2010
  9. doi request reprint Let-7 repression leads to HMGA2 overexpression in uterine leiomyosarcoma
    Guizhi Shi
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    J Cell Mol Med 13:3898-905. 2009
  10. pmc Regulation of HMGA1 expression by microRNA-296 affects prostate cancer growth and invasion
    Jian Jun Wei
    Department of Pathology, Northwestern University, Feinberg Medical School, Chicago, Illinois, USA
    Clin Cancer Res 17:1297-305. 2011

Collaborators

Detail Information

Publications29

  1. pmc Expression and function of androgen receptor coactivator p44/Mep50/WDR77 in ovarian cancer
    Martin Ligr
    Department of Pathology, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 6:e26250. 2011
    ..These findings strongly suggest that p44 plays a role in mediating the effects of hormones during ovarian tumorigenesis...
  2. pmc miR-106a represses the Rb tumor suppressor p130 to regulate cellular proliferation and differentiation in high-grade serous ovarian carcinoma
    Zhaojian Liu
    Department of Pathology, Northwestern University School of Medicine, Feinberg 7 334, 251 East Huron Street, Chicago, IL 60611
    Mol Cancer Res 11:1314-25. 2013
    ..To our knowledge, this is the first study of miR-106a mediating proliferation and tumor differentiation in HGSOC...
  3. doi request reprint HMGA2: a potential biomarker complement to P53 for detection of early-stage high-grade papillary serous carcinoma in fallopian tubes
    Jian Jun Wei
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Am J Surg Pathol 34:18-26. 2010
    ..45), indicating the role of HMGA2 in p53 mediated tumor progression. Our findings of immunoreactivity for HMGA2 may lead to a novel, useful biomarker to complement p53 in the detection of early-stage serous carcinoma...
  4. ncbi request reprint Endometriosis and ovarian cancer: a review of clinical, pathologic, and molecular aspects
    Jian Jun Wei
    Department of Pathology, Division of Reproductive Biology Research, Northwestern University Feinberg School of Medicine, 251 E Huron St, Chicago, IL, 60611, USA
    Int J Gynecol Pathol 30:553-68. 2011
    ..This study is a review of the natural history of endometriosis and the role of microenvironments that favor the accumulation of genetic alterations and endometriosis-associated ovarian cancer progression...
  5. ncbi request reprint MicroRNA: a new tool for biomedical risk assessment and target identification in human uterine leiomyomas
    Jian Jun Wei
    Department of Pathology, Northwestern University, Chicago, Illinois 60611, USA
    Semin Reprod Med 26:515-21. 2008
    ..Among the most highly dysregulated miRNAs, let-7 miRNAs seem to play a critical role in tumorigenesis of ULMs through negative regulation of some key target oncogenes, including high mobility group 2...
  6. doi request reprint MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma
    Zhaojian Liu
    Department of Pathology, Northwestern University School of Medicine, Chicago, IL 60611, USA
    J Pathol 228:204-15. 2012
    ..Our findings suggest that miR-182 dysregulation confers powerful oncogenic potential in the tumourigenesis of HG-SOC. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd...
  7. doi request reprint Antiproliferative effects by Let-7 repression of high-mobility group A2 in uterine leiomyoma
    Yi Peng
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Mol Cancer Res 6:663-73. 2008
    ..Our findings suggest that the Let-7-mediated repression of HMGA2 mechanism can be an important molecular event in leiomyoma growth...
  8. pmc Profiling and functional analyses of microRNAs and their target gene products in human uterine leiomyomas
    Jiri Zavadil
    Department of Pathology, School of Medicine, New York University, New York, New York, United States of America
    PLoS ONE 5:e12362. 2010
    ..In order to identify microRNA::mRNA associations relevant to ULM pathogenesis, we examined global correlation patterns between the altered microRNA expression and the predicted target genes in ULMs and matched myometria...
  9. doi request reprint Let-7 repression leads to HMGA2 overexpression in uterine leiomyosarcoma
    Guizhi Shi
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    J Cell Mol Med 13:3898-905. 2009
    ..We found that overexpression of HMGA2 and let-7-mediated HMGA2 repression is a relevant molecular alteration in ULMS. Disrupting the control of HMGA2 and let-7 pairs promotes ULMS cell growth in vitro...
  10. pmc Regulation of HMGA1 expression by microRNA-296 affects prostate cancer growth and invasion
    Jian Jun Wei
    Department of Pathology, Northwestern University, Feinberg Medical School, Chicago, Illinois, USA
    Clin Cancer Res 17:1297-305. 2011
    ..However, regulation of HMGA1 expression is not well understood. Identification of microRNA-mediated HMGA1 regulation will provide a promising therapeutic target in treating PC...
  11. pmc Inactivation of AKT induces cellular senescence in uterine leiomyoma
    Xiaofei Xu
    Department of Pathology X X, J J W and Department of Obstetrics and Gynecology Z L, W Q, J J K, J J W, V V, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, Illinois and Department of Obstetrics and Gynecology X X, B K, Shandong University, Shandong, China
    Endocrinology 155:1510-9. 2014
    ..Moreover, induction of SIPS was mediated by HMGA2, which colocalized to senescence-associated heterochromatin foci. This study provides a conceivable molecular mechanism of SIPS by AKT inhibition in fibroids. ..
  12. doi request reprint HMGA2: a biomarker significantly overexpressed in high-grade ovarian serous carcinoma
    Aparna Mahajan
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    Mod Pathol 23:673-81. 2010
    ..Our findings suggest that HMGA2 is an important molecular change significantly related to high-grade papillary serous carcinoma and is less common in other histological types of ovarian cancer...
  13. ncbi request reprint Ethnic differences in expression of the dysregulated proteins in uterine leiomyomata
    Jian Jun Wei
    Department of Pathology, New York University School of Medicine, Bellevue Hospital, 560 First Avenue, New York, NY 10016, USA
    Hum Reprod 21:57-67. 2006
    ..Black ethnicity is one of the risk factors for uterine leiomyomata (ULM). Little is known about the ethnic differences in leiomyoma-associated gene products in women with uterine leiomyomata...
  14. ncbi request reprint Cellular senescence in usual type uterine leiomyoma
    Jordan Laser
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    Fertil Steril 93:2020-6. 2010
    ..To evaluate the role of senescence in symptomatic patients with multifibroids...
  15. pmc Down-regulation of miR-29b is essential for pathogenesis of uterine leiomyoma
    Wenan Qiang
    Division of Reproductive Science in Medicine W Q, V A S, S A D, Y L, M E F, T K, Department of Obstetrics and Gynecology, Center of Genetic Medicine Department of Pathology Z L, J J W Robert H Lurie Comprehensive Cancer Center W Q, J J W, T K, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611
    Endocrinology 155:663-9. 2014
    ..Thus, we conclude that ECM production in LMs is regulated by steroid hormones via down-regulation of miR-29b, which is one of the mechanisms underlying the excessive accumulation of ECM. ..
  16. ncbi request reprint Spatial differences in biologic activity of large uterine leiomyomata
    Jian Jun Wei
    Department of Pathology, Bellevue Hospital, New York, New York, USA
    Fertil Steril 85:179-87. 2006
    ..To evaluate the growth pattern of the large uterine leiomyomata (ULM), we examined the spatial gene distributions, vessel density, proliferative activity, and hyaline degeneration...
  17. doi request reprint Expression analysis of MIR182 and its associated target genes in advanced ovarian carcinoma
    Brian D McMillen
    Department of Pathology, Northwestern University, Feinberg Medical School, Chicago, IL, USA
    Mod Pathol 25:1644-53. 2012
    ..02). FOXO3 expression was associated with lower-stage disease (P=0.04) and solid growth pattern (P=0.03). MIR182 expression is significantly higher in high-grade serous ovarian carcinoma than in fallopian tubes...
  18. pmc Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling
    Maria V Guijarro
    Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    Am J Pathol 182:2015-27. 2013
    ..Our results highlight the importance of molecularly subclassifying patients with high-grade sarcoma for targeted treatments...
  19. pmc MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcoma
    Elizabeth Bertsch
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Mod Pathol 27:1144-53. 2014
    ..These findings strongly suggest that MED12 mutations and HMGA2 overexpression are independent genetic events that occur in leiomyomas, and they may act differently in the tumorigenesis of uterine leiomyomas. ..
  20. pmc Genome-wide DNA methylation indicates silencing of tumor suppressor genes in uterine leiomyoma
    Antonia Navarro
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 7:e33284. 2012
    ..Epigenetic dysregulation of individual genes has been demonstrated in leiomyoma cells; however, the in vivo genome-wide distribution of such epigenetic abnormalities remains unknown...
  21. ncbi request reprint Expression profile of the tumorigenic factors associated with tumor size and sex steroid hormone status in uterine leiomyomata
    Jian Jun Wei
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    Fertil Steril 84:474-84. 2005
    ..To use tissue microarray in combination with dendrogram cluster analysis to characterize some potential tumorigenic factors in association with tumor size and sex steroid hormone status in uterine leiomyomata...
  22. doi request reprint Expression of insulin-like growth factors (IGFs) and IGF signaling: molecular complexity in uterine leiomyomas
    Lan Peng
    Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    Fertil Steril 91:2664-75. 2009
    ..To study whether dysregulation of insulin-like growth factors (IGFs) and IGF signaling are common molecular changes in symptomatic leiomyomas (fibroids) and whether IGFs are associated with large fibroids...
  23. pmc A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer
    Ji Young Kim
    Division of Reproductive Science in Medicine, Department of Ob Gyn, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Mol Cell 54:613-25. 2014
    ..Together, these results identify WDR5 as a critical epigenomic integrator of histone phosphorylation and methylation and as a major driver of androgen-dependent prostate cancer cell proliferation. ..
  24. ncbi request reprint Differential expression of selected gene products in uterine leiomyomata and adenomyosis
    Mary Levy
    Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    Fertil Steril 88:220-3. 2007
    ..With appropriate internal controls, there were significant differences in gene expression between adenomyosis and leiomyomata...
  25. doi request reprint Histologic and immunohistochemical analyses of endometrial carcinomas: experiences from endometrial biopsies in 358 consultation cases
    Jian Jun Wei
    From the Department of Pathology, Feinberg Medical School, Northwestern University, Chicago, Illinois
    Arch Pathol Lab Med 137:1574-83. 2013
    ....
  26. ncbi request reprint A large struma ovarii tumor removed via laparoscopy in a 16-year-old adolescent
    Isaac Ezon
    Division of Pediatric Surgery and Department of Surgery, New York University School of Medicine, New York, NY 10016, USA
    J Pediatr Surg 42:E19-22. 2007
    ..We conclude that the diagnosis of struma ovarii should be considered in adolescent girls presenting with large cystic ovarian masses and that a laparoscopic approach to management is the treatment of choice...
  27. ncbi request reprint Utility of p16INK4a, CEA, Ki67, P53 and ER/PR in the differential diagnosis of benign, premalignant, and malignant glandular lesions of the uterine cervix and their relationship with Silverberg scoring system for endocervical glandular lesions
    John Liang
    New York University Medical Center, New York, New York, USA
    Int J Gynecol Pathol 26:71-5. 2007
    ..Most cervical glandular lesions can be differentiated by using a combination of histological scores with a panel of immunomarkers...
  28. pmc Advances in serous tubal intraepithelial carcinoma: correlation with high grade serous carcinoma and ovarian carcinogenesis
    Hong Xia Li
    Department of Pathology, The First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu, P R China Department of Pathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA
    Int J Clin Exp Pathol 7:848-57. 2014
    ..Further molecular genetic studies are required to address this important question. ..
  29. pmc MK-2206, an AKT inhibitor, promotes caspase-independent cell death and inhibits leiomyoma growth
    Elizabeth C Sefton
    PhD, Department of Obstetrics and Gynecology, Division of Reproductive Biology Research, Northwestern University Feinberg School of Medicine, 303 East Superior Street, Lurie 4 117, Chicago, Illinois 60611
    Endocrinology 154:4046-57. 2013
    ..Our data provide molecular evidence for the involvement of AKT in UL cell survival and suggest that AKT inhibition by MK-2206 may be a viable option to consider for the treatment of ULs. ..