Lei Wang

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. doi request reprint SchizConnect: Mediating neuroimaging databases on schizophrenia and related disorders for large-scale integration
    Lei Wang
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Electronic address
    Neuroimage 124:1155-67. 2016
  2. pmc Integrated cortical structural marker for Alzheimer's disease
    Jing Ming
    Biomedical Engineering, University of Illinois at Chicago, Chicago, IL, USA Electronic address
    Neurobiol Aging 36:S53-9. 2015
  3. pmc Cerebrospinal fluid proteins predict longitudinal hippocampal degeneration in early-stage dementia of the Alzheimer type
    Lei Wang
    Northwestern University Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, Chicago, IL 60611
    Alzheimer Dis Assoc Disord 26:314-21. 2012
  4. pmc Fully-automated, multi-stage hippocampus mapping in very mild Alzheimer disease
    Lei Wang
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Hippocampus 19:541-8. 2009
  5. pmc Donepezil treatment and changes in hippocampal structure in very mild Alzheimer disease
    Lei Wang
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Arch Neurol 67:99-106. 2010
  6. pmc Progressive deformation of deep brain nuclei and hippocampal-amygdala formation in schizophrenia
    Lei Wang
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Biol Psychiatry 64:1060-8. 2008
  7. pmc Alcohol use disorders contribute to hippocampal and subcortical shape differences in schizophrenia
    Matthew J Smith
    Northwestern University Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, Chicago, IL 60611, USA
    Schizophr Res 131:174-83. 2011
  8. pmc Cortical thickness in neuropsychologically near-normal schizophrenia
    Derin J Cobia
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 446 E Ontario St, Suite 7 100, Chicago, IL 60611, USA
    Schizophr Res 133:68-76. 2011
  9. pmc Thalamic morphology in schizophrenia and schizoaffective disorder
    Matthew J Smith
    Departments of Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, 446 East Ontario Street, Suite 1000, Chicago, IL 60611, United States
    J Psychiatr Res 45:378-85. 2011
  10. pmc Longitudinal progression of frontal and temporal lobe changes in schizophrenia
    Derin J Cobia
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 446 E Ontario, Suite 7 100, Chicago, IL 60611, USA
    Schizophr Res 139:1-6. 2012

Collaborators

Detail Information

Publications20

  1. doi request reprint SchizConnect: Mediating neuroimaging databases on schizophrenia and related disorders for large-scale integration
    Lei Wang
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Electronic address
    Neuroimage 124:1155-67. 2016
    ..It is our hope that SchizConnect can facilitate testing new hypotheses through aggregated datasets, promoting discovery related to the mechanisms underlying schizophrenic dysfunction. ..
  2. pmc Integrated cortical structural marker for Alzheimer's disease
    Jing Ming
    Biomedical Engineering, University of Illinois at Chicago, Chicago, IL, USA Electronic address
    Neurobiol Aging 36:S53-9. 2015
    ....
  3. pmc Cerebrospinal fluid proteins predict longitudinal hippocampal degeneration in early-stage dementia of the Alzheimer type
    Lei Wang
    Northwestern University Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, Chicago, IL 60611
    Alzheimer Dis Assoc Disord 26:314-21. 2012
    ..The present study was conducted to assess the relationship between CSF Aβ and tau protein levels and longitudinal measures of hippocampal structure in individuals with and without very mild dementia of the Alzheimer type...
  4. pmc Fully-automated, multi-stage hippocampus mapping in very mild Alzheimer disease
    Lei Wang
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Hippocampus 19:541-8. 2009
    ..Some direct comparisons of the two procedures are also presented...
  5. pmc Donepezil treatment and changes in hippocampal structure in very mild Alzheimer disease
    Lei Wang
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Arch Neurol 67:99-106. 2010
    ..To compare longitudinal changes in the hippocampal structure in subjects with very mild dementia of the Alzheimer type (DAT) treated with donepezil hydrochloride, untreated subjects with very mild DAT, and controls without dementia...
  6. pmc Progressive deformation of deep brain nuclei and hippocampal-amygdala formation in schizophrenia
    Lei Wang
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Biol Psychiatry 64:1060-8. 2008
    ..Progressive decreases in cortical gray matter volume have been reported in schizophrenia. However, studies of progressive change in deep brain nuclei and hippocampal-amygdala formation have not yielded consistent findings...
  7. pmc Alcohol use disorders contribute to hippocampal and subcortical shape differences in schizophrenia
    Matthew J Smith
    Northwestern University Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, Chicago, IL 60611, USA
    Schizophr Res 131:174-83. 2011
    ..However, the neurobiological basis of this co-morbid interaction is unknown. The aim of this study was to determine the relationship of co-morbid alcohol use disorder (AUD) with brain structure abnormalities in schizophrenia patients...
  8. pmc Cortical thickness in neuropsychologically near-normal schizophrenia
    Derin J Cobia
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 446 E Ontario St, Suite 7 100, Chicago, IL 60611, USA
    Schizophr Res 133:68-76. 2011
    ..While generally supportive of distinct etiological processes for cognitive subtypes, results provide direction for further examination of additional neuroanatomical differences...
  9. pmc Thalamic morphology in schizophrenia and schizoaffective disorder
    Matthew J Smith
    Departments of Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, 446 East Ontario Street, Suite 1000, Chicago, IL 60611, United States
    J Psychiatr Res 45:378-85. 2011
    ..In this study, we examine whether individuals with schizoaffective disorder have a pattern of thalamic deformation that is similar or different to the pattern found in individuals with schizophrenia...
  10. pmc Longitudinal progression of frontal and temporal lobe changes in schizophrenia
    Derin J Cobia
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 446 E Ontario, Suite 7 100, Chicago, IL 60611, USA
    Schizophr Res 139:1-6. 2012
    ..Maintenance of neuropsychological performance and clinical stability in the face of changing neuroanatomical structure suggests the involvement of alternative compensatory mechanisms...
  11. pmc Cannabis-related working memory deficits and associated subcortical morphological differences in healthy individuals and schizophrenia subjects
    Matthew J Smith
    To whom correspondence should be addressed Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 710 N Lake Shore Drive, 13th Floor, Abbott Hall, Chicago, IL 60611, US tel 1 312 503 2542, fax 1 312 503 0527, E mail
    Schizophr Bull 40:287-99. 2014
    ..Future longitudinal studies could help determine whether cannabis use contributes to these observed shape differences or whether they are biomarkers of a vulnerability to the effects of cannabis that predate its misuse. ..
  12. pmc Cognitively normal individuals with AD parents may be at risk for developing aging-related cortical thinning patterns characteristic of AD
    Katherine Reiter
    Department of Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago, IL 60614, USA
    Neuroimage 61:525-32. 2012
    ..These results suggest that as AD offspring age, cortical atrophy is more prominent, particularly if the parent with AD is mother or if the AD offspring is female...
  13. doi request reprint Cannabis-related episodic memory deficits and hippocampal morphological differences in healthy individuals and schizophrenia subjects
    Matthew J Smith
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois
    Hippocampus 25:1042-51. 2015
    ....
  14. pmc Symmetric abnormalities in sulcal patterning in schizophrenia
    John G Csernansky
    Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, 446 E Ontario Suite 7 200, Chicago, IL 60611, USA
    Neuroimage 43:440-6. 2008
    ..In individuals with schizophrenia, sulcal depth in the left hemisphere was correlated with the severity of impaired performance on tests of working memory and executive function...
  15. pmc Structural pathology underlying neuroendocrine dysfunction in schizophrenia
    Morris B Goldman
    Northwestern University, Department of Psychiatry, 446 East Ontario, Suite 7 100, Chicago, IL 60611, United States
    Behav Brain Res 218:106-13. 2011
    ..The relationship of these findings to the underlying mental illness remains to be established...
  16. pmc A sequence variant in human KALRN impairs protein function and coincides with reduced cortical thickness
    Theron A Russell
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nat Commun 5:4858. 2014
    ..These data suggest that single amino acid changes in proteins involved in dendritic spine function can have significant effects on the structure and function of the cerebral cortex. ..
  17. doi request reprint The Northwestern University Neuroimaging Data Archive (NUNDA)
    Kathryn Alpert
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Electronic address
    Neuroimage 124:1131-6. 2016
    ..NUNDA can be integrated with other research databases to simplify data exploration and discovery. And data on NUNDA can be confidently shared for secure collaboration. ..
  18. doi request reprint Northwestern University schizophrenia data sharing for SchizConnect: A longitudinal dataset for large-scale integration
    Alex Kogan
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Electronic address
    Neuroimage 124:1196-201. 2016
    ..xnat.org/). With the creation of SchizConnect, we were able to link NUSDAST to other neuroimaging data sources and create a powerful, federated neuroimaging resource. ..
  19. doi request reprint White matter microstructure among youth with perinatally acquired HIV is associated with disease severity
    Kristina A Uban
    aDepartment of Pediatrics, Children s Hospital Los Angeles, Los Angeles, California bCenter for Biostatistics in AIDS Research, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts cFeinberg School of Medicine, Northwestern University, Chicago, Illinois dDepartment of Neurosciences, Division of Pediatric Neurology, University of California San Diego, La Jolla eKeck School of Medicine, University of Southern California, Los Angeles, California, USA
    AIDS 29:1035-44. 2015
    ..We investigated whether HIV disease severity was associated with alterations in structural brain connectivity, and whether those alterations in turn were associated with cognitive deficits in youth with perinatally acquired HIV (PHIV)...