Research Topics
| Vladimir TurzhitskySummaryAffiliation: Northwestern University Country: USA Publications
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Detail Information
Publications
Multiple scattering model for the penetration depth of low-coherence enhanced backscatteringVladimir Turzhitsky
Northwestern University, Department of Biomedical Engineering, Evanston, Illinois 60208, USA
J Biomed Opt 16:097006. 2011..The expression is shown to be accurate for a broad range of experimentally relevant optical properties and spatial coherence lengths...
Measurement of optical scattering properties with low-coherence enhanced backscattering spectroscopyVladimir Turzhitsky
Northwestern University, Department of Biomedical Engineering, Evanston, Illinois 60208, USA
J Biomed Opt 16:067007. 2011..Three inverse models for calculating these optical properties are described and the calculations are validated with an experimental measurement from a tissue phantom...
Rectal mucosal microvascular blood supply increase is associated with colonic neoplasiaAndrew J Gomes
Biomedical Engineering Department, Northwestern University, IL, USA
Clin Cancer Res 15:3110-7. 2009..We now investigate whether in situ detection of EIBS in the rectum can predict neoplasia elsewhere in the colon...
Measurement of the spatial backscattering impulse-response at short length scales with polarized enhanced backscatteringAndrew J Radosevich
Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
Opt Lett 36:4737-9. 2011..We conclude by demonstrating the extraordinary sensitivity of our technique to the shape of the scattering phase function, including higher order shape parameters than the anisotropy factor (or first moment)...
Optical measurement of rectal microvasculature as an adjunct to flexible sigmoidosocopy: gender-specific implicationsHemant K Roy
Department of Medicine, NorthShore University Health System, Evanston, IL 60201, USA
Cancer Prev Res (Phila) 3:844-51. 2010..Therefore, using rectal EIBS in combination with flexible sigmoidoscopy mitigated the gender gap and may allow flexible sigmoidoscopy to be considered as a viable colorectal cancer screening test in women...
Investigating population risk factors of pancreatic cancer by evaluation of optical markers in the duodenal mucosaVladimir Turzhitsky
Biomedical Engineering Department, Northwestern University, Evanston, IL, USA
Dis Markers 25:313-21. 2008....
Spectroscopic microvascular blood detection from the endoscopically normal colonic mucosa: biomarker for neoplasia riskHemant K Roy
Department of Internal Medicine, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
Gastroenterology 135:1069-78. 2008..To assess the potential clinical translatability of this putative field effect marker, we characterized the early increase in blood supply (EIBS) in human beings in vivo...
Spectral slope from the endoscopically-normal mucosa predicts concurrent colonic neoplasia: a pilot ex-vivo clinical studyHemant K Roy
Department of Internal Medicine, Evanston Northwestern Healthcare Research Institute, 2650 Ridge Avenue, G208, Evanston, Illinois 60201, USA
Dis Colon Rectum 51:1381-6. 2008..In this study, we assessed the translatability of spectral slope analysis to human colorectal cancer screening...
Association between rectal optical signatures and colonic neoplasia: potential applications for screeningHemant K Roy
Department of Medicine, Evanston Northwestern Healthcare, Northwestern University, Evanston, IL 60201, USA
Cancer Res 69:4476-83. 2009..Further studies with an endoscopically compatible fiber optic probe are under way for multicenter clinical validation...
Monte Carlo model of the penetration depth for polarization gating spectroscopy: influence of illumination-collection geometry and sample optical propertiesAndrew J Gomes
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60218, USA
Appl Opt 51:4627-37. 2012..The penetration depth model derived in this study can be applied to optimizing application-specific fiber-optic probes to target a sampling depth of interest with minimal sensitivity to the optical properties of the sample...
Optical markers in duodenal mucosa predict the presence of pancreatic cancerYang Liu
Biomedical Engineering Department, Northwestern University, Illinois, USA
Clin Cancer Res 13:4392-9. 2007..We propose a novel approach to predict pancreatic cancer through the assessment of the adjacent periampullary duodenal mucosa without any interrogation of the pancreatic duct or imaging of the pancreas...
Alternate formulation of enhanced backscattering as phase conjugation and diffraction: derivation and experimental observationJeremy D Rogers
Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
Opt Express 19:11922-31. 2011..A three dimensional intensity peak is predicted in free space at a point conjugate to the source and is experimentally observed...
A fiber optic probe design to measure depth-limited optical properties in-vivo with low-coherence enhanced backscattering (LEBS) spectroscopyNikhil N Mutyal
Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
Opt Express 20:19643-57. 2012..Additionally, depth-limited capabilities are demonstrated using Monte Carlo modeling and experimental measurements from a two-layered phantom...
Quantification of nanoscale density fluctuations by electron microscopy: probing cellular alterations in early carcinogenesisPrabhakar Pradhan
Biomedical Engineering Department, Northwestern University, Evanston, IL 60208, USA
Phys Biol 8:026012. 2011..Potential applications of the technique for early cancer screening and detection are also discussed...
Risk stratification of colon carcinogenesis through enhanced backscattering spectroscopy analysis of the uninvolved colonic mucosaHemant K Roy
Department of Medicine, Evanston Northwestern Healthcare Research Institute, Feinberg School of Medicine at Northwestern University, Evanston, Illinois 60201, USA
Clin Cancer Res 12:961-8. 2006..In the present study, we investigated the ability of enhanced backscattering analysis of the preneoplastic mucosa to predict risk of colon carcinogenesis...
