C Shad Thaxton

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi request reprint Multiplexed DNA detection with biobarcoded nanoparticle probes
    Savka I Stoeva
    Department of Chemistry, International Institute for Nanotechnology, Northwestern University, Evanston, Il 60208 3113, USA
    Angew Chem Int Ed Engl 45:3303-6. 2006
  2. pmc Nanoparticle-based bio-barcode assay redefines "undetectable" PSA and biochemical recurrence after radical prostatectomy
    C Shad Thaxton
    Department of Urology, Northwestern University Feinberg School of Medicine, 303 East Chicago, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:18437-42. 2009
  3. pmc Templated spherical high density lipoprotein nanoparticles
    C Shad Thaxton
    Northwestern University, Feinberg School of Medicine, Department of Urology, 303 East Chicago Avenue, Tarry 16 703, Chicago, Illinois 60611, USA
    J Am Chem Soc 131:1384-5. 2009
  4. pmc Scanometric microRNA array profiling of prostate cancer markers using spherical nucleic acid-gold nanoparticle conjugates
    Ali H Alhasan
    Interdepartmental Biological Sciences Program, Northwestern University, 2205 Tech Drive, Evanston, Illinois 60208, USA
    Anal Chem 84:4153-60. 2012
  5. ncbi request reprint Glass-bead-based parallel detection of DNA using composite Raman labels
    Rongchao Jin
    Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Small 2:375-80. 2006
  6. pmc Tailoring of biomimetic high-density lipoprotein nanostructures changes cholesterol binding and efflux
    Andrea J Luthi
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    ACS Nano 6:276-85. 2012
  7. pmc Knockdown of intraislet IKKβ by spherical nucleic acid conjugates prevents cytokine-induced injury and enhances graft survival
    Jonathan S Rink
    1 Department of Urology, Northwestern University, Chicago, IL 2 Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, IL 3 Comprehensive Transplant Center, Northwestern University, Chicago, IL 4 Department of Surgery, Northwestern University, Chicago, IL 5 Columbia Center for Translational Immunology, Columbia University, New York, NY 6 International Institute for Nanotechnology, Northwestern University, Evanston, IL 7 Department of Chemistry, Northwestern University, Evanston, IL 8 Division of Transplantation, Department of Surgery, University of Wisconsin, Madison, WI 9 Address correspondence to Dixon B Kaufman, M D, Ph D, Division of Transplantation, Department of Surgery, University of Wisconsin, H5 701 Clinical Sciences Center, 600 Highland Avenue, Madison, WI 53792 7375
    Transplantation 96:877-84. 2013
  8. doi request reprint Templated high density lipoprotein nanoparticles as potential therapies and for molecular delivery
    Marina G Damiano
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Adv Drug Deliv Rev 65:649-62. 2013
  9. pmc Biomimetic high density lipoprotein nanoparticles for nucleic acid delivery
    Kaylin M McMahon
    Department of Urology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Tarry 16 703, Chicago, Illinois 60611, United States
    Nano Lett 11:1208-14. 2011
  10. doi request reprint Combined prostate-specific antigen density and biopsy features to predict "clinically insignificant" prostate cancer
    Stacy Loeb
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Urology 72:143-7. 2008

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Multiplexed DNA detection with biobarcoded nanoparticle probes
    Savka I Stoeva
    Department of Chemistry, International Institute for Nanotechnology, Northwestern University, Evanston, Il 60208 3113, USA
    Angew Chem Int Ed Engl 45:3303-6. 2006
  2. pmc Nanoparticle-based bio-barcode assay redefines "undetectable" PSA and biochemical recurrence after radical prostatectomy
    C Shad Thaxton
    Department of Urology, Northwestern University Feinberg School of Medicine, 303 East Chicago, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:18437-42. 2009
    ..iii) The ability to use PSA levels that are not detectable with conventional assays to follow the response of patients to adjuvant or salvage therapies...
  3. pmc Templated spherical high density lipoprotein nanoparticles
    C Shad Thaxton
    Northwestern University, Feinberg School of Medicine, Department of Urology, 303 East Chicago Avenue, Tarry 16 703, Chicago, Illinois 60611, USA
    J Am Chem Soc 131:1384-5. 2009
    ..The determination of the K(d) for these particles, with respect to cholesterol complexation, provides a key starting and comparison point for measuring and evaluating the properties of subsequently developed synthetic versions of HDL...
  4. pmc Scanometric microRNA array profiling of prostate cancer markers using spherical nucleic acid-gold nanoparticle conjugates
    Ali H Alhasan
    Interdepartmental Biological Sciences Program, Northwestern University, 2205 Tech Drive, Evanston, Illinois 60208, USA
    Anal Chem 84:4153-60. 2012
    ..The platform exhibits 98.8% accuracy when detecting deregulated miRNAs involved in CaP, which demonstrates its potential utility in profiling and identifying clinical and research biomarkers...
  5. ncbi request reprint Glass-bead-based parallel detection of DNA using composite Raman labels
    Rongchao Jin
    Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Small 2:375-80. 2006
  6. pmc Tailoring of biomimetic high-density lipoprotein nanostructures changes cholesterol binding and efflux
    Andrea J Luthi
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    ACS Nano 6:276-85. 2012
    ..From the conjugates tested, the optimum size and surface chemistry for preparing functional Au NP-templated HDL biomimics were identified...
  7. pmc Knockdown of intraislet IKKβ by spherical nucleic acid conjugates prevents cytokine-induced injury and enhances graft survival
    Jonathan S Rink
    1 Department of Urology, Northwestern University, Chicago, IL 2 Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, IL 3 Comprehensive Transplant Center, Northwestern University, Chicago, IL 4 Department of Surgery, Northwestern University, Chicago, IL 5 Columbia Center for Translational Immunology, Columbia University, New York, NY 6 International Institute for Nanotechnology, Northwestern University, Evanston, IL 7 Department of Chemistry, Northwestern University, Evanston, IL 8 Division of Transplantation, Department of Surgery, University of Wisconsin, Madison, WI 9 Address correspondence to Dixon B Kaufman, M D, Ph D, Division of Transplantation, Department of Surgery, University of Wisconsin, H5 701 Clinical Sciences Center, 600 Highland Avenue, Madison, WI 53792 7375
    Transplantation 96:877-84. 2013
    ....
  8. doi request reprint Templated high density lipoprotein nanoparticles as potential therapies and for molecular delivery
    Marina G Damiano
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Adv Drug Deliv Rev 65:649-62. 2013
    ..Importantly, methods that utilize nanoparticle templates to control synthetic HDL size, shape, and surface chemistry are highlighted...
  9. pmc Biomimetic high density lipoprotein nanoparticles for nucleic acid delivery
    Kaylin M McMahon
    Department of Urology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Tarry 16 703, Chicago, Illinois 60611, United States
    Nano Lett 11:1208-14. 2011
    ....
  10. doi request reprint Combined prostate-specific antigen density and biopsy features to predict "clinically insignificant" prostate cancer
    Stacy Loeb
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Urology 72:143-7. 2008
    ..In this study, we examined the ability of PSAD and biopsy features to predict pathologic outcomes in a contemporary RRP population...
  11. doi request reprint Tumor characteristics of carriers and noncarriers of the deCODE 8q24 prostate cancer susceptibility alleles
    Brian T Helfand
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    J Urol 179:2197-201; discussion 2202. 2008
    ..In this study we examine the differences in clinical and pathological tumor features between carriers and noncarriers of these 8q24 alleles in patients with prostate cancer...
  12. ncbi request reprint A bio-bar-code assay based upon dithiothreitol-induced oligonucleotide release
    C Shad Thaxton
    Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208 3113, USA
    Anal Chem 77:8174-8. 2005
    ..When the scanometric readout is used, the sensitivity of the assay is 7 aM and quantification can be accomplished over the low-attomolar to the mid-femtomolar concentration range...
  13. ncbi request reprint Gold nanoparticle probes for the detection of nucleic acid targets
    C Shad Thaxton
    Northwestern University, Department of Chemistry, Evanston, IL 60208, USA
    Clin Chim Acta 363:120-6. 2006
    ....
  14. ncbi request reprint Raman dye-labeled nanoparticle probes for proteins
    Y Charles Cao
    Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    J Am Chem Soc 125:14676-7. 2003
    ....
  15. pmc Treatment outcomes of radical prostatectomy in potential candidates for 3 published active surveillance protocols
    C Shad Thaxton
    Department of Urology, Northwestern Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Urology 75:414-8. 2010
    ..AS protocols are designed to spare the potential morbidity of treatment to patients with low-risk prostate cancer (PCa)...
  16. pmc Update on current and potential nanoparticle cancer therapies
    Jonathan S Rink
    aDepartment of Urology, Feinberg School of Medicine, Northwestern University bDriskill Graduate Program in the Life Sciences, Northwestern University cRobert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois dInternational Institute for Nanotechnology IIN, Northwestern University, Evanston, Illinois eInstitute for Bionanotechnology and Medicine IBNAM, Northwestern University, Chicago, Illinois, USA
    Curr Opin Oncol 25:646-51. 2013
    ..To summarize the most recent preclinical and clinical advancements in therapeutic nano-oncology...
  17. ncbi request reprint Control of nanoparticle assembly by using DNA-modified diatom templates
    Nathaniel L Rosi
    Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Il 60208 3113, USA
    Angew Chem Int Ed Engl 43:5500-3. 2004
  18. pmc Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease
    Dimitra G Georganopoulou
    Department of Chemistry and Institute of Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 102:2273-6. 2005
    ..This study is a step toward a diagnostic tool, based on soluble pathogenic markers for the debilitating disease...
  19. ncbi request reprint Plasmon coupling measures up
    C Shad Thaxton
    Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Nat Biotechnol 23:681-2. 2005
  20. doi request reprint Comparison of prostate specific antigen velocity in screened versus referred patients with prostate cancer
    Joshua J Meeks
    Department of Urology, Northwestern Feinberg School of Medicine, Chicago, Illinois, USA
    J Urol 179:1340-3. 2008
    ..We compared the prostate specific antigen velocity profile between patients with prostate cancer in whom the tumor was detected in a formal screening study and those who were referred for treatment...
  21. ncbi request reprint Hand-assisted laparoscopic pyeloplasty and isthmectomy in a patient with a horseshoe kidney
    Robert B Nadler
    Department of Urology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Tarry Building 11 715, Chicago, IL 60610 3008, USA
    J Endourol 17:909-10. 2003
    ..We believe this to be the first reported case of isthmectomy performed with the Harmonic Scalpel. Follow-up diuretic renal scan and CT revealed improved drainage and separation of the divided horseshoe kidney...
  22. pmc Biomimetic, synthetic HDL nanostructures for lymphoma
    Shuo Yang
    Department of Medicine, Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 110:2511-6. 2013
    ..HDL-NPs are active in B-cell lymphomas and potentially, other malignancies or diseases of pathologic cholesterol accumulation...
  23. ncbi request reprint Multifunctional polymeric nanoparticles from diverse bioactive agents
    Paul A Bertin
    Department of Chemistry, Northwestern University, Evanston, Illinois 60208 3113, USA
    J Am Chem Soc 128:4168-9. 2006
    ..The resulting antibody-functionalized particles were readily uptaken by breast cancer cells that overexpressed the corresponding antigens...
  24. ncbi request reprint Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins
    Jwa Min Nam
    Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60201, USA
    Science 301:1884-6. 2003
    ..Comparable clinically accepted conventional assays for detecting the same target have sensitivity limits of approximately 3 picomdar, six orders of magnitude less sensitive than what is observed with this method...
  25. pmc Nanotechnology for synthetic high-density lipoproteins
    Andrea J Luthi
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Trends Mol Med 16:553-60. 2010
    ....
  26. doi request reprint Retrieval of migrated ureteral stents by coaxial cannulation with a flexible ureteroscope and paired helical basket
    Joshua J Meeks
    Department of Urology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Endourol 22:927-9. 2008
    ..We describe the use of a paired wire helical stone retrieval basket through a flexible ureteroscope to remove proximally migrated ureteral stents...
  27. pmc Transfection of pancreatic islets using polyvalent DNA-functionalized gold nanoparticles
    Jonathan S Rink
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Surgery 148:335-45. 2010
    ..We hypothesize that AuNP-DNA conjugates can efficiently transfect pancreatic islets with no impact on viability or functionality, and can function to regulate targeted gene expression...
  28. doi request reprint Nanoparticle therapeutics: FDA approval, clinical trials, regulatory pathways, and case study
    Aaron C Eifler
    Department of Urology, Feinberg School of Medicine, Institute for BioNanotechnology and Medicine, Northwestern University, Chicago, IL, USA
    Methods Mol Biol 726:325-38. 2011
    ....
  29. doi request reprint Lymphotropic nanoparticle enhanced MRI for the staging of genitourinary tumors
    Samdeep K Mouli
    Department of Radiology, Northwestern University, 303 East Chicago Avenue, Tarry 16 703, Chicago, IL 60611, USA
    Nat Rev Urol 7:84-93. 2010
    ..This technology has been used to assess lymph node metastases in a large number of human cancer types. In this Review, we focus on lymphotropic nanoparticle enhanced MRI and its application for the staging of genitourinary malignancies...