Research Topics
| C Shad ThaxtonSummaryAffiliation: Northwestern University Country: USA Publications
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Detail Information
Publications
Nanoparticle-based bio-barcode assay redefines "undetectable" PSA and biochemical recurrence after radical prostatectomyC Shad Thaxton
Department of Urology, Northwestern University Feinberg School of Medicine, 303 East Chicago, Chicago, IL 60611, USA
Proc Natl Acad Sci U S A 106:18437-42. 2009..iii) The ability to use PSA levels that are not detectable with conventional assays to follow the response of patients to adjuvant or salvage therapies...- Templated spherical high density lipoprotein nanoparticlesC Shad Thaxton
Northwestern University, Feinberg School of Medicine, Department of Urology, 303 East Chicago Avenue, Tarry 16 703, Chicago, Illinois 60611, USA
J Am Chem Soc 131:1384-5. 2009..The determination of the K(d) for these particles, with respect to cholesterol complexation, provides a key starting and comparison point for measuring and evaluating the properties of subsequently developed synthetic versions of HDL... - Scanometric microRNA array profiling of prostate cancer markers using spherical nucleic acid-gold nanoparticle conjugatesAli H Alhasan
Interdepartmental Biological Sciences Program, Northwestern University, 2205 Tech Drive, Evanston, Illinois 60208, USA
Anal Chem 84:4153-60. 2012..The platform exhibits 98.8% accuracy when detecting deregulated miRNAs involved in CaP, which demonstrates its potential utility in profiling and identifying clinical and research biomarkers... 
Glass-bead-based parallel detection of DNA using composite Raman labelsRongchao Jin
Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
Small 2:375-80. 2006
Tailoring of biomimetic high-density lipoprotein nanostructures changes cholesterol binding and effluxAndrea J Luthi
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
ACS Nano 6:276-85. 2012..From the conjugates tested, the optimum size and surface chemistry for preparing functional Au NP-templated HDL biomimics were identified...- Multiplexed DNA detection with biobarcoded nanoparticle probesSavka I Stoeva
Department of Chemistry, International Institute for Nanotechnology, Northwestern University, Evanston, IL 60208-3113, USA
Angew Chem Int Ed Engl 45:3303-6. 2006 - Combined prostate-specific antigen density and biopsy features to predict "clinically insignificant" prostate cancerStacy Loeb
Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Urology 72:143-7. 2008..In this study, we examined the ability of PSAD and biopsy features to predict pathologic outcomes in a contemporary RRP population... - Biomimetic high density lipoprotein nanoparticles for nucleic acid deliveryKaylin M McMahon
Department of Urology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Tarry 16 703, Chicago, Illinois 60611, United States
Nano Lett 11:1208-14. 2011.... - A bio-bar-code assay based upon dithiothreitol-induced oligonucleotide releaseC Shad Thaxton
Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA
Anal Chem 77:8174-8. 2005..When the scanometric readout is used, the sensitivity of the assay is 7 aM and quantification can be accomplished over the low-attomolar to the mid-femtomolar concentration range... - Gold nanoparticle probes for the detection of nucleic acid targetsC Shad Thaxton
Northwestern University, Department of Chemistry, Evanston, IL 60208, USA
Clin Chim Acta 363:120-6. 2006.... - Treatment outcomes of radical prostatectomy in potential candidates for 3 published active surveillance protocolsC Shad Thaxton
Department of Urology, Northwestern Feinberg School of Medicine, Chicago, Illinois 60611, USA
Urology 75:414-8. 2010..AS protocols are designed to spare the potential morbidity of treatment to patients with low-risk prostate cancer (PCa)... - Raman dye-labeled nanoparticle probes for proteinsY Charles Cao
Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
J Am Chem Soc 125:14676-7. 2003.... - Tumor characteristics of carriers and noncarriers of the deCODE 8q24 prostate cancer susceptibility allelesBrian T Helfand
Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
J Urol 179:2197-201; discussion 2202. 2008..In this study we examine the differences in clinical and pathological tumor features between carriers and noncarriers of these 8q24 alleles in patients with prostate cancer... - Control of nanoparticle assembly by using DNA-modified diatom templatesNathaniel L Rosi
Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113, USA
Angew Chem Int Ed Engl 43:5500-3. 2004 - Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's diseaseDimitra G Georganopoulou
Department of Chemistry and Institute of Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
Proc Natl Acad Sci U S A 102:2273-6. 2005..This study is a step toward a diagnostic tool, based on soluble pathogenic markers for the debilitating disease... - Comparison of prostate specific antigen velocity in screened versus referred patients with prostate cancerJoshua J Meeks
Department of Urology, Northwestern Feinberg School of Medicine, Chicago, Illinois, USA
J Urol 179:1340-3. 2008..We compared the prostate specific antigen velocity profile between patients with prostate cancer in whom the tumor was detected in a formal screening study and those who were referred for treatment... - Plasmon coupling measures upC Shad Thaxton
Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
Nat Biotechnol 23:681-2. 2005 - Hand-assisted laparoscopic pyeloplasty and isthmectomy in a patient with a horseshoe kidneyRobert B Nadler
Department of Urology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Tarry Building 11 715, Chicago, IL 60610 3008, USA
J Endourol 17:909-10. 2003..We believe this to be the first reported case of isthmectomy performed with the Harmonic Scalpel. Follow-up diuretic renal scan and CT revealed improved drainage and separation of the divided horseshoe kidney... - Biomimetic, synthetic HDL nanostructures for lymphomaShuo Yang
Department of Medicine, Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Proc Natl Acad Sci U S A 110:2511-6. 2013..HDL-NPs are active in B-cell lymphomas and potentially, other malignancies or diseases of pathologic cholesterol accumulation... - Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteinsJwa-Min Nam
Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60201, USA
Science 301:1884-6. 2003..Comparable clinically accepted conventional assays for detecting the same target have sensitivity limits of approximately 3 picomdar, six orders of magnitude less sensitive than what is observed with this method... - Multifunctional polymeric nanoparticles from diverse bioactive agentsPaul A Bertin
Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, USA
J Am Chem Soc 128:4168-9. 2006..The resulting antibody-functionalized particles were readily uptaken by breast cancer cells that overexpressed the corresponding antigens... - Transfection of pancreatic islets using polyvalent DNA-functionalized gold nanoparticlesJonathan S Rink
Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Surgery 148:335-45. 2010..We hypothesize that AuNP-DNA conjugates can efficiently transfect pancreatic islets with no impact on viability or functionality, and can function to regulate targeted gene expression... - Nanotechnology for synthetic high-density lipoproteinsAndrea J Luthi
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
Trends Mol Med 16:553-60. 2010.... - Retrieval of migrated ureteral stents by coaxial cannulation with a flexible ureteroscope and paired helical basketJoshua J Meeks
Department of Urology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
J Endourol 22:927-9. 2008..We describe the use of a paired wire helical stone retrieval basket through a flexible ureteroscope to remove proximally migrated ureteral stents... - Lymphotropic nanoparticle enhanced MRI for the staging of genitourinary tumorsSamdeep K Mouli
Department of Radiology, Northwestern University, 303 East Chicago Avenue, Tarry 16 703, Chicago, IL 60611, USA
Nat Rev Urol 7:84-93. 2010..This technology has been used to assess lymph node metastases in a large number of human cancer types. In this Review, we focus on lymphotropic nanoparticle enhanced MRI and its application for the staging of genitourinary malignancies... - Nanoparticle therapeutics: FDA approval, clinical trials, regulatory pathways, and case studyAaron C Eifler
Department of Urology, Feinberg School of Medicine, Institute for BioNanotechnology and Medicine, Northwestern University, Chicago, IL, USA
Methods Mol Biol 726:325-38. 2011....