DALTON SURMEIER

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Dopamine and working memory mechanisms in prefrontal cortex
    D James Surmeier
    Northwestern University Medical School, Department of Physiology NUIN, Chicago, IL 60611, USA
    J Physiol 581:885. 2007
  2. ncbi request reprint Autonomous pacemakers in the basal ganglia: who needs excitatory synapses anyway?
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Curr Opin Neurobiol 15:312-8. 2005
  3. ncbi request reprint Calcium, ageing, and neuronal vulnerability in Parkinson's disease
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Lancet Neurol 6:933-8. 2007
  4. pmc Synaptically driven state transitions in distal dendrites of striatal spiny neurons
    Joshua L Plotkin
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Nat Neurosci 14:881-8. 2011
  5. pmc HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease
    C Savio Chan
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Neurosci 14:85-92. 2011
  6. pmc Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson's disease
    Joshua A Goldberg
    Department of Physiology, Feinberg School of Medicine, Northwestern University Chicago, Illinois, USA
    Nat Neurosci 15:1414-21. 2012
  7. pmc Calcium, bioenergetics, and neuronal vulnerability in Parkinson's disease
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 288:10736-41. 2013
  8. pmc The pathology roadmap in Parkinson disease
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Prion 7:85-91. 2013
  9. pmc Physiological phenotype and vulnerability in Parkinson's disease
    D James Surmeier
    Department of Physiology, Northwestern University, Chicago, Illinois, USA
    Cold Spring Harb Perspect Med 2:a009290. 2012
  10. pmc A feud that wasn't: acetylcholine evokes dopamine release in the striatum
    D James Surmeier
    Department of Physiology, Feinberg College of Medicine, Northwestern University, Chicago, IL 60611, USA
    Neuron 75:1-3. 2012

Research Grants

  1. DOPAMINERGIC AND MUSCARINIC SIGNALING IN THE STRIATUM
    DALTON JAMES SURMEIER; Fiscal Year: 2010
  2. DOPAMINERGIC AND MUSCARINIC SIGNALING IN THE STRIATUM
    DALTON JAMES SURMEIER; Fiscal Year: 2010
  3. DOPAMINERGIC AND MUSCARINIC SIGNALING IN THE STRIATUM
    DALTON SURMEIER; Fiscal Year: 2007
  4. MONOAMINERGIC MODULATION OF PREFRONTAL CORTEX
    DALTON SURMEIER; Fiscal Year: 2004
  5. WINTER CONFERENCE ON BRAIN RESEARCH
    DALTON SURMEIER; Fiscal Year: 2005
  6. General Motor Control Mechanisms and Disease Training Program
    DALTON SURMEIER; Fiscal Year: 2007
  7. Rhythmicity and Synchrony in the Basal Ganglia
    DALTON SURMEIER; Fiscal Year: 2007
  8. DOPAMINERGIC AND MUSCARINIC SIGNALING IN THE STRIATUM
    DALTON SURMEIER; Fiscal Year: 2009
  9. MONOAMINERGIC MODULATION OF PREFRONTAL CORTEX
    DALTON SURMEIER; Fiscal Year: 2003
  10. DOPAMINERGIC AND CHOLINERGIC SIGNALING IN THE STRIATUM
    DALTON SURMEIER; Fiscal Year: 1999

Collaborators

Detail Information

Publications61

  1. pmc Dopamine and working memory mechanisms in prefrontal cortex
    D James Surmeier
    Northwestern University Medical School, Department of Physiology NUIN, Chicago, IL 60611, USA
    J Physiol 581:885. 2007
  2. ncbi request reprint Autonomous pacemakers in the basal ganglia: who needs excitatory synapses anyway?
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Curr Opin Neurobiol 15:312-8. 2005
    ....
  3. ncbi request reprint Calcium, ageing, and neuronal vulnerability in Parkinson's disease
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Lancet Neurol 6:933-8. 2007
    ..These studies also suggest that, although genetic and environmental factors can hasten its onset, Parkinson's disease stems from a distinctive neuronal design common to all human beings, making its appearance simply a matter of time...
  4. pmc Synaptically driven state transitions in distal dendrites of striatal spiny neurons
    Joshua L Plotkin
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Nat Neurosci 14:881-8. 2011
    ..This capacity not only changes our model of how up states are generated in SPNs, it also has fundamental implications for the associative process underlying action selection...
  5. pmc HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease
    C Savio Chan
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Neurosci 14:85-92. 2011
    ....
  6. pmc Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson's disease
    Joshua A Goldberg
    Department of Physiology, Feinberg School of Medicine, Northwestern University Chicago, Illinois, USA
    Nat Neurosci 15:1414-21. 2012
    ..These results point to a common mechanism underlying mitochondrial oxidant stress in Parkinson's disease and a therapeutic strategy to ameliorate it...
  7. pmc Calcium, bioenergetics, and neuronal vulnerability in Parkinson's disease
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 288:10736-41. 2013
    ....
  8. pmc The pathology roadmap in Parkinson disease
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Prion 7:85-91. 2013
    ..The review explores the literature on these issues and their translational implications...
  9. pmc Physiological phenotype and vulnerability in Parkinson's disease
    D James Surmeier
    Department of Physiology, Northwestern University, Chicago, Illinois, USA
    Cold Spring Harb Perspect Med 2:a009290. 2012
    ....
  10. pmc A feud that wasn't: acetylcholine evokes dopamine release in the striatum
    D James Surmeier
    Department of Physiology, Feinberg College of Medicine, Northwestern University, Chicago, IL 60611, USA
    Neuron 75:1-3. 2012
    ..These findings call for a fundamental reevaluation of the long-standing view that dopamine and acetylcholine "feud" over control of striatal circuitry...
  11. pmc The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease
    D J Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Neuroscience 198:221-31. 2011
    ....
  12. pmc Dopaminergic modulation of striatal neurons, circuits, and assemblies
    D J Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Neuroscience 198:3-18. 2011
    ....
  13. doi request reprint A lethal convergence of dopamine and calcium
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Neuron 62:163-4. 2009
    ..in this issue of Neuron demonstrate that Ca2+ influx through L-type channels elevates dopamine synthesis to potentially toxic levels in vulnerable ventral mesencephalon neurons...
  14. ncbi request reprint D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA lt j
    Trends Neurosci 30:228-35. 2007
    ..These studies have also shown that long-term alterations in dopamine signaling produce profound and cell-type-specific reshaping of corticostriatal connectivity and function...
  15. pmc Calcium, cellular aging, and selective neuronal vulnerability in Parkinson's disease
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611, USA
    Cell Calcium 47:175-82. 2010
    ....
  16. doi request reprint alpha-Synuclein at the synaptic gate
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Neuron 65:3-4. 2010
    ..show that this modest overexpression of alpha-synuclein does not lead to obvious toxicity in the near term, but impairs glutamate and dopamine release, potentially leading to broad network dysfunction and eventual pathology...
  17. doi request reprint What causes the death of dopaminergic neurons in Parkinson's disease?
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Prog Brain Res 183:59-77. 2010
    ....
  18. doi request reprint The role of dopamine in modulating the structure and function of striatal circuits
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Prog Brain Res 183:149-67. 2010
    ..These tools also have enabled a rapid expansion of our understanding of the striatal adaptations in models of Parkinson's disease. This chapter highlights some of the major advances in these areas...
  19. doi request reprint A molecular basis for the increased vulnerability of substantia nigra dopamine neurons in aging and Parkinson's disease
    C Savio Chan
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Mov Disord 25:S63-70. 2010
    ..Their decades-long track record of safe use in the treatment of hypertension makes dihydropyridines particularly attractive as a therapeutic tool in PD...
  20. ncbi request reprint 'Rejuvenation' protects neurons in mouse models of Parkinson's disease
    C Savio Chan
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Nature 447:1081-6. 2007
    ..Such blocking ('rejuvenation') protects these neurons in both in vitro and in vivo models of Parkinson's disease, pointing to a new strategy that could slow or stop the progression of the disease...
  21. pmc Recurrent collateral connections of striatal medium spiny neurons are disrupted in models of Parkinson's disease
    Stefano Taverna
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 28:5504-12. 2008
    ..Moreover, this recurrent collateral network appears to be disrupted in Parkinson's disease models, potentially contributing to pathological alterations in MSN activity patterns and psychomotor symptoms...
  22. pmc Differential excitability and modulation of striatal medium spiny neuron dendrites
    Michelle Day
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 28:11603-14. 2008
    ..Together, these results suggest that normally D(2) MSN dendrites are more excitable than those of D(1) MSNs and that DA depletion exaggerates this asymmetry, potentially contributing to adaptations in PD models...
  23. pmc MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons
    Xinyong Tian
    Department of Physiology Feinberg School of Medicine Northwestern University 303 E Chicago Ave, Chicago, IL 60611, USA
    Mol Cell Neurosci 44:94-108. 2010
    ..Taken together, these studies establish a translational framework within which striatal adaptations linked to the symptoms of Parkinson's disease can be explored...
  24. pmc Dichotomous dopaminergic control of striatal synaptic plasticity
    Weixing Shen
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Science 321:848-51. 2008
    ..In models of Parkinson's disease, this system is thrown out of balance, leading to unidirectional changes in plasticity that could underlie network pathology and symptoms...
  25. doi request reprint Calcium homeostasis, selective vulnerability and Parkinson's disease
    C Savio Chan
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Trends Neurosci 32:249-56. 2009
    ..We conclude with a discussion of potential therapeutic strategies for slowing the progression of PD...
  26. ncbi request reprint Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models
    Michelle Day
    Department of Physiology, 303 East Chicago Avenue, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Nat Neurosci 9:251-9. 2006
    ..3 L-type Ca(2+) channels. The disconnection of striatopallidal neurons from motor command structures is likely to be a key step in the emergence of pathological activity that is responsible for symptoms in Parkinson disease...
  27. ncbi request reprint Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons
    Zhongfeng Wang
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Neuron 50:443-52. 2006
    ..In addition to reconciling discordant tracts of the striatal literature, these findings point to cholinergic interneurons as key mediators of dopamine-dependent striatal plasticity and learning...
  28. ncbi request reprint RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion
    Jun Ding
    Department of Physiology and Institute for Neuroscience, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Nat Neurosci 9:832-42. 2006
    ..These observations suggest that RGS4-dependent attenuation of interneuronal autoreceptor signaling is a major factor in the elevation of striatal acetylcholine release in Parkinson disease...
  29. pmc Dopamine and synaptic plasticity in dorsal striatal circuits controlling action selection
    D James Surmeier
    Department of Physiology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Curr Opin Neurobiol 19:621-8. 2009
    ....
  30. ncbi request reprint Thalamic gating of corticostriatal signaling by cholinergic interneurons
    Jun B Ding
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Neuron 67:294-307. 2010
    ..This differential regulation of the corticostriatal circuitry provides a neural substrate for attentional shifts and cessation of ongoing motor activity with the appearance of salient environmental stimuli...
  31. pmc Dichotomous anatomical properties of adult striatal medium spiny neurons
    Tracy S Gertler
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 28:10814-24. 2008
    ..Thus, rather than being an intrinsically homogenous population, striatal MSNs have dichotomous somatodendritic properties that mirror differences in their network connections and biochemistry...
  32. ncbi request reprint HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons
    C Savio Chan
    Department of Physiology and Institute for Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 24:9921-32. 2004
    ....
  33. ncbi request reprint Modulation of striatal single units by expected reward: a spiny neuron model displaying dopamine-induced bistability
    Aaron J Gruber
    Department of Biomedical Engineering, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Neurophysiol 90:1095-114. 2003
    ..Our model provides a conceptual framework for understanding the functional significance of the short-term neuromodulatory actions of dopamine on signal processing in the striatum...
  34. ncbi request reprint Cholinergic modulation of Kir2 channels selectively elevates dendritic excitability in striatopallidal neurons
    Weixing Shen
    Department of Physiology and Institute of Neuroscience, Feinberg School of Medicine, Northwestern University, 303 E Chicago Ave, Chicago, Illinois 60611, USA
    Nat Neurosci 10:1458-66. 2007
    ..This cell type-specific enhancement of dendritic excitability is an essential trigger for synaptic pruning after dopamine depletion, as pruning was prevented by genetic deletion of M1 muscarinic receptors...
  35. ncbi request reprint G-protein-coupled receptor modulation of striatal CaV1.3 L-type Ca2+ channels is dependent on a Shank-binding domain
    Patricia A Olson
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 25:1050-62. 2005
    ..Together, these results suggest that Shank promotes the assembly of a signaling complex at corticostriatal synapses that enables key GPCRs to regulate L-type Ca2+ channels and the integration of glutamatergic synaptic events...
  36. pmc Homeostatic regulation of dopaminergic neurons without dopamine
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 101:13103-4. 2004
  37. ncbi request reprint Transmitter modulation of slow, activity-dependent alterations in sodium channel availability endows neurons with a novel form of cellular plasticity
    David B Carr
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Neuron 39:793-806. 2003
    ..This process is strictly associated with neuronal activity and develops over seconds, endowing neurons with a novel form of cellular plasticity shaping synaptic integration, dendritic electrogenesis, and repetitive discharge...
  38. ncbi request reprint Peering into the dendritic machinery of striatal medium spiny neurons
    D James Surmeier
    Institute for Neuroscience, Northwestern University, Chicago, IL 60611, USA
    Neuron 44:401-2. 2004
    ..The results offer new insights into the workings of these clinically important yet mysterious neurons...
  39. pmc Coupling of L-type Ca2+ channels to KV7/KCNQ channels creates a novel, activity-dependent, homeostatic intrinsic plasticity
    Wendy W Wu
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    J Neurophysiol 100:1897-908. 2008
    ....
  40. ncbi request reprint Association of CaV1.3 L-type calcium channels with Shank
    Hua Zhang
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Neurosci 25:1037-49. 2005
    ..3 L-type Ca2+ channels in pCREB signaling...
  41. ncbi request reprint D2 dopamine receptor-mediated modulation of voltage-dependent Na+ channels reduces autonomous activity in striatal cholinergic interneurons
    Nicolas Maurice
    Department of Physiology and Institute for Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 24:10289-301. 2004
    ..These studies establish a cellular mechanism linking dopamine and the reduction in striatal cholinergic interneuron activity seen in the initial stages of associative learning...
  42. pmc Selective participation of somatodendritic HCN channels in inhibitory but not excitatory synaptic integration in neurons of the subthalamic nucleus
    Jeremy F Atherton
    Department of Physiology, Northwestern University, Chicago, IL, USA
    J Neurosci 30:16025-40. 2010
    ..Together the data demonstrate that HCN channels in STN neurons selectively counteract GABA(A) receptor-mediated inhibition arising from the globus pallidus and thus promote single-spike activity rather than rebound burst firing...
  43. ncbi request reprint Nav1.6 sodium channels are critical to pacemaking and fast spiking in globus pallidus neurons
    Jeff N Mercer
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 27:13552-66. 2007
    ..6 Na+ channels with prominent resurgent gating...
  44. pmc Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB
    Hua Zhang
    Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Eur J Neurosci 23:2297-310. 2006
    ..3 channels play a more important role in pCREB signaling in striatal medium spiny neurons than in hippocampal neurons. Our results provide novel insights into the function of CaV1.2 and CaV1.3 L-type Ca2+ channels in the brain...
  45. pmc Robust pacemaking in substantia nigra dopaminergic neurons
    Jaime N Guzman
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 29:11011-9. 2009
    ....
  46. pmc Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines
    Zhong Xie
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Neuron 56:640-56. 2007
    ....
  47. ncbi request reprint Stimulation of 5-HT(2) receptors in prefrontal pyramidal neurons inhibits Ca(v)1.2 L type Ca(2+) currents via a PLCbeta/IP3/calcineurin signaling cascade
    Michelle Day
    Department of Physiology Northwestern University Institute for Neuroscience, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Neurophysiol 87:2490-504. 2002
    ..2 L-type Ca(2+) currents. This modulation and its blockade by atypical neuroleptics could have wide-ranging effects on synaptic integration and long-term gene expression in deep-layer prefrontal pyramidal neurons...
  48. pmc RGS9-2 modulates D2 dopamine receptor-mediated Ca2+ channel inhibition in rat striatal cholinergic interneurons
    Theresa M Cabrera-Vera
    Institute for Neuroscience and Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 101:16339-44. 2004
    ..These results implicate RGS9-2 as a specific regulator of dopamine receptor-mediated signaling in the striatum and identify a role for GAP activity modulation by the DEP-GGL domain...
  49. ncbi request reprint "The little engine that could": voltage-dependent Na(+) channels and the subthalamic nucleus
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Neuron 39:5-6. 2003
    ..Why this strategy works is unclear. The work by Do and Bean shows that the Na channels in STN neurons have distinctive features--like resurgence--that regulate their spiking behavior, providing new insights into the mechanism of DBS...
  50. doi request reprint Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2
    Che Chien Chang
    Department of Chemistry, Center for Molecular Innovation and Drug Discovery, and Chemistry of Life Processes Institute, Northwestern University, Evanston, Il 60208 3113, USA
    Bioorg Med Chem 18:3147-58. 2010
    ..3 selectivity was only about twofold. These results support a highly similar dihydropyridine binding site at both Ca(V)1.2 and Ca(V)1.3 channels and suggests that other classes of compounds need to be identified for Ca(V)1.3 selectivity...
  51. ncbi request reprint Cholinergic suppression of KCNQ channel currents enhances excitability of striatal medium spiny neurons
    Weixing Shen
    Department of Physiology, Institute for Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 25:7449-58. 2005
    ....
  52. pmc Corticostriatal and thalamostriatal synapses have distinctive properties
    Jun Ding
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 28:6483-92. 2008
    ....
  53. ncbi request reprint Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels
    Michelle Day
    Department of Physiology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Neurosci 25:8776-87. 2005
    ..These studies show that HCN channels are key regulators of synaptic integration in prefrontal pyramidal neurons but that their functional contribution is dependent on a partnership with Kir2 and Kleak channels...
  54. ncbi request reprint Striatal information signaling and integration in globus pallidus: timing matters
    C Savio Chan
    Department of Physiology and Institute for Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Neurosignals 14:281-9. 2005
    ....
  55. ncbi request reprint Kv3.4 subunits enhance the repolarizing efficiency of Kv3.1 channels in fast-spiking neurons
    Gytis Baranauskas
    Department of Physiology, Feinberg School of Medicine, 303 E Chicago Ave, Northwestern University, Chicago, Illinois 60611, USA
    Nat Neurosci 6:258-66. 2003
    ..These results suggest that manipulation of K3.4 subunit expression could be a useful means of controlling the dynamic range of FS neurons...
  56. ncbi request reprint Kv1.2-containing K+ channels regulate subthreshold excitability of striatal medium spiny neurons
    Weixing Shen
    Department of Physiology and Institute for Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurophysiol 91:1337-49. 2004
    ..These studies establish a clear functional role for somato-dendritic Kv1.2 channels in the regulation of state transitions and repetitive discharge in striatal medium spiny neurons...
  57. ncbi request reprint Serotonin receptor activation inhibits sodium current and dendritic excitability in prefrontal cortex via a protein kinase C-dependent mechanism
    David B Carr
    Department of Physiology, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 22:6846-55. 2002
    ..These findings show that 5-HT2a,c receptor activation reduces dendritic excitability and may negatively modulate activity-dependent dendritic synaptic plasticity...
  58. pmc Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes
    Michael E Cahill
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:13058-63. 2009
    ..Several of these deficits are delayed and age-dependent. Our study thus links spine morphogenic signaling with age-dependent, delayed, disease-related phenotypes, including cognitive dysfunction...
  59. ncbi request reprint Enhancement of excitatory synaptic integration by GABAergic inhibition in the subthalamic nucleus
    Jerome Baufreton
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 25:8505-17. 2005
    ..These observations suggest that feedback inhibition from the GP is critical for the emergence of coherent beta-oscillations between the cortex and STN in PD...
  60. ncbi request reprint Sodium currents in medullary neurons isolated from the pre-Bötzinger complex region
    Krzysztof Ptak
    Department of Physiology and Institute for Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 3008, USA
    J Neurosci 25:5159-70. 2005
    ..In the rostral ventral respiratory group (immediately caudal to preBötC), I(NaP) was also detected, but peak conductance, current density, and input resistance were smaller than in preBötC region cells...
  61. pmc Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function
    Alan S Lewis
    The Ken and Ruth Davee Department of Neurology and Clinical Neurosciences, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 29:6250-65. 2009
    ..Because I(h) expression is altered in models of several diseases, including temporal lobe epilepsy, TRIP8b may play a role in both normal neuronal function and in aberrant neuronal excitability associated with neurological disease...

Research Grants24

  1. DOPAMINERGIC AND MUSCARINIC SIGNALING IN THE STRIATUM
    DALTON JAMES SURMEIER; Fiscal Year: 2010
    ..Therapeutic strategies based upon insights gained with these tools during the last grant period already have been tested in preclinical studies and yielded encouraging results, providing a strong motivation for continued study. ..
  2. DOPAMINERGIC AND MUSCARINIC SIGNALING IN THE STRIATUM
    DALTON JAMES SURMEIER; Fiscal Year: 2010
    ..Therapeutic strategies based upon insights gained with these tools during the last grant period already have been tested in preclinical studies and yielded encouraging results, providing a strong motivation for continued study. ..
  3. DOPAMINERGIC AND MUSCARINIC SIGNALING IN THE STRIATUM
    DALTON SURMEIER; Fiscal Year: 2007
    ....
  4. MONOAMINERGIC MODULATION OF PREFRONTAL CORTEX
    DALTON SURMEIER; Fiscal Year: 2004
    ..Achieving these specific aims will provide the molecular and cellular framework necessary to begin building an accurate, integrative model of PFC function and dysfunction in schizophrenia. ..
  5. WINTER CONFERENCE ON BRAIN RESEARCH
    DALTON SURMEIER; Fiscal Year: 2005
    ..Particular emphasis will be placed on obtaining a diverse group of fellows with respect to parent institution, gender, and minority status. ..
  6. General Motor Control Mechanisms and Disease Training Program
    DALTON SURMEIER; Fiscal Year: 2007
    ..The program outlined attempts to exemplify the multidisciplinary and interactive type of neuroscience research training encouraged by NINDS. ..
  7. Rhythmicity and Synchrony in the Basal Ganglia
    DALTON SURMEIER; Fiscal Year: 2007
    ..abstract_text> ..
  8. DOPAMINERGIC AND MUSCARINIC SIGNALING IN THE STRIATUM
    DALTON SURMEIER; Fiscal Year: 2009
    ..Therapeutic strategies based upon insights gained with these tools during the last grant period already have been tested in preclinical studies and yielded encouraging results, providing a strong motivation for continued study. ..
  9. MONOAMINERGIC MODULATION OF PREFRONTAL CORTEX
    DALTON SURMEIER; Fiscal Year: 2003
    ..Achieving these specific aims will provide the molecular and cellular framework necessary to begin building an accurate, integrative model of PFC function and dysfunction in schizophrenia. ..
  10. DOPAMINERGIC AND CHOLINERGIC SIGNALING IN THE STRIATUM
    DALTON SURMEIER; Fiscal Year: 1999
    ..In so doing, it should open the door to the development of novel and powerful therapeutic strategies not only for Parkinson's disease but other disorders with neostriatal determinants such as schizophrenia. ..
  11. DOPAMINERGIC AND CHOLINERGIC SIGNALING IN THE STRIATUM
    DALTON SURMEIER; Fiscal Year: 2000
    ..In so doing, it should open the door to the development of novel and powerful therapeutic strategies not only for Parkinson's disease but other disorders with neostriatal determinants such as schizophrenia. ..
  12. MONOAMINERGIC MODULATION OF PREFRONTAL CORTEX
    DALTON SURMEIER; Fiscal Year: 2000
    ..Achieving these specific aims will provide the molecular and cellular framework necessary to begin building an accurate, integrative model of PFC function and dysfunction in schizophrenia. ..
  13. MONOAMINERGIC MODULATION OF PREFRONTAL CORTEX
    DALTON SURMEIER; Fiscal Year: 2001
    ..Achieving these specific aims will provide the molecular and cellular framework necessary to begin building an accurate, integrative model of PFC function and dysfunction in schizophrenia. ..
  14. DOPAMINERGIC AND CHOLINERGIC SIGNALING IN THE STRIATUM
    DALTON SURMEIER; Fiscal Year: 2001
    ..In so doing, it should open the door to the development of novel and powerful therapeutic strategies not only for Parkinson's disease but other disorders with neostriatal determinants such as schizophrenia. ..
  15. MONOAMINERGIC MODULATION OF PREFRONTAL CORTEX
    DALTON SURMEIER; Fiscal Year: 2002
    ..Achieving these specific aims will provide the molecular and cellular framework necessary to begin building an accurate, integrative model of PFC function and dysfunction in schizophrenia. ..