Robin Steinhorn

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi Altered endothelium-dependent relaxations in lambs with high pulmonary blood flow and pulmonary hypertension
    R H Steinhorn
    Department of Pediatrics, Northwestern University, Chicago, Illinois 60614, USA
    Am J Physiol Heart Circ Physiol 280:H311-7. 2001
  2. ncbi Inhaled nitric oxide for premature infants with severe respiratory failure
    Krisa P Van Meurs
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, Calif 94304, USA
    N Engl J Med 353:13-22. 2005
  3. doi Intravenous sildenafil in the treatment of neonates with persistent pulmonary hypertension
    Robin H Steinhorn
    Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital, Chicago, IL 60614, USA
    J Pediatr 155:841-847.e1. 2009
  4. pmc Pharmacotherapy for pulmonary hypertension
    Robin H Steinhorn
    Department of Pediatrics, The Ann and Robert H Lurie Children s Hospital of Chicago, Northwestern University, 225 East Chicago Avenue, Chicago, IL 60611, USA
    Pediatr Clin North Am 59:1129-46. 2012
  5. ncbi Recombinant human superoxide dismutase enhances the effect of inhaled nitric oxide in persistent pulmonary hypertension
    R H Steinhorn
    Department of Pediatrics, Northwestern University, Chicago, Illinois, USA
    Am J Respir Crit Care Med 164:834-9. 2001
  6. pmc Therapeutic approaches using nitric oxide in infants and children
    Robin H Steinhorn
    Department of Pediatrics, Children s Memorial Hospital and Northwestern University s Feinberg School of Medicine, Chicago, IL 60614, USA
    Free Radic Biol Med 51:1027-34. 2011
  7. pmc Neonatal pulmonary hypertension
    Robin H Steinhorn
    Division of Neonatology, Children s Memorial Hospital, Northwestern University s Feinberg School of Medicine, Chicago, IL, USA
    Pediatr Crit Care Med 11:S79-84. 2010
  8. pmc Nitric oxide and beyond: new insights and therapies for pulmonary hypertension
    R H Steinhorn
    Department of Pediatrics, Division of Neonatology, Children s Memorial Hospital, Northwestern University s Feinberg School of Medicine, Chicago, IL 60614, USA
    J Perinatol 28:S67-71. 2008
  9. pmc Superoxide dismutase improves oxygenation and reduces oxidation in neonatal pulmonary hypertension
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York at Buffalo, NY, USA
    Am J Respir Crit Care Med 174:1370-7. 2006
  10. pmc Increased hydrogen peroxide downregulates soluble guanylate cyclase in the lungs of lambs with persistent pulmonary hypertension of the newborn
    Stephen Wedgwood
    Dept of Pediatrics, Northwestern University, Chicago, Illinois, USA
    Am J Physiol Lung Cell Mol Physiol 289:L660-6. 2005

Research Grants

Detail Information

Publications35

  1. ncbi Altered endothelium-dependent relaxations in lambs with high pulmonary blood flow and pulmonary hypertension
    R H Steinhorn
    Department of Pediatrics, Northwestern University, Chicago, Illinois 60614, USA
    Am J Physiol Heart Circ Physiol 280:H311-7. 2001
    ..We conclude that increased pulmonary blood flow induces an impairment of endothelium-dependent relaxation that is selective to PAs. The impaired relaxation may be mediated in part by excess superoxide production...
  2. ncbi Inhaled nitric oxide for premature infants with severe respiratory failure
    Krisa P Van Meurs
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, Calif 94304, USA
    N Engl J Med 353:13-22. 2005
    ..We conducted a multicenter, randomized, blinded, controlled trial to determine whether inhaled nitric oxide reduced the rate of death or bronchopulmonary dysplasia in such infants...
  3. doi Intravenous sildenafil in the treatment of neonates with persistent pulmonary hypertension
    Robin H Steinhorn
    Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital, Chicago, IL 60614, USA
    J Pediatr 155:841-847.e1. 2009
    ..To evaluate the safety of intravenous (IV) sildenafil, an inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase, in treating near-term and term newborns with persistent pulmonary hypertension of the newborn (PPHN)...
  4. pmc Pharmacotherapy for pulmonary hypertension
    Robin H Steinhorn
    Department of Pediatrics, The Ann and Robert H Lurie Children s Hospital of Chicago, Northwestern University, 225 East Chicago Avenue, Chicago, IL 60611, USA
    Pediatr Clin North Am 59:1129-46. 2012
    ..This review discusses currently available therapies for pediatric pulmonary hypertension, their biological rationales, and evidence for their clinical effectiveness...
  5. ncbi Recombinant human superoxide dismutase enhances the effect of inhaled nitric oxide in persistent pulmonary hypertension
    R H Steinhorn
    Department of Pediatrics, Northwestern University, Chicago, Illinois, USA
    Am J Respir Crit Care Med 164:834-9. 2001
    ..We conclude that rhSOD reduces pulmonary vascular resistance and facilitates the action of iNO in a lamb model of PPHN. This suggests that rhSOD may prove to be an effective adjunctive treatment for newborns with PPHN...
  6. pmc Therapeutic approaches using nitric oxide in infants and children
    Robin H Steinhorn
    Department of Pediatrics, Children s Memorial Hospital and Northwestern University s Feinberg School of Medicine, Chicago, IL 60614, USA
    Free Radic Biol Med 51:1027-34. 2011
    ....
  7. pmc Neonatal pulmonary hypertension
    Robin H Steinhorn
    Division of Neonatology, Children s Memorial Hospital, Northwestern University s Feinberg School of Medicine, Chicago, IL, USA
    Pediatr Crit Care Med 11:S79-84. 2010
    ..Finally, this field is rapidly evolving, and the rationale for promising new treatment approaches is reviewed, including inhibition of phosphodiesterases and scavengers of reactive oxygen species...
  8. pmc Nitric oxide and beyond: new insights and therapies for pulmonary hypertension
    R H Steinhorn
    Department of Pediatrics, Division of Neonatology, Children s Memorial Hospital, Northwestern University s Feinberg School of Medicine, Chicago, IL 60614, USA
    J Perinatol 28:S67-71. 2008
    ..Finally, the rationale for new treatment approaches is reviewed, including inhibition of cyclic guanosine monophosphate-specific phosphodiesterases and scavengers of reactive oxygen species...
  9. pmc Superoxide dismutase improves oxygenation and reduces oxidation in neonatal pulmonary hypertension
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York at Buffalo, NY, USA
    Am J Respir Crit Care Med 174:1370-7. 2006
    ....
  10. pmc Increased hydrogen peroxide downregulates soluble guanylate cyclase in the lungs of lambs with persistent pulmonary hypertension of the newborn
    Stephen Wedgwood
    Dept of Pediatrics, Northwestern University, Chicago, Illinois, USA
    Am J Physiol Lung Cell Mol Physiol 289:L660-6. 2005
    ..Overall our data suggest a role for H(2)O(2) in the abnormal vasodilation associated with the pulmonary arteries of PPHN lambs...
  11. doi Implications of the U.S. Food and Drug Administration warning against the use of sildenafil for the treatment of pediatric pulmonary hypertension
    Steven H Abman
    Department of Pediatrics, Pediatric Pulmonary Hypertension Network, University of Colorado School of Medicine, 13123 East 16th Avenue, Aurora, CO 80045, USA
    Am J Respir Crit Care Med 187:572-5. 2013
    ..Pediatric patients with PAH require close surveillance and frequent monitoring, and persistent sildenafil monotherapy is likely insufficient with disease progression...
  12. pmc Regulation of phosphodiesterase 3 in the pulmonary arteries during the perinatal period in sheep
    Bernadette Chen
    Department of Pediatrics, Northwestern University, Chicago, Illinois 60611, USA
    Pediatr Res 66:682-7. 2009
    ..The vasodilatory effects of milrinone were most pronounced in vessels from lambs with the highest PDE3 activity, i.e., 1dSB and 100% O2 + iNO lambs. Thus, milrinone may be most beneficial when used in conjunction with iNO...
  13. pmc Superoxide dismutase restores eNOS expression and function in resistance pulmonary arteries from neonatal lambs with persistent pulmonary hypertension
    Kathryn N Farrow
    Dept of Pediatrics, Northwestern Univ Feinberg School of Medicine, 303 E Chicago Ave, Ward 12 196, Chicago, IL 60611, USA
    Am J Physiol Lung Cell Mol Physiol 295:L979-87. 2008
    ..Thus therapies designed to decrease oxidative stress and restore eNOS coupling, such as rhSOD, may prove useful in the treatment of PPHN in newborn infants...
  14. pmc Oxygen concentration and pulmonary hemodynamics in newborn lambs with pulmonary hypertension
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York, Buffalo, New York 14214, USA
    Pediatr Res 66:539-44. 2009
    ..Hypoxia increases PVR but hyperoxia does not confer significant additional pulmonary vasodilation in lambs with PPHN...
  15. pmc SOD and inhaled nitric oxide normalize phosphodiesterase 5 expression and activity in neonatal lambs with persistent pulmonary hypertension
    Kathryn N Farrow
    Dept of Pediatrics, Northwestern Univ Feinberg School of Medicine, 310 E Superior St, Morton 4 685D, Chicago, IL 60611, USA
    Am J Physiol Lung Cell Mol Physiol 299:L109-16. 2010
    ..The addition of either iNO or rhSOD normalized PDE5 and cGMP levels. Thus therapies designed to decrease PDE5 and increase cGMP, such as iNO and rhSOD, may prove useful in the treatment of PPHN in newborn infants...
  16. pmc Mitochondrial oxidant stress increases PDE5 activity in persistent pulmonary hypertension of the newborn
    Kathryn N Farrow
    Department of Pediatrics, Northwestern University, Chicago, IL 60611, United States
    Respir Physiol Neurobiol 174:272-81. 2010
    ..We conclude that baseline PDE5 activity and oxidative stress is increased in PPHN PASMC, and scavenging H2O2 is sufficient to block oxidant-mediated increases in PDE5 activity in PPHN...
  17. ncbi Alterations in nitric oxide production in 8-week-old lambs with increased pulmonary blood flow
    Stephen M Black
    Department of Pediatrics, Northwestern University, Chicago, Illinois, USA
    Pediatr Res 52:233-44. 2002
    ..We speculate that the progressive decrease in basal NO activity participates in the development of pulmonary hypertension secondary to increased pulmonary blood flow...
  18. pmc Hyperoxia increases phosphodiesterase 5 expression and activity in ovine fetal pulmonary artery smooth muscle cells
    Kathryn N Farrow
    Division of Neonatology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    Circ Res 102:226-33. 2008
    ..These data suggest that PDE5 expression and activity play a critical role in modulating neonatal pulmonary vascular tone in response to common clinical treatments for PPHN, such as oxygen and inhaled NO...
  19. ncbi Use of inhaled nitric oxide in the preterm infant
    Robin H Steinhorn
    Children s Memorial Hospital and Northwestern University, Chicago, Illinois 60614, USA
    Curr Opin Pediatr 19:137-41. 2007
    ..The purpose of this review is to summarize the results of the most recent preclinical studies and clinical trials...
  20. ncbi The diseases treated with ECMO: focus on PPHN
    Kathryn N Farrow
    Division of Neonatology, Children s Memorial Hospital and Northwestern University, Chicago, IL, USA
    Semin Perinatol 29:8-14. 2005
    ..The pathophysiology of each type is dependent on the point in gestation when the normal transition to extrauterine life fails. This article will discuss the known pathophysiology in PPHN and new treatment modalities...
  21. ncbi Neonatal extracorporeal life support: impact of new therapies on survival
    Paola J Fliman
    Division of Neonatology, Northwestern University, Chicago, Illinois, USA
    J Pediatr 148:595-9. 2006
    ..To evaluate the effects of pre-extracorporeal life support (ECLS) management with nitric oxide (NO), high frequency ventilation (HFV), and surfactant on mortality among neonates supported with ECLS...
  22. pmc eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally
    Eugenia Mata-Greenwood
    Dept of Pediatrics, Northwestern Univ, Ward 12 191, 303 E Chicago Ave, Chicago, IL 60611 008, USA
    Am J Physiol Lung Cell Mol Physiol 290:L232-41. 2006
    ..We speculate this may be related to cellular production and/or maintenance of BH4 levels...
  23. pmc The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow
    Satyan Lakshminrusimha
    Department of Pediatrics, Women s and Children s Hospital of Buffalo, State University of New York at Buffalo, NY 14222, USA
    Am J Physiol Heart Circ Physiol 293:H1491-7. 2007
    ..The redox environment, influenced by the balance between production and scavenging of ROS, may have important consequences on pulmonary vascular reactivity in the setting of increased Q(p)...
  24. pmc Selective type 5 phosphodiesterase inhibition alters pulmonary hemodynamics and lung liquid production in near-term fetal lambs
    Robert C Dukarm
    Department of Pediatrics, State University of New York at Buffalo, NY, USA
    J Appl Physiol (1985) 99:2331-6. 2005
    ..In contrast, the effects on E4021 on net lung liquid production appear to be independent of nitric oxide synthase, suggesting that these two critical perinatal events might be modulated independently...
  25. ncbi Increased superoxide generation is associated with pulmonary hypertension in fetal lambs: a role for NADPH oxidase
    Lisa A Brennan
    Department of Pediatrics, Northwestern University, Ward 12 191, 303 E Chicago Ave, Chicago, Ill 60611 3008, USA
    Circ Res 92:683-91. 2003
    ....
  26. pmc Pulmonary arterial contractility in neonatal lambs increases with 100% oxygen resuscitation
    Satyan Lakshminrusimha
    Department of Pediatrics, University at Buffalo, New York 14222, USA
    Pediatr Res 59:137-41. 2006
    ..PA contractility to NE and KCl is increased following both brief (30 min) and prolonged (24 h) exposure to 100% oxygen during mechanical ventilation. In contrast, normoxic resuscitation and ventilation do not increase PA contractility...
  27. pmc Ovine bronchial-derived relaxing factor: changes with development and hyperoxic ventilation
    Satyan Lakshminrusimha
    Division of Neonatology, Department of Pediatrics, Center for Developmental Biology of the Lung, State University of New York at Buffalo, Women and Children s Hospital of Buffalo, 219 Bryant St, Buffalo, New York 14222, USA
    J Appl Physiol (1985) 101:135-9. 2006
    ..We speculate that BrDRF may have an important role in postnatal changes in pulmonary arterial reactivity...
  28. ncbi Alterations in TGF-beta1 expression in lambs with increased pulmonary blood flow and pulmonary hypertension
    Eugenia Mata-Greenwood
    Department of Pediatrics, Northwestern University, Chicago, Illinois 60611 3008, USA
    Am J Physiol Lung Cell Mol Physiol 285:L209-21. 2003
    ..Our data suggest that increased pulmonary blood flow dysregulates TGF-beta1 signaling, producing imbalance between pro- and antiangiogenic signaling that may be important in vascular remodeling in shunted lambs...
  29. pmc Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn
    Satyan Lakshminrusimha
    Department of Pediatrics, University of Buffalo, Buffalo, NY, USA
    Pediatr Crit Care Med 10:106-12. 2009
    ..Forskolin is a direct stimulant of AC. Phosphodiesterase 3 hydrolyzes cAMP and is inhibited by milrinone...
  30. pmc Pulmonary hemodynamics in neonatal lambs resuscitated with 21%, 50%, and 100% oxygen
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Pediatr Res 62:313-8. 2007
    ..We conclude that, while ventilation with 100% O2 at birth results in a greater initial decrease in PVR, subsequent pulmonary vasodilation to NO/acetylcholine is impaired...
  31. ncbi Inhaled prostacyclin for term infants with persistent pulmonary hypertension refractory to inhaled nitric oxide
    Lisa K Kelly
    Department of Pediatrics, Children s Memorial Hospital and Northwestern University Medical School, Chicago, Illinois 60614, USA
    J Pediatr 141:830-2. 2002
    ..The condition of one infant subsequently deteriorated, and alveolar capillary dysplasia was found at autopsy. The surviving infants were discharged with normal oxygen saturations in room air...
  32. pmc Inhaled NO in the experimental setting
    Nicolas F m Porta
    Children s Memorial Hospital and Northwestern University, Chicago, IL, United States
    Early Hum Dev 84:717-23. 2008
    ..In addition, laboratory and clinical studies addressing a potential role for iNO as a therapeutic modality for the preterm infant are reviewed...
  33. ncbi Emergence of smooth muscle cell endothelin B-mediated vasoconstriction in lambs with experimental congenital heart disease and increased pulmonary blood flow
    Stephen M Black
    Department of Pediatrics, Northwestern University, Chicago, Ill, USA
    Circulation 108:1646-54. 2003
    ..The objective of this study was to investigate the role of potential later alterations of the ET cascade in the pathophysiology of pulmonary hypertension secondary to increased pulmonary blood flow...
  34. ncbi Nitric oxide decreases endothelin-1 secretion through the activation of soluble guanylate cyclase
    Lisa K Kelly
    International Heart Institute of Montana, St Patrick Hospital, 554 W Broadway, Missoula, MT 59802, USA
    Am J Physiol Lung Cell Mol Physiol 286:L984-91. 2004
    ..Therefore, we conclude that exposure of 4-wk PAECs to exogenous NO decreases secreted ET-1 resulting from the activation of sGC and increased cGMP generation...
  35. ncbi Type I nitric oxide synthase is decreased in the fetal pulmonary circulation of hypertensive lambs
    Ching Tzao
    Department of Pathology, State University of New York at Buffalo, Buffalo, New York, USA
    Pediatr Pulmonol 33:437-42. 2002
    ..We conclude that there is a heterogeneous distribution of NOS-I in the normal fetal sheep lung, but that NOS-I staining is significantly reduced in lambs with PPHN...

Research Grants9

  1. CGMP REGULATION IN THE DEVELOPING PULMONARY VASCULATURE
    Robin Steinhorn; Fiscal Year: 2006
    ..To accomplish specific aim 2, we will primarily use in vivo studies to test the hypothesis that scavenging superoxide with rhSOD increases endogenous NO production via changes in NOS expression and/or activity. ..
  2. CGMP REGULATION IN THE DEVELOPING PULMONARY VASCULATURE
    Robin Steinhorn; Fiscal Year: 2007
    ..To accomplish specific aim 2, we will primarily use in vivo studies to test the hypothesis that scavenging superoxide with rhSOD increases endogenous NO production via changes in NOS expression and/or activity. ..
  3. CGMP REGULATION IN THE DEVELOPING PULMONARY VASCULATURE
    Robin Steinhorn; Fiscal Year: 2009
    ..To accomplish specific aim 2, we will primarily use in vivo studies to test the hypothesis that scavenging superoxide with rhSOD increases endogenous NO production via changes in NOS expression and/or activity. ..
  4. REDOX REGULATION IN THE PERINATAL PULMONARY VASCULATURE
    Robin H Steinhorn; Fiscal Year: 2010
    ..Our research should lead to therapies that reduce oxygen toxicity, improve immediate and long- term clinical outcomes, and substantially reduce the health care costs associated with this syndrome. ..