Deepak P Srivastava

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Rapid estradiol modulation of neuronal connectivity and its implications for disease
    Deepak P Srivastava
    Department of Physiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA
    Front Endocrinol (Lausanne) 2:77. 2011
  2. pmc Rapid estrogen signaling in the brain: implications for the fine-tuning of neuronal circuitry
    Deepak P Srivastava
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 31:16056-63. 2011
  3. pmc Estrogen receptor ß activity modulates synaptic signaling and structure
    Deepak P Srivastava
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 30:13454-60. 2010
  4. pmc Coordination of synaptic adhesion with dendritic spine remodeling by AF-6 and kalirin-7
    Zhong Xie
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 28:6079-91. 2008
  5. pmc Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines
    Kevin M Woolfrey
    Department of Physiology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Neurosci 12:1275-84. 2009
  6. pmc Rapid enhancement of two-step wiring plasticity by estrogen and NMDA receptor activity
    Deepak P Srivastava
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 105:14650-5. 2008
  7. pmc Social, communication, and cortical structural impairments in Epac2-deficient mice
    Deepak P Srivastava
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 32:11864-78. 2012
  8. pmc Afadin is required for maintenance of dendritic structure and excitatory tone
    Deepak P Srivastava
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Biol Chem 287:35964-74. 2012
  9. pmc Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling
    Kelly A Jones
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:19575-80. 2009
  10. doi Convergent CaMK and RacGEF signals control dendritic structure and function
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Trends Cell Biol 18:405-13. 2008

Collaborators

Detail Information

Publications16

  1. pmc Rapid estradiol modulation of neuronal connectivity and its implications for disease
    Deepak P Srivastava
    Department of Physiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA
    Front Endocrinol (Lausanne) 2:77. 2011
    ..We will then go on to discuss the potential role of 17 β-estradiol modulation of neural circuits and its potential relevance for the treatment of psychiatric and neurodevelopmental disorders...
  2. pmc Rapid estrogen signaling in the brain: implications for the fine-tuning of neuronal circuitry
    Deepak P Srivastava
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 31:16056-63. 2011
    ....
  3. pmc Estrogen receptor ß activity modulates synaptic signaling and structure
    Deepak P Srivastava
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 30:13454-60. 2010
    ..These results implicate ERβ signaling in controlling dendritic spine morphology, in part via a PAK/ERK1/2-dependent pathway, and provide mechanistic insight into the rapid cellular effects of estrogen on brain function...
  4. pmc Coordination of synaptic adhesion with dendritic spine remodeling by AF-6 and kalirin-7
    Zhong Xie
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 28:6079-91. 2008
    ....
  5. pmc Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines
    Kevin M Woolfrey
    Department of Physiology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Neurosci 12:1275-84. 2009
    ..Thus, we identify a previously unknown mechanism that promotes dynamic remodeling and depression of spiny synapses, disruption of which may contribute to some aspects of disease...
  6. pmc Rapid enhancement of two-step wiring plasticity by estrogen and NMDA receptor activity
    Deepak P Srivastava
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 105:14650-5. 2008
    ..This work describes a form of two-step wiring plasticity relevant for cortical memory and identifies targets that may facilitate recovery from brain injuries...
  7. pmc Social, communication, and cortical structural impairments in Epac2-deficient mice
    Deepak P Srivastava
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 32:11864-78. 2012
    ..Together, these findings provide novel insight into the molecular and cellular substrates of social and communication behavior...
  8. pmc Afadin is required for maintenance of dendritic structure and excitatory tone
    Deepak P Srivastava
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Biol Chem 287:35964-74. 2012
    ..Collectively, these data suggest that afadin is required for the maintenance of dendritic structure and excitatory tone...
  9. pmc Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling
    Kelly A Jones
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:19575-80. 2009
    ..These results suggest a potential role for serotonin signaling in modulating spine morphology and kalirin-7's function at cortical synapses...
  10. doi Convergent CaMK and RacGEF signals control dendritic structure and function
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Trends Cell Biol 18:405-13. 2008
    ..Through this pathway, CaMKs and RacGEFs amplify calcium signals and translate them into spatially and temporally regulated structural remodeling of dendritic spines...
  11. pmc Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines
    Zhong Xie
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Neuron 56:640-56. 2007
    ....
  12. pmc Segregated populations of hippocampal principal CA1 neurons mediating conditioning and extinction of contextual fear
    Natalie C Tronson
    Department of Psychiatry and Behavioral Sciences, The Asher Center for the Study, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 29:3387-94. 2009
    ..These results demonstrate that extinction mechanisms based on Erk signaling involve a specific population of CA1 principal neurons distinctively regulated by afferent cholinergic input from the medial septum...
  13. pmc An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice
    Deepak P Srivastava
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS Biol 10:e1001350. 2012
    ....
  14. pmc Epac2-mediated dendritic spine remodeling: implications for disease
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Cell Neurosci 46:368-80. 2011
    ....
  15. doi Not just actin? A role for dynamic microtubules in dendritic spines
    Peter Penzes
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Neuron 61:3-5. 2009
    ..Microtubules, long thought to be absent from dendritic spines, are capable of controlling spine morphology, opening up a new line of investigation into mechanisms of spine plasticity and maintenance...
  16. pmc N-cadherin regulates cytoskeletally associated IQGAP1/ERK signaling and memory formation
    Christina Schrick
    Department of Psychiatry and Behavioral Sciences, The Asher Center for Depressive Disorders, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Neuron 55:786-98. 2007
    ..The data suggest that the newly identified role of hippocampal N-cadherin in memory consolidation may be mediated, at least in part, by cytoskeletal IQGAP1/Erk signaling...